Page last updated: 2024-10-14

ith 4012

Cross-References

ID SourceID
PubMed CID6918662
CHEMBL ID253386
MeSH IDM0474640

Synonyms (6)

Synonym
tk-19
ith-4012
5-amino-2-methyl-4-phenyl-6,7,8,9-tetrahydro-benzo[b][1,8]naphthyridine-3-carboxylic acid ethyl ester
ethyl 5-amino-2-methyl-4-phenyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
bdbm50241350
CHEMBL253386 ,
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (30)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AcetylcholinesteraseElectrophorus electricus (electric eel)IC50 (µMol)0.81550.00000.94539.9400AID1653238; AID366351; AID479748; AID482856
Voltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)IC50 (µMol)20.00000.03700.89152.5000AID1653244
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)IC50 (µMol)20.00000.00032.63119.0000AID1653244
Voltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)IC50 (µMol)20.00000.03201.04793.6000AID1653244
CholinesteraseHomo sapiens (human)IC50 (µMol)5.00000.00001.559910.0000AID1653242; AID1653243
Acetylcholinesterase Bos taurus (cattle)IC50 (µMol)0.82000.00000.61068.7000AID1653241
Voltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)IC50 (µMol)20.00000.02980.06990.1100AID1653244
CholinesteraseEquus caballus (horse)IC50 (µMol)5.01500.00002.22149.4000AID479749; AID482854
Voltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)IC50 (µMol)20.00000.04004.113710.0000AID1653244
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)IC50 (µMol)20.00000.00032.59559.0000AID1653244
Voltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)IC50 (µMol)20.00000.11000.11000.1100AID1653244
Voltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)IC50 (µMol)20.00000.02980.02980.0298AID1653244
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)IC50 (µMol)20.00000.00032.63119.0000AID1653244
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)IC50 (µMol)20.00000.00032.25459.6000AID1653244
Voltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)IC50 (µMol)20.00000.08600.65472.5000AID1653244
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (126)

Processvia Protein(s)Taxonomy
gamma-aminobutyric acid signaling pathwayVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
adult walking behaviorVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
negative regulation of cell population proliferationVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
gamma-aminobutyric acid secretionVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
neuronal action potential propagationVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
synaptic transmission, glutamatergicVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
cAMP metabolic processVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
spleen developmentVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
thymus developmentVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
Peyer's patch developmentVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
T cell receptor signaling pathwayVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
detection of light stimulus involved in visual perceptionVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
muscle cell developmentVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
calcium ion transmembrane transportVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
regulation of presynaptic cytosolic calcium ion concentrationVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
regulation of voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
positive regulation of protein localization to nucleolusVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
cellular response to leukemia inhibitory factorVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
negative regulation of G1/S transition of mitotic cell cycleVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
regulation of synaptic vesicle exocytosisVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
neuromuscular junction developmentVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
chemical synaptic transmissionVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
positive regulation of cytosolic calcium ion concentrationVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
modulation of chemical synaptic transmissionVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
response to amyloid-betaVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
cellular response to amyloid-betaVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
chemical synaptic transmissionVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
sinoatrial node developmentVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
chemical synaptic transmissionVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
response to nickel cationVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
regulation of membrane potentialVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
regulation of atrial cardiac muscle cell membrane depolarizationVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
calcium ion importVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
cardiac muscle cell action potential involved in contractionVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
SA node cell action potentialVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
AV node cell action potentialVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
SA node cell to atrial cardiac muscle cell signalingVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
AV node cell to bundle of His cell signalingVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
membrane depolarization during AV node cell action potentialVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
membrane depolarization during SA node cell action potentialVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
regulation of heart rate by cardiac conductionVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
protein targetingVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
calcium ion transportVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
protein localizationVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
neurotransmitter receptor localization to postsynaptic specialization membraneVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
regulation of AMPA receptor activityVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
transmission of nerve impulseVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
neurotransmitter receptor internalizationVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
positive regulation of synaptic transmission, glutamatergicVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
neurotransmitter receptor transport, postsynaptic endosome to lysosomeVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
postsynaptic neurotransmitter receptor diffusion trappingVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
visual perceptionVoltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)
detection of light stimulus involved in visual perceptionVoltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)
muscle contractionVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
muscle organ developmentVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
myoblast fusionVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
regulation of heart contractionVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
aldosterone biosynthetic processVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
cellular response to hormone stimulusVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
cortisol biosynthetic processVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
cellular response to potassium ionVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
regulation of membrane potentialVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
calcium ion importVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
inorganic cation transmembrane transportVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
positive regulation of acrosome reactionVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
xenobiotic metabolic processCholinesteraseHomo sapiens (human)
learningCholinesteraseHomo sapiens (human)
negative regulation of cell population proliferationCholinesteraseHomo sapiens (human)
neuroblast differentiationCholinesteraseHomo sapiens (human)
peptide hormone processingCholinesteraseHomo sapiens (human)
response to alkaloidCholinesteraseHomo sapiens (human)
cocaine metabolic processCholinesteraseHomo sapiens (human)
negative regulation of synaptic transmissionCholinesteraseHomo sapiens (human)
response to glucocorticoidCholinesteraseHomo sapiens (human)
response to folic acidCholinesteraseHomo sapiens (human)
choline metabolic processCholinesteraseHomo sapiens (human)
acetylcholine catabolic processCholinesteraseHomo sapiens (human)
calcium ion transportVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
T cell receptor signaling pathwayVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
calcium ion transport into cytosolVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
calcium ion transmembrane transport via high voltage-gated calcium channelVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
protein localization to plasma membraneVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
regulation of membrane repolarization during action potentialVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
positive regulation of high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
neuromuscular junction developmentVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
chemical synaptic transmissionVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
regulation of voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
calcium ion transportVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
regulation of calcium ion transportVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
regulation of ventricular cardiac muscle cell membrane repolarizationVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
calcium ion transport into cytosolVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
calcium ion transmembrane transport via high voltage-gated calcium channelVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
cardiac muscle cell action potential involved in contractionVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
membrane depolarization during bundle of His cell action potentialVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
regulation of heart rate by cardiac conductionVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
regulation of membrane repolarization during action potentialVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
positive regulation of high voltage-gated calcium channel activityVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
cellular response to amyloid-betaVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
calcium ion transportVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
regulation of mRNA stabilityVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
neurotransmitter receptor localization to postsynaptic specialization membraneVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
positive regulation of dendrite extensionVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
regulation of AMPA receptor activityVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
neurotransmitter receptor internalizationVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
postsynaptic neurotransmitter receptor diffusion trappingVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
neurotransmitter receptor transport, postsynaptic endosome to lysosomeVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
transmission of nerve impulseVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
positive regulation of synaptic transmission, glutamatergicVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
modulation of chemical synaptic transmissionVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
response to amyloid-betaVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
chemical synaptic transmissionVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
calcium ion transportVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
adenylate cyclase-modulating G protein-coupled receptor signaling pathwayVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
sensory perception of soundVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
positive regulation of adenylate cyclase activityVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
positive regulation of calcium ion transportVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
regulation of atrial cardiac muscle cell membrane repolarizationVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
calcium ion importVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
calcium ion transmembrane transportVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
cardiac muscle cell action potential involved in contractionVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
membrane depolarization during cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
membrane depolarization during SA node cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
regulation of heart rate by cardiac conductionVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
regulation of potassium ion transmembrane transporter activityVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
regulation of potassium ion transmembrane transportVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
positive regulation of muscle contractionVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
calcium ion transmembrane transportVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
cellular response to amyloid-betaVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
regulation of voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
neuromuscular junction developmentVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
chemical synaptic transmissionVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
positive regulation of muscle contractionVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
establishment of localization in cellVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
sarcoplasmic reticulum calcium ion transportVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
visual perceptionVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
positive regulation of muscle contractionVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
positive regulation of calcium ion transportVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
calcium ion importVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
calcium ion transmembrane transportVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
protein localization to plasma membraneVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
membrane depolarization during AV node cell action potentialVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
regulation of heart rate by cardiac conductionVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
membrane depolarization during atrial cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
regulation of presynaptic cytosolic calcium ion concentrationVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
positive regulation of high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channelVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
regulation of voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
chemical synaptic transmissionVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
neuromuscular junction developmentVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
skeletal system developmentVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
extraocular skeletal muscle developmentVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
calcium ion transportVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
muscle contractionVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
striated muscle contractionVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
endoplasmic reticulum organizationVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
myoblast fusionVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
neuromuscular junction developmentVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
skeletal muscle adaptationVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
positive regulation of muscle contractionVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
skeletal muscle fiber developmentVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
release of sequestered calcium ion into cytosolVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
cellular response to caffeineVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
immune system developmentVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
heart developmentVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
embryonic forelimb morphogenesisVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
camera-type eye developmentVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
positive regulation of adenylate cyclase activityVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
positive regulation of muscle contractionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calcium ion transport into cytosolVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
cardiac conductionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calcium ion transmembrane transport via high voltage-gated calcium channelVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
cardiac muscle cell action potential involved in contractionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
membrane depolarization during cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
membrane depolarization during AV node cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
regulation of heart rate by cardiac conductionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
regulation of ventricular cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
membrane depolarization during atrial cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent R-type calcium channel subunit alpha-1EHomo sapiens (human)
chemical synaptic transmissionVoltage-dependent R-type calcium channel subunit alpha-1EHomo sapiens (human)
detection of light stimulus involved in visual perceptionVoltage-dependent calcium channel subunit alpha-2/delta-4Homo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel subunit alpha-2/delta-4Homo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel subunit alpha-2/delta-3Homo sapiens (human)
calcium ion transportVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
regulation of AMPA receptor activityVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
postsynaptic neurotransmitter receptor diffusion trappingVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
neurotransmitter receptor internalizationVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
positive regulation of synaptic transmission, glutamatergicVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
neurotransmitter receptor transport, postsynaptic endosome to lysosomeVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
transmission of nerve impulseVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
calcium ion transportVoltage-dependent calcium channel gamma-6 subunitHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel gamma-6 subunitHomo sapiens (human)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelVoltage-dependent calcium channel gamma-6 subunitHomo sapiens (human)
neuromuscular junction developmentVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
organ growthVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
regulation of multicellular organism growthVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
positive regulation of organ growthVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
muscle cell developmentVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
rhythmic synaptic transmissionVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
signal transductionVoltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)
neuronal action potentialVoltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)
sleepVoltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)
response to cocaineVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
regulation of AMPA receptor activityVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
positive regulation of synaptic transmission, glutamatergicVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
transmission of nerve impulseVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
neurotransmitter receptor internalizationVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
neurotransmitter receptor transport, postsynaptic endosome to lysosomeVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
postsynaptic neurotransmitter receptor diffusion trappingVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
regulation of AMPA receptor activityVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
postsynaptic neurotransmitter receptor diffusion trappingVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
neurotransmitter receptor transport, postsynaptic endosome to lysosomeVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
neurotransmitter receptor internalizationVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
transmission of nerve impulseVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
positive regulation of synaptic transmission, glutamatergicVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
protein targeting to membraneVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
neuromuscular junction developmentVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
response to calcium ionVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
membrane depolarizationVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
membrane hyperpolarizationVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
eye blink reflexVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
neurotransmitter receptor localization to postsynaptic specialization membraneVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
positive regulation of protein localization to basolateral plasma membraneVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
regulation of AMPA receptor activityVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
positive regulation of synaptic transmission, glutamatergicVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
neurotransmitter receptor internalizationVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
postsynaptic neurotransmitter receptor diffusion trappingVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
neurotransmitter receptor transport, postsynaptic endosome to lysosomeVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
transmission of nerve impulseVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (37)

Processvia Protein(s)Taxonomy
voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
protein bindingVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
protein kinase bindingVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levelsVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
amyloid-beta bindingVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
protein bindingVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
syntaxin bindingVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
metal ion bindingVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
low voltage-gated calcium channel activityVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
voltage-gated calcium channel activity involved in AV node cell action potentialVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
voltage-gated calcium channel activity involved SA node cell action potentialVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
scaffold protein bindingVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
PDZ domain bindingVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
ionotropic glutamate receptor bindingVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
channel regulator activityVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)
metal ion bindingVoltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)
voltage-gated monoatomic ion channel activityVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
protein bindingVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
low voltage-gated calcium channel activityVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
metal ion bindingVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
scaffold protein bindingVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
amyloid-beta bindingCholinesteraseHomo sapiens (human)
catalytic activityCholinesteraseHomo sapiens (human)
acetylcholinesterase activityCholinesteraseHomo sapiens (human)
cholinesterase activityCholinesteraseHomo sapiens (human)
protein bindingCholinesteraseHomo sapiens (human)
hydrolase activity, acting on ester bondsCholinesteraseHomo sapiens (human)
enzyme bindingCholinesteraseHomo sapiens (human)
choline bindingCholinesteraseHomo sapiens (human)
identical protein bindingCholinesteraseHomo sapiens (human)
amyloid-beta bindingAcetylcholinesterase Bos taurus (cattle)
protein bindingAcetylcholinesterase Bos taurus (cattle)
voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
calcium channel regulator activityVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
protein bindingVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
voltage-gated calcium channel activity involved in cardiac muscle cell action potentialVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
voltage-gated calcium channel activity involved in bundle of His cell action potentialVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
metal ion bindingVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
calcium channel regulator activityVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
protein bindingVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
channel regulator activityVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
amyloid-beta bindingVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
calcium ion bindingVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
protein bindingVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
ATP bindingVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
protein bindingVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
ankyrin bindingVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
metal ion bindingVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
alpha-actinin bindingVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
voltage-gated calcium channel activity involved in cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
voltage-gated calcium channel activity involved SA node cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
protein bindingVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
calcium channel regulator activityVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
protein bindingVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
voltage-gated calcium channel activity involved in cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
voltage-gated calcium channel activity involved in AV node cell action potentialVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
calcium channel activityVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
protein bindingVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
actin filament bindingVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levelsVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
protein bindingVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
calmodulin bindingVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
small molecule bindingVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
metal ion bindingVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
molecular function activator activityVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel activity involved in cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
protein bindingVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calmodulin bindingVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
metal ion bindingVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
alpha-actinin bindingVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel activity involved in cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel activity involved in AV node cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent R-type calcium channel subunit alpha-1EHomo sapiens (human)
calcium ion bindingVoltage-dependent R-type calcium channel subunit alpha-1EHomo sapiens (human)
voltage-gated monoatomic cation channel activityVoltage-dependent R-type calcium channel subunit alpha-1EHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent R-type calcium channel subunit alpha-1EHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel subunit alpha-2/delta-4Homo sapiens (human)
metal ion bindingVoltage-dependent calcium channel subunit alpha-2/delta-4Homo sapiens (human)
metal ion bindingVoltage-dependent calcium channel subunit alpha-2/delta-3Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel subunit alpha-2/delta-3Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
calcium channel regulator activityVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
channel regulator activityVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel gamma-6 subunitHomo sapiens (human)
calcium channel regulator activityVoltage-dependent calcium channel gamma-6 subunitHomo sapiens (human)
metal ion bindingVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)
protein bindingVoltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)
calcium channel regulator activityVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
ionotropic glutamate receptor bindingVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
channel regulator activityVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
monoatomic ion transmembrane transporter activityVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
channel regulator activityVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
protein bindingVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
ionotropic glutamate receptor bindingVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
channel regulator activityVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (43)

Processvia Protein(s)Taxonomy
cytosolVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
cytoplasmic side of plasma membraneVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
nuclear speckVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
presynapseVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
glutamatergic synapseVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit beta-4Homo sapiens (human)
nucleusVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
cytoplasmVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
plasma membraneVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
membraneVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
cell projectionVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
neuronal cell bodyVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
synapseVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
neuronal cell bodyVoltage-dependent P/Q-type calcium channel subunit alpha-1AHomo sapiens (human)
cytoplasmVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
plasma membraneVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
synapseVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)
plasma membraneVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
dendriteVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
endocytic vesicle membraneVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
somatodendritic compartmentVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
excitatory synapseVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
Schaffer collateral - CA1 synapseVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
glutamatergic synapseVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
AMPA glutamate receptor complexVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
postsynaptic density membraneVoltage-dependent calcium channel gamma-3 subunitHomo sapiens (human)
photoreceptor outer segmentVoltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)
membraneVoltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)
perikaryonVoltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)
plasma membraneVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
membraneVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)
extracellular regionCholinesteraseHomo sapiens (human)
nuclear envelope lumenCholinesteraseHomo sapiens (human)
endoplasmic reticulum lumenCholinesteraseHomo sapiens (human)
blood microparticleCholinesteraseHomo sapiens (human)
plasma membraneCholinesteraseHomo sapiens (human)
extracellular spaceCholinesteraseHomo sapiens (human)
synapseAcetylcholinesterase Bos taurus (cattle)
side of membraneAcetylcholinesterase Bos taurus (cattle)
cytosolVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
membraneVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
synapseVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit beta-3Homo sapiens (human)
