Assay ID | Title | Year | Journal | Article |
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1291443 | Inhibition of Hh signaling pathway in mouse TM3 cells assessed as downregulation of Gli1 gene expression after 48 hrs by luciferase reporter gene assay | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8
| Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action. |
AID1291445 | Inhibition of Hh signaling pathway in Sufu deficient MEF cells assessed as downregulation of Ptch1 mRNA expression at 10 uM after 24 hrs by qRT-PCR analysis | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8
| Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action. |
AID1291441 | Inhibition of Hh signaling pathway in Sufu deficient MEF cells assessed as downregulation of Gli1 mRNA expression at 10 uM after 24 hrs by qRT-PCR analysis | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8
| Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action. |
AID1291449 | Displacement of BODIPY-cyc from SMO receptor (unknown origin) transfected in HEK293T cells at 10 uM after 16 hrs by laser-scanning confocal microscopic analysis | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8
| Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action. |
AID1291444 | Cytotoxicity against mouse TM3 cells assessed as cell viability after 48 hrs by Cell Titer Glo assay | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8
| Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action. |
AID1291448 | Inhibition of PDE4D (unknown origin) preincubated for 5 mins followed by cAMP addition measured after 15 mins by PDE-Glo phosphodiesterase assay | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8
| Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action. |
AID1291451 | Inhibition of luciferase (unknown origin) expressed in BMP-responsive element stable reporter cells | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8
| Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |