| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1167344 | Inhibition of human APE1 after 25 mins by fluorescence assay | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| DNA repair and redox activities and inhibitors of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): a comparative analysis and their scope and limitations toward anticancer drug development. |
| AID1316274 | Inhibition of 5'-[gamma-32P]ATP-labelled 11-nucleotide ssRNA binding to Caenorhabditis elegans GST-tagged CRN-4 expressed in Escherichia coli BL21 (DE3) pLysS at 1 mM preincubated for 10 mins followed by substrate addition measured after 20 mins by TBE ge | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17
| Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES). |
| AID1316272 | Inhibition of GST-tagged Caenorhabditis elegans CRN-4 exonuclease activity expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by [gamma-32P]ATP labelled 11-nucleotide ssRNA substrate addition for 30 mins by PAGE based autorad | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17
| Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES). |
| AID1316276 | Inhibition of 5'-[gamma-32P]ATP-labelled 11-nucleotide ssDNA binding to recombinant Escherichia coli K-12 N-terminal His-tagged RNase T expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL at 1 mM preincubated for 10 mins followed by substrate addition | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17
| Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES). |
| AID1316278 | Inhibition of Lassa virus N-terminal His-tagged NP exonuclease domain (342 to 569 residues) expressed in Escherichia coli Tuner (DE3) using 3'-overhang 4-nucleotide stem-loop RNA preincubated for 10 mins followed by substrate addition measured after 60 mi | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17
| Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES). |
| AID1316273 | Inhibition of N-terminal His-tagged recombinant Escherichia coli K-12 RNase T exonuclease activity expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL preincubated for 10 mins followed by [gamma-32P]ATP labelled 11-nucleotide ssDNA substrate addition f | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17
| Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES). |
| AID672545 | Inhibition of human recombinant APE1 at 57 uM after 15 mins by fluorescence based HTS assay | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. |
| AID1370978 | Inhibition of APE1 in human HeLa cells assessed as reduction in AP site cleavage 5'-[gamma-32P]CTCGCAAGUGGGTACCGA-3' as substrate after 1 hr | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9
| Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1). |
| AID1316277 | Inhibition of Lassa virus N-terminal His-tagged NP exonuclease domain (342 to 569 residues) expressed in Escherichia coli Tuner (DE3) using FAM-labeled 20-nucleotide ssRNA preincubated for 10 mins followed by substrate addition measured after 60 mins by P | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17
| Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |