5,5'-methylenedisalicylic acid profile

5,5'-Methylenedisalicylic acid (MDSA) is a dicarboxylic acid derivative of salicylic acid, a naturally occurring compound known for its analgesic and anti-inflammatory properties. MDSA exhibits a unique structure with two salicylic acid moieties linked by a methylene bridge, which potentially enhances its biological activity. Its synthesis typically involves the reaction of salicylic acid with formaldehyde under acidic conditions. Studies on MDSA are driven by its potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. It has been investigated for its anti-inflammatory, analgesic, and antimicrobial properties. Moreover, MDSA demonstrates antioxidant and anti-cancer activities, making it a subject of research for its potential therapeutic benefits. The molecule's unique structure and diverse biological activities make it a promising candidate for developing novel drugs and materials.'

5,5'-methylenedisalicylic acid: inhibits attachment of ribosomes to microsomal membranes; RN given refers to parent cpd; structure in first source & Merck Index, 9th ed, #5934 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	67145
CHEMBL ID	115145
SCHEMBL ID	160646
MeSH ID	M0087701

Synonym
AKOS015839065
nsc-622445
TIMTEC1_001258
5,5'-methylenedisalicylic acid
benzoic acid,3'-methylenebis[6-hydroxy-
5,5-methylenedisalicylic acid
4,3'-dicarboxylic acid
methylenebis(salicylic acid)
4,3'-dicarboxydiphenylmethane
nsc-14778
3,3'-methylenebis[6-hydroxybenzoic acid]
nsc14778
salicylic acid,5'-methylenedi-
122-25-8
5-(3-carboxy-4-hydroxybenzyl)salicylic acid
5,5-methylenebis(salicylic acid)
CBDIVE_002544
OPREA1_713230
5-[(3-carboxy-4-hydroxy-phenyl)methyl]-2-hydroxy-benzoic acid
bis(3-carboxy-4-hydroxyphenyl)methane
nsc622445
3,3'-dicarboxy-4,4'-dihydroxydiphenylmethane
mgra inhibitor, 1
chemical diversity library compound 4
chembl115145 ,
bdbm11979
5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxybenzoic acid
NCGC00174622-01
HMS1537J04
3-amino-1-methyl-pyrazole-4-carbonitrile
3,3'-methylenebis(6-hydroxybenzoic acid)
5,5'-methylenebis(2-hydroxybenzoic acid)
A804861
einecs 204-530-5
nsc 14778
5,5'-methylenedi(salicylic acid)
2kf4fvv76n ,
ai3-19845
benzoic acid, 3,3'-methylenebis(6-hydroxy-
4,4'-dihydroxy-3,3'-dicarboxydiphenylmethane
5,5'-methylenedisalicyclic acid
unii-2kf4fvv76n
salicylic acid, 5,5'-methylenedi-
4,4'-dihydroxydiphenylmethane-3,3'-dicarboxylic acid
GEO-01817
FT-0619794
5,5'-methylenedisalicylic acid [mi]
5,5'-methylenebis(salicylic acid)
2,2'-dihydroxy-5,5'-methylenedibenzoic acid
SCHEMBL160646
mfcd00016506
5,5-methylene disalicylic acid
Q-100103
5,5 '-methylenedisalicylic acid
JWQFKVGACKJIAV-UHFFFAOYSA-N
benzoic acid, 3,3'-methylenebis[6-hydroxy-
DTXSID4074481
SR-01000529577-1
sr-01000529577
5,5/'-methylenedisalicylic acid
FS-4164
Q27254869
5,5'-methylenebis(2-hydroxybenzoicacid)
CS-0456203
5-[(3-carboxy-4-oxidanyl-phenyl)methyl]-2-oxidanyl-benzoic acid
D5S ,
Z1570803314

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Plasma kallikrein	Homo sapiens (human)	Ki	4.9000	0.0002	3.3474	9.6000	AID269505
Cathepsin B	Homo sapiens (human)	IC50 (µMol)	90.2000	0.0002	1.8453	10.0000	AID269511
HTH-type transcriptional regulator MgrA	Staphylococcus aureus	IC50 (µMol)	8.0000	8.0000	8.0000	8.0000	AID1799558; AID732062
Genome polyprotein	Dengue virus 2 Puerto Rico/PR159-S1/1969	IC50 (µMol)	5.5000	1.5200	5.5000	9.4600	AID458600; AID458601; AID458602; AID458603; AID458604
Matrix metalloproteinase-9	Homo sapiens (human)	IC50 (µMol)	43.4000	0.0000	0.7053	10.0000	AID269507
Lethal factor	Bacillus anthracis	IC50 (µMol)	3.0000	0.0970	2.8597	6.0000	AID269502; AID269503
Lethal factor	Bacillus anthracis	Ki	3.2333	0.0070	1.9581	4.9000	AID1796836; AID269504; AID269505
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	IC50 (µMol)	3,600.0000	0.0005	3.4984	9.7600	AID295185
DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)	IC50 (µMol)	69.5000	0.0186	1.6488	6.0000	AID1624428; AID461003
Integrase	Human immunodeficiency virus 1	IC50 (µMol)	65.3250	0.0005	1.5443	10.0000	AID93700; AID93702; AID93705; AID93707
DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)	IC50 (µMol)	31.0000	0.2000	1.2164	7.5000	AID1624430; AID461004
DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)	IC50 (µMol)	23.2000	0.5000	3.9667	10.0000	AID1624429; AID1624430
DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)	IC50 (µMol)	1.4000	0.5000	3.7333	10.0000	AID1624429
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
Factor XII activation	Plasma kallikrein	Homo sapiens (human)
proteolysis	Plasma kallikrein	Homo sapiens (human)
blood coagulation	Plasma kallikrein	Homo sapiens (human)
zymogen activation	Plasma kallikrein	Homo sapiens (human)
plasminogen activation	Plasma kallikrein	Homo sapiens (human)
fibrinolysis	Plasma kallikrein	Homo sapiens (human)
positive regulation of fibrinolysis	Plasma kallikrein	Homo sapiens (human)
proteolysis	Cathepsin B	Homo sapiens (human)
thyroid hormone generation	Cathepsin B	Homo sapiens (human)
collagen catabolic process	Cathepsin B	Homo sapiens (human)
epithelial cell differentiation	Cathepsin B	Homo sapiens (human)
regulation of apoptotic process	Cathepsin B	Homo sapiens (human)
decidualization	Cathepsin B	Homo sapiens (human)
symbiont entry into host cell	Cathepsin B	Homo sapiens (human)
proteolysis involved in protein catabolic process	Cathepsin B	Homo sapiens (human)
cellular response to thyroid hormone stimulus	Cathepsin B	Homo sapiens (human)
skeletal system development	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of protein phosphorylation	Matrix metalloproteinase-9	Homo sapiens (human)
proteolysis	Matrix metalloproteinase-9	Homo sapiens (human)
apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
embryo implantation	Matrix metalloproteinase-9	Homo sapiens (human)
cell migration	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular matrix disassembly	Matrix metalloproteinase-9	Homo sapiens (human)
macrophage differentiation	Matrix metalloproteinase-9	Homo sapiens (human)
collagen catabolic process	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to reactive oxygen species	Matrix metalloproteinase-9	Homo sapiens (human)
endodermal cell differentiation	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of apoptotic process	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of DNA binding	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
ephrin receptor signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of keratinocyte migration	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to lipopolysaccharide	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to cadmium ion	Matrix metalloproteinase-9	Homo sapiens (human)
cellular response to UV-A	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondria	Matrix metalloproteinase-9	Homo sapiens (human)
regulation of neuroinflammatory response	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of receptor binding	Matrix metalloproteinase-9	Homo sapiens (human)
response to amyloid-beta	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of epithelial cell differentiation involved in kidney development	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of cation channel activity	Matrix metalloproteinase-9	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular matrix organization	Matrix metalloproteinase-9	Homo sapiens (human)
positive regulation of JUN kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein dephosphorylation	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
insulin receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of signal transduction	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of signal transduction	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
actin cytoskeleton organization	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of endocytosis	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endoplasmic reticulum unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of intracellular protein transport	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cellular response to unfolded protein	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
peptidyl-tyrosine dephosphorylation	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
IRE1-mediated unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
insulin receptor recycling	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of MAP kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of type I interferon-mediated signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STAT	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
positive regulation of protein tyrosine kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascade	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
positive regulation of receptor catabolic process	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
DNA methylation-dependent heterochromatin formation	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
DNA-templated transcription	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
positive regulation of gene expression	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
negative regulation of gene expression	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
methylation	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
epigenetic programming of gene expression	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
negative regulation of gene expression via chromosomal CpG island methylation	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
cellular response to amino acid stimulus	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
chromosomal DNA methylation maintenance following DNA replication	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
cellular response to bisphenol A	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell apoptotic process	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
positive regulation of gene expression	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
methylation	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
placenta development	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
DNA methylation-dependent heterochromatin formation	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
male meiosis I	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
spermatogenesis	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
methylation	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
epigenetic programing of female pronucleus	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
negative regulation of gene expression, epigenetic	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
stem cell differentiation	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
chorionic trophoblast cell differentiation	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
genomic imprinting	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
negative regulation of DNA methylation-dependent heterochromatin formation	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
retrotransposon silencing by heterochromatin formation	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
autosome genomic imprinting	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
DNA methylation-dependent heterochromatin formation	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
spermatogenesis	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
response to xenobiotic stimulus	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
response to toxic substance	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
response to ionizing radiation	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
response to lead ion	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
neuron differentiation	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
regulatory ncRNA-mediated heterochromatin formation	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
methylation	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
response to estradiol	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
response to vitamin A	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
response to cocaine	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
negative regulation of gene expression via chromosomal CpG island methylation	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
S-adenosylmethionine metabolic process	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
cellular response to amino acid stimulus	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
cellular response to ethanol	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
cellular response to hypoxia	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
hepatocyte apoptotic process	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
autosome genomic imprinting	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
positive regulation of cellular response to hypoxia	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
cellular response to bisphenol A	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
negative regulation of DNA-templated transcription	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
serine-type endopeptidase activity	Plasma kallikrein	Homo sapiens (human)
protein binding	Plasma kallikrein	Homo sapiens (human)
cysteine-type endopeptidase activity	Cathepsin B	Homo sapiens (human)
protein binding	Cathepsin B	Homo sapiens (human)
collagen binding	Cathepsin B	Homo sapiens (human)
peptidase activity	Cathepsin B	Homo sapiens (human)
cysteine-type peptidase activity	Cathepsin B	Homo sapiens (human)
proteoglycan binding	Cathepsin B	Homo sapiens (human)
endopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
metalloendopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
serine-type endopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
protein binding	Matrix metalloproteinase-9	Homo sapiens (human)
collagen binding	Matrix metalloproteinase-9	Homo sapiens (human)
peptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
metallopeptidase activity	Matrix metalloproteinase-9	Homo sapiens (human)
zinc ion binding	Matrix metalloproteinase-9	Homo sapiens (human)
identical protein binding	Matrix metalloproteinase-9	Homo sapiens (human)
RNA binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein tyrosine phosphatase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
insulin receptor binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
zinc ion binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
enzyme binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein kinase binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
receptor tyrosine kinase binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cadherin binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
ephrin receptor binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein phosphatase 2A binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
DNA binding	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
RNA binding	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
DNA (cytosine-5-)-methyltransferase activity	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
protein binding	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
zinc ion binding	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
methyl-CpG binding	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
DNA-methyltransferase activity	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
promoter-specific chromatin binding	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
transcription corepressor activity	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
DNA (cytosine-5-)-methyltransferase activity	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
protein binding	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
DNA-methyltransferase activity	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
metal ion binding	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
DNA binding	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
protein binding	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
enzyme activator activity	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
enzyme binding	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
metal ion binding	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
DNA binding	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
DNA binding	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
chromatin binding	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
transcription corepressor activity	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
DNA (cytosine-5-)-methyltransferase activity	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
protein binding	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
identical protein binding	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
unmethylated CpG binding	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
metal ion binding	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
lncRNA binding	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
protein-cysteine methyltransferase activity	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Plasma kallikrein	Homo sapiens (human)
extracellular space	Plasma kallikrein	Homo sapiens (human)
plasma membrane	Plasma kallikrein	Homo sapiens (human)
extracellular exosome	Plasma kallikrein	Homo sapiens (human)
collagen-containing extracellular matrix	Cathepsin B	Homo sapiens (human)
extracellular region	Cathepsin B	Homo sapiens (human)
extracellular space	Cathepsin B	Homo sapiens (human)
lysosome	Cathepsin B	Homo sapiens (human)
external side of plasma membrane	Cathepsin B	Homo sapiens (human)
apical plasma membrane	Cathepsin B	Homo sapiens (human)
endolysosome lumen	Cathepsin B	Homo sapiens (human)
melanosome	Cathepsin B	Homo sapiens (human)
perinuclear region of cytoplasm	Cathepsin B	Homo sapiens (human)
collagen-containing extracellular matrix	Cathepsin B	Homo sapiens (human)
extracellular exosome	Cathepsin B	Homo sapiens (human)
peptidase inhibitor complex	Cathepsin B	Homo sapiens (human)
ficolin-1-rich granule lumen	Cathepsin B	Homo sapiens (human)
extracellular space	Cathepsin B	Homo sapiens (human)
lysosome	Cathepsin B	Homo sapiens (human)
extracellular region	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-9	Homo sapiens (human)
collagen-containing extracellular matrix	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular exosome	Matrix metalloproteinase-9	Homo sapiens (human)
tertiary granule lumen	Matrix metalloproteinase-9	Homo sapiens (human)
ficolin-1-rich granule lumen	Matrix metalloproteinase-9	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-9	Homo sapiens (human)
plasma membrane	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytoplasm	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
mitochondrial matrix	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
early endosome	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endoplasmic reticulum	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytosol	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
mitochondrial crista	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endosome lumen	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
sorting endosome	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membrane	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein-containing complex	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endoplasmic reticulum	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytoplasm	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
early endosome	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
female germ cell nucleus	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
nucleus	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
nucleoplasm	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
replication fork	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
pericentric heterochromatin	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
nucleus	DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)
nucleus	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
nucleoplasm	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
catalytic complex	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
nucleus	DNA (cytosine-5)-methyltransferase 3B	Homo sapiens (human)
ESC/E(Z) complex	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
condensed nuclear chromosome	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
nucleus	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
cytosol	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
catalytic complex	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
heterochromatin	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
nucleus	DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)
chromosome, centromeric region	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
XY body	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
nucleus	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
nucleoplasm	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
cytoplasm	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
nuclear matrix	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
catalytic complex	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
euchromatin	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
heterochromatin	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
nucleus	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
cytoplasm	DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (47)

Assay ID	Title	Year	Journal	Article
AID83254	Inhibitory concentration for cytopathicity of HIV-2 (LAV-2ROD) in MT-4 cells	1991	Journal of medicinal chemistry, Jan, Volume: 34, Issue:1	Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds.
AID93705	Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID732062	Inhibition of Staphylococcus aureus Newman His6-tagged MgrA expressed in Escherichia coli BL21(DE3) using 5'-6-F-TAAACAACAAGTTGTCCAAA-3' as substrate after 20 mins by fluorescence anisotropic analysis	2013	Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4	Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective.
AID1624429	Inhibition of DNMT3A/3L (unknown origin) using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assay	2019	Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6	Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity.
AID458604	Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM site	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4	Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid.
AID458601	Inhibition of Dengue virus type 2 NS5 RNA methyltransferase at 8 nM enzyme concentration	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4	Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid.
AID91562	Percentage inhibition against strand transfer of HIV-1 integrase at 100 ug/mL	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID104576	50% cytotoxic concentrations for mock-infected MT-4 cells.	1991	Journal of medicinal chemistry, Jan, Volume: 34, Issue:1	Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds.
AID1624428	Inhibition of DNMT1 (unknown origin) using biotinylated substrate using [3H]-SAM after 1 hr by scintillation proximity assay	2019	Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6	Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity.
AID91561	Percentage inhibition of compound against 3'-processing of HIV-1 integrase at 100 ug/mL	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID458603	Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM site with 0.1 % TX100	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4	Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid.
AID93707	Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID1624433	Induction of DNA intercalation using nucleosomal DNA (unknown origin) up to 1 mM by CYBR Green dye-based fluorescence assay	2019	Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6	Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity.
AID461001	Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system at 100 uM by scintillation counting	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation.
AID295185	Inhibition of PTP1B after 10 mins	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity.
AID93700	Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID1624431	Non-competitive inhibition of DNMT3A/3L (unknown origin) after 1 hr in presence of DNA substrate and varying concentrations of SAM by scintillation proximity assay	2019	Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6	Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity.
AID458600	Inhibition of Dengue virus type 2 NS5 RNA methyltransferase at 80 nM enzyme concentration	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4	Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid.
AID390731	Inhibition of Vaccinia virus DNA synthesis in by rapid plate assay	2008	Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20	Identification of non-nucleoside DNA synthesis inhibitors of vaccinia virus by high-throughput screening.
AID269503	Inhibition of Anthrax lethal factor activity by HPLC assay	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
AID82132	Inhibitory concentration for cytopathicity of HIV-1 (HTLV-IIIB) in CEM cells	1991	Journal of medicinal chemistry, Jan, Volume: 34, Issue:1	Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds.
AID1624434	Inhibition of DNMT3A/3L (unknown origin) up to 1 mM using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assay	2019	Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6	Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity.
AID458599	Antiviral activity against Dengue virus type 2 infected in human A549 cells assessed as decrease in viral E protein production by cell-based flavivirus immunodetection assay	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4	Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid.
AID269507	Inhibition of human MMP9	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
AID269511	Inhibition of human cathepsin B	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
AID269505	Binding affinity to Anthrax lethal factor-substrate complex	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
AID269522	Inhibition of human chymotrypsin at 175 uM	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
AID458596	Cytotoxicity against human A549 cells after 48 hrs	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4	Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid.
AID82133	Inhibitory concentration for cytopathicity of HIV-1 (HTLV-IIIB) in MT-4 cells	1991	Journal of medicinal chemistry, Jan, Volume: 34, Issue:1	Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds.
AID269504	Binding affinity to Anthrax lethal factor	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
AID1624435	Steady state binding affinity to DNMT3A/3L (unknown origin) at 0.12 to 10 uM by SPR assay	2019	Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6	Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity.
AID269534	Inhibition of human neutrophil elastase at 175 uM	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
AID1624432	Non-competitive inhibition of DNMT3A/3L (unknown origin) after 1 hr in presence of SAM and varying concentrations of Poly dI-dC DNA substrate by scintillation proximity assay	2019	Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6	Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity.
AID1624430	Inhibition of DNMT3B/3L (unknown origin) using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assay	2019	Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6	Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity.
AID269502	Inhibition of Anthrax lethal factor activity by microplate assay	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
AID269508	Inhibition of human plasma kallikrein	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
AID93702	Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 2	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID269514	Inhibition of porcine aminopeptidase M at 175 uM	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
AID461003	Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation counting	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation.
AID461004	Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system by scintillation counting	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation.
AID390734	Cytotoxicity against african green monkey BSC1 cells after 20 hrs WST-1 based assay	2008	Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20	Identification of non-nucleoside DNA synthesis inhibitors of vaccinia virus by high-throughput screening.
AID461002	Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system at 100 uM by scintillation counting	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation.
AID458602	Inhibition of Dengue virus type 2 NS5 RNA methyltransferase by spin-down assay	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4	Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1799558	Biochemical Assay from Article 10.1016/j.chembiol.2011.05.014: \\Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus.\\	2011	Chemistry & biology, Aug-26, Volume: 18, Issue:8	Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
AID1796836	HPLC Assay from Article 10.1021/jm0605132: \\Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.\\	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (21.05)	18.7374
1990's	2 (10.53)	18.2507
2000's	3 (15.79)	29.6817
2010's	9 (47.37)	24.3611
2020's	1 (5.26)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
digallic acid digallic acid: structure given in first source	1.99	1	benzoate ester; gallate ester
2-(n-heptyl)-4-hydroxyquinoline n-oxide 2-(n-heptyl)-4-hydroxyquinoline N-oxide: structure. 2-heptyl-4-hydroxyquinoline N-oxide : An inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559.	2.08	1	monohydroxyquinoline
aurintricarboxylic acid Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.. aurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.	1.97	1	monohydroxybenzoic acid; quinomethanes; tricarboxylic acid	fluorochrome; histological dye; insulin-like growth factor receptor 1 antagonist
benzbromarone Benzbromarone: Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.. benzbromarone : 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.	2.08	1	1-benzofurans; aromatic ketone	uricosuric drug
3,4-dihydroxybenzohydroxamic acid [no description available]	1.99	1	benzoic acids
emodin Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.	2.05	1	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor
hydralazine Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.. hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.	2.05	1	azaarene; hydrazines; ortho-fused heteroarene; phthalazines	antihypertensive agent; vasodilator agent
psoromic acid psoromic acid: structure in first source	1.99	1	carbonyl compound
1,4,5,8-naphthalenetetracarboxylic acid 1,4,5,8-naphthalenetetracarboxylic acid: structure given in first source	1.99	1
cidofovir anhydrous Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.	2.04	1	phosphonic acids; pyrimidone	anti-HIV agent; antineoplastic agent; antiviral drug; photosensitizing agent
tipindole tipindole: RN given refers to parent cpd; structure	2.04	1
physodic acid physodic acid: lichen constituent	1.99	1	carbonyl compound
acediasulfone acediasulfone: antibacterial drug for treatment of ear infections; structure in first source	2.05	1	alpha-amino acid
atranorin atranorin: RN given refers to parent cpd; structure given in first source	1.99	1	carbonyl compound
methyl fluorone black methyl fluorone black: structure	1.99	1
stictic acid stictic acid: antioxidant from lichen, Usnea articulata; structure in first source	1.99	1	aromatic ether
diffractaic acid difractaic acid: from Lichen, Usnea steineri; active against Gram-positive, multidrug-resistant bacteria; structure in first source	1.99	1	carbonyl compound
benzyldihydronicotinamide benzyldihydronicotinamide: structure	2.05	1
3,4,5-trihydroxybenzohydroxamic acid [no description available]	1.99	1
ertiprotafib ertiprotafib: a hypoglycemic agent; structure in first source	2.03	1
quinoprazine quinoprazine: structure given in first source	2.04	1
stephenanthrine stephenanthrine: from the root of Stephania tetranda S. Moore & Dennettia tripetala; structure in first source. stephanthrine : An organic heterotetracyclic compound that is 2-(2H-phenanthro[3,4-d][1,3]dioxole in which the hydrogen at position 5 has been replaced by a 2-(dimethylamino)ethyl group.	2.04	1	cyclic acetal; organic heterotetracyclic compound; tertiary amino compound
pannarin pannarin: photoirradiation of above cpd leads to its decomposition which is reduced by oxygen. pannarin : A member of the class of depsidones that is 11H-dibenzo[b,e][1,4]dioxepine substituted by methyl groups at positions 1,6 and 9, chloro group at position 2, hydroxy group at position 3, formyl group at position 4, methoxy group at position 8 and an oxo group at position 11. It is a lichen metabolite isolated from several Psoroma species.	1.99	1	aldehyde; aromatic ether; depsidones; organic heterotricyclic compound; organochlorine compound; phenols	antimicrobial agent; antineoplastic agent; apoptosis inducer; lichen metabolite
benzarone benzarone: antihemorrhagic agent; structure	2.08	1	1-benzofurans
nsc 401077 NSC 401077: inhibits DNA methyltransferase DNMT1; structure in first source	2.05	1
s-adenosylhomocysteine S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.. S-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine.	2.51	2	adenosines; amino acid zwitterion; homocysteine derivative; homocysteines; organic sulfide	cofactor; EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor; EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor; epitope; fundamental metabolite
(+)-usnic acid [no description available]	1.99	1	usnic acid
2-{[(9H-9-fluorenylmethoxy)carbonyl]amino}benzoic acid [no description available]	2.04	1	fluorenes
difurfurylideneacetone [no description available]	2.04	1
chlorogenic acid caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.	1.99	1	cinnamate ester; tannin	food component; plant metabolite
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(3-methyl-1-piperidinyl)-2-phenylacetamide [no description available]	2.08	1	amino acid amide
savirin savirin: savirin - Staphylcoccus aureus virulence inhibitor; inhibits agr quorum sensing; structure in first source	2.08	1	quinazolines
n-(3-oxododecanoyl)homoserine lactone N-(3-oxododecanoyl)-L-homoserine lactone : An N-acyl-L-homoserine lactone having 3-oxododecanoyl as the acyl substituent.	2.08	1	N-(3-oxododecanoyl)homoserine lactone; N-acyl-L-homoserine lactone	bacterial metabolite
N-(1,3-benzodioxol-5-yl)-2-(3-methyl-1-piperidinyl)-2-phenylacetamide [no description available]	2.08	1	amino acid amide
fumarprotocetraric acid fumarprotocetraric acid: RN given refers to (E)-isomer; structure given in first source	1.99	1	carbonyl compound
salazinic acid salazinic acid: lichen metabolite; structure in first source	1.99	1
aluminum Aluminum: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.	6.94	1	boron group element atom; elemental aluminium; metal atom
4,5-di-O-caffeoylquinic acid [no description available]	1.99	1	quinic acid
salicylates Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.	3.6	9	monohydroxybenzoate	plant metabolite
chrome azurol s chrome azurol S: reagent for beryllium determination spectrophotometrically	1.97	1

Condition	Relationship Strength	Studies
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.03	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	2.03	1
Weight Gain Increase in BODY WEIGHT over existing weight.	2.03	1
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1
Infections, Staphylococcal [description not available]	2.48	2
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.48	2

5,5'-methylenedisalicylic acid

Description

Cross-References

Synonyms (67)

Protein Targets (12)

Inhibition Measurements

Biological Processes (109)

Molecular Functions (37)

Ceullar Components (37)

Bioassays (47)

Research

Studies (19)

Market Indicators

Research Demand Index: 11.77

Study Types

5,5'-methylenedisalicylic acid

Description

Cross-References

Synonyms (67)

Protein Targets (12)

Inhibition Measurements

Biological Processes (109)

Molecular Functions (37)

Ceullar Components (37)

Bioassays (47)

Research

Studies (19)

Market Indicators

Research Demand Index: 11.77

Study Types

Related Drugs (40)

Related Conditions (7)