A dihydropyrimidine dehydrogenase [NADP(+)] that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12882]
DHPDHase;
DPD;
EC 1.3.1.2;
Dihydrothymine dehydrogenase;
Dihydrouracil dehydrogenase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| eniluracil | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| 5-iodouracil | Homo sapiens (human) | IC50 | 0.2200 | 1 | 1 |
| 5-cyanouracil | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| 5-vinyluracil | Homo sapiens (human) | IC50 | 0.0890 | 1 | 1 |
This protein enables 8 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| dihydropyrimidine dehydrogenase (NADP+) activity | molecular function | Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+. [EC:1.3.1.2] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| flavin adenine dinucleotide binding | molecular function | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732] |
| NADP binding | molecular function | Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. [GOC:ai] |
| 4 iron, 4 sulfur cluster binding | molecular function | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] |
| uracil binding | molecular function | Binding to uracil. [GOC:hjd] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| purine nucleobase catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. [GOC:go_curators] |
| pyrimidine nucleobase catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. [GOC:go_curators] |
| thymine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. [GOC:go_curators] |
| uracil catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. [GOC:go_curators] |
| thymidine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. [GOC:go_curators] |
| CMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate. [ISBN:0198506732] |
| dCMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate. [ISBN:0198506732] |
| beta-alanine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. [GOC:jl, ISBN:0198506732] |
| UMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate. [GOC:go_curators] |
| dUMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate. [GOC:go_curators] |