| Assay ID | Title | Year | Journal | Article |
|---|
| AID418503 | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells | 2009 | Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
| 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. |
| AID1589323 | Antiproliferative activity against human RL cells assessed as reduction in cell survival incubated for 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Lead optimization and biological evaluation of fragment-based cN-II inhibitors. |
| AID1589309 | Inhibition of recombinant cN-II (unknown origin) assessed as reduction in inorganic phosphate production at 1 mM pre-incubated for 10 mins followed by addition of IMP as substrate and measured after 5 mins by malachite green based assay relative to contro | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Lead optimization and biological evaluation of fragment-based cN-II inhibitors. |
| AID243481 | Inhibition of human cAMP-dependent protein kinase (PKA) | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID157745 | Inhibition of phosphodiesterase 4 at 1 uM cAMP | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors. |
| AID243555 | Inhibition of human Rho-dependent protein kinase-II at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID243566 | Inhibition of human c-Jun N-terminal kinase-2 alpha-2 at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID155650 | Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
| Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase. |
| AID418502 | Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity | 2009 | Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
| 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. |
| AID159485 | Inhibition of phosphodiesterase 3 at 1 uM cAMP | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors. |
| AID418500 | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | 2009 | Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
| 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. |
| AID243585 | Inhibition of human lymphocyte protein tyrosine kinase Lck at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID445467 | Displacement of [3H]adenine from adenine 1 receptor in rat brain cortical membrane by liquid scintillation counting | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. |
| AID243475 | Inhibition of human Protein kinase C alpha | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID243583 | Inhibition of human Mitogen-activated protein kinase 1 at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID243617 | Inhibition of human stress-activated protein kinase-2 alpha (p38 MAP-kinase) at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID40230 | Concentration that inhibits binding of 1.5 nM [3H]diazepam to rat brain benzodiazepine receptor | 1989 | Journal of medicinal chemistry, May, Volume: 32, Issue:5
| Benzodiazepine receptor binding activity of 6,9-disubstituted purines. |
| AID1452128 | Inhibition of ATPgammaS-BODIPY binding to Thermotoga maritima His-tagged HK853 expressed in Escherichia coli BL21(DE3)pLysS Rosetta preincubated for 30 mins prior to ATPgammaS-BODIPY addition measured after 1 hr by coomassie staining-based SDS-PAGE analys | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19
| Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases. |
| AID445468 | Inhibition of [3H]adenine binding to adenine 1 receptor in rat brain cortical membrane at 100 uM by liquid scintillation counting | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. |
| AID243637 | Inhibition of human Mitogen activated protein kinase kinase 1 (MEK1) at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID132946 | Minimum effective concentration required for more than 1 IU/mL induction of IFN using mice spleen cells | 2002 | Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25
| Discovery of 8-hydroxyadenines as a novel type of interferon inducer. |
| AID243554 | Inhibition of human Glycogen synthase kinase-3 beta at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID182838 | Ability to protect Sprague-Dawley male rats against maximal electroshock-induced seizures (MES) intraperitoneally. Inhibition at 25 mg/kg | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 6-(Alkylamino)-9-benzyl-9H-purines. A new class of anticonvulsant agents. |
| AID243690 | Inhibition of human RAF proto-oncogene serine/threonine-protein kinase at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID1911306 | Displacement of [3H]-SAM from PRMT5 (unknown origin) at 10 uM using peptide substrate preincubated for 15 mins followed by substrate addition for 60 mins by radioactive biochemical assay relative to control | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11
| Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5. |
| AID243699 | Inhibition of rat Calcium/calmodulin-dependent protein kinase type II at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID243516 | Inhibition of rat c-Jun N-terminal kinase-3 at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID155653 | Binding affinity (Ki) against human phosphatidylinositol 4-kinase | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
| Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase. |
| AID243584 | Inhibition of human Mitogen-activated protein kinase 2 at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID243565 | Inhibition of human c-Jun N-terminal kinase-1 alpha-1 at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID418501 | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | 2009 | Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
| 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. |
| AID243493 | Inhibition of human Protein kinase B alpha at 30 uM | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3
| Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |