Page last updated: 2024-12-09

4,5-dimethylaminobenzylidene-2-thiobarbituric acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID727443
CHEMBL ID269821
SCHEMBL ID4037782
SCHEMBL ID14050043
MeSH IDM0089168

Synonyms (46)

Synonym
27430-15-5
mls002695027 ,
nsc-90755
nsc90755
AE-848/30739043
dabtb
NCIOPEN2_006091
smr001560940
CHEMBL269821 ,
AKOS000734174
5-[4-(dimethylamino)benzylidene]-2-thioxodihydro-4,6(1h,5h)-pyrimidinedione
AE-848/01000049
HMS1607L07
AKOS002984087
AKOS003628128
NCGC00184563-02
NCGC00184563-01
NCGC00184563-03
HMS3092I13
nsc 90755
silver(i) 5-p-dimethylaminobenzylidene-2-thiobarbituric acid
unii-rtu8z2wnx3
5-p-dimethylaminobenzylidene-2-thiobarbituric acid
4,5-dimethylaminobenzylidene-2-thiobarbituric acid
4,6(1h,5h)-pyrimidinedione, 5-((4-(dimethylamino)phenyl)methylene)dihydro-2-thioxo-
rtu8z2wnx3 ,
bdbm50375164
(5e)-5-[4-(dimethylamino)benzylidene]-2-sulfanylpyrimidine-4,6(1h,5h)-dione
STL281750
SCHEMBL4037782
SCHEMBL14050043
UOUVLKPLCQPNES-UHFFFAOYSA-N
5-[4-(dimethylamino)benzylidene]-2-thioxodihydro-4,6(1h,5h)-pyrimidinedione #
5-[4-(dimethylamino)benzylidene]-2-thiobarbituric acid
5-{[4-(dimethylamino)phenyl]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione
DTXSID40181847
(5e)-5-[4-(dimethylamino)benzylidene]-2-sulfanyl-4,6(1h,5h)-pyrimidinedione
5-[4-(dimethylamino)benzylidene]-4,6-dihydroxy-2(5h)-pyrimidinethione
5-(p-dimeth-ylaminobenzylidene)-2-thiobarbituric
5-((4-(dimethylamino)phenyl)methylene)dihydro-2-thioxo-4,6(1h,5h)-pyrimidinedione
5-(4-(dimethylamino)benzylidene)thiobarbituric acid
barbituric acid, 5-(p-(dimethylamino)benzylidene)-2-thio-
Z57705824
AKOS037445463
5-[[4-(dimethylamino)phenyl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
EN300-26866632
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (18)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency50.11870.631035.7641100.0000AID504339
thioredoxin reductaseRattus norvegicus (Norway rat)Potency6.99060.100020.879379.4328AID588453
WRNHomo sapiens (human)Potency35.48130.168331.2583100.0000AID651768
GLS proteinHomo sapiens (human)Potency17.78280.35487.935539.8107AID624170
TDP1 proteinHomo sapiens (human)Potency8.95160.000811.382244.6684AID686978; AID686979
hypothetical protein, conservedTrypanosoma bruceiPotency31.62280.223911.245135.4813AID624173
regulator of G-protein signaling 4Homo sapiens (human)Potency35.48130.531815.435837.6858AID504845
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency50.11870.016525.307841.3999AID602332
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency56.23410.354828.065989.1251AID504847
flap endonuclease 1Homo sapiens (human)Potency50.11870.133725.412989.1251AID588795
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency2.66790.168316.404067.0158AID720504
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.00000.050127.073689.1251AID588590
gemininHomo sapiens (human)Potency23.72460.004611.374133.4983AID624296; AID624297
VprHuman immunodeficiency virus 1Potency56.23411.584919.626463.0957AID651644
Glycoprotein hormones alpha chainHomo sapiens (human)Potency12.58934.46688.344810.0000AID624291
Guanine nucleotide-binding protein GHomo sapiens (human)Potency50.11871.995325.532750.1187AID624288
TAR DNA-binding protein 43Homo sapiens (human)Potency19.95261.778316.208135.4813AID652104
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (42)

Processvia Protein(s)Taxonomy
G protein-coupled receptor signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of cell population proliferationGlycoprotein hormones alpha chainHomo sapiens (human)
hormone-mediated signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
regulation of signaling receptor activityGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of steroid biosynthetic processGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of cell migrationGlycoprotein hormones alpha chainHomo sapiens (human)
thyroid gland developmentGlycoprotein hormones alpha chainHomo sapiens (human)
luteinizing hormone secretionGlycoprotein hormones alpha chainHomo sapiens (human)
organ growthGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIGlycoprotein hormones alpha chainHomo sapiens (human)
negative regulation of organ growthGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone secretionGlycoprotein hormones alpha chainHomo sapiens (human)
thyroid hormone generationGlycoprotein hormones alpha chainHomo sapiens (human)
regulation of translationMethionine aminopeptidase 1Homo sapiens (human)
proteolysisMethionine aminopeptidase 1Homo sapiens (human)
peptidyl-methionine modificationMethionine aminopeptidase 1Homo sapiens (human)
N-terminal protein amino acid modificationMethionine aminopeptidase 1Homo sapiens (human)
protein maturationMethionine aminopeptidase 1Homo sapiens (human)
platelet aggregationMethionine aminopeptidase 1Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
negative regulation of protein phosphorylationTAR DNA-binding protein 43Homo sapiens (human)
mRNA processingTAR DNA-binding protein 43Homo sapiens (human)
RNA splicingTAR DNA-binding protein 43Homo sapiens (human)
negative regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
regulation of protein stabilityTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of insulin secretionTAR DNA-binding protein 43Homo sapiens (human)
response to endoplasmic reticulum stressTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of protein import into nucleusTAR DNA-binding protein 43Homo sapiens (human)
regulation of circadian rhythmTAR DNA-binding protein 43Homo sapiens (human)
regulation of apoptotic processTAR DNA-binding protein 43Homo sapiens (human)
negative regulation by host of viral transcriptionTAR DNA-binding protein 43Homo sapiens (human)
rhythmic processTAR DNA-binding protein 43Homo sapiens (human)
regulation of cell cycleTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA destabilizationTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA stabilizationTAR DNA-binding protein 43Homo sapiens (human)
nuclear inner membrane organizationTAR DNA-binding protein 43Homo sapiens (human)
amyloid fibril formationTAR DNA-binding protein 43Homo sapiens (human)
regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (19)

Processvia Protein(s)Taxonomy
hormone activityGlycoprotein hormones alpha chainHomo sapiens (human)
protein bindingGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone activityGlycoprotein hormones alpha chainHomo sapiens (human)
aminopeptidase activityMethionine aminopeptidase 1Homo sapiens (human)
initiator methionyl aminopeptidase activityMethionine aminopeptidase 1Homo sapiens (human)
protein bindingMethionine aminopeptidase 1Homo sapiens (human)
metalloexopeptidase activityMethionine aminopeptidase 1Homo sapiens (human)
metal ion bindingMethionine aminopeptidase 1Homo sapiens (human)
metalloaminopeptidase activityMethionine aminopeptidase 1Homo sapiens (human)
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
double-stranded DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
RNA bindingTAR DNA-binding protein 43Homo sapiens (human)
mRNA 3'-UTR bindingTAR DNA-binding protein 43Homo sapiens (human)
protein bindingTAR DNA-binding protein 43Homo sapiens (human)
lipid bindingTAR DNA-binding protein 43Homo sapiens (human)
identical protein bindingTAR DNA-binding protein 43Homo sapiens (human)
pre-mRNA intronic bindingTAR DNA-binding protein 43Homo sapiens (human)
molecular condensate scaffold activityTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (18)

Processvia Protein(s)Taxonomy
extracellular regionGlycoprotein hormones alpha chainHomo sapiens (human)
extracellular spaceGlycoprotein hormones alpha chainHomo sapiens (human)
Golgi lumenGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone complexGlycoprotein hormones alpha chainHomo sapiens (human)
pituitary gonadotropin complexGlycoprotein hormones alpha chainHomo sapiens (human)
extracellular spaceGlycoprotein hormones alpha chainHomo sapiens (human)
cytoplasmMethionine aminopeptidase 1Homo sapiens (human)
cytosolMethionine aminopeptidase 1Homo sapiens (human)
cytosolic ribosomeMethionine aminopeptidase 1Homo sapiens (human)
cytosolMethionine aminopeptidase 1Homo sapiens (human)
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
intracellular non-membrane-bounded organelleTAR DNA-binding protein 43Homo sapiens (human)
nucleusTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
perichromatin fibrilsTAR DNA-binding protein 43Homo sapiens (human)
mitochondrionTAR DNA-binding protein 43Homo sapiens (human)
cytoplasmic stress granuleTAR DNA-binding protein 43Homo sapiens (human)
nuclear speckTAR DNA-binding protein 43Homo sapiens (human)
interchromatin granuleTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
chromatinTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID444567Inhibition of MCP1-induced chemotaxis in mouse RAW264.7 cells at 25 ug/mL relative to control2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.
AID444570Effect on serum aspartate aminotransaminase level in concanavalin A-induced acute hepatitis model of BALB/c mouse at 50 mg/kg, po treated 0.5 hrs after concanavalin A challenge measured after 20 hrs (Rvb= 4997.9 +/- 2619.6)2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.
AID1181957Inhibition of Bacillus pasteurii urease using urea substrate assessed as reduction in ammonia production after 15 mins by indophenol's method2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease.
AID322264Inhibition of human methionine aminopeptidase 12008Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors.
AID444571Decrease in concanavalin A-induced hepatic cell necrosis in acute hepatitis model of BALB/c mouse at 50 mg/kg, ig treated 0.5 hrs after concanavalin A challenge measured after 20 hrs by H and E staining based histopathology study2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.
AID444568Inhibition of MCP1-induced chemotaxis in mouse RAW264.7 cells2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.
AID322263Inhibition of Escherichia coli methionine aminopeptidase 12008Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors.
AID444569Effect on serum alanine aminotransaminase level in concanavalin A-induced acute hepatitis model of BALB/c mouse at 50 mg/kg, po treated 0.5 hrs after concanavalin A challenge measured after 20 hrs (Rvb= 5734.5 +/- 2599.5)2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (16.67)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's7 (58.33)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.59 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.16 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]