Compounds > pinophilin b
Page last updated: 2024-11-13

pinophilin b

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Description

pinophilin B: from cultures of a fungus (Penicillium pinophilum Hedgcok) derived from a seaweed; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID57333718
CHEMBL ID2011647
MeSH IDM0572815

Synonyms (3)

Synonym
pinophilin b
chembl2011647 ,
bdbm50379294
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (17)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Maltase-glucoamylase, intestinalHomo sapiens (human)IC50 (µMol)200.00000.04003.46529.0000AID1378614
DNA polymerase betaRattus norvegicus (Norway rat)IC50 (µMol)200.00003.70006.20008.5000AID654338
Lysosomal alpha-glucosidaseHomo sapiens (human)IC50 (µMol)200.00000.06002.28897.8000AID1378614
Sucrase-isomaltase, intestinalHomo sapiens (human)IC50 (µMol)200.00000.04902.72947.8000AID1378614
DNA polymerase delta catalytic subunitHomo sapiens (human)IC50 (µMol)96.40002.30002.30002.3000AID654336
Probable maltase-glucoamylase 2Homo sapiens (human)IC50 (µMol)200.00000.54004.02447.8000AID1378614
Reverse transcriptase/RNaseH Human immunodeficiency virus 1IC50 (µMol)200.00000.00011.076810.0000AID654351
DNA polymerase kappaHomo sapiens (human)IC50 (µMol)88.90003.40005.95009.2000AID654344
DNA polymerase lambdaHomo sapiens (human)IC50 (µMol)200.00005.20005.30005.4000AID654339
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (52)

Processvia Protein(s)Taxonomy
maltose catabolic processMaltase-glucoamylase, intestinalHomo sapiens (human)
starch catabolic processMaltase-glucoamylase, intestinalHomo sapiens (human)
dextrin catabolic processMaltase-glucoamylase, intestinalHomo sapiens (human)
neutrophil activation involved in immune responseDeoxyribonuclease-1Bos taurus (cattle)
regulation of acute inflammatory responseDeoxyribonuclease-1Bos taurus (cattle)
DNA catabolic processDeoxyribonuclease-1Bos taurus (cattle)
apoptotic processDeoxyribonuclease-1Bos taurus (cattle)
regulation of neutrophil mediated cytotoxicityDeoxyribonuclease-1Bos taurus (cattle)
DNA metabolic processDNA nucleotidylexotransferaseBos taurus (cattle)
DNA modificationDNA nucleotidylexotransferaseBos taurus (cattle)
DNA biosynthetic processDNA nucleotidylexotransferaseBos taurus (cattle)
maltose metabolic processLysosomal alpha-glucosidaseHomo sapiens (human)
regulation of the force of heart contractionLysosomal alpha-glucosidaseHomo sapiens (human)
diaphragm contractionLysosomal alpha-glucosidaseHomo sapiens (human)
heart morphogenesisLysosomal alpha-glucosidaseHomo sapiens (human)
glycogen catabolic processLysosomal alpha-glucosidaseHomo sapiens (human)
sucrose metabolic processLysosomal alpha-glucosidaseHomo sapiens (human)
glucose metabolic processLysosomal alpha-glucosidaseHomo sapiens (human)
lysosome organizationLysosomal alpha-glucosidaseHomo sapiens (human)
locomotory behaviorLysosomal alpha-glucosidaseHomo sapiens (human)
tissue developmentLysosomal alpha-glucosidaseHomo sapiens (human)
aorta developmentLysosomal alpha-glucosidaseHomo sapiens (human)
vacuolar sequesteringLysosomal alpha-glucosidaseHomo sapiens (human)
muscle cell cellular homeostasisLysosomal alpha-glucosidaseHomo sapiens (human)
neuromuscular process controlling postureLysosomal alpha-glucosidaseHomo sapiens (human)
neuromuscular process controlling balanceLysosomal alpha-glucosidaseHomo sapiens (human)
cardiac muscle contractionLysosomal alpha-glucosidaseHomo sapiens (human)
glycophagyLysosomal alpha-glucosidaseHomo sapiens (human)
sucrose catabolic processSucrase-isomaltase, intestinalHomo sapiens (human)
polysaccharide digestionSucrase-isomaltase, intestinalHomo sapiens (human)
DNA synthesis involved in DNA repairDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA replicationDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA-templated DNA replicationDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA repairDNA polymerase delta catalytic subunitHomo sapiens (human)
base-excision repair, gap-fillingDNA polymerase delta catalytic subunitHomo sapiens (human)
nucleotide-excision repair, DNA gap fillingDNA polymerase delta catalytic subunitHomo sapiens (human)
response to UVDNA polymerase delta catalytic subunitHomo sapiens (human)
cellular response to UVDNA polymerase delta catalytic subunitHomo sapiens (human)
fatty acid homeostasisDNA polymerase delta catalytic subunitHomo sapiens (human)
error-free translesion synthesisDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA biosynthetic processDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA replication proofreadingDNA polymerase delta catalytic subunitHomo sapiens (human)
carbohydrate metabolic processProbable maltase-glucoamylase 2Homo sapiens (human)
double-strand break repair via homologous recombinationDNA polymerase nuHomo sapiens (human)
DNA-templated DNA replicationDNA polymerase nuHomo sapiens (human)
translesion synthesisDNA polymerase nuHomo sapiens (human)
interstrand cross-link repairDNA polymerase nuHomo sapiens (human)
double-strand break repairDNA polymerase nuHomo sapiens (human)
double-strand break repair via nonhomologous end joiningDNA-directed DNA/RNA polymerase muHomo sapiens (human)
DNA recombinationDNA-directed DNA/RNA polymerase muHomo sapiens (human)
DNA biosynthetic processDNA-directed DNA/RNA polymerase muHomo sapiens (human)
DNA replicationDNA polymerase kappaHomo sapiens (human)
DNA repairDNA polymerase kappaHomo sapiens (human)
nucleotide-excision repair, DNA gap fillingDNA polymerase kappaHomo sapiens (human)
DNA damage responseDNA polymerase kappaHomo sapiens (human)
cellular response to UVDNA polymerase kappaHomo sapiens (human)
error-prone translesion synthesisDNA polymerase kappaHomo sapiens (human)
double-strand break repair via homologous recombinationDNA polymerase lambdaHomo sapiens (human)
DNA replicationDNA polymerase lambdaHomo sapiens (human)
base-excision repair, gap-fillingDNA polymerase lambdaHomo sapiens (human)
nucleotide-excision repairDNA polymerase lambdaHomo sapiens (human)
double-strand break repair via nonhomologous end joiningDNA polymerase lambdaHomo sapiens (human)
somatic hypermutation of immunoglobulin genesDNA polymerase lambdaHomo sapiens (human)
DNA biosynthetic processDNA polymerase lambdaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (23)

Processvia Protein(s)Taxonomy
catalytic activityMaltase-glucoamylase, intestinalHomo sapiens (human)
glucan 1,4-alpha-glucosidase activityMaltase-glucoamylase, intestinalHomo sapiens (human)
alpha-1,4-glucosidase activityMaltase-glucoamylase, intestinalHomo sapiens (human)
protein bindingMaltase-glucoamylase, intestinalHomo sapiens (human)
amylase activityMaltase-glucoamylase, intestinalHomo sapiens (human)
carbohydrate bindingMaltase-glucoamylase, intestinalHomo sapiens (human)
maltose alpha-glucosidase activityMaltase-glucoamylase, intestinalHomo sapiens (human)
actin bindingDeoxyribonuclease-1Bos taurus (cattle)
protein bindingDeoxyribonuclease-1Bos taurus (cattle)
DNA bindingDNA nucleotidylexotransferaseBos taurus (cattle)
DNA-directed DNA polymerase activityDNA nucleotidylexotransferaseBos taurus (cattle)
DNA nucleotidylexotransferase activityDNA nucleotidylexotransferaseBos taurus (cattle)
metal ion bindingDNA nucleotidylexotransferaseBos taurus (cattle)
alpha-1,4-glucosidase activityLysosomal alpha-glucosidaseHomo sapiens (human)
carbohydrate bindingLysosomal alpha-glucosidaseHomo sapiens (human)
maltose alpha-glucosidase activityLysosomal alpha-glucosidaseHomo sapiens (human)
alpha-glucosidase activityLysosomal alpha-glucosidaseHomo sapiens (human)
oligo-1,6-glucosidase activitySucrase-isomaltase, intestinalHomo sapiens (human)
sucrose alpha-glucosidase activitySucrase-isomaltase, intestinalHomo sapiens (human)
protein bindingSucrase-isomaltase, intestinalHomo sapiens (human)
carbohydrate bindingSucrase-isomaltase, intestinalHomo sapiens (human)
alpha-1,4-glucosidase activitySucrase-isomaltase, intestinalHomo sapiens (human)
nucleotide bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
chromatin bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
damaged DNA bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase delta catalytic subunitHomo sapiens (human)
protein bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
enzyme bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
metal ion bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
4 iron, 4 sulfur cluster bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
3'-5'-DNA exonuclease activityDNA polymerase delta catalytic subunitHomo sapiens (human)
glucan 1,4-alpha-glucosidase activityProbable maltase-glucoamylase 2Homo sapiens (human)
carbohydrate bindingProbable maltase-glucoamylase 2Homo sapiens (human)
alpha-1,4-glucosidase activityProbable maltase-glucoamylase 2Homo sapiens (human)
DNA bindingDNA polymerase nuHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase nuHomo sapiens (human)
protein bindingDNA polymerase nuHomo sapiens (human)
cyclin bindingDNA polymerase nuHomo sapiens (human)
DNA bindingDNA-directed DNA/RNA polymerase muHomo sapiens (human)
DNA-directed DNA polymerase activityDNA-directed DNA/RNA polymerase muHomo sapiens (human)
protein bindingDNA-directed DNA/RNA polymerase muHomo sapiens (human)
metal ion bindingDNA-directed DNA/RNA polymerase muHomo sapiens (human)
damaged DNA bindingDNA polymerase kappaHomo sapiens (human)
metal ion bindingDNA polymerase kappaHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase kappaHomo sapiens (human)
DNA bindingDNA polymerase lambdaHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase lambdaHomo sapiens (human)
protein bindingDNA polymerase lambdaHomo sapiens (human)
metal ion bindingDNA polymerase lambdaHomo sapiens (human)
5'-deoxyribose-5-phosphate lyase activityDNA polymerase lambdaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (28)

Processvia Protein(s)Taxonomy
plasma membraneMaltase-glucoamylase, intestinalHomo sapiens (human)
apical plasma membraneMaltase-glucoamylase, intestinalHomo sapiens (human)
extracellular exosomeMaltase-glucoamylase, intestinalHomo sapiens (human)
tertiary granule membraneMaltase-glucoamylase, intestinalHomo sapiens (human)
ficolin-1-rich granule membraneMaltase-glucoamylase, intestinalHomo sapiens (human)
extracellular regionDeoxyribonuclease-1Bos taurus (cattle)
nuclear envelopeDeoxyribonuclease-1Bos taurus (cattle)
zymogen granuleDeoxyribonuclease-1Bos taurus (cattle)
nucleusDNA nucleotidylexotransferaseBos taurus (cattle)
lysosomeLysosomal alpha-glucosidaseHomo sapiens (human)
lysosomal membraneLysosomal alpha-glucosidaseHomo sapiens (human)
plasma membraneLysosomal alpha-glucosidaseHomo sapiens (human)
membraneLysosomal alpha-glucosidaseHomo sapiens (human)
azurophil granule membraneLysosomal alpha-glucosidaseHomo sapiens (human)
lysosomal lumenLysosomal alpha-glucosidaseHomo sapiens (human)
intracellular membrane-bounded organelleLysosomal alpha-glucosidaseHomo sapiens (human)
extracellular exosomeLysosomal alpha-glucosidaseHomo sapiens (human)
tertiary granule membraneLysosomal alpha-glucosidaseHomo sapiens (human)
ficolin-1-rich granule membraneLysosomal alpha-glucosidaseHomo sapiens (human)
autolysosome lumenLysosomal alpha-glucosidaseHomo sapiens (human)
Golgi apparatusSucrase-isomaltase, intestinalHomo sapiens (human)
plasma membraneSucrase-isomaltase, intestinalHomo sapiens (human)
brush borderSucrase-isomaltase, intestinalHomo sapiens (human)
apical plasma membraneSucrase-isomaltase, intestinalHomo sapiens (human)
extracellular exosomeSucrase-isomaltase, intestinalHomo sapiens (human)
chromosome, telomeric regionDNA polymerase delta catalytic subunitHomo sapiens (human)
nucleusDNA polymerase delta catalytic subunitHomo sapiens (human)
nucleoplasmDNA polymerase delta catalytic subunitHomo sapiens (human)
cytosolDNA polymerase delta catalytic subunitHomo sapiens (human)
membraneDNA polymerase delta catalytic subunitHomo sapiens (human)
aggresomeDNA polymerase delta catalytic subunitHomo sapiens (human)
delta DNA polymerase complexDNA polymerase delta catalytic subunitHomo sapiens (human)
nucleotide-excision repair complexDNA polymerase delta catalytic subunitHomo sapiens (human)
membraneProbable maltase-glucoamylase 2Homo sapiens (human)
nucleolusDNA polymerase nuHomo sapiens (human)
nucleusDNA polymerase nuHomo sapiens (human)
nucleoplasmDNA polymerase nuHomo sapiens (human)
nucleoplasmDNA-directed DNA/RNA polymerase muHomo sapiens (human)
nucleusDNA-directed DNA/RNA polymerase muHomo sapiens (human)
site of DNA damageDNA polymerase kappaHomo sapiens (human)
nucleusDNA polymerase kappaHomo sapiens (human)
nucleoplasmDNA polymerase kappaHomo sapiens (human)
nuclear bodyDNA polymerase kappaHomo sapiens (human)
nucleusDNA polymerase kappaHomo sapiens (human)
site of double-strand breakDNA polymerase lambdaHomo sapiens (human)
nucleusDNA polymerase lambdaHomo sapiens (human)
nucleoplasmDNA polymerase lambdaHomo sapiens (human)
nucleusDNA polymerase lambdaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (48)

Assay IDTitleYearJournalArticle
AID654350Inhibition of calf DNA primase of polymerase alpha2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1378623Cytotoxicity against human HeLa cells by SRB assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Bioactive Azaphilone Derivatives from the Fungus Talaromyces aculeatus.
AID654356Inhibition of cauliflower DNA polymerase alpha assessed as inhibition of incorporation of dTTP into activated DNA primer after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654371Growth inhibition of human A549 cells after 24 hrs by WST-1 assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654344Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1652071Cytotoxicity against human MCF7 cells by MTT assay
AID654358Inhibition of Escherichia coli polymerase DNA polymerase 1 Klenow fragment assessed as inhibition of incorporation of dTTP into activated DNA primer after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1378624Cytotoxicity against human A549 cells by SRB assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Bioactive Azaphilone Derivatives from the Fungus Talaromyces aculeatus.
AID654345Inhibition of cauliflower DNA polymerase alpha assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654375Growth inhibition of human NUGC3 cells after 24 hrs by WST-1 assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654348Inhibition of Thermus aquaticus DNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins at 74 degC2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654346Inhibition of rice cv. Nipponbare recombinant C-terminal-His6-tagged DNA polymerase lambda expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1378614Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl glycoside as substrate treated 20 mins post substrate addition measured for 1 min by spectrophotometric analysis2017Journal of natural products, 08-25, Volume: 80, Issue:8
Bioactive Azaphilone Derivatives from the Fungus Talaromyces aculeatus.
AID654338Inhibition of rat DNA polymerase beta expressed in Escherichia coli JMpbeta5 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654336Inhibition of human DNA polymerase delta assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1378621Cytotoxicity against human HL60 cells by MTT assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Bioactive Azaphilone Derivatives from the Fungus Talaromyces aculeatus.
AID654376Growth inhibition of HDF cells after 72 hrs by WST-1 assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654377Growth inhibition of HUVEC cells after 72 hrs by WST-1 assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1378622Cytotoxicity against human K562 cells by MTT assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Bioactive Azaphilone Derivatives from the Fungus Talaromyces aculeatus.
AID654353Inhibition of mouse IMP dehydrogenase 22012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1652068Cytotoxicity against human MDA-MB-231 cells by MTT assay
AID654354Inhibition of T4 arnN8l pseT 1 polynucleotide kinase assessed as inhibition of Salmon sperm DNA phosphorylation using [gamma32P]ATP by liquid scintillation counting2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654355Inhibition of bovine deoxyribonuclease 1 using [3H]-labelled DNA after 30 mins by agarose gel electrophoresis2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654335Inhibition of calf DNA polymerase alpha assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654379Cell cycle arrest in human HCT116 cells assessed as accumulation at S-phase at GI50 by tritiated thymidine incorporation assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654360Inhibition of T4 bacteriophage DNA polymerase assessed as inhibition of incorporation of dTTP into activated DNA primer after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654342Inhibition of C-terminal-His6-tagged human pol nu expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654337Inhibition of human DNA polymerase epsilon assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654359Inhibition of Thermus aquaticus DNA polymerase assessed as inhibition of incorporation of dTTP into activated DNA primer after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654334Inhibition of human His6-tagged DNA polymerase gamma expressed using baculovirus assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1652072Cytotoxicity against human A549 cells by MTT assay
AID654378Cell cycle arrest in human BALL-1 cells assessed as accumulation at S-phase at GI50 by tritiated thymidine incorporation assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1378615Antibacterial activity against Vibrio anguillarum after 18 hrs by broth dilution method2017Journal of natural products, 08-25, Volume: 80, Issue:8
Bioactive Azaphilone Derivatives from the Fungus Talaromyces aculeatus.
AID654340Inhibition of human His-tagged recombinant DNA polymerase mu expressed in Escherichia coli BL21 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654351Inhibition of HIV-1 reverse transcriptase assessed as inhibition of incorporation of dTTP into poly(rA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1652069Cytotoxicity against human HeLa cells by MTT assay
AID654372Growth inhibition of human BALL-1 cells after 24 hrs by WST-1 assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654374Growth inhibition of human HeLa cells after 24 hrs by WST-1 assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654339Inhibition of human recombinant His-tagged DNA polymerase lambda expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654357Inhibition of rice cv. Nipponbare recombinant C-terminal-His6-tagged DNA polymerase lambda expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into activated DNA primer after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654373Growth inhibition of against human HCT116 cells after 24 hrs by WST-1 assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654347Inhibition of Escherichia coli polymerase DNA polymerase 1 klenow fragment assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654341Inhibition of calf TdT assessed as inhibition of incorporation of dTTP into oligo(dT)18(3'OH) after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654352Inhibition of T7 RNA polymerase assessed as inhibition of incorporation of [3H]UTP after 30 mins by liquid scintillation counting2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID654349Inhibition of T4 bacteriophage DNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1652070Cytotoxicity against human MGC803 cells by MTT assay
AID654343Inhibition of mouse recombinant C-terminal-His6-tagged DNA polymerase iota assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
AID1243497Antifouling activity against larval settlements of Balanus amphitrite Darwin cyprids2015Journal of natural products, Sep-25, Volume: 78, Issue:9
Azaphilone and Diphenyl Ether Derivatives from a Gorgonian-Derived Strain of the Fungus Penicillium pinophilum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.82 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.1510aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
cytarabine
[no description available]		2.0710beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
acarbose
[no description available]		2.1510tetrasaccharide derivativeEC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
geroprotector;
hypoglycemic agent
isocoumarins
Isocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.. isocoumarin : The simplest member of the class of isocoumarins that is 1H-isochromene which is substituted by an oxo group at position 1.		2.5420isocoumarins
kathon 930
Kathon 930: cp was added to finishing agents in textile factories; caused contact dermatitis; structure given in first source. 4,5-dichloro-2-n-octyl-3(2H)-isothiazolone : A 1,2-thiazole that is 1,2-thiazol-3(2H)-one substituted by chloro groups at positions 4 and 5 and an octyl group at position 2. It is used as a fungicide.		2.11101,2-thiazoles;
organochlorine compound		environmental contaminant;
fungicide;
xenobiotic
sch 725680
Sch 725680: an aazaphilone from Aspergillus sp.; structure in first source		2.830
ConditionIndicatedRelationship StrengthStudiesTrials