Compounds > 2',3'-dideoxyadenosine triphosphate
Page last updated: 2024-09-23

2',3'-dideoxyadenosine triphosphate

Cross-References

ID SourceID
PubMed CID65304
CHEMBL ID1383
CHEBI ID172701
SCHEMBL ID79815
MeSH IDM0114061

Synonyms (35)

Synonym
CHEBI:172701
2',3'-dideoxyadenosine-5-triphosphate
[[(2s,5r)-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
[(2s,5r)-5-(6-aminopurin-9-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
gtpl1709
[[(2s,5r)-5-(6-aminopurin-9-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
adenosine 5'-(tetrahydrogen triphosphate), 2',3'-dideoxy-
ddatp
24027-80-3
2',3'-dideoxy-atp
dideoxyadenosine 5'-triphosphate
2',3'-dideoxyadenosine 5'-triphosphate
2',3'-ddatp
2',3'-dideoxyadenosine triphosphate
DB02189
bdbm50164644
dda-tp
[[[5-(6-amino-9h-purin-9-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
atp,2',3'-dideoxy
2'',3''-dideoxyadenosine triphosphate
2'',3''-dideoxyadenosine triphosphate (ddatp)
dda-triphosphate
CHEMBL1383 ,
9mci2h1ej6 ,
unii-9mci2h1ej6
dideoxyadenosine 5'-triphosphate [mi]
SCHEMBL79815
dideoxyadenosine triphosphate
DTXSID90178767
AKOS030589611
((2s,5r)-5-(6-amino-9h-purin-9-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
HY-128036
Q27071868
CS-0095043
(((2s,5r)-5-(6-amino-9h-purin-9-yl)tetrahydrofuran-2-yl)methyl)triphosphoric acid

Drug Classes (1)

ClassDescription
purine deoxyribonucleoside triphosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

2',3'-dideoxyadenosine triphosphate is involved in 1 pathway(s), involving a total of 0 unique proteins and 5 unique compounds

PathwayProteinsCompounds
Didanosine Action Pathway05

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA polymerase betaHomo sapiens (human)IC50 (µMol)8.40001.40006.56679.0000AID1614343
Reverse transcriptase/RNaseH Human immunodeficiency virus 1Ki0.39500.00031.552310.0000AID167232; AID167234; AID198918; AID238445; AID341970; AID341972
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Reverse transcriptase/RNaseH Human immunodeficiency virus 1Kd5.30000.00062.40599.8000AID572771
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (22)

Processvia Protein(s)Taxonomy
nucleotide-excision repair, DNA gap fillingDNA polymerase betaHomo sapiens (human)
in utero embryonic developmentDNA polymerase betaHomo sapiens (human)
DNA-templated DNA replicationDNA polymerase betaHomo sapiens (human)
DNA repairDNA polymerase betaHomo sapiens (human)
base-excision repairDNA polymerase betaHomo sapiens (human)
base-excision repair, gap-fillingDNA polymerase betaHomo sapiens (human)
pyrimidine dimer repairDNA polymerase betaHomo sapiens (human)
inflammatory responseDNA polymerase betaHomo sapiens (human)
DNA damage responseDNA polymerase betaHomo sapiens (human)
salivary gland morphogenesisDNA polymerase betaHomo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damageDNA polymerase betaHomo sapiens (human)
response to gamma radiationDNA polymerase betaHomo sapiens (human)
somatic hypermutation of immunoglobulin genesDNA polymerase betaHomo sapiens (human)
response to ethanolDNA polymerase betaHomo sapiens (human)
lymph node developmentDNA polymerase betaHomo sapiens (human)
spleen developmentDNA polymerase betaHomo sapiens (human)
homeostasis of number of cellsDNA polymerase betaHomo sapiens (human)
neuron apoptotic processDNA polymerase betaHomo sapiens (human)
response to hyperoxiaDNA polymerase betaHomo sapiens (human)
immunoglobulin heavy chain V-D-J recombinationDNA polymerase betaHomo sapiens (human)
DNA biosynthetic processDNA polymerase betaHomo sapiens (human)
double-strand break repair via nonhomologous end joiningDNA polymerase betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
damaged DNA bindingDNA polymerase betaHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase betaHomo sapiens (human)
DNA-(apurinic or apyrimidinic site) endonuclease activityDNA polymerase betaHomo sapiens (human)
protein bindingDNA polymerase betaHomo sapiens (human)
microtubule bindingDNA polymerase betaHomo sapiens (human)
lyase activityDNA polymerase betaHomo sapiens (human)
enzyme bindingDNA polymerase betaHomo sapiens (human)
metal ion bindingDNA polymerase betaHomo sapiens (human)
5'-deoxyribose-5-phosphate lyase activityDNA polymerase betaHomo sapiens (human)
class I DNA-(apurinic or apyrimidinic site) endonuclease activityDNA polymerase betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
nucleusDNA polymerase betaHomo sapiens (human)
nucleoplasmDNA polymerase betaHomo sapiens (human)
cytoplasmDNA polymerase betaHomo sapiens (human)
microtubuleDNA polymerase betaHomo sapiens (human)
spindle microtubuleDNA polymerase betaHomo sapiens (human)
protein-containing complexDNA polymerase betaHomo sapiens (human)
nucleusDNA polymerase betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (28)

Assay IDTitleYearJournalArticle
AID1632252Inhibition of Escherichia coli DNA polymerase 1 Klenow fragment preincubated for 15 mins followed by addition of DNA substrate for 60 mins in presence of dNTPS/TAMRA tracer by fluorescence polarization assay2016Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18
A fluorescence polarization based assay for the identification and characterization of polymerase inhibitors.
AID341364Inhibition of human DNA polymerase gamma using calf thymus DNA as a template2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
AID228136Ratio of inhibitory activity of compound to that of substrate activity of dATP against RT M184I enzyme was determined2003Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.
AID341972Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.
AID167234Inhibitory activity against HIV-1 reverse transcriptase (RT M184V)2003Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.
AID341363Inhibition of human DNA polymerase gamma using D21/D36 DNA as a template2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
AID198918Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt)2003Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.
AID341178Inhibition of human DNA polymerase alpha using calf thymus DNA as a template2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
AID228138Ratio of inhibitory activity of compound to that of substrate activity of dATP against RT wt enzyme was determined2003Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.
AID1614344Inhibition of human DNA polymerase gamma using 5-end radiolabeled 24nt to 48nt DNA as primer template after 120 mins in presence of dCTP/dGTP/dTTP/dATP by PAGE analysis2019Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
AID572770Activity at HIV1 reverse transcriptase measured after 30 mins2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572773Selectivity, ratio of Kpol to Kd for dATP to Kpol to Kd for compound at HIV1 reverse transcriptase2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID1614343Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP by PAGE analysis2019Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
AID341975Ratio of Ki/Km for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant to Ki/Km for wild-type reverse transcriptase2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.
AID1632253Inhibition of Escherichia coli DNA polymerase 1 Klenow fragment preincubated for 15 mins followed by addition of DNA substrate for 60 mins in presence of dNTPS by picoGreen reagent based assay2016Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18
A fluorescence polarization based assay for the identification and characterization of polymerase inhibitors.
AID572772Ratio of Kpol to Kd for HIV1 reverse transcriptase2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID167232Inhibitory activity against HIV-1 reverse transcriptase (RT M184I)2003Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.
AID341361Inhibition of human DNA polymerase beta using D21/D36 DNA as a template2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
AID228137Ratio of inhibitory activity of compound to that of substrate activity of dATP against RT M184V enzyme was determined2003Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.
AID341971Ratio of Ki to Km for HIV1 reverse transcriptase by steady state nucleotide incorporation assay2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.
AID572771Binding affinity to HIV1 reverse transcriptase2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID341970Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.
AID341974Ratio of Ki to Km for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.
AID238445Inhibitory constant against HIV-1 reverse transcriptase2005Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase.
AID341973Ratio of Ki for HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant to Ki for wild-type reverse transcriptase2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.
AID197929Concentration required to inhibit the HIV-1 recombinant Reverse Transcriptase (rRT) activity by 50%. Activated calf thymus DNA was used as template primer1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Synthesis and evaluation of the anti-HIV activity of aza and deaza analogues of isoddA and their phosphates as prodrugs.
AID341362Inhibition of human DNA polymerase beta using calf thymus DNA as a template2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
AID1346309Human P2Y1 receptor (P2Y receptors)1997British journal of pharmacology, May, Volume: 121, Issue:2
An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (65)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (7.69)18.7374
1990's31 (47.69)18.2507
2000's21 (32.31)29.6817
2010's6 (9.23)24.3611
2020's2 (3.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (2.99%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other65 (97.01%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
zidovudine[no description available]medium100azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
ro 24-5098[no description available]medium10
didanosine[no description available]medium180purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor
didanosine[no description available]medium182purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor
suramin[no description available]medium10naphthalenesulfonic acid;
phenylureas;
secondary carboxamide		angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
adenosine diphosphate[no description available]medium40adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
methylthio-adp[no description available]medium10
2'-deoxyadenosine 5'-o-(1-thiotriphosphate)[no description available]medium10
2-methylthio-atp[no description available]medium10
2'-deoxyadenosine triphosphate[no description available]medium602'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite
2'-deoxyadenosine triphosphate[no description available]medium622'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite
synadenol[no description available]medium10
zalcitabine[no description available]medium30pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
thymidine 5'-triphosphate[no description available]medium30pyrimidine 2'-deoxyribonucleoside 5'-triphosphate;
thymidine phosphate		Escherichia coli metabolite;
mouse metabolite
stavudine triphosphate[no description available]medium20
zidovudine triphosphate[no description available]medium80
2',3'-dideoxyuridine-5'-triphosphate[no description available]medium10
3'-fluorothymidine-5'-triphosphate[no description available]medium10
lamivudine triphosphate[no description available]medium20
2',3'-dideoxyadenosine 5'-phosphate[no description available]medium40
3'-azido-3'-deoxythymidine 5'phosphate[no description available]medium10
tenofovir[no description available]medium40nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
tenofovir[no description available]medium41nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
amprenavir[no description available]medium10carbamate ester;
sulfonamide;
tetrahydrofuryl ester		antiviral drug;
HIV protease inhibitor
saquinavir[no description available]medium10L-asparagine derivative;
quinolines		antiviral drug;
HIV protease inhibitor
epoxyfarnesyl diazoacetate[no description available]medium10
stavudine[no description available]medium20dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
lamivudine[no description available]medium40monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
emtricitabine[no description available]medium10monothioacetal;
nucleoside analogue;
organofluorine compound;
pyrimidone		antiviral drug;
HIV-1 reverse transcriptase inhibitor
2'-deoxycytidine 5'-triphosphate[no description available]medium202'-deoxycytidine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-triphosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
2',3'-dideoxycytidine 5'-triphosphate[no description available]medium50
3'-azido-2',3'-dideoxyadenosine[no description available]medium10
tenofovir diphosphate[no description available]medium10
tenofovir disoproxil fumarate[no description available]medium10fumarate saltantiviral drug;
HIV-1 reverse transcriptase inhibitor;
prodrug
deoxyguanosine triphosphate[no description available]medium20deoxyguanosine phosphate;
guanyl deoxyribonucleotide;
purine 2'-deoxyribonucleoside 5'-triphosphate		Arabidopsis thaliana metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
deoxyguanosine triphosphate[no description available]medium21deoxyguanosine phosphate;
guanyl deoxyribonucleotide;
purine 2'-deoxyribonucleoside 5'-triphosphate		Arabidopsis thaliana metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
3'-azido-2',3'-dideoxyguanosine[no description available]medium10
carbovir triphosphate[no description available]medium10organic triphosphate
amitriptyline[no description available]medium10carbotricyclic compound;
tertiary amine		adrenergic uptake inhibitor;
antidepressant;
environmental contaminant;
tropomyosin-related kinase B receptor agonist;
xenobiotic
diclofenac[no description available]medium10amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
propafenone[no description available]medium10aromatic ketone;
secondary alcohol;
secondary amino compound		anti-arrhythmia drug
uridine triphosphate[no description available]medium10pyrimidine ribonucleoside 5'-triphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
aphidicolin[no description available]medium20tetracyclic diterpenoidantimicrobial agent;
antimitotic;
antineoplastic agent;
antiviral drug;
apoptosis inducer;
Aspergillus metabolite;
DNA synthesis inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
fungal metabolite
2'-c-methylcytidine[no description available]medium10
sofosbuvir[no description available]medium10isopropyl ester;
L-alanyl ester;
nucleotide conjugate;
organofluorine compound;
phosphoramidate ester		antiviral drug;
hepatitis C protease inhibitor;
prodrug
hexenuronic acid[no description available]medium10
adenine[no description available]medium216-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
organophosphonates[no description available]medium21divalent inorganic anion;
phosphite ion
urea[no description available]medium11isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
warfarin[no description available]medium10benzenes;
hydroxycoumarin;
methyl ketone
coumarin[no description available]medium10coumarinsfluorescent dye;
human metabolite;
plant metabolite
azides[no description available]medium10pseudohalide anionmitochondrial respiratory-chain inhibitor
2',3'-dideoxyguanosine 5'-triphosphate[no description available]medium90
1-ethyl-3-(3-dimethylaminoethyl)carbodiimide[no description available]medium10
carbodiimides[no description available]medium10carbodiimide
3'-deoxyadenosine 5'-triphosphate[no description available]medium10purine ribonucleoside 5'-triphosphateantifungal agent;
antimetabolite;
antineoplastic agent;
antiviral agent
nsc 614846[no description available]medium10carbovirHIV-1 reverse transcriptase inhibitor
2',3'-dideoxythymidine triphosphate[no description available]medium70pyrimidine 2',3'-dideoxyribonucleoside 5'-triphosphate;
thymidine phosphate
dideoxyadenosine[no description available]medium40adenosines;
purine 2',3'-dideoxyribonucleoside		EC 3.5.4.4 (adenosine deaminase) inhibitor;
EC 4.6.1.1 (adenylate cyclase) inhibitor
ribavirin[no description available]medium101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
edetic acid[no description available]medium10ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
ethylmaleimide[no description available]medium10maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
phosphorus radioisotopes[no description available]medium30
lodenosine[no description available]medium20
fluorescein-5-isothiocyanate[no description available]medium10fluorescein isothiocyanate
8-aminoguanosine[no description available]medium10
hydroxyurea[no description available]medium10one-carbon compound;
ureas		antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent
deoxyinosine[no description available]medium10purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
guanosine[no description available]medium10guanosines;
purines D-ribonucleoside		fundamental metabolite
pentoxifylline[no description available]medium10oxopurine
inosine[no description available]medium20inosines;
purines D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
aspartic acid[no description available]medium10aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
manganese[no description available]medium30elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
pyrophosphate[no description available]medium10diphosphate ion
lysine[no description available]medium10aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
oligonucleotides[no description available]medium20
tyrosine[no description available]medium10amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
2'-deoxy-3'-adenosine monophosphate[no description available]medium102'-deoxyadenosine phosphate;
purine 2'-deoxyribonucleoside 3'-monophosphate
carbachol[no description available]medium10ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
adenosine[no description available]medium10adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
1-(2-nitrophenyl)ethanol[no description available]medium10
inosinic acid[no description available]medium10inosine phosphate;
purine ribonucleoside 5'-monophosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
diadenosine tetraphosphate[no description available]medium10diadenosyl tetraphosphateEscherichia coli metabolite;
mouse metabolite
alanosine[no description available]medium10
alanine[no description available]medium10alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
cladribine triphosphate[no description available]low00purine deoxyribonucleoside triphosphate
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Promyelocytic Leukemia0low10
AML M30low10
Diffuse Large B-Cell Lymphoma0low10
Diffuse Large-Cell Lymphoma0low10
Diffuse, Large B-Cell, Lymphoma0low10
Histiocytic Lymphoma0low10
Histiocytic Lymphoma, Diffuse0low10
HIV0low30
HIV Coinfection0medium72
HIV Infections0medium72
HPV Infection0low10
HTLV-III Infections0medium72
HTLV-III-LAV Infections0medium72
Human Papillomavirus Infection0low10
Large Lymphoid Lymphoma, Diffuse0low10
Large-Cell Lymphoma, Diffuse0low10
Leukemia, Acute Promyelocytic0low10
Leukemia, Myeloid, Acute, M30low10
Leukemia, Progranulocytic0low10
Leukemia, Promyelocytic, Acute0low10
Lymphoma, Diffuse Large-Cell0low10
Lymphoma, Histiocytic0low10
Lymphoma, Histiocytic, Diffuse0low10
Lymphoma, Large B-Cell, Diffuse0low10
Lymphoma, Large Cell, Diffuse0low10
Lymphoma, Large Lymphoid, Diffuse0low10
Lymphoma, Large-Cell, Diffuse0low10
M3 ANLL0low10
Myeloid Leukemia, Acute, M30low10
Papillomavirus Infections0low10
Progranulocytic Leukemia0low10
Promyelocytic Leukemia, Acute0low10
Sensitivity and Specificity0low10
T-Lymphotropic Virus Type III Infections, Human0medium72

Research Highlights

Safety/Toxicity (1)

ArticleYear
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Antimicrobial agents and chemotherapy, Volume: 53, Issue: 9		2009
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (1)

ArticleYear
Simultaneous determination of 2',3'-dideoxyinosine and the active metabolite, 2',3'-dideoxyadenosine-5'-triphosphate in human peripheral-blood mononuclear cell by HPLC-MS/MS and the application to cell pharmacokinetics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Oct-01, Volume: 1002		2015
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
Decay rates of anti-HIV dideoxynucleotides in tissue culture systems: a simple correction for the effect of cell replication.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 25, Issue: 7		1997
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]