| Assay ID | Title | Year | Journal | Article |
|---|
| AID480326 | Inhibition of rabbit osteoclast rab11 prenylation after 24 hrs by Western blot analysis | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID480315 | Inhibition of recombinant RGGT assessed as incorporation of [3H]GGPP into His-tagged canine rab1a after 30 mins | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID480323 | Inhibition of recombinant RGGT by uncompetitive inhibition based Lineweaver-Burke plot using Rab1a as substrate | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID480322 | Inhibition of GGTase1 assessed as incorporation of [3H]GGPP into His-tagged canine rab1a after 30 mins | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID303803 | Inhibition of RGGT mediated Rab11 prenylation in J744 cells | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
| Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| AID318595 | Inhibition of bone resorption in rat assessed as phosphate | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. |
| AID1204209 | Inhibition of GGTase 2 in human RPMI8226 cells assessed as reduction in membrane bound Rab6 protein at 5 mM incubated for 48 hrs by immunoblot method | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
| N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. |
| AID1121273 | Inhibition of rat RabGGTase using [3H]GGPP by scintillation counting | 2013 | MedChemComm, Mar, Volume: 4, Issue:3
| Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections. |
| AID480313 | Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID480314 | Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by alamar blue assay | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID1121272 | Inhibition of human RabGGTase using [3H]GGPP by scintillation counting | 2013 | MedChemComm, Mar, Volume: 4, Issue:3
| Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections. |
| AID1204205 | Inhibition of GGTase 2 (unknown origin) | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
| N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. |
| AID480320 | Inhibition of RGGT-mediated Rap1A prenylation in mouse J774 cells at 2 mM after 24 hrs by Western blot analysis | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID1204214 | Induction of endoplasmic reticulum stress in human RPMI8226 cells assessed as increase in calnexin cleavage at 5 mM incubated for 48 hrs by immunoblot method | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
| N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. |
| AID303799 | Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3) | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
| Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| AID480317 | Inhibition of RGGT-mediated Rab11 prenylation in mouse J774 cells after 24 hrs by Western blot analysis | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID480327 | Antiresorptive activity in rabbit osteoclasts assessed as number of actin rings after 48 hrs using TRITC-phelloidin stain relative to control | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID1204208 | Inhibition of GGTase 1 in human RPMI8226 cells assessed as unmodified Rap1a accumulation at 5 mM incubated for 48 hrs by immunoblot method | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
| N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. |
| AID318593 | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. |
| AID303798 | Bone mineral affinity on hydroxyaptite assessed as retention time by chromatography | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
| Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| AID318594 | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. |
| AID480316 | Inhibition of recombinant RGGT assessed as incorporation of [3H]GGPP into His-tagged canine rab1a after 20 mins | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID1204207 | Inhibition of recombinant GGTase 2 (unknown origin) using recombinant Rab1A and [3H]GGPP as substrate after 20 mins in presence of recombinant REP-2 by liquid scintillation counting analysis | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
| N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. |
| AID471506 | Inhibition of recombinant Rab geranylgeranyltransferase expressed in human MCF7 cells assessed as inhibition of geranylgeranylation of EYFP-Rab7 protein at 100 uM to 0.5 mM by Western blot relative to compactin | 2009 | Journal of medicinal chemistry, Dec-24, Volume: 52, Issue:24
| Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors. |
| AID303802 | Inhibition of RGGT | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
| Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| AID1204215 | Inhibition of GGTase 2 in human RPMI8226 cells assessed as disruption of monoclonal protein trafficking by measuring accumulation of intracellular lambda light chain at 5 mM incubated for 48 hrs by ELISA | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
| N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. |
| AID480319 | Inhibition of RGGT-mediated Rap1A prenylation in mouse J774 cells at 4 mM after 24 hrs by Western blot analysis | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID480329 | Inhibition of human FPPS at 10 uM after 10 mins using [14C]IPP as substrate | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID1204206 | Inhibition of recombinant FDPS (unknown origin) assessed as decrease in radiolabeld GGPP level using GPP and [14C]IPP as substrate treated with enzyme for 10 mins prior to substrate challenge for 30 mins by liquid scintillation counting analysis | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
| N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. |
| AID1204212 | Induction of apoptosis in human RPMI8226 cells assessed as increase in PARP cleavage at 5 mM incubated for 48 hrs by immunoblot method | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
| N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. |
| AID480321 | Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID1204213 | Induction of apoptosis in human RPMI8226 cells assessed as increase in caspase-3 cleavage at 5 mM incubated for 48 hrs by immunoblot method | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
| N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. |
| AID480328 | Antiresorptive activity in Schenk growing rat model assessed as inhibition of bone resorption | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
| AID303800 | Reduction of viability of mouse J744 cells after 48 hrs | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
| Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| AID471507 | Inhibition of recombinant Rab geranylgeranyltransferase expressed in human MCF7 cells assessed as inhibition of geranylgeranylation of EYFP-Rab7 protein by Western blot | 2009 | Journal of medicinal chemistry, Dec-24, Volume: 52, Issue:24
| Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |