Bromodomain and PHD finger-containing protein 3

A bromodomain and PHD finger-containing protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9ULD4]

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
i-bet726	Homo sapiens (human)	IC50	0.0010	1	1

This protein enables 2 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

This protein is located in 3 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is part of 2 target(s):

Target	Category	Definition
MOZ/MORF histone acetyltransferase complex	cellular component	A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. [PMID:18794358]
histone acetyltransferase complex	cellular component	A protein complex that possesses histone acetyltransferase activity. [GOC:mah]

This protein is involved in 6 target(s):

Target	Category	Definition
chromatin remodeling	biological process	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
regulation of DNA-templated transcription	biological process	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of DNA replication	biological process	Any process that activates or increases the frequency, rate or extent of DNA replication. [GOC:go_curators]
regulation of developmental process	biological process	Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:go_curators]
regulation of hemopoiesis	biological process	Any process that modulates the frequency, rate or extent of hemopoiesis. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]