| Assay ID | Title | Year | Journal | Article |
|---|
| AID1811 | Experimentally measured binding affinity data derived from PDB | 2006 | Archives of biochemistry and biophysics, Jul-01, Volume: 451, Issue:1
| IK682, a tight binding inhibitor of TACE. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2006 | Archives of biochemistry and biophysics, Jul-01, Volume: 451, Issue:1
| IK682, a tight binding inhibitor of TACE. |
| AID57001 | The compound was administered intravenously at a dose of 4 mg/Kg for determination area under curve | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID215436 | Inhibition of Tumor necrosis factor alpha secretion in LPS-stimulated human whole blood assay | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID109557 | Affinity for Matrix metalloprotease-14 (MMP-14) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID349377 | Inhibition of MMP13 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID109572 | Affinity for Matrix metalloprotease-16 (MMP-16) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID344653 | Inhibition of pig TACE | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID107857 | Affinity for Matrix metalloprotease-8 (MMP-8) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID349378 | Inhibition of MMP7 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID290501 | Inhibition of pTACE | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
| Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). |
| AID108156 | Affinity towards Matrix metalloprotease-9 (MMP-9) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID173090 | The compound was administered intravenously at a dose of 4 mg/Kg for determination of systemic clearance | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID347023 | Inhibition of TACE | 2009 | Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
| Current perspective of TACE inhibitors: a review. |
| AID292735 | Inhibition of MMP2 | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
| Identification of potent and selective TACE inhibitors via the S1 pocket. |
| AID349415 | Inhibition of MMP15 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID63432 | The compound was administered intravenously at a dose of 4 mg/Kg for determination of volume of distribution at steady state | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID290503 | Binding affinity to MMP3 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
| Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). |
| AID60296 | The compound was administered intravenously at a dose of 4 mg/Kg for determination of systemic clearance | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID347194 | Fraction unbound in human serum | 2009 | Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
| Current perspective of TACE inhibitors: a review. |
| AID292734 | Inhibition of MMP1 | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
| Identification of potent and selective TACE inhibitors via the S1 pocket. |
| AID347195 | Oral bioavailability in rat | 2009 | Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
| Current perspective of TACE inhibitors: a review. |
| AID344621 | Inhibition of LPS-stimulated TNFalpha production in whole blood | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID196512 | The compound was administered orally at a dose of 8 mg/Kg for determination of t max | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID292733 | Inhibition of TACE | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
| Identification of potent and selective TACE inhibitors via the S1 pocket. |
| AID349376 | Inhibition of MMP8 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID347036 | Oral bioavailability in dog | 2009 | Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
| Current perspective of TACE inhibitors: a review. |
| AID107831 | Affinity for Matrix metalloprotease-7 (MMP-7) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID107179 | Affinity for Matrix metalloprotease-2 (MMP-2) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID349374 | Inhibition of MMP2 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID63011 | The compound was administered intravenously at a dose of 4 mg/Kg for determination of terminal half life | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID215269 | Affinity for Tumor necrosis factor alpha converting enzyme (TACE) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID58035 | Bioavailability (dose 8 mg/kg p.o.) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID109386 | Affinity for Matrix metalloprotease-13 (MMP-13) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID109568 | Affinity for Matrix metalloprotease-15 (MMP-15) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID1895846 | Inhibition of porcine TACE | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Zinc enzymes in medicinal chemistry. |
| AID349413 | Inhibition of MMP16 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID349375 | Inhibition of MMP3 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID292736 | Inhibition of MMP3 | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
| Identification of potent and selective TACE inhibitors via the S1 pocket. |
| AID344620 | Inhibition of ADAM33 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID170078 | The compound was administered intravenously at a dose of 4 mg/Kg for determination area under curve | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID290502 | Binding affinity to MMP2 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
| Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). |
| AID411501 | Inhibition of TACE catalytic domain by FRET assay | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1
| Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors. |
| AID349373 | Inhibition of MMP1 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID292738 | Inhibition of MMP13 | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
| Identification of potent and selective TACE inhibitors via the S1 pocket. |
| AID349379 | Inhibition of MMP9 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID108910 | Affinity towards Matrix metalloprotease-1 (MMP-1) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID192013 | The compound was administered intravenously at a dose of 4 mg/Kg for determination of volume of distribution at steady state | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID107519 | Affinity for Matrix metalloprotease-3 (MMP-3) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID172654 | Bioavailability (dose 8 mg/kg p.o.) | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID290506 | Binding affinity to MMP13 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
| Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). |
| AID349381 | Inhibition of MMP14 | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID347193 | Inhibition of TNFalpha production in whole blood | 2009 | Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
| Current perspective of TACE inhibitors: a review. |
| AID63010 | The compound was administered orally at a dose of 8 mg/Kg for determination of t max | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID292737 | Inhibition of MMP9 | 2007 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
| Identification of potent and selective TACE inhibitors via the S1 pocket. |
| AID290504 | Binding affinity to MMP7 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
| Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). |
| AID196522 | The compound was administered intravenously at a dose of 4 mg/Kg for determination of terminal half life | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID215267 | Inhibitory activity against porcine Tumor necrosis factor alpha converting enzyme. | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. |
| AID1345418 | Human ADAM33 (M12: Astacin/Adamalysin) | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID1345458 | Human ADAM17 (M12: Astacin/Adamalysin) | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. |
| AID1798700 | TACE Inhibition Assay from Article 10.1016/j.bmcl.2008.11.034: \\Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors.\\ | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1
| Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |