Page last updated: 2024-12-11

bb-78485

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

BB-78485: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9823454
CHEMBL ID	261713
SCHEMBL ID	5485583
MeSH ID	M0440136

Synonyms (15)

Synonym
(2r)-n-hydroxy-3-naphthalen-2-yl-2-(naphthalen-2-ylsulfonylamino)propanamide
(2r)-n-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide
2VES
bb-78485
CHEMBL261713 ,
DB07861
SCHEMBL5485583
bdbm50478376
(2r)-n-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide (non-preferred name)
Q27097072
(r)-n-hydroxy-3-(naphthalen-2-yl)-2-(naphthalene-2-sulfonamido)propanamide
207732-11-4
AKOS040747921
CS-0079322
HY-121021

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, UDP-3-O-acyl-N-acetylglucosamine deacetylase	Pseudomonas aeruginosa PAO1	Ki	0.0200	0.0200	0.0200	0.0200	AID977610
UDP-3-O-acyl-N-acetylglucosamine deacetylase	Rhizobium leguminosarum bv. trifolii WSM1325	Ki	0.0007	0.0007	0.0293	0.1100	AID330341
72 kDa type IV collagenase	Homo sapiens (human)	IC50 (µMol)	0.0175	0.0000	1.2848	10.0000	AID1683070
Stromelysin-1	Homo sapiens (human)	IC50 (µMol)	0.4160	0.0000	1.1484	10.0000	AID1683069
UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12	Ki	0.0067	0.0001	0.0880	0.6500	AID330337; AID330338; AID652927
Matrix metalloproteinase-9	Homo sapiens (human)	IC50 (µMol)	0.0972	0.0000	0.7053	10.0000	AID1683068
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (74)

Process	via Protein(s)	Taxonomy
angiogenesis	72 kDa type IV collagenase	Homo sapiens (human)
ovarian follicle development	72 kDa type IV collagenase	Homo sapiens (human)
ovulation from ovarian follicle	72 kDa type IV collagenase	Homo sapiens (human)
luteinization	72 kDa type IV collagenase	Homo sapiens (human)
blood vessel maturation	72 kDa type IV collagenase	Homo sapiens (human)
intramembranous ossification	72 kDa type IV collagenase	Homo sapiens (human)
proteolysis	72 kDa type IV collagenase	Homo sapiens (human)
negative regulation of cell adhesion	72 kDa type IV collagenase	Homo sapiens (human)
heart development	72 kDa type IV collagenase	Homo sapiens (human)
embryo implantation	72 kDa type IV collagenase	Homo sapiens (human)
parturition	72 kDa type IV collagenase	Homo sapiens (human)
response to xenobiotic stimulus	72 kDa type IV collagenase	Homo sapiens (human)
response to mechanical stimulus	72 kDa type IV collagenase	Homo sapiens (human)
peripheral nervous system axon regeneration	72 kDa type IV collagenase	Homo sapiens (human)
response to activity	72 kDa type IV collagenase	Homo sapiens (human)
protein metabolic process	72 kDa type IV collagenase	Homo sapiens (human)
extracellular matrix disassembly	72 kDa type IV collagenase	Homo sapiens (human)
protein catabolic process	72 kDa type IV collagenase	Homo sapiens (human)
positive regulation of cell migration	72 kDa type IV collagenase	Homo sapiens (human)
collagen catabolic process	72 kDa type IV collagenase	Homo sapiens (human)
response to retinoic acid	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to reactive oxygen species	72 kDa type IV collagenase	Homo sapiens (human)
response to nicotine	72 kDa type IV collagenase	Homo sapiens (human)
endodermal cell differentiation	72 kDa type IV collagenase	Homo sapiens (human)
response to hydrogen peroxide	72 kDa type IV collagenase	Homo sapiens (human)
response to estrogen	72 kDa type IV collagenase	Homo sapiens (human)
negative regulation of vasoconstriction	72 kDa type IV collagenase	Homo sapiens (human)
ephrin receptor signaling pathway	72 kDa type IV collagenase	Homo sapiens (human)
macrophage chemotaxis	72 kDa type IV collagenase	Homo sapiens (human)
response to electrical stimulus	72 kDa type IV collagenase	Homo sapiens (human)
response to hyperoxia	72 kDa type IV collagenase	Homo sapiens (human)
face morphogenesis	72 kDa type IV collagenase	Homo sapiens (human)
bone trabecula formation	72 kDa type IV collagenase	Homo sapiens (human)
prostate gland epithelium morphogenesis	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to amino acid stimulus	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to interleukin-1	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to estradiol stimulus	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to UV-A	72 kDa type IV collagenase	Homo sapiens (human)
cellular response to fluid shear stress	72 kDa type IV collagenase	Homo sapiens (human)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	72 kDa type IV collagenase	Homo sapiens (human)
response to amyloid-beta	72 kDa type IV collagenase	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	72 kDa type IV collagenase	Homo sapiens (human)
extracellular matrix organization	72 kDa type IV collagenase	Homo sapiens (human)
response to hypoxia	72 kDa type IV collagenase	Homo sapiens (human)
tissue remodeling	72 kDa type IV collagenase	Homo sapiens (human)
proteolysis	Stromelysin-1	Homo sapiens (human)
extracellular matrix disassembly	Stromelysin-1	Homo sapiens (human)
protein catabolic process	Stromelysin-1	Homo sapiens (human)
regulation of cell migration	Stromelysin-1	Homo sapiens (human)
collagen catabolic process	Stromelysin-1	Homo sapiens (human)
positive regulation of protein-containing complex assembly	Stromelysin-1	Homo sapiens (human)
cellular response to reactive oxygen species	Stromelysin-1	Homo sapiens (human)
innate immune response	Stromelysin-1	Homo sapiens (human)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Stromelysin-1	Homo sapiens (human)
cellular response to lipopolysaccharide	Stromelysin-1	Homo sapiens (human)
cellular response to amino acid stimulus	Stromelysin-1	Homo sapiens (human)
cellular response to UV-A	Stromelysin-1	Homo sapiens (human)
cellular response to nitric oxide	Stromelysin-1	Homo sapiens (human)
regulation of neuroinflammatory response	Stromelysin-1	Homo sapiens (human)
response to amyloid-beta	Stromelysin-1	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	Stromelysin-1	Homo sapiens (human)
extracellular matrix organization	Stromelysin-1	Homo sapiens (human)
lipid A biosynthetic process	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
phosphate-containing compound metabolic process	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
lipid A biosynthetic process	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
organophosphate metabolic process	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
carbohydrate derivative metabolic process	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
skeletal system development	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of protein phosphorylation	Matrix metalloproteinase-9	Homo sapiens (human)
proteolysis	Matrix metalloproteinase-9	Homo sapiens (human)
apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
embryo implantation	Matrix metalloproteinase-9	Homo sapiens (human)
cell migration	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular matrix disassembly	Matrix metalloproteinase-9	Homo sapiens (human)
macrophage differentiation	Matrix metalloproteinase-9	Homo sapiens (human)
collagen catabolic process	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to reactive oxygen species	Matrix metalloproteinase-9	Homo sapiens (human)
endodermal cell differentiation	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of DNA binding	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
ephrin receptor signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of keratinocyte migration	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to lipopolysaccharide	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to cadmium ion	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to UV-A	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondria	Matrix metalloproteinase-9	Homo sapiens (human)
regulation of neuroinflammatory response	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of receptor binding	Matrix metalloproteinase-9	Homo sapiens (human)
response to amyloid-beta	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of epithelial cell differentiation involved in kidney development	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of cation channel activity	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular matrix organization	Matrix metalloproteinase-9	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (16)

Process	via Protein(s)	Taxonomy
fibronectin binding	72 kDa type IV collagenase	Homo sapiens (human)
endopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
metalloendopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
serine-type endopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
protein binding	72 kDa type IV collagenase	Homo sapiens (human)
metallopeptidase activity	72 kDa type IV collagenase	Homo sapiens (human)
zinc ion binding	72 kDa type IV collagenase	Homo sapiens (human)
endopeptidase activity	Stromelysin-1	Homo sapiens (human)
metalloendopeptidase activity	Stromelysin-1	Homo sapiens (human)
serine-type endopeptidase activity	Stromelysin-1	Homo sapiens (human)
protein binding	Stromelysin-1	Homo sapiens (human)
peptidase activity	Stromelysin-1	Homo sapiens (human)
metallopeptidase activity	Stromelysin-1	Homo sapiens (human)
zinc ion binding	Stromelysin-1	Homo sapiens (human)
iron ion binding	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
zinc ion binding	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
hydrolase activity	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
deacetylase activity	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
metal ion binding	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
UDP-3-O-acyl-N-acetylglucosamine deacetylase activity	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
endopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
metalloendopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
serine-type endopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
protein binding	Matrix metalloproteinase-9	Homo sapiens (human)
collagen binding	Matrix metalloproteinase-9	Homo sapiens (human)
peptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
metallopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
zinc ion binding	Matrix metalloproteinase-9	Homo sapiens (human)
identical protein binding	Matrix metalloproteinase-9	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (13)

Process	via Protein(s)	Taxonomy
collagen-containing extracellular matrix	72 kDa type IV collagenase	Homo sapiens (human)
extracellular region	72 kDa type IV collagenase	Homo sapiens (human)
extracellular space	72 kDa type IV collagenase	Homo sapiens (human)
nucleus	72 kDa type IV collagenase	Homo sapiens (human)
mitochondrion	72 kDa type IV collagenase	Homo sapiens (human)
plasma membrane	72 kDa type IV collagenase	Homo sapiens (human)
sarcomere	72 kDa type IV collagenase	Homo sapiens (human)
collagen-containing extracellular matrix	72 kDa type IV collagenase	Homo sapiens (human)
extracellular space	72 kDa type IV collagenase	Homo sapiens (human)
extracellular region	Stromelysin-1	Homo sapiens (human)
nucleus	Stromelysin-1	Homo sapiens (human)
mitochondrion	Stromelysin-1	Homo sapiens (human)
cytosol	Stromelysin-1	Homo sapiens (human)
extracellular matrix	Stromelysin-1	Homo sapiens (human)
extracellular space	Stromelysin-1	Homo sapiens (human)
cytoplasm	UDP-3-O-acyl-N-acetylglucosamine deacetylase	Escherichia coli K-12
extracellular region	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-9	Homo sapiens (human)
collagen-containing extracellular matrix	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular exosome	Matrix metalloproteinase-9	Homo sapiens (human)
tertiary granule lumen	Matrix metalloproteinase-9	Homo sapiens (human)
ficolin-1-rich granule lumen	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-9	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (11)

Assay ID	Title	Year	Journal	Article
AID330337	Inhibition of Escherichia coli LpxC	2007	Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47	Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
AID330338	Inhibition of Escherichia coli LpxC Q202W/G210S mutant	2007	Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47	Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
AID652928	Antibacterial activity against Pseudomonas aeruginosa C53	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
AID330339	Inhibition of Rhizobium leguminosarum LpxC	2007	Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47	Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
AID1683068	Inhibition of human MMP-9 by fluorometric assay
AID1683069	Inhibition of human MMP-3 by fluorometric assay
AID652927	Inhibition of Escherichia coli LpxC	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
AID1683070	Inhibition of human MMP-2 by fluorometric assay
AID330341	Inhibition of Rhizobium leguminosarum LpxC W206Q/S214G mutant	2007	Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47	Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
AID330340	Inhibition of Rhizobium leguminosarum LpxC S214G mutant	2007	Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47	Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2008	Protein science : a publication of the Protein Society, Mar, Volume: 17, Issue:3	Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (42.86)	29.6817
2010's	3 (42.86)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.43 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.1	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	2.1	1	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
benzoylphenylalanine N-benzoyl-L-phenylalanine : An N-acyl-L-phenylalanine that is L-phenylalanine in which one of the hydrogens of the amino group has been replaced by a benzoyl group.	2.1	1	2-(benzoylamino)-3-phenylpropanoic acid; N-acyl-L-phenylalanine
tu-514 [no description available]	2.07	1
l 161240 [no description available]	2.46	2
lipid a Lipid A: Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.. lipid A : The glycolipid moiety of bacterial lipopolysaccharide (R can be either hydrogen or a fatty acyl group).	2.1	1	dodecanoate ester; lipid A; tetradecanoate ester	Escherichia coli metabolite
chir 090 CHIR 090: structure in first source. CHIR-090 : An L-threonine derivative obtained by formal condensation of the carboxy group of 4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzoic acid with the amino group of N-hydroxy-L-threoninamide.	2.46	2	acetylenic compound; benzamides; hydroxamic acid; L-threonine derivative; morpholines	antimicrobial agent; EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor; lipopolysaccharide biosynthesis inhibitor
l 161240 L 161240: structure in first source	2.1	1

Condition	Indicated	Relationship Strength	Studies	Trials
Cane-Cutter Fever [description not available]	0	2.1	1	0
Leptospirosis Infections with bacteria of the genus LEPTOSPIRA.	0	2.1	1	0

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