Page last updated: 2024-12-10

pecilocin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pecilocin: fungicidal antibiotic produced by Paecilomyces varioti Bainier var. antibioticus; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5354035
CHEMBL ID3560323
SCHEMBL ID148981
MeSH IDM0041574
PubMed CID5282176
CHEMBL ID486174
CHEBI ID32289
SCHEMBL ID148980
MeSH IDM0041574

Synonyms (56)

Synonym
nsc291839
2-pyrrolidinone,4,6-dodecatrienyl)-, [r-(e,e,e)]-
2-pyrrolidinone,4,6-dodecatrienoyl)-, (e,e,e)-(r)-
51744-78-6
1-[(2e,4e,6e)-8-hydroxy-6-methyldodeca-2,4,6-trienoyl]pyrrolidin-2-one
einecs 257-371-9
(e,e,e)-(1)-1-(8-hydroxy-6-methyl-1-oxododeca-2,4,6-trienyl)pyrrolidin-2-one
SCHEMBL148981
dtxsid5057676 ,
cas-19504-77-9
tox21_113727
dtxcid6031465
NCGC00253590-01
CHEMBL3560323
1-(8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrienyl)-2-pyrrolidinone
2-pyrrolidinone, 1-(8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrienyl)-, (r-(e,e,e))-
antibiotic obtained from cultures of paecyllomyces varioti banier var. antibioticus, or the same substance produced by any other means
pecilocinum [inn-latin]
nsc 291839
einecs 243-116-9
pecilocine [inn-french]
2-pyrrolidinone, 1-(8-hydroxy-6-methyl-2,4,6-dodecatrienoyl)-, (e,e,e)-(r)-
pecilocina [inn-spanish]
pecilocin
19504-77-9
variotin
nsc-291839
leofungine
supral
D01458
variotin (jan)
pecilocin (inn)
CHEMBL486174
chebi:32289 ,
1-[(2e,4e,6z)-8-hydroxy-6-methyldodeca-2,4,6-trienoyl]pyrrolidin-2-one
1-[(2e,4e,6e,8r)-8-hydroxy-6-methyldodeca-2,4,6-trienoyl]pyrrolidin-2-one
pecilocina
tsa7w27mf8 ,
unii-tsa7w27mf8
pecilocin [inn:ban]
pecilocine
pecilocinum
bdbm50448688
SCHEMBL148980
variotin [jan]
2-pyrrolidinone, 1-((2e,4e,6e,8r)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrienyl)-
pecilocin [inn]
pecilocin [mi]
pecilocin [who-dd]
1-[(2e,4e,6e,8r)-8-hydroxy-6-methyl-dodeca-2,4,6-trienoyl]pyrrolidin-2-one
DB13459
Q1231814
leofungine; nsc 291839;supral; variotin
HY-19584
CS-0015867
AKOS040747255

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
N-acylpyrrolidine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (16)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA polymerase betaRattus norvegicus (Norway rat)IC50 (µMol)200.00003.70006.20008.5000AID1074406
DNA polymerase delta catalytic subunitHomo sapiens (human)IC50 (µMol)200.00002.30002.30002.3000AID1074408
Reverse transcriptase/RNaseH Human immunodeficiency virus 1IC50 (µMol)200.00000.00011.076810.0000AID1074391
DNA polymerase kappaHomo sapiens (human)IC50 (µMol)200.00003.40005.95009.2000AID1074401
DNA polymerase lambdaHomo sapiens (human)IC50 (µMol)200.00005.20005.30005.4000AID1074405
DNA polymerase etaHomo sapiens (human)IC50 (µMol)200.00000.06200.06850.0750AID1074402
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (31)

Processvia Protein(s)Taxonomy
neutrophil activation involved in immune responseDeoxyribonuclease-1Bos taurus (cattle)
regulation of acute inflammatory responseDeoxyribonuclease-1Bos taurus (cattle)
DNA catabolic processDeoxyribonuclease-1Bos taurus (cattle)
apoptotic processDeoxyribonuclease-1Bos taurus (cattle)
regulation of neutrophil mediated cytotoxicityDeoxyribonuclease-1Bos taurus (cattle)
DNA metabolic processDNA nucleotidylexotransferaseBos taurus (cattle)
DNA modificationDNA nucleotidylexotransferaseBos taurus (cattle)
DNA biosynthetic processDNA nucleotidylexotransferaseBos taurus (cattle)
DNA synthesis involved in DNA repairDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA replicationDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA-templated DNA replicationDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA repairDNA polymerase delta catalytic subunitHomo sapiens (human)
base-excision repair, gap-fillingDNA polymerase delta catalytic subunitHomo sapiens (human)
nucleotide-excision repair, DNA gap fillingDNA polymerase delta catalytic subunitHomo sapiens (human)
response to UVDNA polymerase delta catalytic subunitHomo sapiens (human)
cellular response to UVDNA polymerase delta catalytic subunitHomo sapiens (human)
fatty acid homeostasisDNA polymerase delta catalytic subunitHomo sapiens (human)
error-free translesion synthesisDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA biosynthetic processDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA replication proofreadingDNA polymerase delta catalytic subunitHomo sapiens (human)
double-strand break repair via nonhomologous end joiningDNA-directed DNA/RNA polymerase muHomo sapiens (human)
DNA recombinationDNA-directed DNA/RNA polymerase muHomo sapiens (human)
DNA biosynthetic processDNA-directed DNA/RNA polymerase muHomo sapiens (human)
DNA replicationDNA polymerase kappaHomo sapiens (human)
DNA repairDNA polymerase kappaHomo sapiens (human)
nucleotide-excision repair, DNA gap fillingDNA polymerase kappaHomo sapiens (human)
DNA damage responseDNA polymerase kappaHomo sapiens (human)
cellular response to UVDNA polymerase kappaHomo sapiens (human)
error-prone translesion synthesisDNA polymerase kappaHomo sapiens (human)
double-strand break repair via homologous recombinationDNA polymerase lambdaHomo sapiens (human)
DNA replicationDNA polymerase lambdaHomo sapiens (human)
base-excision repair, gap-fillingDNA polymerase lambdaHomo sapiens (human)
nucleotide-excision repairDNA polymerase lambdaHomo sapiens (human)
double-strand break repair via nonhomologous end joiningDNA polymerase lambdaHomo sapiens (human)
somatic hypermutation of immunoglobulin genesDNA polymerase lambdaHomo sapiens (human)
DNA biosynthetic processDNA polymerase lambdaHomo sapiens (human)
DNA synthesis involved in DNA repairDNA polymerase etaHomo sapiens (human)
DNA replicationDNA polymerase etaHomo sapiens (human)
DNA repairDNA polymerase etaHomo sapiens (human)
regulation of DNA repairDNA polymerase etaHomo sapiens (human)
pyrimidine dimer repairDNA polymerase etaHomo sapiens (human)
response to UV-CDNA polymerase etaHomo sapiens (human)
error-free translesion synthesisDNA polymerase etaHomo sapiens (human)
cellular response to UV-CDNA polymerase etaHomo sapiens (human)
response to radiationDNA polymerase etaHomo sapiens (human)
error-prone translesion synthesisDNA polymerase etaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (13)

Processvia Protein(s)Taxonomy
actin bindingDeoxyribonuclease-1Bos taurus (cattle)
protein bindingDeoxyribonuclease-1Bos taurus (cattle)
DNA bindingDNA nucleotidylexotransferaseBos taurus (cattle)
DNA-directed DNA polymerase activityDNA nucleotidylexotransferaseBos taurus (cattle)
DNA nucleotidylexotransferase activityDNA nucleotidylexotransferaseBos taurus (cattle)
metal ion bindingDNA nucleotidylexotransferaseBos taurus (cattle)
nucleotide bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
chromatin bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
damaged DNA bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase delta catalytic subunitHomo sapiens (human)
protein bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
enzyme bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
metal ion bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
4 iron, 4 sulfur cluster bindingDNA polymerase delta catalytic subunitHomo sapiens (human)
3'-5'-DNA exonuclease activityDNA polymerase delta catalytic subunitHomo sapiens (human)
DNA bindingDNA-directed DNA/RNA polymerase muHomo sapiens (human)
DNA-directed DNA polymerase activityDNA-directed DNA/RNA polymerase muHomo sapiens (human)
protein bindingDNA-directed DNA/RNA polymerase muHomo sapiens (human)
metal ion bindingDNA-directed DNA/RNA polymerase muHomo sapiens (human)
damaged DNA bindingDNA polymerase kappaHomo sapiens (human)
metal ion bindingDNA polymerase kappaHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase kappaHomo sapiens (human)
DNA bindingDNA polymerase lambdaHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase lambdaHomo sapiens (human)
protein bindingDNA polymerase lambdaHomo sapiens (human)
metal ion bindingDNA polymerase lambdaHomo sapiens (human)
5'-deoxyribose-5-phosphate lyase activityDNA polymerase lambdaHomo sapiens (human)
damaged DNA bindingDNA polymerase etaHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase etaHomo sapiens (human)
protein bindingDNA polymerase etaHomo sapiens (human)
metal ion bindingDNA polymerase etaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (15)

Processvia Protein(s)Taxonomy
extracellular regionDeoxyribonuclease-1Bos taurus (cattle)
nuclear envelopeDeoxyribonuclease-1Bos taurus (cattle)
zymogen granuleDeoxyribonuclease-1Bos taurus (cattle)
nucleusDNA nucleotidylexotransferaseBos taurus (cattle)
chromosome, telomeric regionDNA polymerase delta catalytic subunitHomo sapiens (human)
nucleusDNA polymerase delta catalytic subunitHomo sapiens (human)
nucleoplasmDNA polymerase delta catalytic subunitHomo sapiens (human)
cytosolDNA polymerase delta catalytic subunitHomo sapiens (human)
membraneDNA polymerase delta catalytic subunitHomo sapiens (human)
aggresomeDNA polymerase delta catalytic subunitHomo sapiens (human)
delta DNA polymerase complexDNA polymerase delta catalytic subunitHomo sapiens (human)
nucleotide-excision repair complexDNA polymerase delta catalytic subunitHomo sapiens (human)
nucleoplasmDNA-directed DNA/RNA polymerase muHomo sapiens (human)
nucleusDNA-directed DNA/RNA polymerase muHomo sapiens (human)
site of DNA damageDNA polymerase kappaHomo sapiens (human)
nucleusDNA polymerase kappaHomo sapiens (human)
nucleoplasmDNA polymerase kappaHomo sapiens (human)
nuclear bodyDNA polymerase kappaHomo sapiens (human)
nucleusDNA polymerase kappaHomo sapiens (human)
site of double-strand breakDNA polymerase lambdaHomo sapiens (human)
nucleusDNA polymerase lambdaHomo sapiens (human)
nucleoplasmDNA polymerase lambdaHomo sapiens (human)
nucleusDNA polymerase lambdaHomo sapiens (human)
nucleoplasmDNA polymerase etaHomo sapiens (human)
cytosolDNA polymerase etaHomo sapiens (human)
nucleusDNA polymerase etaHomo sapiens (human)
replication forkDNA polymerase etaHomo sapiens (human)
site of double-strand breakDNA polymerase etaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (63)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347407qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347424RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347425Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1074389Inhibition of T7 RNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074400Inhibition of cherry salmon DNA polymerase delta assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074409Inhibition of calf thymus DNA polymerase alpha assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074399Inhibition of fruit fly DNA polymerase alpha assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074395Inhibition of C-terminal His-6-tagged L. cv.Nipponbare rice recombinant DNA polymerase lambda expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID376552Antifungal activity against Paecilomyces variotii ETH 114646 after 24 hrs by microtiter plate assay2000Journal of natural products, Jul, Volume: 63, Issue:7
New variotin analogues from Aspergillus viridi-nutans.
AID1074385Inhibition of mouse DNA polymerase lambda assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074402Inhibition of C-terminal His-6-tagged human DNA polymerase eta expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074404Inhibition of human His-tagged recombinant DNA polymerase mu expressed in Escherichia coli BL21 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074390Inhibition of calf DNA primase of polymerase alpha assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074393Inhibition of Thermus aquaticus DNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074386Inhibition of bovine deoxyribonuclease 1 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074407Inhibition of DNA polymerase epsilon isolated from human MOLT4 cells assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074410Inhibition of human His-tagged DNA polymerase gamma expressed in baculovirus assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID376550Antifungal activity against Nadsonia fulvescens ATCC 24236 after 24 hrs by microtiter plate assay2000Journal of natural products, Jul, Volume: 63, Issue:7
New variotin analogues from Aspergillus viridi-nutans.
AID376553Antifungal activity against Rhodotorula glutinis ATCC 26085 after 24 hrs by microtiter plate assay2000Journal of natural products, Jul, Volume: 63, Issue:7
New variotin analogues from Aspergillus viridi-nutans.
AID1074391Inhibition of HIV-1 reverse transcriptase assessed as inhibition of incorporation of dTTP into poly(rA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074397Inhibition of fruit fly DNA polymerase epsilon assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074406Inhibition of recombinant rat DNA polymerase beta expressed in Escherichia coli JMpbeta5 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074392Inhibition of T4 bacteriophage DNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID376551Antifungal activity against Nematospora coryli ATCC 10647 after 24 hrs by microtiter plate assay2000Journal of natural products, Jul, Volume: 63, Issue:7
New variotin analogues from Aspergillus viridi-nutans.
AID1074401Inhibition of C-terminal His-6-tagged human DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074387Inhibition of T4 bacteriophage polynucleotide kinase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074405Inhibition of human recombinant His-tagged DNA polymerase lambda expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074403Inhibition of calf thymus TdT assessed as inhibition of incorporation of dTTP into oligo(dT)18(3'OH) after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074388Inhibition of mouse IMP dehydrogenase 2 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074408Inhibition of DNA polymerase delta isolated from human MOLT4 cells assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074398Inhibition of fruit fly DNA polymerase delta assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074396Inhibition of cauliflower DNA polymerase alpha assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
AID1074394Inhibition of Escherichia coli polymerase DNA polymerase 1 klenow fragment assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (37)

TimeframeStudies, This Drug (%)All Drugs %
pre-199025 (67.57)18.7374
1990's0 (0.00)18.2507
2000's1 (2.70)29.6817
2010's4 (10.81)24.3611
2020's7 (18.92)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.33 (24.57)
Research Supply Index3.37 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
Other28 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]