Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

A guanine nucleotide-binding protein G(s) subunit alpha (human), isoforms XLas-1, XLas-2, and XLas-3. [PRO:DAN, UniProtKB:Q5JWF2]

Synonyms

Adenylate cyclase-stimulating G alpha protein;
Extra large alphas protein;
XLalphas

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ym-254890	Homo sapiens (human)	IC50	100.0000	1	1

Enables

This protein enables 12 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
GTP binding	molecular function	Binding to GTP, guanosine triphosphate. [GOC:ai]
adenylate cyclase activator activity	molecular function	Binds to and increases the activity of adenylate cyclase. [GOC:dph, GOC:tb]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
GTPase activity	molecular function	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. [PMID:26832457, PMID:27218782]
D1 dopamine receptor binding	molecular function	Binding to a D1 dopamine receptor. [GOC:mah, GOC:nln]
beta-2 adrenergic receptor binding	molecular function	Binding to a beta-2 adrenergic receptor. [GOC:mah, GOC:nln]
G-protein beta/gamma-subunit complex binding	molecular function	Binding to a complex of G-protein beta/gamma subunits. [GOC:nln, GOC:vw]
corticotropin-releasing hormone receptor 1 binding	molecular function	Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system. [PMID:15134857]
ionotropic glutamate receptor binding	molecular function	Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. [GOC:bf, ISBN:0198506732]
mu-type opioid receptor binding	molecular function	Binding to a mu-type opioid receptor. [GOC:mah, GOC:nln, GOC:sl]
insulin-like growth factor receptor binding	molecular function	Binding to an insulin-like growth factor receptor. [GOC:jl]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
heterotrimeric G-protein complex	cellular component	Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein. [ISBN:0198547684]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
developmental growth	biological process	The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. [GOC:go_curators]
bone development	biological process	The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. [GOC:dph]
platelet aggregation	biological process	The adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF, GOC:vk]
positive regulation of cold-induced thermogenesis	biological process	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
sensory perception of chemical stimulus	biological process	The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]
adenylate cyclase-activating dopamine receptor signaling pathway	biological process	An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:mah, GOC:signaling]