trichostatin C: glycosylated trichostatin A; structure given in first source; do not confuse with TRICHOSANTHIN [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6438637 |
| CHEMBL ID | 3353924 |
| CHEBI ID | 39147 |
| SCHEMBL ID | 207836 |
| MeSH ID | M0150366 |
| Synonym |
|---|
| 68676-88-0 |
| 1-o-({(2e,4e,6r)-7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxohepta-2,4-dienoyl}amino)-beta-d-glucopyranose |
| 7-(4-(dimethylamino)phenyl)-n-(beta-d-glucopyranosyloxy)-4,6-dimethyl-7-oxo-2,4-heptadienamide |
| trichostatin c |
| CHEBI:39147 , |
| 8k9y0c8yn4 , |
| 7-(4-(dimethylamino)phenyl)-n-(glucopyranosyloxy)-4,6-dimethyl-7-oxo-2,4-heptadienamide |
| 2,4-heptadienamide, 7-(4-(dimethylamino)phenyl)-n-(beta-d-glucopyranosyloxy)-4,6-dimethyl-7-oxo- |
| unii-8k9y0c8yn4 |
| trichostatin c [mi] |
| 2,4-heptadienamide, 7-(4-(dimethylamino)phenyl)-n-(.beta.-d-glucopyranosyloxy)-4,6-dimethyl-7-oxo-, (2e,4e,6r)- |
| SCHEMBL207836 |
| CHEMBL3353924 , |
| Q27118157 |
| (2e,4e,6r)-7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxo-n-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhepta-2,4-dienamide |
| DTXSID601317397 |
| bdbm50577996 |
| AKOS040754859 |
| Class | Description |
|---|---|
| trichostatin | |
| O-amino sugar | Any sugar having one or more alcoholic hydrogen moieties replaced by amino groups. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Histone deacetylase 3 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0004 | 0.6196 | 10.0000 | AID1781513 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0006 | 1.0526 | 10.0000 | AID1781513 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0001 | 0.5543 | 9.9000 | AID1781513 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0007 | 1.0260 | 9.9000 | AID1781513 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0001 | 0.7221 | 9.9700 | AID1781513 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0005 | 0.7245 | 9.9000 | AID1781513 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0003 | 0.9298 | 9.9000 | AID1781513 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0007 | 0.9947 | 9.9000 | AID1781513 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0000 | 0.5376 | 9.9000 | AID1781513 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0005 | 0.9413 | 9.9000 | AID1781513 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 (µMol) | 23.6300 | 0.0007 | 0.9610 | 10.0000 | AID1781513 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1656939 | Inhibition of mushroom tyrosinase using L-DOPA as substrate | |||
| AID1781511 | Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by EZ-Cytox colorimetric assay | 2021 | Journal of natural products, 09-24, Volume: 84, Issue:9 | Ulleunganilines A-C, Trichostatin Analogues Bearing a Modified Side Chain from |
| AID1656942 | Cytotoxicity against human A549 cells assessed as reduction in cell viability | |||
| AID1781512 | Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by EZ-Cytox colorimetric assay | 2021 | Journal of natural products, 09-24, Volume: 84, Issue:9 | Ulleunganilines A-C, Trichostatin Analogues Bearing a Modified Side Chain from |
| AID1656941 | Cytotoxicity against human A2058 cells assessed as reduction in cell viability | |||
| AID1656940 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability | |||
| AID1177036 | Up-regulation of transcriptional activity of human CLA-1 promoter region -1055 to -62bp transfected in HepG2 cells by luciferase reporter gene assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1177039 | Cytotoxicity against human HeLa cells after 96 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1177040 | Cytotoxicity against human LO2 cells after 96 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1177041 | Cytotoxicity against human HEK293 cells after 96 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1656943 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability | |||
| AID1781513 | Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate incubated for 20 mins by fluorometric assay | 2021 | Journal of natural products, 09-24, Volume: 84, Issue:9 | Ulleunganilines A-C, Trichostatin Analogues Bearing a Modified Side Chain from |
| AID1656944 | Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability | |||
| AID1177037 | Cytotoxicity against human U2OS cells after 96 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1177038 | Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.69) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||