Assay ID | Title | Year | Journal | Article |
AID1202421 | Selectivity index, ratio of IC50 for MDCK cells to IC50 human DU145 cells | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
AID764724 | Reduction of HO-2 mRNA expression in human imatinib mesylate-resistant LAMA-84 cells at 10 uM by RT-PCR analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID1422094 | Cytotoxicity against human K562R cells assessed as decrease in cell viability after 24 hrs by XTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines. |
AID1202416 | Cytotoxicity against human PC3 cells incubated for 72 hrs by sulforhodamine B assay | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
AID1202413 | Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by sulforhodamine B assay | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
AID764720 | Potentiation of imatinib mesylate-induced ROS production in human imatinib mesylate-resistant LAMA-84 cells at 10 uM by spectrofluorometric analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID1202420 | Selectivity index, ratio of IC50 for MDCK cells to IC50 human MCF7 cells | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
AID1202415 | Cytotoxicity against human DU145 cells incubated for 72 hrs by sulforhodamine B assay | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
AID764722 | Induction of apoptosis in human imatinib mesylate-resistant LAMA-84 cells at 10 uM after 3 hrs using propidium iodide staining by FACS analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID1422093 | Inhibition of heme oxygenase 1 in Sprague-Dawley rat spleen microsomal fraction assessed as decrease in bilirubin formation using biliverdin reductase as substrate after 60 mins by spectrophotometric method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines. |
AID1422092 | Cytotoxicity against imatinib-sensitive human K562 cells assessed as decrease in cell viability after 24 hrs by XTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines. |
AID1633157 | Inhibition of HO-1 in Sprague-Dawley rat spleen microsomes using NADPH as substrate incubated for 60 mins by spectrometry based assay | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application. |
AID1202423 | Selectivity index, ratio of IC50 for MDCK cells to IC50 human LNCAP cells | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
AID1202419 | Selectivity index, ratio of IC50 for MDCK cells to IC50 human MDA-MB-231 cells | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
AID764727 | Cell cycle arrest in human imatinib mesylate-resistant LAMA-84 cells assessed as accumulation at S and G2/M phase at 10 uM after 3 hrs by FACS analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID764732 | Inhibition of HO-1 (unknown origin) expressed in human imatinib mesylate-resistant LAMA-84 cells assessed as bilirubin formation at 10 uM after 24 hrs relative to control | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID764721 | Potentiation of imatinib mesylate-induced apoptosis in human imatinib mesylate-resistant LAMA-84 cells at 10 uM after 3 hrs using propidium iodide staining by FACS analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID1202422 | Selectivity index, ratio of IC50 for MDCK cells to IC50 human PC3 cells | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
AID1202418 | Cytotoxicity against MDCK cells incubated for 72 hrs by sulforhodamine B assay | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
AID1633152 | Inhibition of HO-2 (unknown origin) | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application. |
AID764729 | Potentiation of imatinib mesylate-induced cytotoxicity in human imatinib mesylate-resistant LAMA-84 cells assessed as reduction of cell survival at 10 uM after 20 mins by ATP-lite1step assay | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID764730 | Cytotoxicity against human imatinib mesylate-resistant LAMA-84 cells assessed as reduction of cell survival at 10 uM after 20 mins by ATP-lite1step assay | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID1202417 | Cytotoxicity against human LNCAP cells incubated for 72 hrs by sulforhodamine B assay | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
AID764735 | Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID404423 | Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline | 2008 | Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
| Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase. |
AID1422106 | Induction of ROS production in human K562R cells at 10 uM by DCFH-DA dye based spectrofluorometric method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines. |
AID764734 | Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID1422103 | Inhibition of heme oxygenase 1 in human K562R cell lysates assessed as decrease in bilirubin formation at 10 uM after 60 mins by spectrophotometric method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines. |
AID764726 | Potentiation of imatinib mesylate-induced cell cycle arrest in human imatinib mesylate-resistant LAMA-84 cells assessed as accumulation at S and G2/M phase at 10 uM after 3 hrs by FACS analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID764725 | Reduction of HO-1 mRNA expression in human imatinib mesylate-resistant LAMA-84 cells at 10 uM by RT-PCR analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
AID1202414 | Cytotoxicity against human MCF7 cells incubated for 72 hrs by sulforhodamine B assay | 2015 | European journal of medicinal chemistry, , Volume: 96 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |