Page last updated: 2024-12-08

3-hydroxy-quinazoline-2,4-dione

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-hydroxy-quinazoline-2,4-dione: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID220188
CHEMBL ID183852
SCHEMBL ID1520708
MeSH IDM0477912

Synonyms (19)

Synonym
nsc-2552
nsc2552
5329-43-1
3-hydroxy-2,3h)-quinazolinedione
bdbm33412
chembl183852 ,
n-hydroxy quinazolinedione, 4
3-hydroxy-quinazoline-2,4-dione
3-hydroxy-1h-quinazoline-2,4-dione
3-hydroxyquinazoline-2,4(1h,3h)-dione
SCHEMBL1520708
DTXSID00277492
3-hydroxyquinazoline-2,4-dione
3-hydroxy-1,2,3,4-tetrahydroquinazoline-2,4-dione
EN300-7464714
nsc 2552
3-hydroxy-2,4(1h,3h)-quinazolinedione
PD181419
Z1509143415
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (10)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase 12Homo sapiens (human)Ki0.10420.00021.10439.9000AID1446104
Ribonuclease H1Homo sapiens (human)IC50 (µMol)5.95000.12002.23946.0000AID1799248; AID431467
Carbonic anhydrase 1Homo sapiens (human)Ki10.00000.00001.372610.0000AID1446105
Carbonic anhydrase 2Homo sapiens (human)Ki10.00000.00000.72369.9200AID1446106
Deoxyribonuclease-1Homo sapiens (human)IC50 (µMol)100.00000.35000.35000.3500AID1247800
DNA repair protein complementing XP-G cellsHomo sapiens (human)IC50 (µMol)0.00020.00020.00020.0002AID241035
Flap endonuclease 1Homo sapiens (human)IC50 (µMol)0.15000.00010.20000.3000AID1247799; AID240866
Carbonic anhydrase 9Homo sapiens (human)Ki0.48000.00010.78749.9000AID1446103
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (77)

Processvia Protein(s)Taxonomy
estrous cycleCarbonic anhydrase 12Homo sapiens (human)
chloride ion homeostasisCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 12Homo sapiens (human)
RNA catabolic processRibonuclease H1Homo sapiens (human)
DNA replication, removal of RNA primerRibonuclease H1Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 1Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 2Homo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 2Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 2Homo sapiens (human)
angiotensin-activated signaling pathwayCarbonic anhydrase 2Homo sapiens (human)
regulation of monoatomic anion transportCarbonic anhydrase 2Homo sapiens (human)
secretionCarbonic anhydrase 2Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 2Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 2Homo sapiens (human)
positive regulation of dipeptide transmembrane transportCarbonic anhydrase 2Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 2Homo sapiens (human)
carbon dioxide transportCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 2Homo sapiens (human)
DNA repairDNA excision repair protein ERCC-1Homo sapiens (human)
nucleotide-excision repairDNA excision repair protein ERCC-1Homo sapiens (human)
pyrimidine dimer repair by nucleotide-excision repairDNA excision repair protein ERCC-1Homo sapiens (human)
nucleotide-excision repairDNA excision repair protein ERCC-1Homo sapiens (human)
double-strand break repair via nonhomologous end joiningDNA excision repair protein ERCC-1Homo sapiens (human)
mitotic recombinationDNA excision repair protein ERCC-1Homo sapiens (human)
syncytium formationDNA excision repair protein ERCC-1Homo sapiens (human)
response to oxidative stressDNA excision repair protein ERCC-1Homo sapiens (human)
spermatogenesisDNA excision repair protein ERCC-1Homo sapiens (human)
response to nutrientDNA excision repair protein ERCC-1Homo sapiens (human)
cell population proliferationDNA excision repair protein ERCC-1Homo sapiens (human)
determination of adult lifespanDNA excision repair protein ERCC-1Homo sapiens (human)
male gonad developmentDNA excision repair protein ERCC-1Homo sapiens (human)
UV protectionDNA excision repair protein ERCC-1Homo sapiens (human)
response to sucroseDNA excision repair protein ERCC-1Homo sapiens (human)
response to X-rayDNA excision repair protein ERCC-1Homo sapiens (human)
negative regulation of telomere maintenanceDNA excision repair protein ERCC-1Homo sapiens (human)
post-embryonic hemopoiesisDNA excision repair protein ERCC-1Homo sapiens (human)
multicellular organism growthDNA excision repair protein ERCC-1Homo sapiens (human)
response to immobilization stressDNA excision repair protein ERCC-1Homo sapiens (human)
interstrand cross-link repairDNA excision repair protein ERCC-1Homo sapiens (human)
isotype switchingDNA excision repair protein ERCC-1Homo sapiens (human)
response to cadmium ionDNA excision repair protein ERCC-1Homo sapiens (human)
insulin-like growth factor receptor signaling pathwayDNA excision repair protein ERCC-1Homo sapiens (human)
oogenesisDNA excision repair protein ERCC-1Homo sapiens (human)
embryonic organ developmentDNA excision repair protein ERCC-1Homo sapiens (human)
positive regulation of transcription initiation by RNA polymerase IIDNA excision repair protein ERCC-1Homo sapiens (human)
telomeric DNA-containing double minutes formationDNA excision repair protein ERCC-1Homo sapiens (human)
replicative senescenceDNA excision repair protein ERCC-1Homo sapiens (human)
t-circle formationDNA excision repair protein ERCC-1Homo sapiens (human)
positive regulation of t-circle formationDNA excision repair protein ERCC-1Homo sapiens (human)
negative regulation of protection from non-homologous end joining at telomereDNA excision repair protein ERCC-1Homo sapiens (human)
UV-damage excision repairDNA excision repair protein ERCC-1Homo sapiens (human)
neutrophil activation involved in immune responseDeoxyribonuclease-1Homo sapiens (human)
regulation of acute inflammatory responseDeoxyribonuclease-1Homo sapiens (human)
DNA catabolic processDeoxyribonuclease-1Homo sapiens (human)
apoptotic processDeoxyribonuclease-1Homo sapiens (human)
regulation of neutrophil mediated cytotoxicityDeoxyribonuclease-1Homo sapiens (human)
double-strand break repair via homologous recombinationDNA repair protein complementing XP-G cellsHomo sapiens (human)
transcription-coupled nucleotide-excision repairDNA repair protein complementing XP-G cellsHomo sapiens (human)
base-excision repair, AP site formationDNA repair protein complementing XP-G cellsHomo sapiens (human)
nucleotide-excision repairDNA repair protein complementing XP-G cellsHomo sapiens (human)
response to UVDNA repair protein complementing XP-G cellsHomo sapiens (human)
response to UV-CDNA repair protein complementing XP-G cellsHomo sapiens (human)
negative regulation of apoptotic processDNA repair protein complementing XP-G cellsHomo sapiens (human)
double-strand break repair via homologous recombinationFlap endonuclease 1Homo sapiens (human)
DNA replicationFlap endonuclease 1Homo sapiens (human)
DNA repairFlap endonuclease 1Homo sapiens (human)
base-excision repair, gap-fillingFlap endonuclease 1Homo sapiens (human)
double-strand break repairFlap endonuclease 1Homo sapiens (human)
memoryFlap endonuclease 1Homo sapiens (human)
UV protectionFlap endonuclease 1Homo sapiens (human)
telomere maintenance via semi-conservative replicationFlap endonuclease 1Homo sapiens (human)
DNA replication, removal of RNA primerFlap endonuclease 1Homo sapiens (human)
positive regulation of sister chromatid cohesionFlap endonuclease 1Homo sapiens (human)
nucleic acid metabolic processFlap endonuclease 1Homo sapiens (human)
response to hypoxiaCarbonic anhydrase 9Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 9Homo sapiens (human)
response to xenobiotic stimulusCarbonic anhydrase 9Homo sapiens (human)
response to testosteroneCarbonic anhydrase 9Homo sapiens (human)
secretionCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 9Homo sapiens (human)
negative regulation of telomerase activityDNA repair endonuclease XPFHomo sapiens (human)
nucleotide-excision repairDNA repair endonuclease XPFHomo sapiens (human)
telomere maintenanceDNA repair endonuclease XPFHomo sapiens (human)
double-strand break repair via homologous recombinationDNA repair endonuclease XPFHomo sapiens (human)
DNA repairDNA repair endonuclease XPFHomo sapiens (human)
nucleotide-excision repairDNA repair endonuclease XPFHomo sapiens (human)
double-strand break repair via nonhomologous end joiningDNA repair endonuclease XPFHomo sapiens (human)
response to UVDNA repair endonuclease XPFHomo sapiens (human)
UV protectionDNA repair endonuclease XPFHomo sapiens (human)
regulation of autophagyDNA repair endonuclease XPFHomo sapiens (human)
negative regulation of telomere maintenanceDNA repair endonuclease XPFHomo sapiens (human)
cellular response to UVDNA repair endonuclease XPFHomo sapiens (human)
telomeric DNA-containing double minutes formationDNA repair endonuclease XPFHomo sapiens (human)
nucleotide-excision repair involved in interstrand cross-link repairDNA repair endonuclease XPFHomo sapiens (human)
negative regulation of telomere maintenance via telomere lengtheningDNA repair endonuclease XPFHomo sapiens (human)
negative regulation of protection from non-homologous end joining at telomereDNA repair endonuclease XPFHomo sapiens (human)
negative regulation of double-stranded telomeric DNA bindingDNA repair endonuclease XPFHomo sapiens (human)
resolution of meiotic recombination intermediatesDNA repair endonuclease XPFHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (38)

Processvia Protein(s)Taxonomy
zinc ion bindingCarbonic anhydrase 12Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 12Homo sapiens (human)
magnesium ion bindingRibonuclease H1Homo sapiens (human)
nucleic acid bindingRibonuclease H1Homo sapiens (human)
RNA bindingRibonuclease H1Homo sapiens (human)
RNA-DNA hybrid ribonuclease activityRibonuclease H1Homo sapiens (human)
RNA nuclease activityRibonuclease H1Homo sapiens (human)
protein bindingRibonuclease H1Homo sapiens (human)
arylesterase activityCarbonic anhydrase 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 1Homo sapiens (human)
protein bindingCarbonic anhydrase 1Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 1Homo sapiens (human)
hydro-lyase activityCarbonic anhydrase 1Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 1Homo sapiens (human)
arylesterase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 2Homo sapiens (human)
protein bindingCarbonic anhydrase 2Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 2Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 2Homo sapiens (human)
single-stranded DNA endodeoxyribonuclease activityDNA excision repair protein ERCC-1Homo sapiens (human)
DNA bindingDNA excision repair protein ERCC-1Homo sapiens (human)
3' overhang single-stranded DNA endodeoxyribonuclease activityDNA excision repair protein ERCC-1Homo sapiens (human)
TFIID-class transcription factor complex bindingDNA excision repair protein ERCC-1Homo sapiens (human)
damaged DNA bindingDNA excision repair protein ERCC-1Homo sapiens (human)
single-stranded DNA bindingDNA excision repair protein ERCC-1Homo sapiens (human)
protein bindingDNA excision repair protein ERCC-1Homo sapiens (human)
promoter-specific chromatin bindingDNA excision repair protein ERCC-1Homo sapiens (human)
actin bindingDeoxyribonuclease-1Homo sapiens (human)
protein bindingDeoxyribonuclease-1Homo sapiens (human)
DNA bindingDeoxyribonuclease-1Homo sapiens (human)
deoxyribonuclease I activityDeoxyribonuclease-1Homo sapiens (human)
bubble DNA bindingDNA repair protein complementing XP-G cellsHomo sapiens (human)
RNA polymerase II complex bindingDNA repair protein complementing XP-G cellsHomo sapiens (human)
damaged DNA bindingDNA repair protein complementing XP-G cellsHomo sapiens (human)
double-stranded DNA bindingDNA repair protein complementing XP-G cellsHomo sapiens (human)
single-stranded DNA bindingDNA repair protein complementing XP-G cellsHomo sapiens (human)
endonuclease activityDNA repair protein complementing XP-G cellsHomo sapiens (human)
DNA endonuclease activityDNA repair protein complementing XP-G cellsHomo sapiens (human)
protein bindingDNA repair protein complementing XP-G cellsHomo sapiens (human)
enzyme activator activityDNA repair protein complementing XP-G cellsHomo sapiens (human)
protein homodimerization activityDNA repair protein complementing XP-G cellsHomo sapiens (human)
protein-containing complex bindingDNA repair protein complementing XP-G cellsHomo sapiens (human)
metal ion bindingDNA repair protein complementing XP-G cellsHomo sapiens (human)
DNA bindingFlap endonuclease 1Homo sapiens (human)
damaged DNA bindingFlap endonuclease 1Homo sapiens (human)
double-stranded DNA bindingFlap endonuclease 1Homo sapiens (human)
endonuclease activityFlap endonuclease 1Homo sapiens (human)
RNA-DNA hybrid ribonuclease activityFlap endonuclease 1Homo sapiens (human)
exonuclease activityFlap endonuclease 1Homo sapiens (human)
protein bindingFlap endonuclease 1Homo sapiens (human)
double-stranded DNA exodeoxyribonuclease activityFlap endonuclease 1Homo sapiens (human)
5'-3' exonuclease activityFlap endonuclease 1Homo sapiens (human)
5'-flap endonuclease activityFlap endonuclease 1Homo sapiens (human)
flap endonuclease activityFlap endonuclease 1Homo sapiens (human)
manganese ion bindingFlap endonuclease 1Homo sapiens (human)
magnesium ion bindingFlap endonuclease 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 9Homo sapiens (human)
protein bindingCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 9Homo sapiens (human)
molecular function activator activityCarbonic anhydrase 9Homo sapiens (human)
telomerase inhibitor activityDNA repair endonuclease XPFHomo sapiens (human)
DNA bindingDNA repair endonuclease XPFHomo sapiens (human)
DNA endonuclease activityDNA repair endonuclease XPFHomo sapiens (human)
3' overhang single-stranded DNA endodeoxyribonuclease activityDNA repair endonuclease XPFHomo sapiens (human)
TFIID-class transcription factor complex bindingDNA repair endonuclease XPFHomo sapiens (human)
damaged DNA bindingDNA repair endonuclease XPFHomo sapiens (human)
single-stranded DNA bindingDNA repair endonuclease XPFHomo sapiens (human)
DNA endonuclease activityDNA repair endonuclease XPFHomo sapiens (human)
protein bindingDNA repair endonuclease XPFHomo sapiens (human)
identical protein bindingDNA repair endonuclease XPFHomo sapiens (human)
promoter-specific chromatin bindingDNA repair endonuclease XPFHomo sapiens (human)
single-stranded DNA endodeoxyribonuclease activityDNA repair endonuclease XPFHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (23)

Processvia Protein(s)Taxonomy
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
membraneCarbonic anhydrase 12Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 12Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 12Homo sapiens (human)
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
cytoplasmRibonuclease H1Homo sapiens (human)
cytosolCarbonic anhydrase 1Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 1Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
myelin sheathCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 2Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
chromosome, telomeric regionDNA excision repair protein ERCC-1Homo sapiens (human)
nucleoplasmDNA excision repair protein ERCC-1Homo sapiens (human)
cytoplasmDNA excision repair protein ERCC-1Homo sapiens (human)
nucleotide-excision repair complexDNA excision repair protein ERCC-1Homo sapiens (human)
nucleotide-excision repair factor 1 complexDNA excision repair protein ERCC-1Homo sapiens (human)
ERCC4-ERCC1 complexDNA excision repair protein ERCC-1Homo sapiens (human)
extracellular regionDeoxyribonuclease-1Homo sapiens (human)
nuclear envelopeDeoxyribonuclease-1Homo sapiens (human)
zymogen granuleDeoxyribonuclease-1Homo sapiens (human)
extracellular exosomeDeoxyribonuclease-1Homo sapiens (human)
nucleusDeoxyribonuclease-1Homo sapiens (human)
DNA replication factor A complexDNA repair protein complementing XP-G cellsHomo sapiens (human)
nucleusDNA repair protein complementing XP-G cellsHomo sapiens (human)
nucleoplasmDNA repair protein complementing XP-G cellsHomo sapiens (human)
nucleotide-excision repair complexDNA repair protein complementing XP-G cellsHomo sapiens (human)
protein-containing complexDNA repair protein complementing XP-G cellsHomo sapiens (human)
nucleusDNA repair protein complementing XP-G cellsHomo sapiens (human)
chromosome, telomeric regionFlap endonuclease 1Homo sapiens (human)
chromosome, telomeric regionFlap endonuclease 1Homo sapiens (human)
nucleusFlap endonuclease 1Homo sapiens (human)
nucleoplasmFlap endonuclease 1Homo sapiens (human)
nucleolusFlap endonuclease 1Homo sapiens (human)
mitochondrionFlap endonuclease 1Homo sapiens (human)
membraneFlap endonuclease 1Homo sapiens (human)
protein-containing complexFlap endonuclease 1Homo sapiens (human)
nucleusFlap endonuclease 1Homo sapiens (human)
nucleolusCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
membraneCarbonic anhydrase 9Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 9Homo sapiens (human)
microvillus membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
chromosome, telomeric regionDNA repair endonuclease XPFHomo sapiens (human)
nucleusDNA repair endonuclease XPFHomo sapiens (human)
nucleoplasmDNA repair endonuclease XPFHomo sapiens (human)
ERCC4-ERCC1 complexDNA repair endonuclease XPFHomo sapiens (human)
nucleotide-excision repair complexDNA repair endonuclease XPFHomo sapiens (human)
nucleotide-excision repair factor 1 complexDNA repair endonuclease XPFHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID240866Inhibitory concentration against the Flap endonuclease-12005Bioorganic & medicinal chemistry letters, Jan-17, Volume: 15, Issue:2
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors.
AID1446103Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.
AID1446105Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.
AID431469Antiviral activity against HIV infected in human MT4 cells up to 100 uM by multicycle infectivity assay2009Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
AID431468Inhibition of HIV1 recombinant reverse transcriptase p66/p51 heterodimer in presence of Mg2+2009Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
AID1446104Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.
AID241035Inhibitory concentration against the xeroderma pigmentosum G2005Bioorganic & medicinal chemistry letters, Jan-17, Volume: 15, Issue:2
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors.
AID1247800Inhibition of DNAse1 (unknown origin)2015Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.
AID1446106Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.
AID431467Inhibition of human RNase H assessed as substrate cleavage by fluorescence assay2009Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
AID1247798Inhibition of ERCC1-XPF (unknown origin) by high-throughput fluorescence based in-vitro endonuclease assay2015Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.
AID1247799Inhibition of FEN1 (unknown origin)2015Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.
AID1799248Fluorescence-Based RNase H Assay from Article 10.1021/jm900597q: \\RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.\\2009Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.43 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]