A large ribosomal subunit protein eL37 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61927]
G1.16;
Large ribosomal subunit protein eL37
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
gentamicin sulfate | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
PF-06446846 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
This protein enables 6 target(s):
Target | Category | Definition |
---|---|---|
RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
structural constituent of ribosome | molecular function | The action of a molecule that contributes to the structural integrity of the ribosome. [GOC:mah] |
rRNA binding | molecular function | Binding to a ribosomal RNA. [GOC:jl] |
metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
MDM2/MDM4 family protein binding | molecular function | Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53. [InterPro:IPR016495] |
ubiquitin ligase inhibitor activity | molecular function | Binds to and stops, prevents or reduces the activity of a ubiquitin ligase. [GOC:dph, GOC:vw, PMID:21389117] |
This protein is located in 3 target(s):
Target | Category | Definition |
---|---|---|
cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
cytosolic ribosome | cellular component | A ribosome located in the cytosol. [GOC:mtg_sensu] |
This protein is part of 1 target(s):
Target | Category | Definition |
---|---|---|
cytosolic large ribosomal subunit | cellular component | The large subunit of a ribosome located in the cytosol. [GOC:mtg_sensu] |
This protein is involved in 3 target(s):
Target | Category | Definition |
---|---|---|
cytoplasmic translation | biological process | The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd] |
translation | biological process | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators] |
positive regulation of signal transduction by p53 class mediator | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie] |