2,4-diamino-6-benzyloxy-5-nitrosopyrimidine: inhibits O(6)-alkylguanine-DNA alkyltransferase; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 181029 |
| CHEMBL ID | 71484 |
| SCHEMBL ID | 2054835 |
| MeSH ID | M0272639 |
| Synonym |
|---|
| 6-(benzyloxy)-5-nitrosopyrimidine-2,4-diamine |
| pyrimidine deriv. 1g |
| bdbm5573 |
| chembl71484 , |
| 5-nitroso-6-phenylmethoxypyrimidine-2,4-diamine |
| nu 6039 |
| 101724-61-2 |
| 2,4-pyrimidinediamine, 5-nitroso-6-(phenylmethoxy)- |
| MBQPVHNJEDDVCF-UHFFFAOYSA-N |
| 5-nitroso-2,4-diamino-6-benzyloxy-primidine |
| 5-nitroso-2, 4-diamino-6-benzyloxy-primidine |
| 2,6-diamino-4-benzyloxy-5-nitrosopyrimidine |
| SCHEMBL2054835 |
| DTXSID50144145 |
| 6-benzyloxy-5-nitroso-pyrimidine-2,4-diamine |
| 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine |
| D85698 |
| A937147 |
| WS-02623 |
| PD182842 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 (µMol) | 27.0000 | 0.0004 | 1.3452 | 10.0000 | AID55510 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 (µMol) | 27.0000 | 0.0013 | 1.4518 | 10.0000 | AID55510 |
| G2/mitotic-specific cyclin-B | Marthasterias glacialis (spiny starfish) | IC50 (µMol) | 27.0000 | 0.0040 | 2.1093 | 9.4000 | AID1795789 |
| Methylated-DNA--protein-cysteine methyltransferase | Homo sapiens (human) | IC50 (µMol) | 0.1300 | 0.0030 | 0.3779 | 2.6000 | AID147600 |
| Cyclin-A2 | Homo sapiens (human) | IC50 (µMol) | 27.0000 | 0.0004 | 1.0339 | 10.0000 | AID1795789; AID53363 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 (µMol) | 27.0000 | 0.0004 | 1.0444 | 10.0000 | AID1795789; AID53363 |
| Cyclin-A1 | Homo sapiens (human) | IC50 (µMol) | 27.0000 | 0.0005 | 1.4715 | 10.0000 | AID53363 |
| Cyclin-dependent kinase 1 | Oryzias latipes (Japanese medaka) | IC50 (µMol) | 27.0000 | 0.0040 | 2.1093 | 9.4000 | AID1795789 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Methylated-DNA--protein-cysteine methyltransferase | Homo sapiens (human) | ED50 | 0.0400 | 0.0200 | 0.6300 | 4.7000 | AID147596; AID147597 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1795789 | Kinase Inhibition Assay from Article 10.1016/s0960-894x(02)00884-3: \\4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.\\ | 2003 | Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2 | 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2. |
| AID55510 | Inhibition of Cyclin dependent kinase 1-cyclin B1 from starfish oocytes at 12.5 uM ATP | 2003 | Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2 | 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2. |
| AID147596 | AGT-inactivating activity was determined by 50% inactivation in HT-29 cell free extract upon incubation for 30 min | 1995 | Journal of medicinal chemistry, Jan-20, Volume: 38, Issue:2 | 8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase. |
| AID87737 | The compound was tested for its ability to enhance the cytotoxicity of ACNU toward HeLa S3 cells at 0.01 uM dose | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4 | Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues. |
| AID53363 | Inhibition of human Cyclin-dependent kinase 2 cyclin A3 at 12.5 uM ATP | 2003 | Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2 | 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2. |
| AID87739 | The compound was tested for its ability to enhance the cytotoxicity of ACNU toward HeLa S3 cells at 1 uM dose | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4 | Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues. |
| AID87738 | The compound was tested for its ability to enhance the cytotoxicity of ACNU toward HeLa S3 cells at 0.1 uM dose | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4 | Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues. |
| AID147600 | In vitro inhibitory activity against human O6-alkylguanine-DNA alkyltransferase (AGAT) | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4 | Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues. |
| AID211500 | The compound was tested for its ability to enhance the cytotoxicity of ACNU toward HeLa S3 cells at 10 uM dose; 'b' means toxicity appeared at this dose | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4 | Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues. |
| AID147597 | AGT-inactivating activity was determined by 50% inactivation in HT-29 cells upon incubation for 4 h | 1995 | Journal of medicinal chemistry, Jan-20, Volume: 38, Issue:2 | 8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.60) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||