| Assay ID | Title | Year | Journal | Article |
|---|
| AID92115 | Tested for in vitro inhibitory activity against drug concentration causing total cell growth inhibition in 56 human tumor cell lines derived from leukemia in test 9; log10 TGI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID92107 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell death inhibition in 56 human tumor cell lines derived from small cell lung cancer in test 3; log10 LC50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID492487 | Cytotoxicity against human vincristine-resistant KB cells after 72 hrs by MTT assay | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. |
| AID52060 | Effect on cellular protein DNA complex formation(%) at 10 uM in comparison with etoposide | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins. |
| AID399596 | Inhibition of human DNA topoisomerase 2 assessed as DNA cleavage at 20 uM | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2
| Current developments in the discovery and design of new drug candidates from plant natural product leads. |
| AID335667 | Inhibition of human DNA topoisomerase 2 | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8
| Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID91970 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell growth inhibition in 56 human tumor cell lines derived from colon cancer in test 4; log10 GI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID399597 | Inhibition of human DNA topoisomerase 2 | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2
| Current developments in the discovery and design of new drug candidates from plant natural product leads. |
| AID96350 | Concentration required for 50% reduction in KB cell number after 3-day incubation | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins. |
| AID92114 | Tested for in vitro inhibitory activity against drug concentration causing total cell growth inhibition in 56 human tumor cell lines derived from leukemia in test 1; log10 TGI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID91976 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell death inhibition in 56 human tumor cell lines derived from CNS cancer in test 5; log10 LC50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID91968 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell growth inhibition in 56 human tumor cell lines derived from Melanoma in test 6; log10 GI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID91979 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell death inhibition in 56 human tumor cell lines derived from Renal cancer in test 8; log10 LC50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID57205 | Inhibitory activity against human DNA topoisomerase II | 1990 | Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
| Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID221633 | Cellular protein-DNA complex formation at 10 uM. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID57204 | Inhibition of human DNA topoisomerase II | 1991 | Journal of medicinal chemistry, Dec, Volume: 34, Issue:12
| Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID92117 | Tested for in vitro inhibitory activity against drug concentration causing total cell growth inhibition in 56 human tumor cell lines derived from small-cell-lung cancer in test 3; log10 TGI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID335666 | Cytotoxicity against human KB cells assessed as reduction in cell number after 3 days | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8
| Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID91971 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell growth inhibition in 56 human tumor cell lines derived from leukemia in test 9; log10 GI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID53302 | Inhibition of DNA topoisomerase II at 100 uM. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID92110 | Tested for in vitro inhibitory activity against drug concentration causing total cell growth inhibition in 56 human tumor cell lines derived from Melanoma in test 6; log10 TGI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID492485 | Cytotoxicity against human KB1 cells after 72 hrs by MTT assay | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. |
| AID94175 | Cytotoxicity against KB-ATCC cell lines after a 3-day incubation | 1994 | Journal of medicinal chemistry, Jan-21, Volume: 37, Issue:2
| Antitumor agents. 144. New gamma-lactone ring-modified arylamino etoposide analogs as inhibitors of human DNA topoisomerase II. |
| AID211458 | Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Antitumor agents. 163. Three-dimensional quantitative structure-activity relationship study of 4'-O-demethylepipodophyllotoxin analogs using the modified CoMFA/q2-GRS approach. |
| AID52064 | Inhibition of cellular protein-DNA complex formation at 10 uM | 1990 | Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
| Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID91969 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell growth inhibition in 56 human tumor cell lines derived from Ovarian cancer in test 7; log10 GI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID80116 | Inhibitory activity against human cytomegalovirus (HCMV) | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents. |
| AID91967 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell growth inhibition in 56 human tumor cell lines derived from CNS cancer in test 5; log10 GI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID92105 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell death inhibition in 56 human tumor cell lines derived from leukemia in test 1; log10 LC50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID93836 | GI values against KB cells (nasopharyngeal carcinoma) | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents. |
| AID492486 | Cytotoxicity against human KB-7d cells after 72 hrs by MTT assay | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. |
| AID42742 | GI values against CAKI-1 cells(renal carcinoma) | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents. |
| AID92116 | Tested for in vitro inhibitory activity against drug concentration causing total cell growth inhibition in 56 human tumor cell lines derived from ovarian cancer in test 7; log10 TGI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID53303 | Percent of cellular protein-DNA complex formation at concentration of 20 uM | 1994 | Journal of medicinal chemistry, Jan-21, Volume: 37, Issue:2
| Antitumor agents. 144. New gamma-lactone ring-modified arylamino etoposide analogs as inhibitors of human DNA topoisomerase II. |
| AID9244 | GI values against A549 cells (lung cancer) | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents. |
| AID92104 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell death inhibition in 56 human tumor cell lines derived from colon cancer in test 4; log10 LC50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID96389 | Concentration for 50% reduction in cell number after 3-day incubation | 1990 | Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
| Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID492484 | Cytotoxicity against human KB cells after 72 hrs by MTT assay | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. |
| AID211300 | Inhibition of human DNA topoisomerase II activity | 1994 | Journal of medicinal chemistry, Jan-21, Volume: 37, Issue:2
| Antitumor agents. 144. New gamma-lactone ring-modified arylamino etoposide analogs as inhibitors of human DNA topoisomerase II. |
| AID92109 | Tested for in vitro inhibitory activity against drug concentration causing total cell growth inhibition in 56 human tumor cell lines derived from CNS cancer in test 5; log10 TGI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID335669 | Inhibition of strand rejoining activity of human DNA topoisomerase 2 assessed as protein-DNA complex formation at 10 uM by cell-based assay | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8
| Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID91977 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell death inhibition in 56 human tumor cell lines derived from Non small cell lung cancer in test 2; log10 LC50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID92111 | Tested for in vitro inhibitory activity against drug concentration causing total cell growth inhibition in 56 human tumor cell lines derived from Non small cell lung cancer in test 2; log10 TGI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID52061 | Effect on cellular protein DNA complex formation(%) at 10 uM in comparison with etoposide | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 124. New 4 beta-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID57201 | Inhibition of human DNA Topoisomerase II | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 124. New 4 beta-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID91975 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell growth inhibition in 56 human tumor cell lines derived from small-cell-lung cancer in test 3; log10 GI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID92108 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell death inhibition in 56 uman tumor cell lines derived from Melanoma in test 6; log10 LC50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID92112 | Tested for in vitro inhibitory activity against drug concentration causing total cell growth inhibition in 56 human tumor cell lines derived from Renal cancer in test 8; log10 TGI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID91978 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell death inhibition in 56 human tumor cell lines derived from Ovarian cancer in test 7; log10 LC50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID96390 | In vitro cytotoxicity against KB cells after a 3-day incubation. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID92106 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell death inhibition in 56 human tumor cell lines derived from leukemia in test 9; log10 LC50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID96351 | Concentration required for 50% reduction in KB cell number after 3-day incubation | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 124. New 4 beta-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID92113 | Tested for in vitro inhibitory activity against drug concentration causing total cell growth inhibition in 56 human tumor cell lines derived from colon cancer in test 4 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID96388 | 50% reduction in KB cell number after a 3-day incubation. | 1991 | Journal of medicinal chemistry, Dec, Volume: 34, Issue:12
| Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID57200 | Evaluated for the inhibition of human DNA Topoisomerase II | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins. |
| AID53301 | Evaluated for inhibitory activity against DNA topoisomerase II | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID57061 | Percentage of intracellular covalent DNA-topoisomerase II complexes formed | 2002 | Journal of medicinal chemistry, May-23, Volume: 45, Issue:11
| Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method. |
| AID91972 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell growth inhibition in 56 human tumor cell lines derived from leukemia in test 1; log10 GI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID91974 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell growth inhibition in 56 human tumor cell lines derived from renal cancer in test 8; log10 GI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| AID52063 | % complex formation of cellular protein -DNA complex at a concentration of 10 uM | 1991 | Journal of medicinal chemistry, Dec, Volume: 34, Issue:12
| Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID147562 | Tested for in vitro inhibitory activity against drug concentration causing 50% cell growth inhibition in 56 human tumor cell lines derived from Non-small-cell lung cancer in test 2; log10 GI50 | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |