| Assay ID | Title | Year | Journal | Article |
|---|
| AID391290 | Displacement of [3H]GR125743 from human 5HT1D receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211030 | AUC (0 to 4 hrs) in wild-type Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391303 | Displacement of [3H]QNB from human muscarinic M4 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211113 | Ratio of AUC (0 to 4 hrs) for metabolite to AUC (0 to 4 hrs) for parent compound in MRP2 knockout Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID1211091 | Half life in wild-type Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID1211110 | Ratio of AUC (0 to 4 hrs) for metabolite to AUC (0 to 4 hrs) for parent compound in wild-type Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391304 | Displacement of [3H]U69593 from rat kappa opioid receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211088 | Tmax in MDR1A knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391602 | Displacement of [3H]alpha-methylhistamine from human histamine H3 receptor | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391299 | Displacement of [3H]SCH23390 from human dopamine D5 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211084 | Cmax in MDR1A knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID1211086 | Cmax in MRP2 knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID1211081 | AUC (infinity) in BCRP knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID1370523 | Plasma concentration in human cardiac arrhythmia model | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K |
| AID1211112 | Ratio of AUC (0 to 4 hrs) for metabolite to AUC (0 to 4 hrs) for parent compound in BCRP knockout Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID1211111 | Ratio of AUC (0 to 4 hrs) for metabolite to AUC (0 to 4 hrs) for parent compound in MDR1A knockout Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391597 | Displacement of [125I]HEAT from adrenergic Alpha-2C receptor | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391294 | Displacement of [3H]mesulergine from human 5HT2C receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391314 | Displacement of [3H]tiotidine from human histamine H2 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391606 | Displacement of [3H]citalopram from human SERT | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211083 | Cmax in wild-type Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391305 | Displacement of [3H]DADLE from human delta opioid receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391603 | Displacement of [3H]DAMGO from mu opioid receptor | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391301 | Displacement of [3H]QNB from human muscarinic M2 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391295 | Displacement of [3H]iodopindolol from adrenergic beta-1 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1370520 | Inhibition of human KvLQT1/minK channel expressed in CHO cells at 10 uM at holding potential of -80 mV by whole cell patch clamp assay relative to control | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K |
| AID1370522 | Inhibition of human ERG expressed in HEK293 cells at holding potential of -80 mV by whole cell patch clamp assay | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K |
| AID391300 | Displacement of [3H]QNB from human muscarinic M1 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211082 | AUC (infinity) in MRP2 knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID1211089 | Tmax in BCRP knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391600 | Displacement of [3H]pyrilamine from human histamine H1 receptor | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391287 | Dissociation constant, pKa of the compound | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391311 | Displacement of [125I]HEAT from adrenergic Alpha-2C receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391302 | Displacement of [3H]QNB from human muscarinic M3 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211029 | AUC (0 to 4 hrs) in MDR1A knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391599 | Displacement of [3H]N-methylspiperone from dopamine D4 receptor | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391298 | Displacement of [3H]N-methylspiperone from human dopamine D2 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1370524 | Inhibition of human ERG expressed in HEK293 cells at 30 nM at holding potential of -80 mV by whole cell patch clamp assay relative to control | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K |
| AID1370526 | Fraction unbound in human plasma at 30 to 1000 ng/ml after 2 to 6 hrs by LC-MS/MS based rapid equilibrium dialysis method | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K |
| AID391297 | Displacement of [3H]SCH23390 from human dopamine D1 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391596 | Displacement of [125I]HEAT from adrenergic alpha2A receptor | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391316 | Displacement of [3H]DAMGO from mu opioid receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391595 | Displacement of [125I]HEAT from adrenergic alpha1A receptor | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211087 | Tmax in wild-type Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID1211085 | Cmax in BCRP knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391312 | Displacement of [3H]N-methylspiperone from dopamine D4 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391318 | Displacement of [3H]DTG from rat sigma 2 receptor in rat PC12 cells at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391306 | Displacement of [3H]nisoxetine from human NET at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391313 | Displacement of [3H]pyrilamine from human histamine H1 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211090 | Tmax in MRP2 knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391288 | Displacement of [3H]8-OH-DPAT from human 5HT1A receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391296 | Displacement of [3H]iodopindolol from adrenergic beta2 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1370525 | Protein binding to human plasma at 30 to 1000 ng/ml after 2 to 6 hrs by LC-MS/MS based rapid equilibrium dialysis method | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K |
| AID391307 | Displacement of [3H]WIN-35428 from human DAT at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391315 | Displacement of [3H]alpha-methylhistamine from human histamine H3 receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1370521 | Inhibition of human Nav1.5 channel expressed in HEK293 cells at holding potential of -70 mV by whole cell patch clamp assay | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K |
| AID391604 | Displacement of [3H]Pentazocine from rat sigma 1 receptor in rat PC12 cells | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391309 | Displacement of [125I]HEAT from adrenergic alpha2A receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211080 | AUC (infinity) in wild-type Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391293 | Displacement of [3H]LSD from human 5HT2B receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391317 | Displacement of [3H]pentazocine from rat sigma 1 receptor in rat PC12 cells at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391310 | Displacement of [125I]HEAT from adrenergic alpha2B receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391308 | Displacement of [125I]HEAT from adrenergic alpha1A receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391319 | Displacement of [3H]citalopram from human SERT at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391292 | Displacement of [3H]ketanserin from human 5HT2A receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391601 | Displacement of [3H]tiotidine from human histamine H2 receptor | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391291 | Displacement of [3H]5HT from human 5HT1E receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391605 | Displacement of [3H]DTG from rat sigma 2 receptor in rat PC12 cells | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1211028 | Half life in MRP2 knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID1211027 | Half life in BCRP knockout Sprague-Dawley rat treated with loperamide at 10 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Sep, Volume: 40, Issue:9
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. |
| AID391598 | Displacement of [125I]HEAT from adrenergic alpha2B receptor | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID391289 | Displacement of [3H]GR125743 from human 5HT1B receptor at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
| AID1370519 | Inhibition of human KvLQT1/minK channel expressed in CHO cells at 1 uM at holding potential of -80 mV by whole cell patch clamp assay relative to control | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3
| Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |