Compounds > mimulone
Page last updated: 2024-12-11

mimulone

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Description

mimulone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5716903
CHEMBL ID374130
SCHEMBL ID12780391
SCHEMBL ID16105830
MeSH IDM000605791

Synonyms (15)

Synonym
4h-1-benzopyran-4-one, 6-[(2e)-3,7-dimethyl-2,6-octadienyl]-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (2s)-
4h-1-benzopyran-4-one, 6-[(2e)-3,7-dimethyl-2,6-octadienyl]-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (2s)- (9ci)
97126-57-3
bonannione a
6-geranylnaringenin
4h-1-benzopyran-4-one, 6-(3,7-dimethyl-2,6-octadienyl)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, [s-(e)]-
mimulone
CHEMBL374130
(2s)-6-[(2e)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
bdbm50380198
SCHEMBL12780391
SCHEMBL16105830
DTXSID10420836
AKOS032954162
FS-7457
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Prostaglandin G/H synthase 1Ovis aries (sheep)IC50 (µMol)3.70000.00032.177410.0000AID1424043
AcetylcholinesteraseHomo sapiens (human)IC50 (µMol)91.50000.00000.933210.0000AID654699
AcetylcholinesteraseHomo sapiens (human)Ki120.50000.00001.27869.7300AID654700
Prostaglandin G/H synthase 2Homo sapiens (human)IC50 (µMol)6.00000.00010.995010.0000AID1424044
Carboxylic ester hydrolase Equus caballus (horse)IC50 (µMol)20.60000.00512.69848.5000AID654701
Carboxylic ester hydrolase Equus caballus (horse)Ki22.20000.00200.95708.0000AID654839
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (73)

Processvia Protein(s)Taxonomy
acetylcholine catabolic process in synaptic cleftAcetylcholinesteraseHomo sapiens (human)
regulation of receptor recyclingAcetylcholinesteraseHomo sapiens (human)
osteoblast developmentAcetylcholinesteraseHomo sapiens (human)
acetylcholine catabolic processAcetylcholinesteraseHomo sapiens (human)
cell adhesionAcetylcholinesteraseHomo sapiens (human)
nervous system developmentAcetylcholinesteraseHomo sapiens (human)
synapse assemblyAcetylcholinesteraseHomo sapiens (human)
receptor internalizationAcetylcholinesteraseHomo sapiens (human)
negative regulation of synaptic transmission, cholinergicAcetylcholinesteraseHomo sapiens (human)
amyloid precursor protein metabolic processAcetylcholinesteraseHomo sapiens (human)
positive regulation of protein secretionAcetylcholinesteraseHomo sapiens (human)
retina development in camera-type eyeAcetylcholinesteraseHomo sapiens (human)
acetylcholine receptor signaling pathwayAcetylcholinesteraseHomo sapiens (human)
positive regulation of cold-induced thermogenesisAcetylcholinesteraseHomo sapiens (human)
prostaglandin biosynthetic processProstaglandin G/H synthase 2Homo sapiens (human)
angiogenesisProstaglandin G/H synthase 2Homo sapiens (human)
response to oxidative stressProstaglandin G/H synthase 2Homo sapiens (human)
embryo implantationProstaglandin G/H synthase 2Homo sapiens (human)
learningProstaglandin G/H synthase 2Homo sapiens (human)
memoryProstaglandin G/H synthase 2Homo sapiens (human)
regulation of blood pressureProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of cell population proliferationProstaglandin G/H synthase 2Homo sapiens (human)
response to xenobiotic stimulusProstaglandin G/H synthase 2Homo sapiens (human)
response to nematodeProstaglandin G/H synthase 2Homo sapiens (human)
response to fructoseProstaglandin G/H synthase 2Homo sapiens (human)
response to manganese ionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of vascular endothelial growth factor productionProstaglandin G/H synthase 2Homo sapiens (human)
cyclooxygenase pathwayProstaglandin G/H synthase 2Homo sapiens (human)
bone mineralizationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of prostaglandin biosynthetic processProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of fever generationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of synaptic plasticityProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of synaptic transmission, dopaminergicProstaglandin G/H synthase 2Homo sapiens (human)
prostaglandin secretionProstaglandin G/H synthase 2Homo sapiens (human)
response to estradiolProstaglandin G/H synthase 2Homo sapiens (human)
response to lipopolysaccharideProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylationProstaglandin G/H synthase 2Homo sapiens (human)
response to vitamin DProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to heatProstaglandin G/H synthase 2Homo sapiens (human)
response to tumor necrosis factorProstaglandin G/H synthase 2Homo sapiens (human)
maintenance of blood-brain barrierProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of protein import into nucleusProstaglandin G/H synthase 2Homo sapiens (human)
hair cycleProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of apoptotic processProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of nitric oxide biosynthetic processProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of cell cycleProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of vasoconstrictionProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of smooth muscle contractionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of smooth muscle contractionProstaglandin G/H synthase 2Homo sapiens (human)
decidualizationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of smooth muscle cell proliferationProstaglandin G/H synthase 2Homo sapiens (human)
regulation of inflammatory responseProstaglandin G/H synthase 2Homo sapiens (human)
brown fat cell differentiationProstaglandin G/H synthase 2Homo sapiens (human)
response to glucocorticoidProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of calcium ion transportProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergicProstaglandin G/H synthase 2Homo sapiens (human)
response to fatty acidProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to mechanical stimulusProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to lead ionProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to ATPProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to hypoxiaProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to non-ionic osmotic stressProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to fluid shear stressProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of transforming growth factor beta productionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesisProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of fibroblast growth factor productionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of brown fat cell differentiationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of platelet-derived growth factor productionProstaglandin G/H synthase 2Homo sapiens (human)
cellular oxidant detoxificationProstaglandin G/H synthase 2Homo sapiens (human)
regulation of neuroinflammatory responseProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stressProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to homocysteineProstaglandin G/H synthase 2Homo sapiens (human)
response to angiotensinProstaglandin G/H synthase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (16)

Processvia Protein(s)Taxonomy
amyloid-beta bindingAcetylcholinesteraseHomo sapiens (human)
acetylcholinesterase activityAcetylcholinesteraseHomo sapiens (human)
cholinesterase activityAcetylcholinesteraseHomo sapiens (human)
protein bindingAcetylcholinesteraseHomo sapiens (human)
collagen bindingAcetylcholinesteraseHomo sapiens (human)
hydrolase activityAcetylcholinesteraseHomo sapiens (human)
serine hydrolase activityAcetylcholinesteraseHomo sapiens (human)
acetylcholine bindingAcetylcholinesteraseHomo sapiens (human)
protein homodimerization activityAcetylcholinesteraseHomo sapiens (human)
laminin bindingAcetylcholinesteraseHomo sapiens (human)
peroxidase activityProstaglandin G/H synthase 2Homo sapiens (human)
prostaglandin-endoperoxide synthase activityProstaglandin G/H synthase 2Homo sapiens (human)
protein bindingProstaglandin G/H synthase 2Homo sapiens (human)
enzyme bindingProstaglandin G/H synthase 2Homo sapiens (human)
heme bindingProstaglandin G/H synthase 2Homo sapiens (human)
protein homodimerization activityProstaglandin G/H synthase 2Homo sapiens (human)
metal ion bindingProstaglandin G/H synthase 2Homo sapiens (human)
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenProstaglandin G/H synthase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (22)

Processvia Protein(s)Taxonomy
extracellular regionAcetylcholinesteraseHomo sapiens (human)
basement membraneAcetylcholinesteraseHomo sapiens (human)
extracellular spaceAcetylcholinesteraseHomo sapiens (human)
nucleusAcetylcholinesteraseHomo sapiens (human)
Golgi apparatusAcetylcholinesteraseHomo sapiens (human)
plasma membraneAcetylcholinesteraseHomo sapiens (human)
cell surfaceAcetylcholinesteraseHomo sapiens (human)
membraneAcetylcholinesteraseHomo sapiens (human)
neuromuscular junctionAcetylcholinesteraseHomo sapiens (human)
synaptic cleftAcetylcholinesteraseHomo sapiens (human)
synapseAcetylcholinesteraseHomo sapiens (human)
perinuclear region of cytoplasmAcetylcholinesteraseHomo sapiens (human)
side of membraneAcetylcholinesteraseHomo sapiens (human)
nuclear inner membraneProstaglandin G/H synthase 2Homo sapiens (human)
nuclear outer membraneProstaglandin G/H synthase 2Homo sapiens (human)
cytoplasmProstaglandin G/H synthase 2Homo sapiens (human)
endoplasmic reticulumProstaglandin G/H synthase 2Homo sapiens (human)
endoplasmic reticulum lumenProstaglandin G/H synthase 2Homo sapiens (human)
endoplasmic reticulum membraneProstaglandin G/H synthase 2Homo sapiens (human)
caveolaProstaglandin G/H synthase 2Homo sapiens (human)
neuron projectionProstaglandin G/H synthase 2Homo sapiens (human)
protein-containing complexProstaglandin G/H synthase 2Homo sapiens (human)
neuron projectionProstaglandin G/H synthase 2Homo sapiens (human)
cytoplasmProstaglandin G/H synthase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (40)

Assay IDTitleYearJournalArticle
AID654701Inhibition of equine BChE assessed as butyrylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometry2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID654839Mixed type inhibition of equine BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk double-reciprocal-plot and dixon plot analysis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID750049Inhibition of SARS coronavirus papain-like protease (1541 to 1855 amino acids) expressed in Escherichia coli BL21 (DE3) using Z-RLRGG-AMC as substrate by fluorogenic assay2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa.
AID1424045Inhibition of human recombinant COX2 assessed as reduction in PGE2 formation at 20 uM pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID311089Cytotoxicity against rat WB344 cells at 100 uM after 24 hrs2007Journal of natural products, Aug, Volume: 70, Issue:8
C-geranyl compounds from Paulownia tomentosa fruits.
AID654700Mixed type inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk double-reciprocal-plot and dixon plot analysis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID477846Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID477845Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID1424046Selectivity index, ratio of IC50 for ram seminal vesicle COX1 to IC50 for human recombinant COX22017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID385176Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID1424043Inhibition of ram seminal vesicle COX1 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID311088Cytotoxicity against rat WB344 cells at 25 uM after 24 hrs2007Journal of natural products, Aug, Volume: 70, Issue:8
C-geranyl compounds from Paulownia tomentosa fruits.
AID1235535Cytotoxicity against mouse C3H10T1/2 cells after 24 hrs by fluorometric microculture assay2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens.
AID280644Antiproliferative activity against drug-sensitive human A2780 cells2007Journal of natural products, Mar, Volume: 70, Issue:3
Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.
AID385169Antibacterial activity against Bacillus cereus ATCC 11778 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID378531Cytotoxicity against human A2780 cells2005Journal of natural products, Mar, Volume: 68, Issue:3
Cytotoxic flavanones of Schizolaena hystrix from the Madagascar rainforest.
AID385173Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID477848Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID477847Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID385174Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID385172Antibacterial activity against Listeria monocytogenes ATCC 7644 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID385175Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID1235533Cytotoxicity against Hh signaling abnormally activated human PANC1 cells after 24 hrs by fluorometric microculture assay2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens.
AID1235532Inhibition of hedgehog signaling pathway in human HaCaT cells assessed as GLI1-mediated transcriptional activity after 12 hrs by luciferase assay2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens.
AID385177Antibacterial activity against Salmonella enteritidis ATCC 13076 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID1424048Inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 production pre-incubated for 10 mins before arachidonic acid addition and measured after 10 mins by ELISA2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID477849Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID385170Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID1424044Inhibition of human recombinant COX2 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA2017Journal of natural products, 04-28, Volume: 80, Issue:4
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
AID1227987Cytotoxicity against human THP1 cells at 2 uM after 24 hrs by WST assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production.
AID750048Mixed-type of inhibition of SARS coronavirus papain-like protease (1541 to 1855 amino acids) expressed in Escherichia coli BL21 (DE3) using Z-RLRGG-AMC as substrate by Dixon plot analysis2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa.
AID654699Inhibition of human erythrocyte AChE assessed as acetylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometry2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
AID385340Antibacterial activity against Candida albicans ATCC 10231 after 48 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID311086Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM by TEAC assay2007Journal of natural products, Aug, Volume: 70, Issue:8
C-geranyl compounds from Paulownia tomentosa fruits.
AID477850Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID1227986Cytotoxicity against human THP1 cells assessed as cell viability after 24 hrs by WST assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production.
AID477851Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method2010Journal of natural products, Apr-23, Volume: 73, Issue:4
Cytotoxic activities of several geranyl-substituted flavanones.
AID385171Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth microdilution method2008Journal of natural products, Apr, Volume: 71, Issue:4
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
AID311087Cytotoxicity against rat WB344 cells at 5 uM after 24 hrs2007Journal of natural products, Aug, Volume: 70, Issue:8
C-geranyl compounds from Paulownia tomentosa fruits.
AID654843Reversible inhibition of human erythrocyte AChE using assessed as acetylthiocholine iodide hydrolysis by spectrophotometry2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (33.33)29.6817
2010's10 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
toluene
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.		2.110methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0410aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
ibuprofen
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine		2.1510monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
pifithrin
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source		2.110aromatic ketone
physostigmine
Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.		2.0710carbamate ester;
indole alkaloid		antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic
thioflavin t
thioflavin T: RN given refers to chloride; structure. thioflavine T : An organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo.		2.2110organic chloride saltfluorochrome;
geroprotector;
histological dye
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0510delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
diaziquone
diaziquone: RN given refers to parent cpd. diaziquone : A 1,4-benzoquinone that is substituted at positions 2 and 5 have been replaced by aziridin-1-yl groups and at positions 3 and 6 by (ethoxycarbonyl)amino groups.		2.05101,4-benzoquinones;
aziridines;
carbamate ester;
enamine		alkylating agent;
antineoplastic agent
zileuton
[no description available]		2.15101-benzothiophenes;
ureas		anti-asthmatic drug;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
ferroptosis inhibitor;
leukotriene antagonist;
non-steroidal anti-inflammatory drug
hesperetin
[no description available]		2.47203'-hydroxyflavanones;
4'-methoxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone		antineoplastic agent;
antioxidant;
plant metabolite
naringenin
(S)-naringenin : The (S)-enantiomer of naringenin.		2.7730(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite
taxifolin
(+)-taxifolin : A taxifolin that has (2R,3R)-configuration.		2.0510taxifolinmetabolite
eriodictyol
eriodictyol: structure. eriodictyol : A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.		2.49203'-hydroxyflavanones;
tetrahydroxyflavanone
dactinomycin
Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)		2.0210actinomycinmutagen
propolin c
propolin C: a PAK1 inhibitor; from Taiwanese propolis; structure in first source. nymphaeol A : A tetrahydroxyflavanone that is (2S)-flavanone substituted by hydroxy group at positions 5, 7, 3' and 4' and a geranyl group at position 6. Isolated from Macaranga tanarius and propolis collected in Okinawa, it exhibits radical scavenging activity.		3.67904'-hydroxyflavanones;
tetrahydroxyflavanone		metabolite;
radical scavenger
vedelianin
vedelianin: Cytotoxic; from Macaranga tanarius; structure in first source. vedelianin : A stilbenoid derivative isolated from Macaranga alnifolia and Macaranga alnifolia and has been shown to exhibit cytotoxic activity.		2.0310cyclic ether;
organic heterotricyclic compound;
resorcinols;
stilbenoid		antineoplastic agent;
plant metabolite
1,1-diphenyl-2-picrylhydrazyl
1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)		2.0710
olomoucine ii
olomoucine II: structure in first source		2.0510
ovatodiolide
ovatodiolide: from Anisomeles indica; structure in first source		2.1110
sophoraflavanone a
sophoraflavanone A: structure in first source. sophoraflavanone A : A trihydroxyflavanone that is (S)-naringenin substituted by a geranyl group at position 8. Isolated from Macaranga bicolor, it exhibits antibacterial and antineoplastic activities.		2.4420(2S)-flavan-4-one;
4'-hydroxyflavanones;
trihydroxyflavanone		antibacterial agent;
antineoplastic agent;
metabolite
nystatin a1
Nystatin: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.. nystatin : A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections.. nystatin A1 : A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.		2.0410nystatins
diplacone
diplacone: structure in first source		2.5520
schweinfurthin g
schweinfurthin G: structure in first source. schweinfurthin G : A stilbenoid that is the 3-deoxy derivative of vedelianin. Isolated from Macaranga alnifolia, it exhibits cytotoxic activity.		2.0310cyclic ether;
organic heterotricyclic compound;
resorcinols;
stilbenoid		antineoplastic agent;
metabolite
schweinfurthin f
schweinfurthin F: structure in first source. schweinfurthin F : A stilbenoid isolated from Macaranga alnifolia and has been shown to exhibit cytotoxic activity.		2.0310cyclic ether;
organic heterotricyclic compound;
resorcinols;
stilbenoid		metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Ovary
[description not available]		02.0310
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.0310
Encephalopathy, Toxic
[description not available]		02.2110
Lung Adenocarcinoma
[description not available]		02.110
Adenocarcinoma, Basal Cell
[description not available]		02.110
Cancer of Lung
[description not available]		02.110
Adenocarcinoma of Lung
A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.		02.110
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		02.110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1110
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.		07.1110