| Assay ID | Title | Year | Journal | Article |
|---|
| AID314336 | Inhibition of MMP2 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314340 | Inhibition of MMP7 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID349375 | Inhibition of MMP3 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314341 | Inhibition of MMP8 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID344653 | Inhibition of pig TACE | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314359 | AUC in Sprague-Dawley rat at 8.0 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314353 | Oral bioavailability in Sprague-Dawley rat at 8.0 mg/kg | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314367 | Oral bioavailability in Beagle dog at 8.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314348 | Inhibition of ADAMTS1 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID623362 | Inhibition of TACE in human whole blood assessed as reduction of of LPS-induced TNFalpha production at 0.3 uM pretreated 15 mins before LPS challenge measured 5 hrs post LPS challenge | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11
| Synthesis, preliminary biological evaluation and molecular modeling of some new heterocyclic inhibitors of TACE. |
| AID344624 | Inhibition of ADAMTS5 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314368 | Protein binding in rat serum | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314356 | AUC in Sprague-Dawley rat at 5.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314360 | Half life in Beagle dog at 2.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314366 | AUC in Beagle dog at 8.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314342 | Inhibition of MMP10 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314351 | Inhibition of ADAM10 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314333 | Inhibition of semi purified pig TACE | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID349415 | Inhibition of MMP15 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID349377 | Inhibition of MMP13 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314365 | Half life in Beagle dog at 8.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314361 | Clearance in Beagle dog at 2.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID349376 | Inhibition of MMP8 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314349 | Inhibition of ADAMTS4 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314345 | Inhibition of MMP14 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314338 | Apparent permeability across human Caco-2 cells | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID349373 | Inhibition of MMP1 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID623363 | Inhibition of TACE in human whole blood assessed as reduction of of LPS-induced TNFalpha production at 1 uM pretreated 15 mins before LPS challenge measured 5 hrs post LPS challenge | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11
| Synthesis, preliminary biological evaluation and molecular modeling of some new heterocyclic inhibitors of TACE. |
| AID314343 | Inhibition of MMP12 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314371 | Reduction of LPS-induced TNFalpha level in orally dosed mouse after 1 hr | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314352 | Clearance in Sprague-Dawley rat at 5.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID349414 | Inhibition of MMP10 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314355 | Volume of distribution at steady state in Sprague-Dawley rat at 5.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID349385 | Inhibition of MMP12 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID349381 | Inhibition of MMP14 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314362 | Volume of distribution at steady state in Beagle dog at 2.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID349379 | Inhibition of MMP9 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314364 | Tmax in Beagle dog at 8.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314339 | Inhibition of MMP3 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314334 | Reduction of LPS-induced TNFalpha in human whole blood | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314347 | Inhibition of MMP16 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID344625 | Inhibition of ADAM10 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314369 | Protein binding in dog serum | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314335 | Inhibition of MMP1 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314358 | Half life in Sprague-Dawley rat at 8.0 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID349378 | Inhibition of MMP7 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314337 | Inhibition of MMP9 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314344 | Inhibition of MMP13 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314363 | AUC in Beagle dog at 2.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID349374 | Inhibition of MMP2 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID314354 | Half life in Sprague-Dawley rat at 5.0 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314370 | Protein binding in human serum | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID349413 | Inhibition of MMP16 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID344622 | Inhibition of ADAMTS1 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID344623 | Inhibition of ADAMTS4 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID623364 | Inhibition of TACE in human whole blood assessed as reduction of of LPS-induced TNFalpha production pretreated 15 mins before LPS challenge measured 5 hrs post LPS challenge | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11
| Synthesis, preliminary biological evaluation and molecular modeling of some new heterocyclic inhibitors of TACE. |
| AID314350 | Inhibition of ADAMTS5 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID314357 | Tmax in Sprague-Dawley rat at 8.0 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| AID1798732 | Enzyme Inhibition Assay from Article 10.1016/j.bmcl.2008.01.075: \\Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.\\ | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |