Serum paraoxonase/lactonase 3

A serum paraoxonase/lactonase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15166]

EC 3.1.1.2;
EC 3.1.1.81;
EC 3.1.8.1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
t-tucb	Homo sapiens (human)	IC50	10.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
aryldialkylphosphatase activity	molecular function	Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. [EC:3.1.8.1]
arylesterase activity	molecular function	Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. [EC:3.1.1.2]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
acyl-L-homoserine-lactone lactonohydrolase activity	molecular function	Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone = H+ + an N-acyl-L-homoserine. [EC:3.1.1.81]

This protein is located in 3 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

This protein is involved in 7 target(s):

Target	Category	Definition
renal sodium ion transport	biological process	The directed movement of sodium ions (Na+) by the renal system. [GOC:mtg_cardio]
negative regulation of superoxide anion generation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell. [GOC:mah]
carboxylic acid catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. [ISBN:0198506732]
establishment of localization in cell	biological process	Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
lactone catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of lactone. [GOC:TermGenie]
regulation of cellular response to drug	biological process	Any process that modulates the frequency, rate or extent of cellular response to drug. [GOC:obol]
response to toxic substance	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr]