| Assay ID | Title | Year | Journal | Article |
|---|
| AID280297 | Agonist activity at human recombinant P2Y2 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
| Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. |
| AID618865 | Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNA | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides. |
| AID618875 | Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNA | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides. |
| AID618877 | Ratio Kpol to Kd for wild type HIV 1 reverse transcriptase M184V mutant | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides. |
| AID53489 | Compound was evaluated for the inhibition of cellular DNA polymerase (gamma) | 1998 | Journal of medicinal chemistry, Jun-04, Volume: 41, Issue:12
| Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. |
| AID618876 | Ratio Kpol to Kd for wild type HIV 1 reverse transcriptase | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides. |
| AID18096 | Kinetic parameter Km was determined | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| 2-Amino-7-deazaadenine forms stable base pairs with cytosine and thymine. |
| AID160325 | Compound was evaluated for 50% inhibition of HBV polymerases (Hepatitis B virus) | 1998 | Journal of medicinal chemistry, Jun-04, Volume: 41, Issue:12
| Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. |
| AID280299 | Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
| Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. |
| AID229453 | Efficiency expressed as ratio of Vmax to that of Km was determined | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| 2-Amino-7-deazaadenine forms stable base pairs with cytosine and thymine. |
| AID280298 | Agonist activity at human recombinant P2Y4 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
| Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. |
| AID53475 | Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus) | 1998 | Journal of medicinal chemistry, Jun-04, Volume: 41, Issue:12
| Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. |
| AID53474 | Compound was evaluated for the inhibition of cellular DNA polymerase (epsilon) | 1998 | Journal of medicinal chemistry, Jun-04, Volume: 41, Issue:12
| Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. |
| AID100248 | Effect (10e-3 M) on DNA synthesis in mouse LM(TK-) cells blocked in DNA synthesis with Aminopterin | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5
| Zwitterionic 3'-O-acyl derivatives of thymidine 5'-phosphate as potential sources of intracellular thymidine 5'-phosphate in cells in culture. |
| AID53486 | Compound was evaluated for the inhibition of cellular DNA polymerase (beta) | 1998 | Journal of medicinal chemistry, Jun-04, Volume: 41, Issue:12
| Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. |
| AID126597 | Evaluated for the mixed objective Non-competitive inhibition constant Ki against TdR varied rat mitochondrial thymidine kinase | 1982 | Journal of medicinal chemistry, Jul, Volume: 25, Issue:7
| Species- or isozyme-specific enzyme inhibitors. 6. Synthesis and evaluation of two-substrate condensation products as inhibitors of hexokinases and thymidine kinases. |
| AID53485 | Compound was evaluated for the inhibition of cellular DNA polymerase (alpha) | 1998 | Journal of medicinal chemistry, Jun-04, Volume: 41, Issue:12
| Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. |
| AID200174 | Compound was evaluated for 50% inhibition of HIV-RT (HIV reverse transcriptase) | 1998 | Journal of medicinal chemistry, Jun-04, Volume: 41, Issue:12
| Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. |
| AID22610 | Kinetic parameter Vmax was determined | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| 2-Amino-7-deazaadenine forms stable base pairs with cytosine and thymine. |
| AID53473 | Compound was evaluated for the inhibition of cellular DNA polymerase (delta) | 1998 | Journal of medicinal chemistry, Jun-04, Volume: 41, Issue:12
| Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. |
| AID203053 | Evaluated for the Non-competitive inhibition constant Ki against TdR varied rat cytoplasmic soluble thymidine kinase | 1982 | Journal of medicinal chemistry, Jul, Volume: 25, Issue:7
| Species- or isozyme-specific enzyme inhibitors. 6. Synthesis and evaluation of two-substrate condensation products as inhibitors of hexokinases and thymidine kinases. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |