n-trans-p-coumaroyl-l-tyrosine profile

N-trans-p-coumaroyl-L-tyrosine: from Theobroma cacao; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Theobroma	genus	[no description available]	Malvaceae	The mallow family of the order MALVALES, subclass Dilleniidae, class Magnoliopsida. The common names of hollyhock and mallow are used for several genera of Malvaceae.[MeSH]

ID Source	ID
PubMed CID	15825666
CHEMBL ID	4129983
CHEBI ID	181160
MeSH ID	M0461304

Synonym
CHEBI:181160
(2s)-3-(4-hydroxyphenyl)-2-[[(e)-3-(4-hydroxyphenyl)prop-2-enoyl]amino]propanoic acid
trans-dideoxyclovamide
l-tyrosine, n-[(2e)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-
77201-66-2
n-trans-p-coumaroyltyrosine
ncgc00385093-01_c18h17no5_l-tyrosine, n-[(2e)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-
NCGC00385093-01
FS-8366
bdbm50272457
chembl4129983 ,
(2s)-3-(4-hydroxyphenyl)-2-(3-(4-hydroxyphenyl)prop-2-enoylamino)propanoic acid
n-trans-p-coumaroyl-l-tyrosine
l-tyrosine, n-(3-(4-hydroxyphenyl)-1-oxo-2-propenyl)-, (e)-
NBS8NYY2M5 ,
n-p-coumaroyltyrosine
l-tyrosine, n-((2e)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl)-
n-(e)-p-coumaroyl-l-tyrosine
n-coumaroyltyrosine
n-((2e)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl)-l-tyrosine
unii-nbs8nyy2m5
AKOS040763557

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

Class	Description
tyrosine derivative	An amino acid derivative resulting from reaction of tyrosine at the amino group or the carboxy group, any substitution of phenyl hydrogens, or from the replacement of any hydrogen of tyrosine by a heteroatom. The definition normally excludes peptides containing tyrosine residues.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Amyloid-beta precursor protein	Homo sapiens (human)	IC50 (µMol)	100.0000	0.0005	3.8895	10.0000	AID1495590
Nitric oxide synthase, inducible	Homo sapiens (human)	IC50 (µMol)	2.1000	0.0002	2.3190	10.0000	AID1395931
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (108)

Process	via Protein(s)	Taxonomy
regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
cognition	Amyloid-beta precursor protein	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
microglial cell activation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of protein phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
suckling behavior	Amyloid-beta precursor protein	Homo sapiens (human)
astrocyte activation involved in immune response	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of translation	Amyloid-beta precursor protein	Homo sapiens (human)
protein phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
intracellular copper ion homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
endocytosis	Amyloid-beta precursor protein	Homo sapiens (human)
response to oxidative stress	Amyloid-beta precursor protein	Homo sapiens (human)
cell adhesion	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of epidermal growth factor-activated receptor activity	Amyloid-beta precursor protein	Homo sapiens (human)
Notch signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
axonogenesis	Amyloid-beta precursor protein	Homo sapiens (human)
learning or memory	Amyloid-beta precursor protein	Homo sapiens (human)
learning	Amyloid-beta precursor protein	Homo sapiens (human)
mating behavior	Amyloid-beta precursor protein	Homo sapiens (human)
locomotory behavior	Amyloid-beta precursor protein	Homo sapiens (human)
axo-dendritic transport	Amyloid-beta precursor protein	Homo sapiens (human)
cholesterol metabolic process	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of cell population proliferation	Amyloid-beta precursor protein	Homo sapiens (human)
adult locomotory behavior	Amyloid-beta precursor protein	Homo sapiens (human)
visual learning	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of peptidyl-threonine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
microglia development	Amyloid-beta precursor protein	Homo sapiens (human)
axon midline choice point recognition	Amyloid-beta precursor protein	Homo sapiens (human)
neuron remodeling	Amyloid-beta precursor protein	Homo sapiens (human)
dendrite development	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of Wnt signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular matrix organization	Amyloid-beta precursor protein	Homo sapiens (human)
forebrain development	Amyloid-beta precursor protein	Homo sapiens (human)
neuron projection development	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of chemokine production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of interleukin-6 production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
ionotropic glutamate receptor signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of multicellular organism growth	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of neuron differentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of glycolytic process	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of JNK cascade	Amyloid-beta precursor protein	Homo sapiens (human)
astrocyte activation	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of long-term neuronal synaptic plasticity	Amyloid-beta precursor protein	Homo sapiens (human)
collateral sprouting in absence of injury	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of inflammatory response	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of synapse structure or activity	Amyloid-beta precursor protein	Homo sapiens (human)
synapse organization	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of calcium-mediated signaling	Amyloid-beta precursor protein	Homo sapiens (human)
neuromuscular process controlling balance	Amyloid-beta precursor protein	Homo sapiens (human)
synaptic assembly at neuromuscular junction	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of protein metabolic process	Amyloid-beta precursor protein	Homo sapiens (human)
neuron apoptotic process	Amyloid-beta precursor protein	Homo sapiens (human)
smooth endoplasmic reticulum calcium ion homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
neuron cellular homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Amyloid-beta precursor protein	Homo sapiens (human)
response to interleukin-1	Amyloid-beta precursor protein	Homo sapiens (human)
modulation of excitatory postsynaptic potential	Amyloid-beta precursor protein	Homo sapiens (human)
NMDA selective glutamate receptor signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of spontaneous synaptic transmission	Amyloid-beta precursor protein	Homo sapiens (human)
cytosolic mRNA polyadenylation	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of long-term synaptic potentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of long-term synaptic potentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Amyloid-beta precursor protein	Homo sapiens (human)
cellular response to amyloid-beta	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of presynapse assembly	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of amyloid fibril formation	Amyloid-beta precursor protein	Homo sapiens (human)
amyloid fibril formation	Amyloid-beta precursor protein	Homo sapiens (human)
neuron projection maintenance	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of T cell migration	Amyloid-beta precursor protein	Homo sapiens (human)
central nervous system development	Amyloid-beta precursor protein	Homo sapiens (human)
response to hypoxia	Nitric oxide synthase, inducible	Homo sapiens (human)
positive regulation of leukocyte mediated cytotoxicity	Nitric oxide synthase, inducible	Homo sapiens (human)
innate immune response in mucosa	Nitric oxide synthase, inducible	Homo sapiens (human)
arginine catabolic process	Nitric oxide synthase, inducible	Homo sapiens (human)
superoxide metabolic process	Nitric oxide synthase, inducible	Homo sapiens (human)
nitric oxide biosynthetic process	Nitric oxide synthase, inducible	Homo sapiens (human)
circadian rhythm	Nitric oxide synthase, inducible	Homo sapiens (human)
response to bacterium	Nitric oxide synthase, inducible	Homo sapiens (human)
negative regulation of gene expression	Nitric oxide synthase, inducible	Homo sapiens (human)
peptidyl-cysteine S-nitrosylation	Nitric oxide synthase, inducible	Homo sapiens (human)
prostaglandin secretion	Nitric oxide synthase, inducible	Homo sapiens (human)
positive regulation of interleukin-6 production	Nitric oxide synthase, inducible	Homo sapiens (human)
positive regulation of interleukin-8 production	Nitric oxide synthase, inducible	Homo sapiens (human)
regulation of cell population proliferation	Nitric oxide synthase, inducible	Homo sapiens (human)
negative regulation of protein catabolic process	Nitric oxide synthase, inducible	Homo sapiens (human)
defense response to bacterium	Nitric oxide synthase, inducible	Homo sapiens (human)
regulation of cellular respiration	Nitric oxide synthase, inducible	Homo sapiens (human)
cell redox homeostasis	Nitric oxide synthase, inducible	Homo sapiens (human)
regulation of insulin secretion	Nitric oxide synthase, inducible	Homo sapiens (human)
defense response to Gram-negative bacterium	Nitric oxide synthase, inducible	Homo sapiens (human)
positive regulation of killing of cells of another organism	Nitric oxide synthase, inducible	Homo sapiens (human)
cellular response to lipopolysaccharide	Nitric oxide synthase, inducible	Homo sapiens (human)
cellular response to type II interferon	Nitric oxide synthase, inducible	Homo sapiens (human)
cellular response to xenobiotic stimulus	Nitric oxide synthase, inducible	Homo sapiens (human)
regulation of cytokine production involved in inflammatory response	Nitric oxide synthase, inducible	Homo sapiens (human)
negative regulation of blood pressure	Nitric oxide synthase, inducible	Homo sapiens (human)
response to hormone	Nitric oxide synthase, inducible	Homo sapiens (human)
nitric oxide mediated signal transduction	Nitric oxide synthase, inducible	Homo sapiens (human)
response to lipopolysaccharide	Nitric oxide synthase, inducible	Homo sapiens (human)
inflammatory response	Nitric oxide synthase, inducible	Homo sapiens (human)
positive regulation of guanylate cyclase activity	Nitric oxide synthase, inducible	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (23)

Process	via Protein(s)	Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Amyloid-beta precursor protein	Homo sapiens (human)
DNA binding	Amyloid-beta precursor protein	Homo sapiens (human)
serine-type endopeptidase inhibitor activity	Amyloid-beta precursor protein	Homo sapiens (human)
signaling receptor binding	Amyloid-beta precursor protein	Homo sapiens (human)
protein binding	Amyloid-beta precursor protein	Homo sapiens (human)
heparin binding	Amyloid-beta precursor protein	Homo sapiens (human)
enzyme binding	Amyloid-beta precursor protein	Homo sapiens (human)
identical protein binding	Amyloid-beta precursor protein	Homo sapiens (human)
transition metal ion binding	Amyloid-beta precursor protein	Homo sapiens (human)
receptor ligand activity	Amyloid-beta precursor protein	Homo sapiens (human)
PTB domain binding	Amyloid-beta precursor protein	Homo sapiens (human)
protein serine/threonine kinase binding	Amyloid-beta precursor protein	Homo sapiens (human)
signaling receptor activator activity	Amyloid-beta precursor protein	Homo sapiens (human)
nitric-oxide synthase activity	Nitric oxide synthase, inducible	Homo sapiens (human)
protein binding	Nitric oxide synthase, inducible	Homo sapiens (human)
calmodulin binding	Nitric oxide synthase, inducible	Homo sapiens (human)
FMN binding	Nitric oxide synthase, inducible	Homo sapiens (human)
heme binding	Nitric oxide synthase, inducible	Homo sapiens (human)
tetrahydrobiopterin binding	Nitric oxide synthase, inducible	Homo sapiens (human)
arginine binding	Nitric oxide synthase, inducible	Homo sapiens (human)
protein homodimerization activity	Nitric oxide synthase, inducible	Homo sapiens (human)
metal ion binding	Nitric oxide synthase, inducible	Homo sapiens (human)
flavin adenine dinucleotide binding	Nitric oxide synthase, inducible	Homo sapiens (human)
NADP binding	Nitric oxide synthase, inducible	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (46)

Process	via Protein(s)	Taxonomy
extracellular space	Amyloid-beta precursor protein	Homo sapiens (human)
dendrite	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular region	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular space	Amyloid-beta precursor protein	Homo sapiens (human)
nuclear envelope lumen	Amyloid-beta precursor protein	Homo sapiens (human)
cytoplasm	Amyloid-beta precursor protein	Homo sapiens (human)
mitochondrial inner membrane	Amyloid-beta precursor protein	Homo sapiens (human)
endosome	Amyloid-beta precursor protein	Homo sapiens (human)
early endosome	Amyloid-beta precursor protein	Homo sapiens (human)
endoplasmic reticulum	Amyloid-beta precursor protein	Homo sapiens (human)
endoplasmic reticulum lumen	Amyloid-beta precursor protein	Homo sapiens (human)
smooth endoplasmic reticulum	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi apparatus	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi lumen	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi-associated vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
cytosol	Amyloid-beta precursor protein	Homo sapiens (human)
plasma membrane	Amyloid-beta precursor protein	Homo sapiens (human)
clathrin-coated pit	Amyloid-beta precursor protein	Homo sapiens (human)
cell-cell junction	Amyloid-beta precursor protein	Homo sapiens (human)
synaptic vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
cell surface	Amyloid-beta precursor protein	Homo sapiens (human)
membrane	Amyloid-beta precursor protein	Homo sapiens (human)
COPII-coated ER to Golgi transport vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
axon	Amyloid-beta precursor protein	Homo sapiens (human)
growth cone	Amyloid-beta precursor protein	Homo sapiens (human)
platelet alpha granule lumen	Amyloid-beta precursor protein	Homo sapiens (human)
neuromuscular junction	Amyloid-beta precursor protein	Homo sapiens (human)
endosome lumen	Amyloid-beta precursor protein	Homo sapiens (human)
trans-Golgi network membrane	Amyloid-beta precursor protein	Homo sapiens (human)
ciliary rootlet	Amyloid-beta precursor protein	Homo sapiens (human)
dendritic spine	Amyloid-beta precursor protein	Homo sapiens (human)
dendritic shaft	Amyloid-beta precursor protein	Homo sapiens (human)
perikaryon	Amyloid-beta precursor protein	Homo sapiens (human)
membrane raft	Amyloid-beta precursor protein	Homo sapiens (human)
apical part of cell	Amyloid-beta precursor protein	Homo sapiens (human)
synapse	Amyloid-beta precursor protein	Homo sapiens (human)
perinuclear region of cytoplasm	Amyloid-beta precursor protein	Homo sapiens (human)
presynaptic active zone	Amyloid-beta precursor protein	Homo sapiens (human)
spindle midzone	Amyloid-beta precursor protein	Homo sapiens (human)
recycling endosome	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular exosome	Amyloid-beta precursor protein	Homo sapiens (human)
receptor complex	Amyloid-beta precursor protein	Homo sapiens (human)
early endosome	Amyloid-beta precursor protein	Homo sapiens (human)
membrane raft	Amyloid-beta precursor protein	Homo sapiens (human)
cell surface	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi apparatus	Amyloid-beta precursor protein	Homo sapiens (human)
plasma membrane	Amyloid-beta precursor protein	Homo sapiens (human)
nucleus	Nitric oxide synthase, inducible	Homo sapiens (human)
nucleoplasm	Nitric oxide synthase, inducible	Homo sapiens (human)
cytoplasm	Nitric oxide synthase, inducible	Homo sapiens (human)
peroxisome	Nitric oxide synthase, inducible	Homo sapiens (human)
peroxisomal matrix	Nitric oxide synthase, inducible	Homo sapiens (human)
cytosol	Nitric oxide synthase, inducible	Homo sapiens (human)
cortical cytoskeleton	Nitric oxide synthase, inducible	Homo sapiens (human)
perinuclear region of cytoplasm	Nitric oxide synthase, inducible	Homo sapiens (human)
plasma membrane	Nitric oxide synthase, inducible	Homo sapiens (human)
nucleus	Nitric oxide synthase, inducible	Homo sapiens (human)
cytosol	Nitric oxide synthase, inducible	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (11)

Assay ID	Title	Year	Journal	Article
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1395931	Inhibition of LPS-induced iNOS in human BV2 cells after 4 hrs by DAF-FMDA dye-based fluorescence assay	2018	European journal of medicinal chemistry, May-10, Volume: 151	Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo.
AID1495591	Inhibition of amyloid beta (1 to 42) (unknown origin) fibril formation at 100 uM after 24 hrs by silicotungstic acid staining based transmission electron microscopic analysis	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Structure-activity relationship of clovamide and its related compounds for the inhibition of amyloid β aggregation.
AID1495590	Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by thioflavin T fluorescence assay	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Structure-activity relationship of clovamide and its related compounds for the inhibition of amyloid β aggregation.
AID1395928	Anti-neuroinflammatory activity in human BV2 cells assessed as reduction in LPS-induced NO production at 10 uM preincubated for 4 hrs followed by LPS stimulation for 24 hrs by Griess assay relative to control	2018	European journal of medicinal chemistry, May-10, Volume: 151	Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo.
AID1395930	Cytotoxicity against human BV2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	2018	European journal of medicinal chemistry, May-10, Volume: 151	Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo.
AID1395929	Anti-neuroinflammatory activity in human BV2 cells assessed as reduction in LPS-induced NO production preincubated for 4 hrs followed by LPS stimulation for 24 hrs by Griess assay	2018	European journal of medicinal chemistry, May-10, Volume: 151	Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	3 (50.00)	24.3611
2020's	2 (33.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	2.01	1	0	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
clovamide clovamide: RN given for (Z)-isomer; structure in first source	2.46	2	0	tyrosine derivative

Condition	Relationship Strength	Studies
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.61	2
Atherosclerotic Parkinsonism [description not available]	2.17	1
Parkinson Disease, Secondary Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)	2.17	1
Acute Confusional Senile Dementia [description not available]	2.17	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.17	1
Congenital Zika Syndrome [description not available]	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1

n-trans-p-coumaroyl-l-tyrosine

Description

Cross-References

Synonyms (22)

Research Excerpts

Bioavailability

Drug Classes (1)

Protein Targets (2)

Inhibition Measurements

Biological Processes (108)

Molecular Functions (23)

Ceullar Components (46)

Bioassays (11)

Research

Studies (6)

Study Types

n-trans-p-coumaroyl-l-tyrosine

Description

Related Flora

Cross-References

Synonyms (22)

Research Excerpts

Bioavailability

Drug Classes (1)

Protein Targets (2)

Inhibition Measurements

Biological Processes (108)

Molecular Functions (23)

Ceullar Components (46)

Bioassays (11)

Research

Studies (6)

Study Types

Related Drugs (2)

Related Conditions (7)