Transient receptor potential cation channel subfamily V member 6

A transient receptor potential cation channel subfamily V member 6 that is encoded in the genome of human. [PRO:HJD, UniProtKB:Q9H1D0]

TrpV6;
CaT-like;
CaT-L;
Calcium transport protein 1;
CaT1;
Epithelial calcium channel 2;
ECaC2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
diphenylborinic acid	Homo sapiens (human)	IC50	25.3000	2	2
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	IC50	9.4000	1	1

This protein enables 5 target(s):

Target	Category	Definition
calcium channel activity	molecular function	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

This protein is located in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is part of 1 target(s):

Target	Category	Definition
calcium channel complex	cellular component	An ion channel complex through which calcium ions pass. [GOC:mah]

This protein is involved in 7 target(s):

Target	Category	Definition
calcium ion transport	biological process	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
regulation of calcium ion-dependent exocytosis	biological process	Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. [GOC:go_curators]
parathyroid hormone secretion	biological process	The regulated release of parathyroid hormone into the circulatory system. [GOC:cjm, PMID:12171519, PMID:21164021]
response to calcium ion	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:ai]
calcium ion homeostasis	biological process	Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. [GOC:ceb, GOC:jid, GOC:mah]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
calcium ion import across plasma membrane	biological process	The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]