Epididymis-specific alpha-mannosidase

An epididymis-specific alpha-mannosidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2E5]

EC 3.2.1.24;
Alpha-1,6-mannosidase;
Mannosidase alpha class 2B member 2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1-deoxymannojirimycin	Homo sapiens (human)	IC50	560.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
carbohydrate binding	molecular function	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
alpha-mannosidase activity	molecular function	Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. [EC:3.2.1.24]

This protein is located in 2 target(s):

Target	Category	Definition
lysosomal lumen	cellular component	The volume enclosed within the lysosomal membrane. [GOC:jl, PMID:15213228]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]

This protein is involved in 2 target(s):

Target	Category	Definition
mannose metabolic process	biological process	The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. [ISBN:0198506732]
oligosaccharide catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]