| Assay ID | Title | Year | Journal | Article |
|---|
| AID198609 | Motor impairment by impaired spontaneous locomotor activity after oral administration of 56 umol/kg; not effective | 2001 | Journal of medicinal chemistry, Feb-15, Volume: 44, Issue:4
| Current and novel approaches to the drug treatment of schizophrenia. |
| AID61788 | In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]spiperone displacement. | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID198458 | Antipsychotic potential by blockade of apomorphine disruption in PPI after (sc) administration | 2001 | Journal of medicinal chemistry, Feb-15, Volume: 44, Issue:4
| Current and novel approaches to the drug treatment of schizophrenia. |
| AID232372 | Ratio of affinity for D2 and D4 receptors | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID10638 | In vivo half life of compound in rat plasma after a oral dose of 10 mg/kg (in water, N=4) | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID182772 | Compound was tested for antagonistic activity against APO-induced stereotypy in rats when administered po | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID183607 | in vivo for inhibition against hyperactivity induced by apomorphine (1.78 mg/kg) in habituated rats by oral administration | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID11609 | In vivo maximum concentration of compound in rat plasma after a oral dose of 10 mg/kg (in water, N=4) | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID183606 | in vivo for inhibition against hyperactivity induced by apomorphine (1.78 mg/kg) in habituated rats by subcutaneous administration | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID1456732 | Inhibition of serotonin 5-HT2 receptor (unknown origin) | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Return of D |
| AID1456728 | Inhibition of human dopamine D2 receptor | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Return of D |
| AID198600 | EPS liability measured by blockade of stereotypy after oral administration of 56 umol/kg; not effective | 2001 | Journal of medicinal chemistry, Feb-15, Volume: 44, Issue:4
| Current and novel approaches to the drug treatment of schizophrenia. |
| AID182777 | Compound was tested for inhibition of APO-induced blockade of prepulse inhibition in rats when administered sc | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID5367 | In vitro binding affinity against 5-hydroxytryptamine 2A receptor in CHO cells | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID198453 | Antipsychotic potential by blockade of apomorphine or amphetamine hyperactivity after oral administration | 2001 | Journal of medicinal chemistry, Feb-15, Volume: 44, Issue:4
| Current and novel approaches to the drug treatment of schizophrenia. |
| AID13445 | In vivo percentage mean absolute bioavailability of compound in rat after an oral dose of 10 mg/kg (in water, N=4) | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID198604 | Extrapyramidal liability by induction of catalepsy after oral administration of 56 umol/kg; not effective | 2001 | Journal of medicinal chemistry, Feb-15, Volume: 44, Issue:4
| Current and novel approaches to the drug treatment of schizophrenia. |
| AID1456731 | Inhibition of serotonin 5-HT1A receptor (unknown origin) | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Return of D |
| AID4462 | In vitro binding affinity against 5-hydroxytryptamine 1A receptor in CHO cells | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID1456729 | Inhibition of human dopamine D3 receptor | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Return of D |
| AID63543 | Binding affinity at human Dopamine receptor D4 by [3H]- YM 09151 displacement; Not active. | 2000 | Bioorganic & medicinal chemistry letters, Sep-18, Volume: 10, Issue:18
| Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: a novel series of mixed dopamine D2/D4 receptor antagonists. |
| AID63080 | Binding affinity at human Dopamine receptor D2 by [3H]- YM 09151 displacement; Not active. | 2000 | Bioorganic & medicinal chemistry letters, Sep-18, Volume: 10, Issue:18
| Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: a novel series of mixed dopamine D2/D4 receptor antagonists. |
| AID61316 | In vitro binding affinity against human D2 dopamine receptor in CHO cells by [3H]spiperone displacement. | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID1456726 | Inhibition of human dopamine D4.4 receptor | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Return of D |
| AID61633 | In vitro binding affinity against human D3 dopamine receptor in CHO cells using [3H]spiperone | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID182779 | Compound was tested for spontaneous locomotor activity in nonhabituated rats when administered po | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID8000 | The compound was tested In Vitro for half life in human liver microsomes. | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7
| Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. |
| AID1347024 | Rat D4 receptor (Dopamine receptors) | 2004 | Molecular pharmacology, Dec, Volume: 66, Issue:6
| Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |