1-amino-1-phenylmethyl phosphonic acid : A member of the class of phosphonic acids that is phosphonic acid having a amino(phenyl)methyl group attached to the phosphorus. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 98449 |
| CHEMBL ID | 1090366 |
| CHEBI ID | 86535 |
| SCHEMBL ID | 233491 |
| Synonym |
|---|
| 18108-22-0 |
| nsc133874 |
| nsc-133874 |
| nsc-669595 |
| nsc 133874 |
| phosphonic acid, (alpha-aminobenzyl)- (6ci,8ci) |
| (alpha-aminobenzyl)phosphonic acid |
| brn 2049498 |
| (aminophenylmethyl)phosphonic acid |
| OPREA1_794855 |
| nsc669595 |
| phosphonic acid, (aminophenylmethyl)- |
| [amino(phenyl)methyl]phosphonic acid |
| BMSE000171 |
| chebi:86535 , |
| amino(phenyl)methylphosphonic acid |
| CHEMBL1090366 , |
| bdbm50316031 |
| AKOS001016495 |
| 4-07-00-00555 (beilstein handbook reference) |
| phosphonic acid, (alpha-aminobenzyl)- |
| 37714-05-9 |
| AKOS017344475 |
| SCHEMBL233491 |
| melengestrolacetate |
| 1-amino-1-phenylmethyl phosphonic acid |
| (r)-1-phosphono-benzylamine |
| a-aminobenzylphosphonic acid |
| (amino(phenyl)methyl)phosphonic acid |
| Q27159222 |
| CS-0269760 |
| phosphonic acid, p-(aminophenylmethyl)- |
| (1-amino-1-phenylmethyl)phosphonic acid |
| DTXSID501305747 |
| Z55625577 |
| EN300-7832206 |
| Class | Description |
|---|---|
| benzenes | Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives. |
| phosphonic acids | HP(=O)(OH)2 (phosphonic acid) and its P-substituted derivatives. |
| primary amino compound | A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Aminopeptidase N | Sus scrofa (pig) | IC50 (µMol) | 220.0000 | 0.0005 | 3.5354 | 8.9000 | AID472434 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| regulation of translation | Methionine aminopeptidase 1 | Homo sapiens (human) |
| proteolysis | Methionine aminopeptidase 1 | Homo sapiens (human) |
| peptidyl-methionine modification | Methionine aminopeptidase 1 | Homo sapiens (human) |
| N-terminal protein amino acid modification | Methionine aminopeptidase 1 | Homo sapiens (human) |
| protein maturation | Methionine aminopeptidase 1 | Homo sapiens (human) |
| platelet aggregation | Methionine aminopeptidase 1 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| aminopeptidase activity | Methionine aminopeptidase 1 | Homo sapiens (human) |
| initiator methionyl aminopeptidase activity | Methionine aminopeptidase 1 | Homo sapiens (human) |
| protein binding | Methionine aminopeptidase 1 | Homo sapiens (human) |
| metalloexopeptidase activity | Methionine aminopeptidase 1 | Homo sapiens (human) |
| metal ion binding | Methionine aminopeptidase 1 | Homo sapiens (human) |
| metalloaminopeptidase activity | Methionine aminopeptidase 1 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| cytoplasm | Methionine aminopeptidase 1 | Homo sapiens (human) |
| cytosol | Methionine aminopeptidase 1 | Homo sapiens (human) |
| cytosolic ribosome | Methionine aminopeptidase 1 | Homo sapiens (human) |
| cytosol | Methionine aminopeptidase 1 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1091063 | Inhibition of Arabidopsis thaliana P5C assessed as reduction in NADH oxidation incubated at 35 degC up to 10 min | 2008 | Journal of agricultural and food chemistry, May-14, Volume: 56, Issue:9 | Tailoring the structure of aminobisphosphonates to target plant P5C reductase. |
| AID513949 | Effect on human cytoplasmic protein tyrosine phosphatase B assessed as change in enzyme activity at 100 uM at pH 5 | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14 | Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screening. |
| AID513947 | Effect on human cytoplasmic protein tyrosine phosphatase A assessed as change in enzyme activity at 100 uM at pH 5 | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14 | Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screening. |
| AID513948 | Effect on human cytoplasmic protein tyrosine phosphatase A assessed as change in enzyme activity at 100 uM at pH 7 | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14 | Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screening. |
| AID1111047 | Inhibition of Zea mays cv. Jeff (maize) leaf glutamine synthetase using L-glutamate as substrate assessed as inorganic phosphate production at 1 mM after 20 min by malachite green assay relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Effectiveness and mode of action of phosphonate inhibitors of plant glutamine synthetase. |
| AID1200778 | Inhibition of human MetAP1b F309M mutant using Met-pNA as substrate | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases. |
| AID1200777 | Inhibition of Streptococcus pneumoniae MetAP1a using Met-pNA as substrate | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases. |
| AID1111046 | Inhibition of Zea mays cv. Jeff (maize) leaf glutamine synthetase using L-glutamate as substrate assessed as inorganic phosphate production after 20 min by malachite green assay relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Effectiveness and mode of action of phosphonate inhibitors of plant glutamine synthetase. |
| AID1200776 | Inhibition of Human MetAP1b using Met-pNA as substrate | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases. |
| AID1200780 | Inhibition of Enterococcus faecalis MetAP1a using Met-pNA as substrate | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases. |
| AID1200779 | Inhibition of Mycobacterium tuberculosis MetAP1c using Met-pNA as substrate | 2015 | Journal of medicinal chemistry, Mar-12, Volume: 58, Issue:5 | Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases. |
| AID472434 | Inhibition of pig kidney aminopeptidase N using Leu-AMC as substrate | 2010 | Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8 | New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.50) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||