C-type lectin domain family 4 member M

A C-type lectin domain family 4 member M that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H2X3]

Synonyms

CD209 antigen-like protein 1;
DC-SIGN-related protein;
DC-SIGNR;
Dendritic cell-specific ICAM-3-grabbing non-integrin 2;
DC-SIGN2;
Liver/lymph node-specific ICAM-3-grabbing non-integrin;
L-SIGN

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	2 (100.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
methyl mannoside, (alpha-d)-isomer	Homo sapiens (human)	IC50	1,270.0000	1	1
fixb protein, e coli	Homo sapiens (human)	IC50	3,386.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-quinolone-3-carboxylic acid	Homo sapiens (human)	Kd	2,200.0000	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
virus receptor activity	molecular function	Combining with a virus component and mediating entry of the virus into the cell. [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
carbohydrate binding	molecular function	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]
ICAM-3 receptor activity	molecular function	Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813]
signaling receptor activity	molecular function	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]
peptide antigen binding	molecular function	Binding to an antigen peptide. [GOC:add, GOC:jl, GOC:rv]
virion binding	molecular function	Binding to a virion, either by binding to components of the capsid or the viral envelope. [GOC:ai]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
calcium-dependent protein binding	molecular function	Binding to a protein or protein complex in the presence of calcium. [GOC:jid, PMID:10485905]
mannose binding	molecular function	Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. [GOC:jl, ISBN:0192800981]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
host cell	cellular component	A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope. [GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]

Involved In

This protein is involved in 15 target(s):

Target	Category	Definition
adaptive immune response	biological process	An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
leukocyte cell-cell adhesion	biological process	The attachment of a leukocyte to another cell via adhesion molecules. [GOC:go_curators]
cell-cell recognition	biological process	Cell recognition between cells. May involve the formation of specialized cell junctions. [ISBN:0824072820]
virion attachment to host cell	biological process	The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection. [GOC:bf, GOC:jl, UniProtKB-KW:KW-1161, VZ:956]
receptor-mediated endocytosis of virus by host cell	biological process	Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell. [GOC:bf, GOC:jl, ISBN:0781702534]
viral genome replication	biological process	Any process involved directly in viral genome replication, including viral nucleotide metabolism. [ISBN:0781702534]
antigen processing and presentation	biological process	The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
intracellular signal transduction	biological process	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
innate immune response	biological process	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
symbiont entry into host cell	biological process	The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. [GOC:jl]
receptor-mediated virion attachment to host cell	biological process	The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface. [ISBN:0879694971]
peptide antigen transport	biological process	The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. [GOC:add, ISBN:0781735149, PMID:15771591]
intracellular transport of virus	biological process	The directed movement of a virus, or part of a virus, within the host cell. [GOC:ai, GOC:bf, GOC:jl, PMID:11733033]
immune response	biological process	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
biological process involved in interspecies interaction between organisms	biological process	Any process evolved to enable an interaction with an organism of a different species. [GOC:cc]

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