bemoradan: RN & structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 5362399 |
CHEMBL ID | 46765 |
SCHEMBL ID | 121664 |
MeSH ID | M0172862 |
Synonym |
---|
bemoradan |
rwj-22867 |
orf-22867 |
bemoradan (usan/inn) |
D03075 |
112018-01-6 |
orf 22867 |
CHEMBL46765 |
AKOS000279097 |
7-(4-methyl-6-oxo-4,5-dihydro-1h-pyridazin-3-yl)-4h-1,4-benzoxazin-3-one |
2h-1,4-benzoxazin-3(4h)-one, 7-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)- |
bemoradanum [inn-latin] |
bemoradanum |
7-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-2h-1,4-benzoxazin-3(4h)-one |
g2s2v1etbq , |
unii-g2s2v1etbq |
bemoradan [usan:inn] |
6-(3,4-dihydo-3-oxo-1,4(2h)-benzoxazin-7-yl)-2,3,4,5-tetrahydro-5-methylpyridazin-3-one |
2h-1,4-benzoxazin-3(4h)-one, 7-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-, (+-)- |
123169-88-0 |
bemoradan [usan] |
bemoradan [inn] |
SCHEMBL121664 |
6-(3,4-dihydro-3-oxo-1,4(2h)-benzoxazin-7-yl)-2,3,4,5-tetrahydro-5-methylpyridazin-3-one |
XZPGINPFWXLYNW-UHFFFAOYSA-N |
7-[(1,4,5,6-tetrahydro-4-methyl-6-oxopyridazin)-3-yl]-4h-1,4-benzoxazin-3(2h)-one |
bdbm50228430 |
Q27278659 |
7-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-2h-1,4-benzoxazin-3(4h)-one |
DTXSID50869548 |
AKOS040764860 |
HY-153168 |
CS-0653058 |
Bemoradan is a potent, long-acting orally active inodilator.
Excerpt | Reference | Relevance |
---|---|---|
"Bemoradan is a potent, long-acting orally active inodilator. " | ( Pharmacokinetics and bioavailability of bemoradan, a long-acting inodilator in healthy males. Abrams, LS; Brusser, L; Chien, SC; Huang, SM; Lasseter, K; Simon, D; Smith, IL, 1994) | 2 |
Excerpt | Reference | Relevance |
---|---|---|
" The pharmacokinetics and bioavailability of bemoradan were studied in twelve normal males following oral administration of single, ascending doses of the bemoradan HCL salt in capsules." | ( Pharmacokinetics and bioavailability of bemoradan, a long-acting inodilator in healthy males. Abrams, LS; Brusser, L; Chien, SC; Huang, SM; Lasseter, K; Simon, D; Smith, IL, 1994) | 0.82 |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | IC50 (µMol) | 0.3000 | 0.0000 | 2.0724 | 10.0000 | AID159204; AID159206 |
cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | IC50 (µMol) | 0.3000 | 0.0003 | 1.9901 | 10.0000 | AID159204; AID159206 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
endoplasmic reticulum | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) |
Golgi apparatus | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) |
cytosol | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) |
membrane | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) |
guanyl-nucleotide exchange factor complex | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) |
cytosol | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) |
membrane | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) |
cytosol | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID229994 | Index of contractility was determined as the ratio of % of dP/dtmax in conscious dog after (po) administration of 0.10 mg/kg | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID59676 | Effective dose required to increase the myocardial contractile force (CF) 50% above base line when administered intravenously. | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID57021 | Mean arterial blood pressure (MAP) in dog after intravenous dose of 0.075 mg/kg | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID59626 | Percent change in activity 8 hr after peroral administration in conscious dog at 0.10 mg/kg | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID59624 | Percent change in activity 8 hr after peroral administration in conscious dog at 0.01 mg/kg (Not determined) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID220557 | 50% increase in cardiac force in dog by intravenous dose | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Heteroatom analogues of bemoradan: chemistry and cardiotonic activity of 1,4-benzothiazinylpyridazinones. |
AID220555 | 50% increase in cardiac force in dog by id dose | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Heteroatom analogues of bemoradan: chemistry and cardiotonic activity of 1,4-benzothiazinylpyridazinones. |
AID159204 | Inhibition of cardiac phosphodiesterase-3 isolated from canine heart. | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID59627 | Percent change in activity 8 hr after peroral administration in conscious dog at 0.30 mg/kg | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID229996 | Index of contractility was determined as the ratio of % of dP/dtmax in conscious dog after (po) administration of a dose of 0.01 mg/kg | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID57016 | Heart rate (HR) in dog after intravenous dose of 0.075 mg/kg | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID229995 | Index of contractility was determined as the ratio of % of dP/dtmax in conscious dog after (po) administration of 0.30 mg/kg | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID57027 | Myocardial contractile force (CF) in dog after intravenous dose of 0.075 mg/kg | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. |
AID159206 | Inhibition of canine cardiac Phosphodiesterase 3 | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Heteroatom analogues of bemoradan: chemistry and cardiotonic activity of 1,4-benzothiazinylpyridazinones. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 7 (100.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 8 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |