BB-78485: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 9823454 |
| CHEMBL ID | 261713 |
| SCHEMBL ID | 5485583 |
| MeSH ID | M0440136 |
| Synonym |
|---|
| (2r)-n-hydroxy-3-naphthalen-2-yl-2-(naphthalen-2-ylsulfonylamino)propanamide |
| (2r)-n-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide |
| 2VES |
| bb-78485 |
| CHEMBL261713 , |
| DB07861 |
| SCHEMBL5485583 |
| bdbm50478376 |
| (2r)-n-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide (non-preferred name) |
| Q27097072 |
| (r)-n-hydroxy-3-(naphthalen-2-yl)-2-(naphthalene-2-sulfonamido)propanamide |
| 207732-11-4 |
| AKOS040747921 |
| CS-0079322 |
| HY-121021 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, UDP-3-O-acyl-N-acetylglucosamine deacetylase | Pseudomonas aeruginosa PAO1 | Ki | 0.0200 | 0.0200 | 0.0200 | 0.0200 | AID977610 |
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | Rhizobium leguminosarum bv. trifolii WSM1325 | Ki | 0.0007 | 0.0007 | 0.0293 | 0.1100 | AID330341 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 (µMol) | 0.0175 | 0.0000 | 1.2848 | 10.0000 | AID1683070 |
| Stromelysin-1 | Homo sapiens (human) | IC50 (µMol) | 0.4160 | 0.0000 | 1.1484 | 10.0000 | AID1683069 |
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | Escherichia coli K-12 | Ki | 0.0067 | 0.0001 | 0.0880 | 0.6500 | AID330337; AID330338; AID652927 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 (µMol) | 0.0972 | 0.0000 | 0.7053 | 10.0000 | AID1683068 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID330337 | Inhibition of Escherichia coli LpxC | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47 | Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID330338 | Inhibition of Escherichia coli LpxC Q202W/G210S mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47 | Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID652928 | Antibacterial activity against Pseudomonas aeruginosa C53 | 2012 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7 | Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC. |
| AID330339 | Inhibition of Rhizobium leguminosarum LpxC | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47 | Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID1683068 | Inhibition of human MMP-9 by fluorometric assay | |||
| AID1683069 | Inhibition of human MMP-3 by fluorometric assay | |||
| AID652927 | Inhibition of Escherichia coli LpxC | 2012 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7 | Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC. |
| AID1683070 | Inhibition of human MMP-2 by fluorometric assay | |||
| AID330341 | Inhibition of Rhizobium leguminosarum LpxC W206Q/S214G mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47 | Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID330340 | Inhibition of Rhizobium leguminosarum LpxC S214G mutant | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47 | Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2008 | Protein science : a publication of the Protein Society, Mar, Volume: 17, Issue:3 | Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.43) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||