| Assay ID | Title | Year | Journal | Article |
|---|
| AID262000 | Antibacterial activity against Escherichia coli upto 50 ug/mL | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5
| Synthesis and antihyperglycemic evaluation of various protoberberine derivatives. |
| AID1432569 | Displacement of [3H]N-methylspiperone from human dopamine D2 receptor after 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
| Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
| AID136551 | In vivo Mean survival time of Plasmodium berghei parasitized mice dosed at 160 mg/kg | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID729716 | Inhibition of [3H]8-OH-DPAT binding to 5-HT1A receptor (unknown origin) expressed in HEK293 cells at 10 uM by liquid scintillation counter relative to control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID1432568 | Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
| Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
| AID1092091 | Adulticidal activity against adult Drosophila melanogaster (males/females 1:1 ratio) assessed as mortality measured after 3 hr | 2011 | Journal of agricultural and food chemistry, Jul-13, Volume: 59, Issue:13
| Insecticidal effect and chemical composition of the volatile oil from Bergenia ligulata. |
| AID1432572 | Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
| Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
| AID378595 | Antiplasmodial activity against Plasmodium falciparum W2 | 2000 | Journal of natural products, Dec, Volume: 63, Issue:12
| In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. |
| AID262001 | Binding affinity to sulfonylurea receptor in pancreatic islet beta cell membranes | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5
| Synthesis and antihyperglycemic evaluation of various protoberberine derivatives. |
| AID377111 | Vasorelaxation activity in rat aorta assessed as inhibition of norepinephrine-induced phasic contraction at 15 ug/ml preincubated for 15 mins relative to control | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| AID381939 | Antioxidant effect in Sprague-Dawley rat primary hepatocytes assessed as prevention of tert-butyl hydroperoxide-induced reduction in glutathione content administered 50 ug/ml for 7 hrs followed by combined exposure of tert-butyl hydroperoxide and drug for | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. |
| AID729718 | Inhibition of [3H]SCH23390 binding to dopamine D1 receptor (unknown origin) expressed in human HEK293 cells at 10 uM by liquid scintillation counter relative to control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729712 | Displacement of [3H]8-OH-DPAT from 5-HT1A receptor (unknown origin) expressed in HEK293 cells by liquid scintillation counter | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729717 | Inhibition of [3H]spiperone binding to dopamine D2 receptor (unknown origin) expressed in human HEK293 cells at 10 uM by liquid scintillation counter relative to control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID293733 | Cytotoxicity against MRC5 cells | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Antiviral activity of berberine and related compounds against human cytomegalovirus. |
| AID402387 | Antimicrobial activity against Staphylococcus aureus ATCC 13709 at 1000 ug/ml | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID376843 | Vasorelaxation activity in rat aorta assessed as inhibition of K+-induced contraction at 50 ug/ml preincubated for 15 mins relative to control | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| AID402391 | Antimicrobial activity against Mycobacterium smegmatis ATCC 607 at 1000 ug/ml | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID151349 | In vitro antimalarial activity against Plasmodium falciparum W2 | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID402390 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 at 1000 ug/ml | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID381940 | Antioxidant effect in Sprague-Dawley rat primary hepatocytes assessed as prevention of tert-butyl hydroperoxide-induced reduction in glutathione content administered 100 ug/ml for 7 hrs followed by combined exposure of tert-butyl hydroperoxide and drug fo | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. |
| AID381934 | Cytotoxicity against rat primary hepatocytes at 300 ug/ml after 24 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. |
| AID381937 | Antioxidant effect in Sprague-Dawley rat primary hepatocytes assessed as decrease in tert-butyl hydroperoxide-induced malondialdehyde accumulation administered 50 ug/ml for 7 hrs followed by combined exposure of tert-butyl hydroperoxide and drug for 12 hr | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. |
| AID656691 | Cytotoxicity against human fibroblasts assessed as cell viability by microplate reader | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii. |
| AID293734 | Antiviral activity against HCMV in MRC5 cells by plaque reduction assay | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Antiviral activity of berberine and related compounds against human cytomegalovirus. |
| AID136554 | In vivo Mean survival time of Plasmodium berghei parasitized mice dosed at 40 mg/kg | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID136556 | In vivo Mean survival time of Plasmodium berghei parasitized mice dosed at 640 mg/kg | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID293735 | Selectivity index, ratio of CC50 for MRC5 cells to IC50 for HCMV | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Antiviral activity of berberine and related compounds against human cytomegalovirus. |
| AID656692 | Therapeutic index, ratio of TD50 for human fibroblast cell to ID 50 for Toxoplasma gondii ATCC 50839 | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii. |
| AID376844 | Vasorelaxation activity in rat aorta assessed as inhibition of K+-induced contraction at 15 ug/ml preincubated for 15 mins relative to control | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| AID377125 | Antiplatelet activity against rabbit platelets assessed as inhibition of arachidonic acid-induced platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| AID729711 | Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin) expressed in HEK293 cells by liquid scintillation counter | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729714 | Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID377110 | Vasorelaxation activity in rat aorta assessed as inhibition of norepinephrine-induced phasic contraction at 50 ug/ml preincubated for 15 mins relative to control | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| AID378592 | Antiamnesic activity against Entamoeba histolytica NIH 200 after 72 hrs by microdilution technique | 2000 | Journal of natural products, Dec, Volume: 63, Issue:12
| In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. |
| AID376845 | Vasorelaxation activity in rat aorta assessed as inhibition of K+-induced contraction at 5 ug/ml preincubated for 15 mins relative to control | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| AID151209 | In vitro antimalarial activity against Plasmodium falciparum D6 | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID402385 | Antimicrobial activity against recombinant Mycobacterium bovis BCG expressing pMV361 lux after 5 days by luciferase assay | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID381938 | Antioxidant effect in Sprague-Dawley rat primary hepatocytes assessed as decrease in tert-butyl hydroperoxide-induced malondialdehyde accumulation administered 100 ug/ml for 7 hrs followed by combined exposure of tert-butyl hydroperoxide and drug for 12 h | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. |
| AID729713 | Displacement of [3H]spiperone from dopamine D2 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID378593 | Cytotoxicity against human KB cells after 72 hrs | 2000 | Journal of natural products, Dec, Volume: 63, Issue:12
| In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. |
| AID402386 | Antimicrobial activity against recombinant Mycobacterium intracellular expressing pMV361 lux after 3 days by luciferase assay | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID656690 | Antiparasitic activity against Toxoplasma gondii ATCC 50839 infected in human fibroblasts assessed as inhibition of replication of tachyzoites after 4 days by bacterial beta-galactosidase assay | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii. |
| AID729715 | Inhibition of [3H]Ketanserin binding to 5-HT2A receptor (unknown origin) expressed in HEK293 cells at 10 uM by liquid scintillation counter relative to control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID377116 | Vasorelaxation activity in rat aorta assessed as inhibition of norepinephrine-induced tonic contraction at 15 ug/ml preincubated for 15 mins relative to control | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| AID1432570 | Displacement of [3H]N-methylspiperone from human dopamine D3 receptor after 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
| Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
| AID381936 | Cytotoxicity against human HeLa cells at 300 ug/ml after 24 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. |
| AID377115 | Vasorelaxation activity in rat aorta assessed as inhibition of norepinephrine-induced tonic contraction at 50 ug/ml preincubated for 15 mins relative to control | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| AID378591 | Antiplasmodial activity against multi drug-resistant Plasmodium falciparum K1 in erythrocytes by [3H]hypoxanthine uptake | 2000 | Journal of natural products, Dec, Volume: 63, Issue:12
| In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. |
| AID377131 | Antiplatelet activity against rabbit platelets assessed as inhibition of collagen-induced platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| AID1320512 | Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assa | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
| Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective α |
| AID346755 | Induction of LDLR mRNA expression in human HepG2 cells after 12 hrs by RT-PCR assay relative to untreated control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID381935 | Cytotoxicity against human HepG2 cells at 300 ug/ml after 24 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. |
| AID1432571 | Displacement of [3H]N-methylspiperone from human dopamine D4 receptor after 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
| Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
| AID378594 | Antiplasmodial activity against Plasmodium falciparum D6 | 2000 | Journal of natural products, Dec, Volume: 63, Issue:12
| In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. |
| AID377120 | Antiplatelet activity against rabbit platelets assessed as inhibition of thrombin-induced platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| AID402392 | Antimicrobial activity against Candida albicans ATCC 10231 at 1000 ug/ml | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID377136 | Antiplatelet activity against rabbit platelets assessed as inhibition of PAF-induced platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
| Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |