Page last updated: 2024-11-12

evomonoside

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Description

evomonoside: a cytotoxic cardiac glycoside from Lepidium apetalum; RN refers to (3beta,5beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

evomonoside : A cardenolide glycoside consisting of digitoxigenin having an alpha-L-rhamnosyl moiety attached at the O(3)-position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
LepidiumgenusA plant genus of the family BRASSICACEAE growing in Peru mountains. It is the source of maca root.[MeSH]BrassicaceaeA plant family of the order Capparales, subclass Dilleniidae, class Magnoliopsida. They are mostly herbaceous plants with peppery-flavored leaves, due to gluconapin (GLUCOSINOLATES) and its hydrolysis product butenylisotrhiocyanate. The family includes many plants of economic importance that have been extensively altered and domesticated by humans. Flowers have 4 petals. Podlike fruits contain a number of seeds. Cress is a general term used for many in the Brassicacea family. Rockcress is usually ARABIS; Bittercress is usually CARDAMINE; Yellowcress is usually RORIPPA; Pennycress is usually THLASPI; Watercress refers to NASTURTIUM; or RORIPPA or TROPAEOLUM; Gardencress refers to LEPIDIUM; Indiancress refers to TROPAEOLUM.[MeSH]

Cross-References

ID SourceID
PubMed CID12308635
CHEMBL ID1651648
CHEBI ID71000
MeSH IDM0249394

Synonyms (13)

Synonym
evomonosid
508-93-0
digitoxigenin alpha-l-rhamnoside
digitoxigenin 3-rhamnoside
evomonoside
digitoxigenin rhamnoside
chebi:71000 ,
CHEMBL1651648
3beta-(alpha-l-rhamnopyranosyloxy)-14-hydroxy-5beta-card-20(22)-enolide
3beta-(6-deoxy-alpha-l-mannopyranosyloxy)-14-hydroxy-5beta-card-20(22)-enolide
Q27139243
3-[(3s,5r,8r,9s,10s,13r,14s,17r)-14-hydroxy-10,13-dimethyl-3-[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2h-furan-5-one
DTXSID501318097
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
cardenolide glycosideAny member of the class of cardenolides with glycosyl residues attached to position 3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)IC50 (µMol)0.00580.00480.78076.0000AID146845
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)IC50 (µMol)0.00580.00480.81346.0000AID146845
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)IC50 (µMol)0.00580.00480.81346.0000AID146845
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)IC50 (µMol)0.00580.00480.81346.0000AID146845
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)IC50 (µMol)0.00580.00480.81346.0000AID146845
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)IC50 (µMol)0.00580.00480.81346.0000AID146845
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)IC50 (µMol)0.00580.00480.81346.0000AID146845
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)IC50 (µMol)0.00580.00480.81346.0000AID146845
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (95)

Processvia Protein(s)Taxonomy
regulation of the force of heart contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
regulation of sodium ion transportSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
osmosensory signaling pathwaySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
regulation of blood pressureSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
response to xenobiotic stimulusSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
negative regulation of glucocorticoid biosynthetic processSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
negative regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
positive regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
positive regulation of striated muscle contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
relaxation of cardiac muscleSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
cellular response to steroid hormone stimulusSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
cardiac muscle cell action potential involved in contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membrane repolarization during cardiac muscle cell action potentialSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
response to glycosideSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
intracellular calcium ion homeostasisSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
cell adhesionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
regulation of gene expressionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
regulation of cardiac muscle contraction by calcium ion signalingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of ATP-dependent activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein transport into plasma membrane raftSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
innate immune responseSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
ATP metabolic processSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein stabilizationSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
relaxation of cardiac muscleSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
cardiac muscle contractionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein localization to plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
membrane repolarization during cardiac muscle cell action potentialSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
monoatomic cation transmembrane transportSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of potassium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of calcium:sodium antiporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
regulation of resting membrane potentialSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
cellular response to steroid hormone stimulusSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
response to glycosideSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
cellular response to amyloid-betaSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuron projection maintenanceSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
retina homeostasisSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
lateral ventricle developmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
third ventricle developmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
neuronal-glial interaction involved in hindbrain glial-mediated radial cell migrationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
photoreceptor cell maintenanceSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
motor behaviorSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
plasma membrane bounded cell projection organizationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of neuron projection developmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell-substrate adhesionSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of ATP-dependent activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein stabilizationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
transport across blood-brain barrierSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of potassium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
negative regulation of glial cell migrationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
behavioral fear responseSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of the force of heart contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of respiratory gaseous exchange by nervous system processSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
amygdala developmentSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
olfactory cortex developmentSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
locomotionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
positive regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of cytosolic calcium ion concentrationSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
neurotransmitter uptakeSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of smooth muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of striated muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of blood pressureSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
adult locomotory behaviorSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
visual learningSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to auditory stimulusSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
neuronal action potential propagationSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of vasoconstrictionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
L-ascorbic acid metabolic processSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to nicotineSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
locomotory exploration behaviorSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to potassium ionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of striated muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATP metabolic processSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of glutamate uptake involved in transmission of nerve impulseSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of synaptic transmission, glutamatergicSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
relaxation of cardiac muscleSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cardiac muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cellular response to mechanical stimulusSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cellular response to steroid hormone stimulusSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of cardiac muscle cell contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
membrane depolarization during cardiac muscle cell action potentialSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
monoatomic cation transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
transport across blood-brain barrierSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of calcium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of calcium:sodium antiporter activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to glycosideSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of ATP-dependent activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein stabilizationSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
potassium ion transmembrane transportSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein localization to plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of potassium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
transmembrane transportSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
positive regulation of P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
regulation of sodium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
monoatomic ion transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
potassium ion transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium ion transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
cell surface receptor signaling pathwaySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
spermatogenesisSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
fertilizationSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
flagellated sperm motilitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
regulation of cellular pHSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
regulation of membrane potentialSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
establishment of localization in cellSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
potassium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
transport across blood-brain barrierSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (22)

Processvia Protein(s)Taxonomy
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
phosphatase activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
potassium ion bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sodium ion bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
transmembrane transporter bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein-folding chaperone bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
steroid hormone bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein kinase bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
MHC class II protein complex bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
ATPase bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
amyloid-beta bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
metal ion bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
protein-folding chaperone bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
steroid hormone bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
ATPase bindingSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
steroid bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
phosphatase activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATPase-coupled monoatomic cation transmembrane transporter activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
protein-folding chaperone bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
steroid hormone bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
ATPase bindingSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
sodium channel regulator activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
ATPase-coupled monoatomic cation transmembrane transporter activitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
kinase bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
metal ion bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (41)

Processvia Protein(s)Taxonomy
endoplasmic reticulumSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
Golgi apparatusSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
postsynaptic densitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
basolateral plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
lateral plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
T-tubuleSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
axonSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sperm flagellumSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sarcolemmaSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
melanosomeSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membrane raftSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
photoreceptor inner segment membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein-containing complexSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sarcolemmaSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intercalated discSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
basolateral plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
lateral plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
T-tubuleSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sperm flagellumSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sarcolemmaSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
photoreceptor inner segmentSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
endoplasmic reticulumSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
Golgi apparatusSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
axonSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuronal cell body membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuronal cell bodySodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
synapseSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
photoreceptor inner segment membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuron to neuron synapseSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
photoreceptor inner segmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cytoplasmSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
external side of plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
lateral plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell projection membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell body membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell peripherySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
astrocyte projectionSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
astrocyte end-footSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
neuron to neuron synapseSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cytoplasmSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
endosomeSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
endoplasmic reticulumSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
caveolaSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell surfaceSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intercalated discSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
T-tubuleSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell projectionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
neuronal cell bodySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
dendritic spineSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell projectionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
basolateral plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sperm flagellumSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
melanosomeSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
membrane raftSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sperm midpieceSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
photoreceptor cell ciliumSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
rod photoreceptor outer segmentSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
cell projectionSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (101)

Assay IDTitleYearJournalArticle
AID553290Growth inhibition of human HT-29 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553296Growth inhibition of human SNB19 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID1137817Selectivity index, ratio of CC50 for HFF to EC50 for Human cytomegalovirus Towne infected in human foreskin fibroblasts2014ACS medicinal chemistry letters, Apr-10, Volume: 5, Issue:4
Digitoxin analogues with improved anticytomegalovirus activity.
AID553402Induction of apoptosis human NCI-H460 cells assessed as cellular degradation at 50 nM after 12 hrs by Hoechst-33342 staining2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612867Ratio of digitoxin IC50 to compound IC50 for human NCI-H460 cells after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553285Growth inhibition of human NCI-H522 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553391Growth inhibition of human DU145 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID613386Cytotoxicity against human NCI-H460 cell assessed as cell death at 500 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.
AID612936Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID612860Cytotoxicity against human NCI-H460 cells assessed as cell death in serum free medium at 75 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID613384Cytotoxicity against human NCI-H460 cell assessed as cell death at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.
AID553273Growth inhibition of human K562 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553384Growth inhibition of human ACHN cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID1137813Antiviral activity against Human cytomegalovirus Towne infected in HFF assessed as inhibition of viral replication by measuring pp28 expression at 72 hrs post-infection by luciferase assay2014ACS medicinal chemistry letters, Apr-10, Volume: 5, Issue:4
Digitoxin analogues with improved anticytomegalovirus activity.
AID553275Growth inhibition of human RPMI8266 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553401Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612857Cytotoxicity against human NCI-H460 cells assessed as cell death in serum free medium at 10 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID77374Relative ionotropic activity evaluated in guinea pig left atria.1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Conformational factors in cardiac glycoside activity.
AID612868Cytotoxicity against human NCI-H460 cells assessed as cell viability at 1 nM after 48 hrs by MTT assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID612864Cytotoxicity against human NCI-H460 cells assessed as cell death in serum free medium at 1000 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID613389Cytotoxicity against human NCI-H460 cell assessed as cell death at 100 uM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.
AID553382Growth inhibition of human 786-0 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553278Growth inhibition of human EKVX cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID613391Induction of apoptosis in human NCI-H460 cells in at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.
AID553378Growth inhibition of human OVCAR4 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID613385Cytotoxicity against human NCI-H460 cell assessed as cell death at 100 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.
AID553284Growth inhibition of human NCI-H460 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID1137814Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay2014ACS medicinal chemistry letters, Apr-10, Volume: 5, Issue:4
Digitoxin analogues with improved anticytomegalovirus activity.
AID553385Growth inhibition of human Caki1 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553399Growth inhibition of human T47D cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553397Growth inhibition of human MDA-N cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID613387Cytotoxicity against human NCI-H460 cell assessed as cell death at 1 uM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.
AID553379Growth inhibition of human OVCAR5 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID613388Cytotoxicity against human NCI-H460 cells in serum free medium assessed as cell death at 10 uM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.
AID553283Growth inhibition of human NCI-H322M cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553289Growth inhibition of human HCT15 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612865Cytotoxicity against human NCI-H460 cells assessed as cell death in serum free medium at 10000 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553376Growth inhibition of human IGROV1 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612858Cytotoxicity against human NCI-H460 cells assessed as cell death in serum free medium at 25 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID146845Inhibition of hog kidney Na+, K+-dependent ATPase1986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Cardiac glycosides. 7. Sugar stereochemistry and cardiac glycoside activity.
AID553392Growth inhibition of human MCF7 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553372Growth inhibition of human SK-MEL-28 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553393Growth inhibition of human NCI/ADR-RES cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553381Growth inhibition of human SKOV3 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID613383Cytotoxicity against human NCI-H460 cell assessed as cell death at 10 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.
AID553396Growth inhibition of human MDA-MB-435 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612862Cytotoxicity against human NCI-H460 cells assessed as cell death in serum free medium at 250 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID612875Cytotoxicity against human NCI-H460 cells assessed as cell viability after 48 hrs by MTT assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553281Growth inhibition of human NCI-H226 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553277Growth inhibition of human A549 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612863Cytotoxicity against human NCI-H460 cells assessed as cell death in serum free medium at 500 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID612871Cytotoxicity against human NCI-H460 cells assessed as cell viability at 50 nM after 48 hrs by MTT assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID612874Cytotoxicity against human NCI-H460 cells assessed as cell viability at 1000 nM after 48 hrs by MTT assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553377Growth inhibition of human OVCAR3 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553279Growth inhibition of human HOP62 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612866Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553272Growth inhibition of human HL-60(TB) cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553403Growth inhibition of human NCI-H460 cells by MTT assay2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553282Growth inhibition of human NCI-H23 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553383Growth inhibition of human A498 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553280Growth inhibition of human HOP92 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553293Growth inhibition of human SF268 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID1137815Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay2014ACS medicinal chemistry letters, Apr-10, Volume: 5, Issue:4
Digitoxin analogues with improved anticytomegalovirus activity.
AID553394Growth inhibition of human MDA-MB-231 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553395Growth inhibition of human Hs 578T cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553274Growth inhibition of human MOLT4 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553398Growth inhibition of human BT549 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553288Growth inhibition of human HCT116 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553400Growth inhibition of human NCI60 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553386Growth inhibition of human RXF393 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553418Growth inhibition of human LOXIMVI cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553369Growth inhibition of human M14 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553291Growth inhibition of human KM12 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553389Growth inhibition of human UO31 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612861Cytotoxicity against human NCI-H460 cells assessed as cell death in serum free medium at 100 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553380Growth inhibition of human OVCAR8 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553295Growth inhibition of human SF539 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553370Growth inhibition of human MALME-3M cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612870Cytotoxicity against human NCI-H460 cells assessed as cell viability at 25 nM after 48 hrs by MTT assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553297Growth inhibition of human SNB75 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553371Growth inhibition of human SK-MEL-2 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553286Growth inhibition of human COLO205 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553373Growth inhibition of human SK-MEL-5 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553375Growth inhibition of human UACC62 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553292Growth inhibition of human SW620 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612873Cytotoxicity against human NCI-H460 cells assessed as cell viability at 500 nM after 48 hrs by MTT assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553276Growth inhibition of human SR cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID613390Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.
AID553287Growth inhibition of human HCC2998 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612937Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553390Growth inhibition of human PC3 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612872Cytotoxicity against human NCI-H460 cells assessed as cell viability at 100 nM after 48 hrs by MTT assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID612856Induction of apoptosis in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553374Growth inhibition of human UACC257 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553271Growth inhibition of human CCRF-CEM cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612859Cytotoxicity against human NCI-H460 cells assessed as cell death in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553294Growth inhibition of human SF295 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID612869Cytotoxicity against human NCI-H460 cells assessed as cell viability at 10 nM after 48 hrs by MTT assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
AID553298Growth inhibition of human U251 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553387Growth inhibition of human SN12C cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
AID553388Growth inhibition of human TK10 cells2011ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]