plasma membraneVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
sarcoplasmic reticulumVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
extracellular exosomeVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
neuronal dense core vesicleVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent calcium channel subunit alpha-2/delta-1Homo sapiens (human)
early endosomeVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
plasma membraneVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
neuronal cell bodyVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
cerebellar mossy fiberVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
glutamatergic synapseVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
AMPA glutamate receptor complexVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
postsynaptic density membraneVoltage-dependent calcium channel gamma-7 subunitHomo sapiens (human)
plasma membraneVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
synapseVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
neuronal cell bodyVoltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)
plasma membraneVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
Z discVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)
plasma membraneVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
T-tubuleVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
synapseVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit beta-1Homo sapiens (human)
plasma membraneVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
T-tubuleVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
sarcolemmaVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent calcium channel gamma-1 subunitHomo sapiens (human)
plasma membraneVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
photoreceptor ribbon synapseVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
presynapseVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit beta-2Homo sapiens (human)
cytoplasmVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
plasma membraneVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
sarcoplasmic reticulumVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
T-tubuleVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
I bandVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)
cytoplasmVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
plasma membraneVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
postsynaptic densityVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
membraneVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
Z discVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
dendriteVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
perikaryonVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
postsynaptic density membraneVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
plasma membraneVoltage-dependent R-type calcium channel subunit alpha-1EHomo sapiens (human)
synapseVoltage-dependent R-type calcium channel subunit alpha-1EHomo sapiens (human)
neuronal cell bodyVoltage-dependent R-type calcium channel subunit alpha-1EHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent R-type calcium channel subunit alpha-1EHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent calcium channel subunit alpha-2/delta-4Homo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent calcium channel subunit alpha-2/delta-3Homo sapiens (human)
plasma membraneVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
postsynaptic densityVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
endocytic vesicle membraneVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
AMPA glutamate receptor complexVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
postsynaptic density membraneVoltage-dependent calcium channel gamma-8 subunitHomo sapiens (human)
plasma membraneVoltage-dependent calcium channel gamma-6 subunitHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent calcium channel gamma-6 subunitHomo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent calcium channel gamma-6 subunitHomo sapiens (human)
plasma membraneVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent calcium channel subunit alpha-2/delta-2Homo sapiens (human)
plasma membraneVoltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)
plasma membraneVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
cell surfaceVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
endocytic vesicle membraneVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
somatodendritic compartmentVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
cell bodyVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
glutamatergic synapseVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
AMPA glutamate receptor complexVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
postsynaptic density membraneVoltage-dependent calcium channel gamma-4 subunitHomo sapiens (human)
glutamatergic synapseVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
postsynaptic densityVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
AMPA glutamate receptor complexVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
postsynaptic density membraneVoltage-dependent calcium channel gamma-5 subunitHomo sapiens (human)
plasma membraneVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
cell surfaceVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
endocytic vesicle membraneVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
somatodendritic compartmentVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
cerebellar mossy fiberVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
Schaffer collateral - CA1 synapseVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
hippocampal mossy fiber to CA3 synapseVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
glutamatergic synapseVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
AMPA glutamate receptor complexVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
postsynaptic density membraneVoltage-dependent calcium channel gamma-2 subunitHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1653238Inhibition of electric eel AChE2019European journal of medicinal chemistry, Mar-15, Volume: 166Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.
AID1653242Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate by Ellman's methods2019European journal of medicinal chemistry, Mar-15, Volume: 166Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.
AID479749Inhibition of Equus caballus BuChE2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.
AID482856Inhibition of electric eel AChE by Ellman's method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
AID310880Inhibition of AchE relative to tacrine2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Quantitative structure-activity relationship (QSAR) of tacrine derivatives against acetylcholinesterase (AChE) activity using variable selections.
AID482868Neuroprotective activity in human SH-SY5Y cells assessed as protection against okadaic acid-induced cell death at 1 uM after 24 hrs by MTT assay2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
AID1653243Inhibition of BuChE (unknown origin)2019European journal of medicinal chemistry, Mar-15, Volume: 166Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.
AID482867Neuroprotective activity in human SH-SY5Y cells assessed as protection against rotenone/oligomycin A-induced cell death at 1 uM after 24 hrs by LDH release assay2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
AID1653244Inhibition of VGCC (unknown origin)2019European journal of medicinal chemistry, Mar-15, Volume: 166Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.
AID366351Inhibition of Electrophorus electricus AChE by spectrophotometry2008Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.
AID482853Selectivity ratio of IC50 for equine serum BuChE to IC50 for electric eel AChE2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
AID1653241Inhibition of bovine erythrocytes AChE using acetylthiocholine iodide as substrate by Ellman's methods2019European journal of medicinal chemistry, Mar-15, Volume: 166Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.
AID479748Inhibition of electric eel AChE2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.
AID482854Inhibition of equine serum BuChE by Ellman's method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]