Inhibitor of growth protein 2

An inhibitor of growth protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H160]

Synonyms

Inhibitor of growth 1-like protein;
ING1Lp;
p32;
p33ING2

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
di-n-desethylamiodarone	Homo sapiens (human)	IC50	97.0000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
chromatin binding	molecular function	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
histone deacetylase regulator activity	molecular function	Binds to and modulates the activity of histone deacetylase. [GOC:bf]
methylated histone binding	molecular function	Binding to a histone in which a residue has been modified by methylation. [GOC:bf, PMID:14585615]
phosphatidylinositol binding	molecular function	Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417]
protein-containing complex binding	molecular function	Binding to a macromolecular complex. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
histone reader activity	molecular function	A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. [PMID:11498575, PMID:25688442, PMID:31082667, PMID:32260176, PMID:34726351]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
Sin3-type complex	cellular component	Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. [PMID:15565322, PMID:18292778]
CCAAT-binding factor complex	cellular component	A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. [GOC:bhm, PMID:7828851]

Involved In

This protein is involved in 19 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
regulation of DNA-templated transcription	biological process	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
DNA damage response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]
male meiosis I	biological process	A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. [GOC:dph, GOC:mah]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
spermatogenesis	biological process	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
spermatid development	biological process	The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. [GOC:dph, GOC:go_curators]
flagellated sperm motility	biological process	The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]
negative regulation of cell migration	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators]
positive regulation of transforming growth factor beta receptor signaling pathway	biological process	Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. [GOC:go_curators]
negative regulation of transforming growth factor beta receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. [GOC:mah]
negative regulation of gene expression, epigenetic	biological process	An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation. [PMID:22243696]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
male germ-line stem cell asymmetric division	biological process	The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes. [GOC:jid]
seminiferous tubule development	biological process	The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa. [GOC:BHF, GOC:mah, UBERON:0001343]
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. [GOC:TermGenie, PMID:17719541]
negative regulation of stem cell population maintenance	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance. [GOC:hjd, GOC:TermGenie, PMID:22969033]
positive regulation of stem cell population maintenance	biological process	Any process that activates or increases the frequency, rate or extent of stem cell population maintenance. [GOC:hjd, GOC:TermGenie, PMID:22969033]
regulation of cellular senescence	biological process	Any process that modulates the frequency, rate or extent of cellular senescence. [GOC:BHF]