astrogorgiadiol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5283727 |
| CHEMBL ID | 517956 |
| CHEBI ID | 187939 |
| SCHEMBL ID | 4865385 |
| MeSH ID | M0394521 |
| Synonym |
|---|
| (8s,9r)-9,10-seco-1,3,5(10)-cholestatriene-3,9-diol |
| LMST03020242 , |
| astrogorgiadiol b |
| astrogorgiadiol |
| CHEMBL517956 |
| CHEBI:187939 |
| (1r,3as,4s,5r,7ar)-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-1-[(2r)-6-methylheptan-2-yl]-1,2,3,3a,4,5,6,7-octahydroinden-5-ol |
| bdbm50358247 |
| SCHEMBL4865385 |
| Class | Description |
|---|---|
| sesquiterpenoid | Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups). |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| NUAK family SNF1-like kinase 1 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0013 | 0.2918 | 5.0900 | AID633320 |
| Insulin-like growth factor 1 receptor | Homo sapiens (human) | IC50 (µMol) | 2.7700 | 0.0003 | 0.4308 | 8.0000 | AID633324 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 (µMol) | 78.0000 | 0.0004 | 0.3722 | 10.0000 | AID633326 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0004 | 0.8871 | 10.0000 | AID633329 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 (µMol) | 1.9100 | 0.0002 | 0.5335 | 10.0000 | AID633332 |
| Tyrosine-protein kinase receptor UFO | Homo sapiens (human) | IC50 (µMol) | 16.9000 | 0.0007 | 0.4116 | 9.1000 | AID633322 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0002 | 0.7387 | 10.0000 | AID633318 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 (µMol) | 4.3500 | 0.0000 | 0.4830 | 8.8000 | AID633333 |
| Serine/threonine-protein kinase Nek2 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.1580 | 2.5160 | 8.0000 | AID633327 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0001 | 0.7734 | 9.0000 | AID633330 |
| Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens (human) | IC50 (µMol) | 48.9000 | 0.0002 | 0.6813 | 9.7000 | AID633325 |
| Focal adhesion kinase 1 | Homo sapiens (human) | IC50 (µMol) | 13.2000 | 0.0002 | 0.5416 | 8.3000 | AID633323 |
| Serine/threonine-protein kinase N1 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0010 | 1.1157 | 5.8000 | AID633331 |
| Aurora kinase B | Homo sapiens (human) | IC50 (µMol) | 25.1000 | 0.0003 | 0.9634 | 9.8000 | AID633321 |
| Serine/threonine-protein kinase Nek6 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 1.0650 | 2.6475 | 4.2300 | AID633328 |
| ALK tyrosine kinase receptor | Homo sapiens (human) | IC50 (µMol) | 7.5500 | 0.0001 | 0.3107 | 10.0000 | AID633319 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID633324 | Inhibition of recombinant human IGF1-R using poly(Glu,Tyr)4:1 as substrate | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633318 | Inhibition of recombinant human AKT1 using GSK3 (amino acids 14 to 27) as substrate | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633320 | Inhibition of recombinant human ARK5 | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID403166 | Inhibition of PLA2 at 50 ug/mL | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11 | New secosteroids from a gorgonian of the genus Muricella. |
| AID633332 | Inhibition of recombinant human SRC using poly(Glu,Tyr)4:1 as substrate | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID1776769 | Cytotoxicity against C57BL/6 mouse spleen mononuclear cells assessed as cell viability at 0.5 to 1 uM measured after 48 hrs by CCK-8 assay | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Immunosuppressive 9,10-Secosteroids from the Gorgonian |
| AID633325 | Inhibition of wild type human MEK1 | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633331 | Inhibition of recombinant human PRK1 | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633327 | Inhibition of recombinant human NEK2 | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633322 | Inhibition of recombinant human AXL | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633329 | Inhibition of recombinant human PIM1 | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633328 | Inhibition of recombinant human NEK6 | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID398692 | Toxicity against brine shrimp larvae | 1995 | Journal of natural products, Aug, Volume: 58, Issue:8 | New secosteroids from an undescribed gorgonian of the genus Muricella. |
| AID633333 | Inhibition of recombinant human VEGF-R2 using poly(Glu,Tyr)4:1 as substrate | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633319 | Inhibition of recombinant human ALK | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633330 | Inhibition of recombinant human PLK1 using casein as substrate | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633326 | Inhibition of wild type human MET using poly(Ala,Glu,Lys,Tyr) as substrate | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID403165 | Cytotoxicity against human K562 cells | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11 | New secosteroids from a gorgonian of the genus Muricella. |
| AID633321 | Inhibition of recombinant human Aurora-B using tetra(LRRWLSG) as substrate | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID633323 | Inhibition of recombinant human FAK using poly(Glu,Tyr)4:1 as substrate | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. |
| AID1776770 | Immunosuppressive activity in C57BL/6 mouse SMNCs-derived CD4+ T cells assessed as inhibition of concanavalinA-stimulated cell proliferation at 1 uM measured after 5 to 7 days by CFSE staining based FACScan flowcytometry | 2021 | Journal of natural products, 05-28, Volume: 84, Issue:5 | Immunosuppressive 9,10-Secosteroids from the Gorgonian |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.94) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||