| Assay ID | Title | Year | Journal | Article |
|---|
| AID5483 | Binding affinity towards 5-hydroxytryptamine 2A receptor from rat frontal cortex using [3H]ketanserin as radioligand | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID141549 | Concentration required (in vitro) to displace 50% specific binding of [3H]clozapine to Muscarinic acetylcholine receptor in rat brain: Not determined | 1981 | Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
| Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. |
| AID231654 | Binding ratio of -log Ki between D2 and D1 receptors | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
| AID64461 | Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatum | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID63371 | Binding affinity against dopamine receptor D1 | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study. |
| AID142687 | Binding affinity against muscarinic (M) receptor | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study. |
| AID141422 | Binding activity against muscarinic receptor in rat brain using [3H]QNB as the radioligand | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. |
| AID147426 | Concentration required (in vitro) to displace 50% specific binding of [3H]clozapine to muscarinic sites in rat brain | 1981 | Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
| Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. |
| AID6134 | Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 3 receptor | 1994 | Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
| Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
| AID61193 | Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID5123 | In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor. | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
| AID61079 | Binding affinity against dopamine D2 receptor | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study. |
| AID5490 | Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brain | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID140974 | In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain. | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
| AID61521 | In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
| AID231655 | Binding ratio of -log Ki between D2 and M receptors | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
| AID231653 | Binding ratio of -log Ki between 5-HT2 and D2 receptors | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
| AID36849 | Binding affinity towards alpha-1 adrenergic receptor from rat brain membranes using [3H]prazosin as radioligand | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID5508 | Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 2A receptor | 1994 | Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
| Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
| AID231681 | Ratio between Ki values of D2 and D4 receptors | 1994 | Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
| Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
| AID176500 | Inhibition of catalepsy in rat by subcutaneous administration of compound | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID61151 | Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID61365 | Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand | 1994 | Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
| Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
| AID5708 | Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranes | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID186044 | Locomotor activity in male Wistar rats after a dose of 0.3 uM/kg, 30 min before 1 mg/kg of apomorphine administration | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID177508 | In vivo inhibition of apomorphine-mediated stereotypy in rats administered subcutaneously at 20 mg/kg expressed as ED50 (mg/kg) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
| AID5042 | Binding affinity against serotonin 5-hydroxytryptamine 2 receptor | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study. |
| AID61804 | Binding affinity towards human D4.2 receptor | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID231522 | Ratio of binding affinity towards 5-HT2 to D2 receptor was measured | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study. |
| AID186187 | Locomotor activity in male Wistar rats after a dose of 1.0 uM/kg, 30 min before 1 mg/kg of apomorphine administration | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID141055 | Inhibitory binding of [3H]pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cells | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID171694 | Catalytic action on male Wistar rats after subcutaneous administration of 10 mg/kg dose of compound | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID171692 | Catalytic action on male Wistar rats after subcutaneous administration of 1.0 mg/kg dose of compound | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID5715 | Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 2C receptor | 1994 | Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
| Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
| AID228677 | Delta ED50 value by Subcutaneous administration (ED50 catalepsy-ED50 Climbing) | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID65733 | In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligand | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents. |
| AID64825 | Binding affinity towards human Dopamine receptor D3 | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID235774 | Therapeutic ratio by Subcutaneous dose of administration (quotient ED50 catalepsy/ED50 climbing) | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID64271 | Binding affinity towards Dopamine receptor D2 of rat corpus striatum using [3H]spiperone as radioligand | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID64201 | Affinity was evaluated as inhibition constant for dopamine D-4 receptor | 1994 | Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
| Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
| AID87515 | Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand; Not tested | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID186188 | Locomotor activity in male Wistar rats after a dose of 10 uM/kg, 30 min before 1 mg/kg of apomorphine administration | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID231682 | Ratio between Ki values of D2 and S-2A receptors | 1994 | Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
| Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
| AID176235 | Inhibitory activity in apomorphine antagonism test at a dose of 20 mg/kg, sc | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study. |
| AID231683 | Ratio between Ki values of D2 and S-3 receptors | 1994 | Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
| Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
| AID186192 | Locomotor activity in male Wistar rats after a dose of 30 uM/kg, 30 min before 1 mg/kg of apomorphine administration | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID141527 | Binding affinity was determined against Muscarinic acetylcholine receptor using [3H]QNB as radioligand in rat brain. | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. |
| AID112272 | Inhibition of apomorphine induced climbing affects in mice by administering the compound subcutaneously in mice | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID61027 | Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. |
| AID62769 | Binding affinity towards human Dopamine receptor D2 | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID141680 | Tested in vitro for its ability to displace 3[H] clozapine from Muscarinic acetylcholine receptor in rat brain | 1982 | Journal of medicinal chemistry, Jul, Volume: 25, Issue:7
| Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. |
| AID171695 | Catalytic action on male Wistar rats after subcutaneous administration of 3.0 mg/kg dose of compound | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID171691 | Catalytic action on male Wistar rats after subcutaneous administration of 0.3 mg/kg dose of compound | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID186191 | Locomotor activity in male Wistar rats after a dose of 3.0 uM/kg, 30 min before 1 mg/kg of apomorphine administration | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID147425 | Tested in vitro for its ability to displace 3[H] clozapine from non-muscarinic receptor in rat brain | 1982 | Journal of medicinal chemistry, Jul, Volume: 25, Issue:7
| Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. |
| AID62913 | Affinity was evaluated as inhibition constant for dopamine D-2 receptor | 1994 | Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
| Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
| AID231528 | Ratio of binding affinity towards D2 to muscarinic receptor (M) was measured | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study. |
| AID171696 | Catalytic action on male Wistar rats after subcutaneous administration of 30 mg/kg dose of compound | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID61400 | Binding activity against Dopamine receptor D2 in rat brain, using [3H]spiperone as the radioligand | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. |
| AID5703 | Binding affinity towards 5-HT2C receptor from rat using [3H]mesulergine as radioligand | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID37001 | Inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
| AID62876 | Relative affinity for dopamine receptor by displacement of [3H]spiroperidol (2.2 nM) from (in vitro) dopamine binding sites in rat caudate nuclei | 1981 | Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
| Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. |
| AID23695 | Partition coefficient (logP) | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID231526 | Ratio of binding affinity towards D2 to D1 receptor was measured | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study. |
| AID61025 | Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. |
| AID64154 | In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue. | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
| AID61544 | Binding affinity for Dopamine receptor D2 using [3H]spiperone in rat brain | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. |
| AID62882 | Displacement of 3[H]spiroperidol from Dopamine receptor in rat brain | 1982 | Journal of medicinal chemistry, Jul, Volume: 25, Issue:7
| Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. |
| AID141053 | Inhibition of binding of 1.0 nM [3H]pirenzepine to cloned human Muscarinic acetylcholine receptor M1 expressed in membranes from CHO-K1 cells | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID493017 | Wombat Data for BeliefDocking | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |