| Assay ID | Title | Year | Journal | Article |
|---|
| AID341170 | Antiviral activity against HCV infected human Huh7 replicon cells assessed as viral levels by luciferase assay | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. |
| AID509676 | Absorption rate constant for depot compartment in CD1 mouse at 0.1 to 10 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID1666732 | Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6
| Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity. |
| AID270228 | Maximal IFNalpha production in human PBMC at 10 uM | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
| Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. |
| AID270227 | Induction of IFNalpha production in human PBMC | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
| Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. |
| AID509679 | Induction of IFNalpha production in CD1 mouse assessed as elimination rate constant for interferon alpha at 0.1 to 10 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID1666740 | Agonist activity at TLR8 in human PBMC assessed as TNFalpha level at 10 uM | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6
| Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity. |
| AID1666737 | Agonist activity at TLR7/TLR8 in human PBMC assessed as IFN alpha level | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6
| Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity. |
| AID509678 | Induction of IFNalpha production in CD1 mouse assessed as concentration of compound required for half-maximal synthesis of INF-alpha at 0.1 to 10 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID474845 | Half life in human plasma by LS-MS analysis | 2010 | Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
| Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. |
| AID509832 | Antiviral activity against HCV infected in human Huh7 cells with persistent PFK1389-Luc-Ubi-Neo-NS3-3'/ET replicon after 48 hrs by luminescence based assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID509830 | Apparent volume of distribution in CD1 mouse at 0.1 to 10 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID1666739 | Agonist activity at TLR8 in human PBMC assessed as TNFalpha level | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6
| Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity. |
| AID509677 | Intercompartmental clearance in CD1 mouse at 0.1 to 10 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID474844 | Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay | 2010 | Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
| Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. |
| AID1645924 | Antiviral activity against HCV | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | A review on HCV inhibitors: Significance of non-structural polyproteins. |
| AID341160 | Induction of IFNalpha2a level in human PBMC assessed as drug level causing maximal cytokine induction after 24 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. |
| AID509675 | Volume of distribution in peripheral compartment in CD1 mouse at 0.1 to 10 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID349531 | Induction of TLR7 receptor-mediated C57BL/6 mouse BMD cells activation assessed as upregulation of CD40 at 1 uM after 48 hrs by flow cytometry | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8
| 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation. |
| AID341176 | Antiviral activity against HCV infected human Huh7 replicon cells treated with 200 nM drug-induced human PBMC supernatants assessed as viral levels in presence of type I IFN receptor antibody by luciferase assay | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. |
| AID341161 | Toxic induction of IL6 level in human PBMC assessed as drug level causing maximal cytokine induction after 24 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. |
| AID509673 | Clearance in CD1 mouse at 0.1 to 10 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID349532 | Induction of TLR7 receptor-mediated C57BL/6 mouse BMD cells activation assessed as IL12 production at 5 uM after 24 hrs by ELISA | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8
| 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation. |
| AID509680 | Induction of IFNalpha production in CD1 mouse assessed as maximum rate of interferon alpha synthesis at 0.1 to 10 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID509674 | Volume of distribution in central compartment in CD1 mouse at 0.1 to 10 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID509831 | Oral bioavailability in rat at 3 mg/kg | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. |
| AID341159 | Toxic induction of IL1-beta level in human PBMC assessed as drug level causing maximal cytokine induction after 24 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. |
| AID341177 | Toxic induction of TNFalpha level in human PBMC assessed as drug level causing maximal cytokine induction after 24 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. |
| AID341171 | Increase in 2',5'-oligoadenylate synthase level in human PBMC after 24 hrs by PCR method relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. |
| AID265527 | Induction of IL-12p40 in dendritic cells | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12
| Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines. |
| AID341169 | Antiviral activity against HCV infected human Huh7 replicon cells treated with drug-induced human PBMC supernatants assessed as viral levels by luciferase assay | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. |
| AID341172 | Increase in IFNalpha level in human PBMC after 24 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. |
| AID270226 | Induction of IFNalpha production in human PBMC at 1 uM | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
| Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. |
| AID1679178 | Agonist activity at TLR7 in human PBMC assessed as induction of IN-12 stimulation | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID349529 | Induction of TLR7 receptor-mediated C57BL/6 mouse BMD cells activation assessed as upregulation of CD86 at 1 uM after 48 hrs by flow cytometry | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8
| 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation. |
| AID1666738 | Agonist activity at TLR7 in human PBMC assessed as IFNalpha stimulation at 10 uM | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6
| Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity. |
| AID1679179 | Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins by PPiLight detection reagent based luminescence assay | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID349530 | Induction of TLR7 receptor-mediated C57BL/6 mouse BMD cells activation assessed as upregulation of MHC class-2 at 1 uM after 48 hrs by flow cytometry | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8
| 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |