Compounds > 2-amino-3-methylpyridine
Page last updated: 2024-12-05

2-amino-3-methylpyridine

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Description

2-amino-3-methylpyridine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID15347
CHEMBL ID291544
SCHEMBL ID17639
SCHEMBL ID8091109
MeSH IDM0284676

Synonyms (64)

Synonym
y2wwd85qy6 ,
unii-y2wwd85qy6
einecs 216-501-4
ai3-14684
3-methyl-2-pyridylamine
2-amino-beta-picoline
nsc 450
3-methylpyridin-2-amine
inchi=1/c6h8n2/c1-5-3-2-4-8-6(5)7/h2-4h,1h3,(h2,7,8
2-amino-3-methyl-pyridine
2-amino-.beta.-picoline
wln: t6nj bz c1
pyridine, 2-amino-3-methyl-
3-picoline, 2-amino-
3-methyl-2-pyridinamine
nsc450
2-amino-3-methylpyridine
2-amino-3-picoline ,
3-methyl-2-aminopyridine
2-pyridinamine, 3-methyl-
1603-40-3
nsc-450
2-amino-3-methylpyridine, 95%
nsc-176169
AC-5930
A0400
bdbm50091797
3-methyl-pyridin-2-ylamine
CHEMBL291544 ,
AKOS000119102
A24640
2-amino-?-picoline;amino-3-methyl pyridine
A-6700
2-amino-3-methyl pyridine
STK510033
(3-methyl-pyridin-2-yl)-amine
FT-0611065
AM20050849
3-methylpyridin-2-ylamine
amino-3-methylpyridine, 2-
AB2930
SCHEMBL17639
SCHEMBL8091109
DTXSID3051759
3-methyl-2-pyridineamine
3-methylpyridine-2-amine
3-methyl-2-amino-pyridine
(3-methylpyridin-2-yl)amine
(3-methyl-pyridin-2-yl)amine
3-methyl-amino pyridine
3-methylpyridyl amine
mfcd00006320
3-methylpyridin-2(1h)-imine
STL453498
F2190-0488
GS-5903
methylpyridonimid
CS-W020056
93q ,
BCP22962
Q27294187
SB40521
EN300-21468
Z203045034
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Nitric oxide synthase, endothelialHomo sapiens (human)IC50 (µMol)1.20000.07202.58738.7000AID68131
Nitric oxide synthase, brainHomo sapiens (human)IC50 (µMol)1.30000.03502.711910.0000AID146109
Nitric oxide synthase, inducibleHomo sapiens (human)IC50 (µMol)0.94000.00022.319010.0000AID92001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (89)

Processvia Protein(s)Taxonomy
positive regulation of gene expressionNitric oxide synthase, endothelialHomo sapiens (human)
angiogenesisNitric oxide synthase, endothelialHomo sapiens (human)
ovulation from ovarian follicleNitric oxide synthase, endothelialHomo sapiens (human)
in utero embryonic developmentNitric oxide synthase, endothelialHomo sapiens (human)
blood vessel remodelingNitric oxide synthase, endothelialHomo sapiens (human)
regulation of sodium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
regulation of the force of heart contraction by chemical signalNitric oxide synthase, endothelialHomo sapiens (human)
regulation of systemic arterial blood pressure by endothelinNitric oxide synthase, endothelialHomo sapiens (human)
aortic valve morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
pulmonary valve morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
endocardial cushion morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
arginine catabolic processNitric oxide synthase, endothelialHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, endothelialHomo sapiens (human)
potassium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
calcium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
mitochondrion organizationNitric oxide synthase, endothelialHomo sapiens (human)
regulation of blood pressureNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of cell population proliferationNitric oxide synthase, endothelialHomo sapiens (human)
response to heatNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of platelet activationNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of muscle hyperplasiaNitric oxide synthase, endothelialHomo sapiens (human)
smooth muscle hyperplasiaNitric oxide synthase, endothelialHomo sapiens (human)
removal of superoxide radicalsNitric oxide synthase, endothelialHomo sapiens (human)
lung developmentNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, endothelialHomo sapiens (human)
regulation of nervous system processNitric oxide synthase, endothelialHomo sapiens (human)
lipopolysaccharide-mediated signaling pathwayNitric oxide synthase, endothelialHomo sapiens (human)
response to fluid shear stressNitric oxide synthase, endothelialHomo sapiens (human)
vasodilationNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of potassium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of blood vessel endothelial cell migrationNitric oxide synthase, endothelialHomo sapiens (human)
endothelial cell migrationNitric oxide synthase, endothelialHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of Notch signaling pathwayNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of angiogenesisNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of smooth muscle cell proliferationNitric oxide synthase, endothelialHomo sapiens (human)
homeostasis of number of cells within a tissueNitric oxide synthase, endothelialHomo sapiens (human)
establishment of localization in cellNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of calcium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
ventricular septum morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of biomineral tissue developmentNitric oxide synthase, endothelialHomo sapiens (human)
blood vessel diameter maintenanceNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsNitric oxide synthase, endothelialHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, endothelialHomo sapiens (human)
response to hormoneNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, endothelialHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, endothelialHomo sapiens (human)
response to hypoxiaNitric oxide synthase, brainHomo sapiens (human)
regulation of sodium ion transportNitric oxide synthase, brainHomo sapiens (human)
arginine catabolic processNitric oxide synthase, brainHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, brainHomo sapiens (human)
striated muscle contractionNitric oxide synthase, brainHomo sapiens (human)
myoblast fusionNitric oxide synthase, brainHomo sapiens (human)
response to heatNitric oxide synthase, brainHomo sapiens (human)
negative regulation of calcium ion transport into cytosolNitric oxide synthase, brainHomo sapiens (human)
regulation of cardiac muscle contraction by calcium ion signalingNitric oxide synthase, brainHomo sapiens (human)
peptidyl-cysteine S-nitrosylationNitric oxide synthase, brainHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationNitric oxide synthase, brainHomo sapiens (human)
multicellular organismal response to stressNitric oxide synthase, brainHomo sapiens (human)
xenobiotic catabolic processNitric oxide synthase, brainHomo sapiens (human)
vasodilationNitric oxide synthase, brainHomo sapiens (human)
negative regulation of potassium ion transportNitric oxide synthase, brainHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, brainHomo sapiens (human)
positive regulation of DNA-templated transcriptionNitric oxide synthase, brainHomo sapiens (human)
positive regulation of transcription by RNA polymerase IINitric oxide synthase, brainHomo sapiens (human)
negative regulation of hydrolase activityNitric oxide synthase, brainHomo sapiens (human)
negative regulation of serotonin uptakeNitric oxide synthase, brainHomo sapiens (human)
negative regulation of calcium ion transportNitric oxide synthase, brainHomo sapiens (human)
regulation of cardiac muscle contractionNitric oxide synthase, brainHomo sapiens (human)
regulation of ryanodine-sensitive calcium-release channel activityNitric oxide synthase, brainHomo sapiens (human)
cellular response to growth factor stimulusNitric oxide synthase, brainHomo sapiens (human)
positive regulation of the force of heart contractionNitric oxide synthase, brainHomo sapiens (human)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayNitric oxide synthase, brainHomo sapiens (human)
positive regulation of sodium ion transmembrane transportNitric oxide synthase, brainHomo sapiens (human)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelNitric oxide synthase, brainHomo sapiens (human)
positive regulation of membrane repolarization during ventricular cardiac muscle cell action potentialNitric oxide synthase, brainHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, brainHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, brainHomo sapiens (human)
response to hormoneNitric oxide synthase, brainHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, brainHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, brainHomo sapiens (human)
response to hypoxiaNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of leukocyte mediated cytotoxicityNitric oxide synthase, inducibleHomo sapiens (human)
innate immune response in mucosaNitric oxide synthase, inducibleHomo sapiens (human)
arginine catabolic processNitric oxide synthase, inducibleHomo sapiens (human)
superoxide metabolic processNitric oxide synthase, inducibleHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, inducibleHomo sapiens (human)
circadian rhythmNitric oxide synthase, inducibleHomo sapiens (human)
response to bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of gene expressionNitric oxide synthase, inducibleHomo sapiens (human)
peptidyl-cysteine S-nitrosylationNitric oxide synthase, inducibleHomo sapiens (human)
prostaglandin secretionNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of interleukin-6 productionNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of interleukin-8 productionNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cell population proliferationNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of protein catabolic processNitric oxide synthase, inducibleHomo sapiens (human)
defense response to bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cellular respirationNitric oxide synthase, inducibleHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, inducibleHomo sapiens (human)
regulation of insulin secretionNitric oxide synthase, inducibleHomo sapiens (human)
defense response to Gram-negative bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of killing of cells of another organismNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to lipopolysaccharideNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to type II interferonNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to xenobiotic stimulusNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cytokine production involved in inflammatory responseNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, inducibleHomo sapiens (human)
response to hormoneNitric oxide synthase, inducibleHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, inducibleHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, inducibleHomo sapiens (human)
inflammatory responseNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, inducibleHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (18)

Processvia Protein(s)Taxonomy
actin monomer bindingNitric oxide synthase, endothelialHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, endothelialHomo sapiens (human)
protein bindingNitric oxide synthase, endothelialHomo sapiens (human)
calmodulin bindingNitric oxide synthase, endothelialHomo sapiens (human)
FMN bindingNitric oxide synthase, endothelialHomo sapiens (human)
heme bindingNitric oxide synthase, endothelialHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, endothelialHomo sapiens (human)
arginine bindingNitric oxide synthase, endothelialHomo sapiens (human)
cadmium ion bindingNitric oxide synthase, endothelialHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, endothelialHomo sapiens (human)
NADP bindingNitric oxide synthase, endothelialHomo sapiens (human)
scaffold protein bindingNitric oxide synthase, endothelialHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, brainHomo sapiens (human)
calcium channel regulator activityNitric oxide synthase, brainHomo sapiens (human)
protein bindingNitric oxide synthase, brainHomo sapiens (human)
calmodulin bindingNitric oxide synthase, brainHomo sapiens (human)
FMN bindingNitric oxide synthase, brainHomo sapiens (human)
sodium channel regulator activityNitric oxide synthase, brainHomo sapiens (human)
heme bindingNitric oxide synthase, brainHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, brainHomo sapiens (human)
arginine bindingNitric oxide synthase, brainHomo sapiens (human)
transmembrane transporter bindingNitric oxide synthase, brainHomo sapiens (human)
cadmium ion bindingNitric oxide synthase, brainHomo sapiens (human)
calcium-dependent protein bindingNitric oxide synthase, brainHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, brainHomo sapiens (human)
NADP bindingNitric oxide synthase, brainHomo sapiens (human)
scaffold protein bindingNitric oxide synthase, brainHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, inducibleHomo sapiens (human)
protein bindingNitric oxide synthase, inducibleHomo sapiens (human)
calmodulin bindingNitric oxide synthase, inducibleHomo sapiens (human)
FMN bindingNitric oxide synthase, inducibleHomo sapiens (human)
heme bindingNitric oxide synthase, inducibleHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, inducibleHomo sapiens (human)
arginine bindingNitric oxide synthase, inducibleHomo sapiens (human)
protein homodimerization activityNitric oxide synthase, inducibleHomo sapiens (human)
metal ion bindingNitric oxide synthase, inducibleHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, inducibleHomo sapiens (human)
NADP bindingNitric oxide synthase, inducibleHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (24)

Processvia Protein(s)Taxonomy
Golgi membraneNitric oxide synthase, endothelialHomo sapiens (human)
nucleusNitric oxide synthase, endothelialHomo sapiens (human)
cytoplasmNitric oxide synthase, endothelialHomo sapiens (human)
Golgi apparatusNitric oxide synthase, endothelialHomo sapiens (human)
cytosolNitric oxide synthase, endothelialHomo sapiens (human)
cytoskeletonNitric oxide synthase, endothelialHomo sapiens (human)
plasma membraneNitric oxide synthase, endothelialHomo sapiens (human)
caveolaNitric oxide synthase, endothelialHomo sapiens (human)
endocytic vesicle membraneNitric oxide synthase, endothelialHomo sapiens (human)
nucleusNitric oxide synthase, endothelialHomo sapiens (human)
plasma membraneNitric oxide synthase, endothelialHomo sapiens (human)
cytosolNitric oxide synthase, endothelialHomo sapiens (human)
photoreceptor inner segmentNitric oxide synthase, brainHomo sapiens (human)
nucleoplasmNitric oxide synthase, brainHomo sapiens (human)
cytoplasmNitric oxide synthase, brainHomo sapiens (human)
mitochondrionNitric oxide synthase, brainHomo sapiens (human)
cytosolNitric oxide synthase, brainHomo sapiens (human)
cytoskeletonNitric oxide synthase, brainHomo sapiens (human)
plasma membraneNitric oxide synthase, brainHomo sapiens (human)
sarcoplasmic reticulumNitric oxide synthase, brainHomo sapiens (human)
sarcolemmaNitric oxide synthase, brainHomo sapiens (human)
dendritic spineNitric oxide synthase, brainHomo sapiens (human)
membrane raftNitric oxide synthase, brainHomo sapiens (human)
synapseNitric oxide synthase, brainHomo sapiens (human)
perinuclear region of cytoplasmNitric oxide synthase, brainHomo sapiens (human)
cell peripheryNitric oxide synthase, brainHomo sapiens (human)
protein-containing complexNitric oxide synthase, brainHomo sapiens (human)
plasma membraneNitric oxide synthase, brainHomo sapiens (human)
postsynaptic densityNitric oxide synthase, brainHomo sapiens (human)
cytosolNitric oxide synthase, brainHomo sapiens (human)
nucleusNitric oxide synthase, brainHomo sapiens (human)
nucleusNitric oxide synthase, inducibleHomo sapiens (human)
nucleoplasmNitric oxide synthase, inducibleHomo sapiens (human)
cytoplasmNitric oxide synthase, inducibleHomo sapiens (human)
peroxisomeNitric oxide synthase, inducibleHomo sapiens (human)
peroxisomal matrixNitric oxide synthase, inducibleHomo sapiens (human)
cytosolNitric oxide synthase, inducibleHomo sapiens (human)
cortical cytoskeletonNitric oxide synthase, inducibleHomo sapiens (human)
perinuclear region of cytoplasmNitric oxide synthase, inducibleHomo sapiens (human)
plasma membraneNitric oxide synthase, inducibleHomo sapiens (human)
nucleusNitric oxide synthase, inducibleHomo sapiens (human)
cytosolNitric oxide synthase, inducibleHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID146109Inhibitory activity against neuronal nitric oxide synthase2000Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
AID92001Inhibitory activity against inducible nitric oxide synthase (iNOS)2000Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
AID68131Inhibitory activity against endothelial nitric oxide synthase (eNOS)2000Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
AID234086Selectivity for inhibition of neuronal nitric oxide synthases to that of inhibition of inducible nitric oxide synthases; Not determined2000Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
AID234084Selectivity for inhibition of inducible nitric oxide synthases to that of inhibition of endothelial cell nitric oxide synthases; Not determined2000Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.58 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (25.58)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2-amino-4-picoline
2-amino-4-picoline: RN given refers to parent cpd		210
acetazolamide
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)		2.0610monocarboxylic acid amide;
sulfonamide;
thiadiazoles		anticonvulsant;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.		210guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
beta-naphthoflavone
beta-Naphthoflavone: A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308). beta-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.		1.9910extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound		aryl hydrocarbon receptor agonist
ethylenediamine
ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.		2.0610alkane-alpha,omega-diamineGABA agonist
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.		1.9910barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
proadifen
Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.		1.9910diarylmethane
octylamine
octylamine: RN given refers to 1-octylamine. octan-1-amine : An 8-carbon primary aliphatic amine.		1.9910primary aliphatic aminemetabolite
alpha-aminopyridine
alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485. aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups.		2.9240
1,2-Dihydroquinolin-2-imine
[no description available]		210aminoquinoline
2,4-dichloro-5-sulfamoylbenzoic acid
2,4-dichloro-5-sulfamoylbenzoic acid: used in the manufacture of furosemide; occupational asthma and rhinitis was observed in workers from a lasamide production line		2.0610
1-aminoisoquinoline
[no description available]		210
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		210amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
n(6)-(1-iminoethyl)lysine
N(6)-acetimidoyl-L-lysine : An L-lysine derivative that is L-lysine in which one of the hydrogens attached to N(6) is substituted by an acetimidoyl group		210L-lysine derivative;
non-proteinogenic L-alpha-amino acid
2,4-dichloro-6-phenylphenoxyethylamine
2,4-dichloro-6-phenylphenoxyethylamine: RN given refers to parent cpd; structure		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials
Glaucoma
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)		02.0610