Page last updated: 2024-08-08 00:40:20

C-type lectin domain family 4 member M

A C-type lectin domain family 4 member M that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H2X3]

Synonyms

CD209 antigen-like protein 1;
DC-SIGN-related protein;
DC-SIGNR;
Dendritic cell-specific ICAM-3-grabbing non-integrin 2;
DC-SIGN2;
Liver/lymph node-specific ICAM-3-grabbing non-integrin;
L-SIGN

Research

Bioassay Publications (2)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (100.00)2.80

Compounds (3)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
methyl mannoside, (alpha-d)-isomerHomo sapiens (human)IC501,270.000011
fixb protein, e coliHomo sapiens (human)IC503,386.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-quinolone-3-carboxylic acidHomo sapiens (human)Kd2,200.000011

Enables

This protein enables 10 target(s):

TargetCategoryDefinition
virus receptor activitymolecular functionCombining with a virus component and mediating entry of the virus into the cell. [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
carbohydrate bindingmolecular functionBinding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]
ICAM-3 receptor activitymolecular functionCombining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813]
signaling receptor activitymolecular functionReceiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]
peptide antigen bindingmolecular functionBinding to an antigen peptide. [GOC:add, GOC:jl, GOC:rv]
virion bindingmolecular functionBinding to a virion, either by binding to components of the capsid or the viral envelope. [GOC:ai]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
calcium-dependent protein bindingmolecular functionBinding to a protein or protein complex in the presence of calcium. [GOC:jid, PMID:10485905]
mannose bindingmolecular functionBinding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. [GOC:jl, ISBN:0192800981]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
host cellcellular componentA cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope. [GOC:jl]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
external side of plasma membranecellular componentThe leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]

Involved In

This protein is involved in 15 target(s):

TargetCategoryDefinition
adaptive immune responsebiological processAn immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
leukocyte cell-cell adhesionbiological processThe attachment of a leukocyte to another cell via adhesion molecules. [GOC:go_curators]
cell-cell recognitionbiological processCell recognition between cells. May involve the formation of specialized cell junctions. [ISBN:0824072820]
virion attachment to host cellbiological processThe process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection. [GOC:bf, GOC:jl, UniProtKB-KW:KW-1161, VZ:956]
receptor-mediated endocytosis of virus by host cellbiological processAny receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell. [GOC:bf, GOC:jl, ISBN:0781702534]
viral genome replicationbiological processAny process involved directly in viral genome replication, including viral nucleotide metabolism. [ISBN:0781702534]
antigen processing and presentationbiological processThe process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
intracellular signal transductionbiological processThe process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
innate immune responsebiological processInnate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
symbiont entry into host cellbiological processThe process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. [GOC:jl]
receptor-mediated virion attachment to host cellbiological processThe process by which a virion attaches to a host cell by binding to a receptor on the host cell surface. [ISBN:0879694971]
peptide antigen transportbiological processThe directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. [GOC:add, ISBN:0781735149, PMID:15771591]
intracellular transport of virusbiological processThe directed movement of a virus, or part of a virus, within the host cell. [GOC:ai, GOC:bf, GOC:jl, PMID:11733033]
immune responsebiological processAny immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
biological process involved in interspecies interaction between organismsbiological processAny process evolved to enable an interaction with an organism of a different species. [GOC:cc]