| Assay ID | Title | Year | Journal | Article |
|---|
| AID419549 | Displacement of [3H]spiperone from human cloned dopamine D2L receptor V2.61F mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419721 | Selectivity ratio of Ki for human cloned dopamine D2L receptor E181V/I183S mutant to Ki for wild type human cloned dopamine D2L receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID1456729 | Inhibition of human dopamine D3 receptor | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Return of D |
| AID419546 | Selectivity ratio of Ki for human cloned dopamine D3 receptor to Ki for human cloned dopamine D4 receptor expressed in CHO cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID1456759 | Inhibition of human dopamine D2 (long) receptor (unknown origin) | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Return of D |
| AID277668 | Selectivity for dopamine D3 over dopamine D2 | 2007 | Journal of medicinal chemistry, Feb-08, Volume: 50, Issue:3
| Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands. |
| AID419726 | Selectivity ratio of Ki for human cloned dopamine D3 receptor L2.64F mutant to Ki for wild type human cloned dopamine D3 receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID319911 | Selectivity for human dopamine D4.4 receptor over human dopamine D2L receptor | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID419728 | Selectivity ratio of Ki for human cloned dopamine D3 receptor V2.61F/FV3.28,3.29LM mutant to Ki for wild type human cloned dopamine D3 receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419555 | Displacement of [3H]spiperone from human cloned dopamine D2L receptor H6.55F mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID767067 | Displacement of [3H]spiperone from human dopamine D2 receptor | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Discovery of highly potent and selective D4 ligands by interactive SAR study. |
| AID419733 | Selectivity ratio of Ki for wild type human cloned dopamine D2L receptor to Ki for human cloned dopamine D2L receptor V2.61F/FV3.28,3.29LM mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419547 | Displacement of [3H]spiperone from wild type human cloned dopamine D2L receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID320345 | Binding affinity to human D3 receptor | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker. |
| AID64179 | Ability to displace [3H]spiperone from dopamine receptor D4.4 expressed in CHO-K1 cells | 2001 | Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8
| Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapi |
| AID319908 | Displacement of [3H]8-OH-DPAT from 5HT1A receptor in pig cortical membranes | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID277677 | Binding affinity to dopamine D2 | 2007 | Journal of medicinal chemistry, Feb-08, Volume: 50, Issue:3
| Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands. |
| AID63528 | Binding affinity against human Dopamine receptor D4 by [3H]-spiperone displacement. | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. |
| AID419554 | Displacement of [3H]spiperone from human cloned dopamine D2L receptor H6.55A mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID242945 | Ratio of dopamine receptor D2 long and D4 ki values | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. |
| AID277673 | Displacement of [3H]spiperone from human dopamine D3 expressed in CHO cell membrane | 2007 | Journal of medicinal chemistry, Feb-08, Volume: 50, Issue:3
| Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands. |
| AID419550 | Displacement of [3H]spiperone from human cloned dopamine D2L receptor L2.64F mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID319904 | Displacement of [3H]spiperone from cloned human dopamine D2S receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID319915 | Agonist activity at rat dopamine D4.2 receptor expressed in CHO10001A cells assessed as incorporation of [3H]thymidine | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID65921 | Intrinsic activity was measured in the human Dopamine receptor D4 calcium flux assay wiht co-transfected G-alpha-qo5 protein | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. |
| AID64976 | Binding affinity against dopamine receptor D3 using radioligand [3H]spiperone | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). |
| AID320346 | Binding affinity to human dopamine D4.4 receptor | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker. |
| AID226201 | Rate of incorporation of [3H]thymidine as evidence of mitogenetic activity | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). |
| AID238699 | Binding affinity for human dopamine receptor D2 long | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. |
| AID419715 | Displacement of [3H]spiperone from wild type human cloned dopamine D4 receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID238274 | Binding affinity for Dopamine receptor D4 | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. |
| AID419557 | Displacement of [3H]spiperone from human cloned dopamine D3 receptor D3.32E mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419724 | Selectivity ratio of Ki for human cloned dopamine D3 receptor D3.32E mutant to Ki for wild type human cloned dopamine D3 receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419730 | Selectivity ratio of Ki for human cloned dopamine D3 receptor H6.55A mutant to Ki for wild type human cloned dopamine D3 receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419551 | Displacement of [3H]spiperone from human cloned dopamine D2L receptor FV3.28,3.29LM mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419553 | Displacement of [3H]spiperone from human cloned dopamine D2L receptor E181V/I183S mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419563 | Displacement of [3H]spiperone from human cloned dopamine D3 receptor H6.55A mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419717 | Selectivity ratio of Ki for human cloned dopamine D2L receptor V2.61F mutant to Ki for wild type human cloned dopamine D2L receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID319912 | Selectivity for human dopamine D4.4 receptor over human dopamine D2S receptor | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID64661 | Binding affinity against dopamine receptor D2S using radioligand [3H]spiperone | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). |
| AID320340 | Binding affinity to pig cortical membrane dopamine D1 receptor | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker. |
| AID232502 | Selectivity ratio of D2 receptor to that of D4 receptor | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. |
| AID419729 | Selectivity ratio of Ki for human cloned dopamine D3 receptor V180E/S182I mutant to Ki for wild type human cloned dopamine D3 receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID1456758 | Inhibition of human dopamine D2 (short) receptor | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Return of D |
| AID419723 | Selectivity ratio of Ki for human cloned dopamine D2L receptor H6.55F mutant to Ki for wild type human cloned dopamine D2L receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419722 | Selectivity ratio of Ki for human cloned dopamine D2L receptor H6.55A mutant to Ki for wild type human cloned dopamine D2L receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419545 | Selectivity ratio of Ki for human cloned dopamine D2L receptor to Ki for human cloned dopamine D4 receptor expressed in CHO cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419731 | Selectivity ratio of dopamine D2L receptor V2.61F/FV3.28,3.29LM mutant over wild type dopamine D2L receptor | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419559 | Displacement of [3H]spiperone from human cloned dopamine D3 receptor L2.64F mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID242944 | Ratio of dopamine receptor D2 long and D3 ki values | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. |
| AID767065 | Binding affinity to human dopamine D3 receptor by radioligand binding assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Discovery of highly potent and selective D4 ligands by interactive SAR study. |
| AID419543 | Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419544 | Selectivity ratio of Ki for human cloned dopamine D2L receptor to Ki for human cloned dopamine D3 receptor expressed in CHO cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID238613 | Binding affinity for human dopamine receptor D3 | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. |
| AID63182 | Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390 | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). |
| AID419542 | Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID767064 | Binding affinity to human dopamine D4 receptor by radioligand binding assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Discovery of highly potent and selective D4 ligands by interactive SAR study. |
| AID419552 | Displacement of [3H]spiperone from human cloned dopamine D2L receptor V2.61F/FV3.28,3.29LM mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID320344 | Binding affinity to human dopamine D2 long receptor | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker. |
| AID62931 | Binding affinity against human Dopamine receptor D2 using [3H]spiperone as radioligand | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. |
| AID320341 | Binding affinity to pig cortical membrane 5HT1A receptor | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker. |
| AID277674 | Displacement of [3H]spiperone from human dopamine D4.4 expressed in CHO cell membrane | 2007 | Journal of medicinal chemistry, Feb-08, Volume: 50, Issue:3
| Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands. |
| AID419718 | Selectivity ratio of Ki for human cloned dopamine D2L receptor L2.64F mutant to Ki for wild type human cloned dopamine D2L receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID64333 | Binding affinity against dopamine receptor D2L using radioligand [3H]-spiperone | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). |
| AID419556 | Displacement of [3H]spiperone from wild type human cloned dopamine D3 receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419734 | Selectivity ratio of Ki for wild type human cloned dopamine D3 receptor to Ki for human cloned dopamine D3 receptor V2.61F/FV3.28,3.29LM mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID767062 | Modulation of human dopamine D4 receptor by fluorescent calcium assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Discovery of highly potent and selective D4 ligands by interactive SAR study. |
| AID419725 | Selectivity ratio of Ki for human cloned dopamine D3 receptor V2.61F mutant to Ki for wild type human cloned dopamine D3 receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419541 | Displacement of [3H]spiperone from human cloned dopamine D2L receptor expressed in CHO cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419732 | Selectivity ratio of dopamine D3 receptor V2.61F/FV3.28,3.29LM mutant over wild type dopamine D3 receptor | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID1456726 | Inhibition of human dopamine D4.4 receptor | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Return of D |
| AID1456727 | Inhibition of human dopamine D1 receptor | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Return of D |
| AID64031 | Binding affinity against human dopamine receptor D4.4 using radioligand [3H]spiperone | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). |
| AID319913 | Selectivity for human dopamine D4.4 receptor over human dopamine D3 receptor | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID277669 | Selectivity for dopamine D3 over dopamine D4 | 2007 | Journal of medicinal chemistry, Feb-08, Volume: 50, Issue:3
| Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands. |
| AID320343 | Displacement of [3H]ketanserin from pig cortical membrane 5HT2 receptor | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker. |
| AID319910 | Displacement of [3H]prazosin from adrenergic alpha1 receptor in pig cortical membranes | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID419558 | Displacement of [3H]spiperone from human cloned dopamine D3 receptor V2.61F mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID242943 | Ratio of dopamine receptor D3 and D4 ki values | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. |
| AID419562 | Displacement of [3H]spiperone from human cloned dopamine D3 receptor V180E/S182I mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419719 | Selectivity ratio of Ki for human cloned dopamine D2L receptor FV3.28,3.29LM mutant to Ki for wild type human cloned dopamine D2L receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419561 | Displacement of [3H]spiperone from human cloned dopamine D3 receptor V2.61F/FV3.28,3.29LM mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419716 | Selectivity ratio of Ki for human cloned dopamine D2L receptor D3.32E mutant to Ki for wild type human cloned dopamine D2L receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID319907 | Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID419720 | Selectivity ratio of Ki for human cloned dopamine D2L receptor V2.61F/FV3.28,3.29LM mutant to Ki for wild type human cloned dopamine D2L receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID319903 | Displacement of [3H]spiperone from cloned human dopamine D2L receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID319918 | Displacement of 2-[4-(2-(2-[18F]fluoroethoxy)phenyl)piperazin-1-ylmethyl]pyrazolo[1,5-alpha]pyridine from dopamine D4 receptor in Sprague-Dawley rat brain | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID419560 | Displacement of [3H]spiperone from human cloned dopamine D3 receptor FV3.28,3.29LM mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID319914 | Agonist activity at rat dopamine D4.2 receptor expressed in CHO10001A cells assessed as incorporation of [3H]thymidine relative to quinpirole | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID319905 | Displacement of [3H]spiperone from cloned human dopamine D3 receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID419548 | Displacement of [3H]spiperone from human cloned dopamine D2L receptor D3.32E mutant expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID419727 | Selectivity ratio of Ki for human cloned dopamine D3 receptor FV3.28,3.29LM mutant to Ki for wild type human cloned dopamine D3 receptor expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. |
| AID319909 | Displacement of [3H]ketanserin from 5HT2 receptor in pig cortical membranes | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID319906 | Displacement of [3H]spiperone from cloned human dopamine D4.4 receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. |
| AID320342 | Displacement of [3H]prazosin from pig cortical membrane adrenergic alpha-1 receptor | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker. |
| AID65925 | Effective concentration against human Dopamine receptor D4 | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
| AID1347024 | Rat D4 receptor (Dopamine receptors) | 2004 | Molecular pharmacology, Dec, Volume: 66, Issue:6
| Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |