cussonoside B: triterpene saponin from Cussonia barteri bark; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Cussonia | genus | A plant genus of the family ARALIACEAE that contains cussonosides or sieboldianosides (oleanane saponins).[MeSH] | Araliaceae | The ginseng plant family of the order Apiales, subclass Rosidae, class Magnoliopsida. Leaves are generally alternate, large, and compound. Flowers are five-parted and arranged in compound flat-topped umbels. The fruit is a berry or (rarely) a drupe (a one-seeded fruit). It is well known for plant preparations used as adaptogens (immune support and anti-fatigue).[MeSH] |
| Cussonia barteri | species | [no description available] | Araliaceae | The ginseng plant family of the order Apiales, subclass Rosidae, class Magnoliopsida. Leaves are generally alternate, large, and compound. Flowers are five-parted and arranged in compound flat-topped umbels. The fruit is a berry or (rarely) a drupe (a one-seeded fruit). It is well known for plant preparations used as adaptogens (immune support and anti-fatigue).[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 169187 |
| CHEMBL ID | 1171448 |
| MeSH ID | M0141537 |
| Synonym |
|---|
| 30688-36-9 |
| cussonoside b |
| bdbm50322753 |
| cirensenoside o |
| CHEMBL1171448 , |
| [(2s,3r,4s,5s,6r)-6-[[(2r,3r,4r,5s,6r)-6-(hydroxymethyl)-5-[(2s,3r,4r,5r,6s)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,4-bis(oxidanyl)oxan-2-yl]oxymethyl]-3,4,5-tris(oxidanyl)oxan-2-yl] (4as,6ar,6as,6br,8ar,10s,12ar,14bs)-2,2,6a,6b,9,9,12a-heptamethyl- |
| (4as,6ar,6as,6br,8ar,10s,12ar,14bs)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid [(2s,3r,4s,5s,6r)-6-[[(2r,3r,4r,5s,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-[[(2s,3r,4r,5r,6s)-3,4,5-trih |
| A822854 |
| oleanolic acid-28-o-(rhamnopyranosyl(1-4)glucopyranosyl(1-6))glucopyranosyl ester |
| olean-12-en-28-oic acid, 3-hydroxy-, o-6-deoxy-alpha-l-mannopyranosyl-(1-4)-o-beta-d-glucopyranosyl-(1-6)-beta-d-glucopyranosyl ester, (3beta)- |
| oleanolic acid 28-o-(rhamnopyranosyl(1-4)glucopyranosyl(1-6))glucopyranosyl ester |
| DTXSID201317602 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 (µMol) | 50.0000 | 0.0002 | 1.5574 | 10.0000 | AID491943 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 (µMol) | 50.0000 | 0.0001 | 0.9950 | 10.0000 | AID491942 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID491942 | Inhibition of COX2 by microplate reader | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7 | Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity. |
| AID772914 | Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | Bioactive oleanane-type saponins from the rhizomes of Anemone taipaiensis. |
| AID772916 | Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | Bioactive oleanane-type saponins from the rhizomes of Anemone taipaiensis. |
| AID1602967 | Cytotoxicity against mouse RAW264.7 cells at anti-inflammatory IC50 after 19 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 29, Issue:8 | Isolation, structural elucidation, and insights into the anti-inflammatory effects of triterpene saponins from the leaves of Stauntonia hexaphylla. |
| AID772915 | Cytotoxicity against human U87MG cells assessed as cell viability after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | Bioactive oleanane-type saponins from the rhizomes of Anemone taipaiensis. |
| AID491943 | Inhibition of COX1 by microplate reader | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7 | Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity. |
| AID772917 | Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | Bioactive oleanane-type saponins from the rhizomes of Anemone taipaiensis. |
| AID772918 | Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | Bioactive oleanane-type saponins from the rhizomes of Anemone taipaiensis. |
| AID1602966 | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess reagent-based assay | 2019 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 29, Issue:8 | Isolation, structural elucidation, and insights into the anti-inflammatory effects of triterpene saponins from the leaves of Stauntonia hexaphylla. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.72) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||