thiophene-3-carboxylic acid profile

Thiophene-3-carboxylic acid is a heterocyclic organic compound with a thiophene ring and a carboxylic acid group attached at the 3-position. It is a versatile building block for the synthesis of various pharmaceutical and agrochemical compounds. It is commonly synthesized through the reaction of thiophene with carbon monoxide and hydrogen in the presence of a palladium catalyst. Thiophene-3-carboxylic acid has shown potential as an anti-inflammatory agent, antioxidant, and antibacterial agent in various studies. The unique structural features of thiophene-3-carboxylic acid, including its electron-rich thiophene ring and the acidic carboxylic acid group, contribute to its biological activities and its potential as a lead compound for drug discovery. Research on this compound is ongoing to explore its therapeutic applications and optimize its synthesis and properties.'

thiophene-3-carboxylic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	6918
CHEMBL ID	164585
SCHEMBL ID	152166
MeSH ID	M0546448

Synonym
AC-4905
3-thiophenecarboxylic
BIDD:GT0807
3-thiophenezoic acid
bdbm50074328
EN300-22996
NCIOPEN2_000030
thiophene-3-carboxylic acid
.beta.-thiophenic acid
3-thiophenecarboxylic acid ,
3-thenoic acid
88-13-1
nsc66314
nsc-66314
.beta.-thiophenecarboxylic acid
3-thiophenecarboxylic acid, 99%
einecs 201-802-5
nsc 66314
beta-thiophenic acid
3-thienylcarboxylic acid
beta-thiophenecarboxylic acid
brn 0001994
STK373639
AKOS000276783
CHEMBL164585 ,
ynvomsditjmnet-uhfffaoysa-
inchi=1/c5h4o2s/c6-5(7)4-1-2-8-3-4/h1-3h,(h,6,7)
T1084
HMS1738H11
3-thiophene carboxylic acid
thiophene-3-carboxylicacid
3-carboxythiophene
unii-6v3012q6be
6v3012q6be ,
5-18-06-00199 (beilstein handbook reference)
BP-20550
FT-0616409
AM20110264
PB18386
3-thenoic acid [mi]
SCHEMBL152166
mfcd00005467
SY001582
PS-5325
thiophen-3-carboxylic acid
3-thiophencarboxylic acid
3-thienoic acid
thiophene-3-caboxylic acid
thiophene-3-formic acid
Q-101197
F2191-0103
DTXSID40236745
P17867
CS-W004615
5-nitro-3,4-dihydro-1h-isoquinoline-2-carboxylicacidtert-butylester
Q27265560
HY-W004615
Z147647094

Protein Targets (7)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	24.7000	0.0000	0.1234	5.5000	AID726215
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	24.7000	0.0000	0.1082	5.5000	AID726215
D-amino-acid oxidase	Homo sapiens (human)	IC50 (µMol)	26.5333	0.0040	1.1199	10.0000	AID1422158; AID726221; AID726222
D-amino-acid oxidase	Homo sapiens (human)	Ki	17.8200	0.0130	2.1386	8.1600	AID726213; AID726214; AID726215
D-aspartate oxidase	Homo sapiens (human)	IC50 (µMol)	10,000.0000	0.0040	0.3937	0.8550	AID726223
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	0.2600	0.0002	1.1174	24.2210	AID224294
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	0.7000	0.0008	1.4238	8.4000	AID72281
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (92)

Process	via Protein(s)	Taxonomy
protein phosphorylation	Tyrosine-protein kinase Lck	Homo sapiens (human)
intracellular zinc ion homeostasis	Tyrosine-protein kinase Lck	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Tyrosine-protein kinase Lck	Homo sapiens (human)
response to xenobiotic stimulus	Tyrosine-protein kinase Lck	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase Lck	Homo sapiens (human)
hemopoiesis	Tyrosine-protein kinase Lck	Homo sapiens (human)
platelet activation	Tyrosine-protein kinase Lck	Homo sapiens (human)
T cell differentiation	Tyrosine-protein kinase Lck	Homo sapiens (human)
T cell costimulation	Tyrosine-protein kinase Lck	Homo sapiens (human)
positive regulation of heterotypic cell-cell adhesion	Tyrosine-protein kinase Lck	Homo sapiens (human)
intracellular signal transduction	Tyrosine-protein kinase Lck	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Tyrosine-protein kinase Lck	Homo sapiens (human)
Fc-gamma receptor signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
T cell receptor signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
positive regulation of T cell receptor signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
positive regulation of T cell activation	Tyrosine-protein kinase Lck	Homo sapiens (human)
leukocyte migration	Tyrosine-protein kinase Lck	Homo sapiens (human)
release of sequestered calcium ion into cytosol	Tyrosine-protein kinase Lck	Homo sapiens (human)
regulation of lymphocyte activation	Tyrosine-protein kinase Lck	Homo sapiens (human)
positive regulation of leukocyte cell-cell adhesion	Tyrosine-protein kinase Lck	Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase Lck	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
B cell receptor signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
response to singlet oxygen	Tyrosine-protein kinase Fyn	Homo sapiens (human)
neuron migration	Tyrosine-protein kinase Fyn	Homo sapiens (human)
stimulatory C-type lectin receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
adaptive immune response	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Tyrosine-protein kinase Fyn	Homo sapiens (human)
heart process	Tyrosine-protein kinase Fyn	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
calcium ion transport	Tyrosine-protein kinase Fyn	Homo sapiens (human)
G protein-coupled glutamate receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
axon guidance	Tyrosine-protein kinase Fyn	Homo sapiens (human)
learning	Tyrosine-protein kinase Fyn	Homo sapiens (human)
feeding behavior	Tyrosine-protein kinase Fyn	Homo sapiens (human)
regulation of cell shape	Tyrosine-protein kinase Fyn	Homo sapiens (human)
gene expression	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of gene expression	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of hydrogen peroxide biosynthetic process	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of neuron projection development	Tyrosine-protein kinase Fyn	Homo sapiens (human)
protein ubiquitination	Tyrosine-protein kinase Fyn	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
protein catabolic process	Tyrosine-protein kinase Fyn	Homo sapiens (human)
forebrain development	Tyrosine-protein kinase Fyn	Homo sapiens (human)
T cell costimulation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of protein ubiquitination	Tyrosine-protein kinase Fyn	Homo sapiens (human)
intracellular signal transduction	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to platelet-derived growth factor stimulus	Tyrosine-protein kinase Fyn	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of protein catabolic process	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Tyrosine-protein kinase Fyn	Homo sapiens (human)
response to ethanol	Tyrosine-protein kinase Fyn	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
ephrin receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
dendrite morphogenesis	Tyrosine-protein kinase Fyn	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
activated T cell proliferation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
modulation of chemical synaptic transmission	Tyrosine-protein kinase Fyn	Homo sapiens (human)
T cell receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
leukocyte migration	Tyrosine-protein kinase Fyn	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to hydrogen peroxide	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of protein targeting to membrane	Tyrosine-protein kinase Fyn	Homo sapiens (human)
dendritic spine maintenance	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of protein localization to nucleus	Tyrosine-protein kinase Fyn	Homo sapiens (human)
regulation of glutamate receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of dendritic spine maintenance	Tyrosine-protein kinase Fyn	Homo sapiens (human)
response to amyloid-beta	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to amyloid-beta	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to L-glutamate	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to glycine	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of protein localization to membrane	Tyrosine-protein kinase Fyn	Homo sapiens (human)
regulation of calcium ion import across plasma membrane	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of cysteine-type endopeptidase activity	Tyrosine-protein kinase Fyn	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cell differentiation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
proline catabolic process	D-amino-acid oxidase	Homo sapiens (human)
digestion	D-amino-acid oxidase	Homo sapiens (human)
D-amino acid catabolic process	D-amino-acid oxidase	Homo sapiens (human)
D-serine catabolic process	D-amino-acid oxidase	Homo sapiens (human)
dopamine biosynthetic process	D-amino-acid oxidase	Homo sapiens (human)
D-alanine catabolic process	D-amino-acid oxidase	Homo sapiens (human)
D-serine metabolic process	D-amino-acid oxidase	Homo sapiens (human)
neutrophil-mediated killing of gram-negative bacterium	D-amino-acid oxidase	Homo sapiens (human)
insemination	D-aspartate oxidase	Homo sapiens (human)
grooming behavior	D-aspartate oxidase	Homo sapiens (human)
regulation of cell communication	D-aspartate oxidase	Homo sapiens (human)
D-amino acid catabolic process	D-aspartate oxidase	Homo sapiens (human)
hormone metabolic process	D-aspartate oxidase	Homo sapiens (human)
nervous system process	D-aspartate oxidase	Homo sapiens (human)
aspartate catabolic process	D-aspartate oxidase	Homo sapiens (human)
L-serine metabolic process	Serine racemase	Homo sapiens (human)
serine family amino acid metabolic process	Serine racemase	Homo sapiens (human)
response to xenobiotic stimulus	Serine racemase	Homo sapiens (human)
response to organic cyclic compound	Serine racemase	Homo sapiens (human)
response to lipopolysaccharide	Serine racemase	Homo sapiens (human)
pyruvate biosynthetic process	Serine racemase	Homo sapiens (human)
D-serine metabolic process	Serine racemase	Homo sapiens (human)
D-serine biosynthetic process	Serine racemase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (43)

Process	via Protein(s)	Taxonomy
phosphotyrosine residue binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase Lck	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein serine/threonine phosphatase activity	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
phospholipase activator activity	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein kinase binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein phosphatase binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
SH2 domain binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
T cell receptor binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
CD4 receptor binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
CD8 receptor binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
identical protein binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
phospholipase binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
phosphatidylinositol 3-kinase binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
ATPase binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
signaling receptor binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase Fyn	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase Fyn	Homo sapiens (human)
protein binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
phospholipase activator activity	Tyrosine-protein kinase Fyn	Homo sapiens (human)
enzyme binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
type 5 metabotropic glutamate receptor binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
identical protein binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
alpha-tubulin binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
phospholipase binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
transmembrane transporter binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
metal ion binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
ephrin receptor binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
tau protein binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
tau-protein kinase activity	Tyrosine-protein kinase Fyn	Homo sapiens (human)
growth factor receptor binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
scaffold protein binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
disordered domain specific binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
signaling receptor binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
D-amino-acid oxidase activity	D-amino-acid oxidase	Homo sapiens (human)
protein binding	D-amino-acid oxidase	Homo sapiens (human)
identical protein binding	D-amino-acid oxidase	Homo sapiens (human)
FAD binding	D-amino-acid oxidase	Homo sapiens (human)
protein binding	D-aspartate oxidase	Homo sapiens (human)
D-aspartate oxidase activity	D-aspartate oxidase	Homo sapiens (human)
D-glutamate oxidase activity	D-aspartate oxidase	Homo sapiens (human)
FAD binding	D-aspartate oxidase	Homo sapiens (human)
magnesium ion binding	Serine racemase	Homo sapiens (human)
L-serine ammonia-lyase activity	Serine racemase	Homo sapiens (human)
calcium ion binding	Serine racemase	Homo sapiens (human)
protein binding	Serine racemase	Homo sapiens (human)
ATP binding	Serine racemase	Homo sapiens (human)
D-serine ammonia-lyase activity	Serine racemase	Homo sapiens (human)
glycine binding	Serine racemase	Homo sapiens (human)
threonine racemase activity	Serine racemase	Homo sapiens (human)
PDZ domain binding	Serine racemase	Homo sapiens (human)
pyridoxal phosphate binding	Serine racemase	Homo sapiens (human)
serine racemase activity	Serine racemase	Homo sapiens (human)
identical protein binding	Serine racemase	Homo sapiens (human)
protein homodimerization activity	Serine racemase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (27)

Process	via Protein(s)	Taxonomy
pericentriolar material	Tyrosine-protein kinase Lck	Homo sapiens (human)
immunological synapse	Tyrosine-protein kinase Lck	Homo sapiens (human)
cytosol	Tyrosine-protein kinase Lck	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Lck	Homo sapiens (human)
membrane raft	Tyrosine-protein kinase Lck	Homo sapiens (human)
extracellular exosome	Tyrosine-protein kinase Lck	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Lck	Homo sapiens (human)
membrane raft	Tyrosine-protein kinase Fyn	Homo sapiens (human)
dendrite	Tyrosine-protein kinase Fyn	Homo sapiens (human)
nucleus	Tyrosine-protein kinase Fyn	Homo sapiens (human)
mitochondrion	Tyrosine-protein kinase Fyn	Homo sapiens (human)
endosome	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cytosol	Tyrosine-protein kinase Fyn	Homo sapiens (human)
actin filament	Tyrosine-protein kinase Fyn	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Fyn	Homo sapiens (human)
postsynaptic density	Tyrosine-protein kinase Fyn	Homo sapiens (human)
dendrite	Tyrosine-protein kinase Fyn	Homo sapiens (human)
perikaryon	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cell body	Tyrosine-protein kinase Fyn	Homo sapiens (human)
membrane raft	Tyrosine-protein kinase Fyn	Homo sapiens (human)
perinuclear region of cytoplasm	Tyrosine-protein kinase Fyn	Homo sapiens (human)
perinuclear endoplasmic reticulum	Tyrosine-protein kinase Fyn	Homo sapiens (human)
glial cell projection	Tyrosine-protein kinase Fyn	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Tyrosine-protein kinase Fyn	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Fyn	Homo sapiens (human)
mitochondrial outer membrane	D-amino-acid oxidase	Homo sapiens (human)
extracellular region	D-amino-acid oxidase	Homo sapiens (human)
cytoplasm	D-amino-acid oxidase	Homo sapiens (human)
peroxisomal matrix	D-amino-acid oxidase	Homo sapiens (human)
cytosol	D-amino-acid oxidase	Homo sapiens (human)
cell projection	D-amino-acid oxidase	Homo sapiens (human)
presynaptic active zone	D-amino-acid oxidase	Homo sapiens (human)
cytoplasm	D-amino-acid oxidase	Homo sapiens (human)
peroxisome	D-aspartate oxidase	Homo sapiens (human)
peroxisome	D-aspartate oxidase	Homo sapiens (human)
peroxisomal matrix	D-aspartate oxidase	Homo sapiens (human)
cytosol	D-aspartate oxidase	Homo sapiens (human)
cytoplasm	D-aspartate oxidase	Homo sapiens (human)
cytoplasm	Serine racemase	Homo sapiens (human)
cytosol	Serine racemase	Homo sapiens (human)
neuronal cell body	Serine racemase	Homo sapiens (human)
apical part of cell	Serine racemase	Homo sapiens (human)
cytoplasm	Serine racemase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (20)

Assay ID	Title	Year	Journal	Article
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID726210	Effect on L-alanine level in G418-resistant HEK293 cells at 83 uM by HPLC analysis relative to vehicle-treated control	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726215	Inhibition of human recombinant N-terminal His-tagged DAO Y224F mutant expressed in Escherichia coli BL21(DE3) using D-alanine as substrate after 10 mins by Lineweaver-Burk plot analysis	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726221	Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by colorimetric assay	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726214	Inhibition of human recombinant N-terminal His-tagged DAO Y224A mutant expressed in Escherichia coli BL21(DE3) using D-alanine as substrate after 10 mins by Lineweaver-Burk plot analysis	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726220	Inhibition of human recombinant N-terminal His-tagged serine racemase expressed in Escherichia coli BL21(DE3) using L-serine as substrate after 10 mins by fluorescence assay	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID72281	Dissociation constant for binding to SH2 domain of Fyn protein kinase	1999	Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5	Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.
AID1422158	Inhibition of human DAO using D-serine as substrate after 20 mins in presence of FAD	2018	European journal of medicinal chemistry, Nov-05, Volume: 159	Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids.
AID726216	Competitive inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by Lineweaver-Burk plot analysis	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726212	Inhibition of N-terminal HA-tagged human recombinant DAO overexpressed in G418-resistant HEK293 cells assessed as increase in D-alanine levels at 83 uM incubated for 30 mins prior to D-alanine addition measured after 24 hrs by HPLC analysis relative to ve	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726222	Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assay	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726205	Inhibition of human recombinant DAO expressed in G418-resistant HEK293/NEO cells assessed as effect on D-alanine level at 83 uM incubated for 30 mins prior to D-alanine addition measured after 24 hrs by HPLC analysis relative to vehicle-treated control	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726223	Inhibition of human recombinant N-terminal His-tagged DDO expressed in Escherichia coli BL21(DE3) using D-aspartate as substrate by colorimetric assay	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID224294	Dissociation constant for binding to SH2 domain of p56 lck tyrosine kinase	1999	Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5	Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.
AID726207	Effect on L-alanine level in G418-resistant HEK293/NEO cells at 17 uM by HPLC analysis relative to vehicle-treated control	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726213	Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by Lineweaver-Burk plot analysis	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726206	Effect on L-alanine level in G418-resistant HEK293 cells at 17 uM by HPLC analysis relative to vehicle-treated control	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726211	Effect on L-alanine level in G418-resistant HEK293/NEO cells at 83 uM by HPLC analysis relative to vehicle-treated control	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
AID726218	Binding affinity to human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) at 40 uM after 2 to 30 mins by absorption spectra analysis	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (10.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	9 (90.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2	1	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
benzoic acid Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.. benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.. aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.	2.08	1	benzoic acids	algal metabolite; antimicrobial food preservative; drug allergen; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor; human xenobiotic metabolite; plant metabolite
malonic acid malonic acid : An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.. dicarboxylic acid : Any carboxylic acid containing two carboxy groups.	2.08	1	alpha,omega-dicarboxylic acid	human metabolite
adrenalone adrenalone: RN given refers to parent cpd	2.08	1	aromatic ketone
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	3.18	5	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
thiophene-2-carboxylate thiophene-2-carboxylic acid : A thiophenecarboxylic acid in which the carboxy group is located at position 2.	2.5	2	thiophenecarboxylic acid
3-hydroxy-1-benzopyran-2-one 3-hydroxycoumarin: Photoprotective from sea urchin gametes and embryonic cells; structure in first source. hydroxycoumarin : Any coumarin carrying at least one hydroxy substituent.	2.08	1	hydroxycoumarin
oxiniacic acid [no description available]	2.08	1	aromatic carboxylic acid; pyridines
4-nitrohippuric acid 4-nitrohippuric acid: major metabolite of 4-nitrobenzoic acid	2	1
n-butyllithium [no description available]	2.06	1
7-methoxycoumarin-4-acetic acid [no description available]	2	1	monocarboxylic acid	fluorochrome
5-aminonicotinic acid 5-aminonicotinic acid: an inhibitor of D-aspartate oxidase; structure in first source. 5-aminonicotinic acid : An aminonicotinic acid in which the amino group is situated at position 5 of the pyridine ring.	2.08	1	aminonicotinic acid; aminopyridine; aromatic amine	metabolite
crotonic acid crotonic acid: a stereospecific unsaturated carboxylic acid found in CROTON OIL. butenoic acid : Any C4, straight-chain fatty acid containing one double bond.. crotonic acid : A but-2-enoic acid with a trans- double bond at C-2. It has been isolated from Daucus carota.	2.08	1	2-butenoic acid	plant metabolite
3-coumaric acid 3-coumaric acid: RN given refers to cpd without isomeric designation in Chemline. trans-3-coumaric acid : A 3-coumaric acid that is phenol substituted with trans-2-propenoic acid at position C-3.. 3-coumaric acid : A monohydroxycinnamic acid in which the hydroxy substituent is located at C-3 of the phenyl ring.	2.08	1	3-coumaric acid
pseudoginsenoside f11 [no description available]	2.08	1
7-hydroxycoumarin-4-acetic acid 7-hydroxycoumarin-4-acetic acid: pH-indicator dye; structure in first source	2	1
sun [no description available]	2.08	1

Condition	Relationship Strength	Studies
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1
Infections, Pneumococcal [description not available]	2.15	1
Pneumococcal Infections Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.	2.15	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	2.11	1

thiophene-3-carboxylic acid

Description

Cross-References

Synonyms (58)

Protein Targets (7)

Inhibition Measurements

Activation Measurements

Biological Processes (92)

Molecular Functions (43)

Ceullar Components (27)

Bioassays (20)

Research

Studies (10)

Market Indicators

Research Demand Index: 27.37

Study Types

thiophene-3-carboxylic acid

Description

Cross-References

Synonyms (58)

Protein Targets (7)

Inhibition Measurements

Activation Measurements

Biological Processes (92)

Molecular Functions (43)

Ceullar Components (27)

Bioassays (20)

Research

Studies (10)

Market Indicators

Research Demand Index: 27.37

Study Types

Related Drugs (17)

Related Conditions (5)