rebeccamycin profile

Rebeccamycin is a natural product isolated from the bacterium Streptomyces rebeccae. It is a potent inhibitor of DNA topoisomerase I, an enzyme that plays a crucial role in DNA replication and repair. Rebeccamycin's unique structure, containing a pyrrolo[1,4]benzodiazepine (PBD) ring system, has attracted considerable interest in the field of cancer chemotherapy. Studies have shown that rebeccamycin exhibits significant antitumor activity against a range of human cancer cell lines, including leukemia, lung, and breast cancer. Its mechanism of action involves binding to DNA topoisomerase I and trapping the enzyme in a covalent complex with DNA, leading to DNA damage and cell death. However, rebeccamycin's clinical development was hampered by its poor pharmacokinetic properties, including low bioavailability and rapid metabolism. Despite these challenges, rebeccamycin has served as a valuable lead compound for the development of new anticancer agents with improved properties. Researchers have synthesized numerous analogs of rebeccamycin, aiming to optimize its pharmacological profile. These efforts have led to the development of several promising candidates, such as the rebeccamycin analog, which has demonstrated improved activity and reduced toxicity in preclinical studies. The study of rebeccamycin and its analogs continues to contribute to the advancement of cancer chemotherapy.'

rebeccamycin: from actinomycete strain C-38,383; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

rebeccamycin : An N-glycosyl compound consisting of a heteropolycyclic ring system with a glucosyl group attached to one of the indolic nitrogens. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	73110
CHEMBL ID	370100
CHEBI ID	135511
SCHEMBL ID	24695
MeSH ID	M0151075

Synonym
nsc 359079
brn 4732638
nsc359079
93908-02-2
rebeccamycin
nsc-359079
5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione, 1,11-dichloro-12,13-dihydro-12-(4-o-methyl-beta-d-glucopyranosyl)-
dichloro-[(2r,3r,4r,5s,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl][?]dione
rebeccamycin, solid, >=98% (hplc), from saccharothrix aerocolonigenes
1,11-dichloro-12-(4-o-methyl-beta-d-glucopyranosyl)-12,13-dihydro-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione
CHEBI:135511 ,
1,11-dichloro-12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahydro-2h-2-pyranyl)-6,7,12,13-tetrahydro-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
bdbm50162287
(rebeccamycin)1,11-dichloro-12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahydro-2h-2-pyranyl)-6,7,12,13-tetrahydro-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
1,11-dichloro-12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahydro-2h-2-pyranyl)-6,7,12,13-tetrahydro-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione(rebeccamycin)
1,11-dichloro-12-[3,4-dihydroxy-6-hydroxymethyl-5-methoxy-(2r,3r,4s,5r,6r)-tetrahydro-2h-2-pyranyl]-6,7,12,13-tetrahydro-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
CHEMBL370100 ,
C19701
unii-y96mqm21v9
y96mqm21v9 ,
SCHEMBL24695
QEHOIJJIZXRMAN-QZQSLCQPSA-N
mfcd23105147
HB4052
AKOS030213234
DTXSID70239880
DB14729
Q7301989
HY-19825
CS-0016893

Excerpt	Reference	Relevance
"Rebeccamycin is an antibiotic and antitumor substance isolated from the filamentous bacterium Lentzea aerocolonigenes. "	( The antitumor antibiotic rebeccamycin-challenges and advanced approaches in production processes. Ebersbach, A; Krull, R; Pommerehne, K; Walisko, J, 2019)	2.26
"Rebeccamycin is an indolocarbazole class inhibitor of topoisomerase I. "	( Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors. Anizon, F; David-Cordonnier, MH; Golsteyn, RM; Hildebrand, MP; Lozach, O; Marminon, C; Meijer, L; Moreau, P; Peixoto, P; Pfeiffer, B; Pierré, A; Prudhomme, M, 2008)	3.23
"Rebeccamycin is a member of the family of indolocarbazole antibiotics with broad spectrum antitumor activity. "	( Enzymatic assembly of the bis-indole core of rebeccamycin. Grüschow, S; Jayamaha, DH; Nishizawa, T; Nishizawa-Harada, C; Sherman, DH, 2006)	2.04
"Rebeccamycin is an antitumor antibiotic possessing a DNA-intercalating indolocarbazole chromophore linked to a glycosyl residue. "	( Cellular uptake and interaction with purified membranes of rebeccamycin derivatives. Anizon, F; Bailly, C; Dugave, C; Goossens, JF; Hénichart, JP; Prudhomme, M; Riou, J, 2000)	1.99

Excerpt	Reference	Relevance
" Pharmacokinetic analysis was performed using compartmental and noncompartmental methods."	( Plasma and cerebrospinal fluid pharmacokinetics of rebeccamycin (NSC 655649) in nonhuman primates. Aleksic, A; Berg, SL; Bernacky, B; Blaney, SM; Dauser, R; McGuffey, L; Nuchtern, J, 2004)	0.58
" The terminal half-life was 730+/-410 min, the AUC was 3130+/-425 microM min, and the clearance was 190+/-25 ml/min/m2."	( Plasma and cerebrospinal fluid pharmacokinetics of rebeccamycin (NSC 655649) in nonhuman primates. Aleksic, A; Berg, SL; Bernacky, B; Blaney, SM; Dauser, R; McGuffey, L; Nuchtern, J, 2004)	0.58

Excerpt	Reference	Relevance
" aerocolonigenes was combined with soy lecithin addition to further increase the rebeccamycin concentration."	( Macroparticle-enhanced cultivation of Lentzea aerocolonigenes: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production. Althof, K; Dinius, A; Krull, R; Kwade, A; Niebusch, J; Nowka, PF; Schrader, M; Schrinner, K; Schwarzer, FA, 2021)	1.04

Excerpt	Relevance	Reference
"The development of a practical and pharmaceutically acceptable parenteral dosage form of 1 is described."	( Parenteral formulation and thermal degradation pathways of a potent rebeccamycin based indolocarbazole topoisomerase I inhibitor. Breslin, D; Karki, SB; Kitada, H; Minagawa, W; Nomoto, T; Qin, XZ; Sato, Y, 2010)	0.6

Class	Description
N-glycosyl compound	A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond.
indolocarbazole	Compounds based upon an indolo[2,3-a]carbazole skeleton.
organochlorine compound	An organochlorine compound is a compound containing at least one carbon-chlorine bond.
organic heterohexacyclic compound
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
rebeccamycin biosynthesis	7	23

Protein Targets (14)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Serine/threonine-protein kinase D3	Homo sapiens (human)	IC50 (µMol)	175.0000	0.0001	1.1701	10.0000	AID165270
Protein kinase C gamma type	Homo sapiens (human)	IC50 (µMol)	175.0000	0.0001	1.0354	10.0000	AID165270
Protein kinase C beta type	Homo sapiens (human)	IC50 (µMol)	175.0000	0.0001	0.5542	10.0000	AID165270
Protein kinase C alpha type	Homo sapiens (human)	IC50 (µMol)	125.0000	0.0001	0.9720	10.0000	AID163166; AID165134; AID165270
Protein kinase C eta type	Homo sapiens (human)	IC50 (µMol)	175.0000	0.0001	0.7971	10.0000	AID165270
Protein kinase C iota type	Homo sapiens (human)	IC50 (µMol)	175.0000	0.0001	2.0378	10.0000	AID165270
Protein kinase C epsilon type	Homo sapiens (human)	IC50 (µMol)	175.0000	0.0001	0.8029	10.0000	AID165270
Protein kinase C theta type	Homo sapiens (human)	IC50 (µMol)	175.0000	0.0001	0.9897	10.0000	AID165270
Protein kinase C zeta type	Homo sapiens (human)	IC50 (µMol)	175.0000	0.0001	2.4453	10.0000	AID165270
Protein kinase C delta type	Homo sapiens (human)	IC50 (µMol)	175.0000	0.0001	0.8448	10.0000	AID165270
Serine/threonine-protein kinase D1	Homo sapiens (human)	IC50 (µMol)	175.0000	0.0001	1.2319	10.0000	AID165270
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
DNA topoisomerase 1	Homo sapiens (human)	MIC	1.7500	0.0100	2.0017	5.0000	AID210944; AID211093; AID211110; AID56701
DNA topoisomerase 2-alpha	Homo sapiens (human)	MIC	17.5000	10.0000	10.0000	10.0000	AID211126
DNA topoisomerase 2-beta	Homo sapiens (human)	MIC	17.5000	0.1000	3.4500	10.0000	AID211126
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (264)

Process	via Protein(s)	Taxonomy
protein phosphorylation	Serine/threonine-protein kinase D3	Homo sapiens (human)
protein kinase C-activating G protein-coupled receptor signaling pathway	Serine/threonine-protein kinase D3	Homo sapiens (human)
sphingolipid biosynthetic process	Serine/threonine-protein kinase D3	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase D3	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Serine/threonine-protein kinase D3	Homo sapiens (human)
protein phosphorylation	Protein kinase C gamma type	Homo sapiens (human)
chemical synaptic transmission	Protein kinase C gamma type	Homo sapiens (human)
learning or memory	Protein kinase C gamma type	Homo sapiens (human)
chemosensory behavior	Protein kinase C gamma type	Homo sapiens (human)
response to toxic substance	Protein kinase C gamma type	Homo sapiens (human)
phosphorylation	Protein kinase C gamma type	Homo sapiens (human)
negative regulation of protein ubiquitination	Protein kinase C gamma type	Homo sapiens (human)
regulation of response to food	Protein kinase C gamma type	Homo sapiens (human)
positive regulation of mismatch repair	Protein kinase C gamma type	Homo sapiens (human)
negative regulation of protein catabolic process	Protein kinase C gamma type	Homo sapiens (human)
regulation of circadian rhythm	Protein kinase C gamma type	Homo sapiens (human)
response to morphine	Protein kinase C gamma type	Homo sapiens (human)
negative regulation of neuron apoptotic process	Protein kinase C gamma type	Homo sapiens (human)
response to pain	Protein kinase C gamma type	Homo sapiens (human)
rhythmic process	Protein kinase C gamma type	Homo sapiens (human)
regulation of phagocytosis	Protein kinase C gamma type	Homo sapiens (human)
long-term synaptic potentiation	Protein kinase C gamma type	Homo sapiens (human)
innervation	Protein kinase C gamma type	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Protein kinase C gamma type	Homo sapiens (human)
negative regulation of proteasomal protein catabolic process	Protein kinase C gamma type	Homo sapiens (human)
response to psychosocial stress	Protein kinase C gamma type	Homo sapiens (human)
regulation of synaptic vesicle exocytosis	Protein kinase C gamma type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C gamma type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C gamma type	Homo sapiens (human)
adaptive immune response	Protein kinase C beta type	Homo sapiens (human)
chromatin remodeling	Protein kinase C beta type	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Protein kinase C beta type	Homo sapiens (human)
protein phosphorylation	Protein kinase C beta type	Homo sapiens (human)
calcium ion transport	Protein kinase C beta type	Homo sapiens (human)
intracellular calcium ion homeostasis	Protein kinase C beta type	Homo sapiens (human)
apoptotic process	Protein kinase C beta type	Homo sapiens (human)
mitotic nuclear membrane disassembly	Protein kinase C beta type	Homo sapiens (human)
signal transduction	Protein kinase C beta type	Homo sapiens (human)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Protein kinase C beta type	Homo sapiens (human)
response to xenobiotic stimulus	Protein kinase C beta type	Homo sapiens (human)
response to glucose	Protein kinase C beta type	Homo sapiens (human)
regulation of glucose transmembrane transport	Protein kinase C beta type	Homo sapiens (human)
negative regulation of glucose transmembrane transport	Protein kinase C beta type	Homo sapiens (human)
regulation of dopamine secretion	Protein kinase C beta type	Homo sapiens (human)
dibenzo-p-dioxin metabolic process	Protein kinase C beta type	Homo sapiens (human)
positive regulation of vascular endothelial growth factor receptor signaling pathway	Protein kinase C beta type	Homo sapiens (human)
positive regulation of insulin secretion	Protein kinase C beta type	Homo sapiens (human)
response to vitamin D	Protein kinase C beta type	Homo sapiens (human)
regulation of growth	Protein kinase C beta type	Homo sapiens (human)
B cell activation	Protein kinase C beta type	Homo sapiens (human)
positive regulation of odontogenesis of dentin-containing tooth	Protein kinase C beta type	Homo sapiens (human)
lipoprotein transport	Protein kinase C beta type	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Protein kinase C beta type	Homo sapiens (human)
post-translational protein modification	Protein kinase C beta type	Homo sapiens (human)
response to ethanol	Protein kinase C beta type	Homo sapiens (human)
positive regulation of angiogenesis	Protein kinase C beta type	Homo sapiens (human)
positive regulation of DNA-templated transcription	Protein kinase C beta type	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Protein kinase C beta type	Homo sapiens (human)
B cell receptor signaling pathway	Protein kinase C beta type	Homo sapiens (human)
positive regulation of B cell receptor signaling pathway	Protein kinase C beta type	Homo sapiens (human)
cellular response to carbohydrate stimulus	Protein kinase C beta type	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Protein kinase C beta type	Homo sapiens (human)
regulation of synaptic vesicle exocytosis	Protein kinase C beta type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C beta type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C beta type	Homo sapiens (human)
DNA topological change	DNA topoisomerase 1	Homo sapiens (human)
chromatin remodeling	DNA topoisomerase 1	Homo sapiens (human)
circadian rhythm	DNA topoisomerase 1	Homo sapiens (human)
response to xenobiotic stimulus	DNA topoisomerase 1	Homo sapiens (human)
programmed cell death	DNA topoisomerase 1	Homo sapiens (human)
phosphorylation	DNA topoisomerase 1	Homo sapiens (human)
peptidyl-serine phosphorylation	DNA topoisomerase 1	Homo sapiens (human)
circadian regulation of gene expression	DNA topoisomerase 1	Homo sapiens (human)
embryonic cleavage	DNA topoisomerase 1	Homo sapiens (human)
chromosome segregation	DNA topoisomerase 1	Homo sapiens (human)
DNA replication	DNA topoisomerase 1	Homo sapiens (human)
hematopoietic progenitor cell differentiation	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA topological change	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA ligation	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA damage response	DNA topoisomerase 2-alpha	Homo sapiens (human)
chromosome segregation	DNA topoisomerase 2-alpha	Homo sapiens (human)
female meiotic nuclear division	DNA topoisomerase 2-alpha	Homo sapiens (human)
apoptotic chromosome condensation	DNA topoisomerase 2-alpha	Homo sapiens (human)
embryonic cleavage	DNA topoisomerase 2-alpha	Homo sapiens (human)
regulation of circadian rhythm	DNA topoisomerase 2-alpha	Homo sapiens (human)
positive regulation of apoptotic process	DNA topoisomerase 2-alpha	Homo sapiens (human)
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	DNA topoisomerase 2-alpha	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	DNA topoisomerase 2-alpha	Homo sapiens (human)
rhythmic process	DNA topoisomerase 2-alpha	Homo sapiens (human)
negative regulation of DNA duplex unwinding	DNA topoisomerase 2-alpha	Homo sapiens (human)
resolution of meiotic recombination intermediates	DNA topoisomerase 2-alpha	Homo sapiens (human)
sister chromatid segregation	DNA topoisomerase 2-alpha	Homo sapiens (human)
angiogenesis	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Protein kinase C alpha type	Homo sapiens (human)
desmosome assembly	Protein kinase C alpha type	Homo sapiens (human)
chromatin remodeling	Protein kinase C alpha type	Homo sapiens (human)
protein phosphorylation	Protein kinase C alpha type	Homo sapiens (human)
mitotic nuclear membrane disassembly	Protein kinase C alpha type	Homo sapiens (human)
cell adhesion	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of endothelial cell migration	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of cardiac muscle hypertrophy	Protein kinase C alpha type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C alpha type	Homo sapiens (human)
peptidyl-threonine phosphorylation	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of cell migration	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of lipopolysaccharide-mediated signaling pathway	Protein kinase C alpha type	Homo sapiens (human)
negative regulation of glial cell apoptotic process	Protein kinase C alpha type	Homo sapiens (human)
regulation of mRNA stability	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Protein kinase C alpha type	Homo sapiens (human)
post-translational protein modification	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of macrophage differentiation	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of angiogenesis	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of bone resorption	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of cell adhesion	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of mitotic cell cycle	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Protein kinase C alpha type	Homo sapiens (human)
response to interleukin-1	Protein kinase C alpha type	Homo sapiens (human)
regulation of platelet aggregation	Protein kinase C alpha type	Homo sapiens (human)
apoptotic signaling pathway	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of angiotensin-activated signaling pathway	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of dense core granule biogenesis	Protein kinase C alpha type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of insulin secretion	Protein kinase C alpha type	Homo sapiens (human)
protein phosphorylation	Protein kinase C eta type	Homo sapiens (human)
signal transduction	Protein kinase C eta type	Homo sapiens (human)
positive regulation of macrophage derived foam cell differentiation	Protein kinase C eta type	Homo sapiens (human)
cell differentiation	Protein kinase C eta type	Homo sapiens (human)
negative regulation of glial cell apoptotic process	Protein kinase C eta type	Homo sapiens (human)
positive regulation of keratinocyte differentiation	Protein kinase C eta type	Homo sapiens (human)
positive regulation of B cell receptor signaling pathway	Protein kinase C eta type	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Protein kinase C eta type	Homo sapiens (human)
positive regulation of glial cell proliferation	Protein kinase C eta type	Homo sapiens (human)
protein kinase C signaling	Protein kinase C eta type	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Protein kinase C eta type	Homo sapiens (human)
regulation of bicellular tight junction assembly	Protein kinase C eta type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C eta type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C eta type	Homo sapiens (human)
protein phosphorylation	Protein kinase C iota type	Homo sapiens (human)
protein targeting to membrane	Protein kinase C iota type	Homo sapiens (human)
cytoskeleton organization	Protein kinase C iota type	Homo sapiens (human)
actin filament organization	Protein kinase C iota type	Homo sapiens (human)
positive regulation of neuron projection development	Protein kinase C iota type	Homo sapiens (human)
vesicle-mediated transport	Protein kinase C iota type	Homo sapiens (human)
cell migration	Protein kinase C iota type	Homo sapiens (human)
cellular response to insulin stimulus	Protein kinase C iota type	Homo sapiens (human)
negative regulation of glial cell apoptotic process	Protein kinase C iota type	Homo sapiens (human)
establishment of apical/basal cell polarity	Protein kinase C iota type	Homo sapiens (human)
eye photoreceptor cell development	Protein kinase C iota type	Homo sapiens (human)
negative regulation of apoptotic process	Protein kinase C iota type	Homo sapiens (human)
negative regulation of neuron apoptotic process	Protein kinase C iota type	Homo sapiens (human)
establishment or maintenance of epithelial cell apical/basal polarity	Protein kinase C iota type	Homo sapiens (human)
cell-cell junction organization	Protein kinase C iota type	Homo sapiens (human)
positive regulation of Notch signaling pathway	Protein kinase C iota type	Homo sapiens (human)
positive regulation of glucose import	Protein kinase C iota type	Homo sapiens (human)
secretion	Protein kinase C iota type	Homo sapiens (human)
Golgi vesicle budding	Protein kinase C iota type	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Protein kinase C iota type	Homo sapiens (human)
positive regulation of glial cell proliferation	Protein kinase C iota type	Homo sapiens (human)
membrane organization	Protein kinase C iota type	Homo sapiens (human)
cellular response to chemical stress	Protein kinase C iota type	Homo sapiens (human)
response to interleukin-1	Protein kinase C iota type	Homo sapiens (human)
regulation of postsynaptic membrane neurotransmitter receptor levels	Protein kinase C iota type	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Protein kinase C iota type	Homo sapiens (human)
positive regulation of endothelial cell apoptotic process	Protein kinase C iota type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C iota type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C iota type	Homo sapiens (human)
MAPK cascade	Protein kinase C epsilon type	Homo sapiens (human)
macrophage activation involved in immune response	Protein kinase C epsilon type	Homo sapiens (human)
protein phosphorylation	Protein kinase C epsilon type	Homo sapiens (human)
apoptotic process	Protein kinase C epsilon type	Homo sapiens (human)
signal transduction	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of epithelial cell migration	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of fibroblast migration	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of cell-substrate adhesion	Protein kinase C epsilon type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C epsilon type	Homo sapiens (human)
insulin secretion	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of actin filament polymerization	Protein kinase C epsilon type	Homo sapiens (human)
negative regulation of protein ubiquitination	Protein kinase C epsilon type	Homo sapiens (human)
cell-substrate adhesion	Protein kinase C epsilon type	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of insulin secretion	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of synaptic transmission, GABAergic	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of cytokinesis	Protein kinase C epsilon type	Homo sapiens (human)
locomotory exploration behavior	Protein kinase C epsilon type	Homo sapiens (human)
TRAM-dependent toll-like receptor 4 signaling pathway	Protein kinase C epsilon type	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Protein kinase C epsilon type	Homo sapiens (human)
response to morphine	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of MAPK cascade	Protein kinase C epsilon type	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of lipid catabolic process	Protein kinase C epsilon type	Homo sapiens (human)
regulation of release of sequestered calcium ion into cytosol	Protein kinase C epsilon type	Homo sapiens (human)
cell division	Protein kinase C epsilon type	Homo sapiens (human)
establishment of localization in cell	Protein kinase C epsilon type	Homo sapiens (human)
synaptic transmission, GABAergic	Protein kinase C epsilon type	Homo sapiens (human)
regulation of insulin secretion involved in cellular response to glucose stimulus	Protein kinase C epsilon type	Homo sapiens (human)
mucus secretion	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of mucus secretion	Protein kinase C epsilon type	Homo sapiens (human)
cellular response to ethanol	Protein kinase C epsilon type	Homo sapiens (human)
cellular response to prostaglandin E stimulus	Protein kinase C epsilon type	Homo sapiens (human)
cellular response to hypoxia	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of wound healing	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Protein kinase C epsilon type	Homo sapiens (human)
negative regulation of sodium ion transmembrane transporter activity	Protein kinase C epsilon type	Homo sapiens (human)
positive regulation of cellular glucuronidation	Protein kinase C epsilon type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C epsilon type	Homo sapiens (human)
neuron migration	DNA topoisomerase 2-beta	Homo sapiens (human)
DNA topological change	DNA topoisomerase 2-beta	Homo sapiens (human)
axonogenesis	DNA topoisomerase 2-beta	Homo sapiens (human)
B cell differentiation	DNA topoisomerase 2-beta	Homo sapiens (human)
forebrain development	DNA topoisomerase 2-beta	Homo sapiens (human)
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	DNA topoisomerase 2-beta	Homo sapiens (human)
cellular response to hydrogen peroxide	DNA topoisomerase 2-beta	Homo sapiens (human)
cellular response to ATP	DNA topoisomerase 2-beta	Homo sapiens (human)
cellular senescence	DNA topoisomerase 2-beta	Homo sapiens (human)
positive regulation of double-strand break repair via nonhomologous end joining	DNA topoisomerase 2-beta	Homo sapiens (human)
sister chromatid segregation	DNA topoisomerase 2-beta	Homo sapiens (human)
resolution of meiotic recombination intermediates	DNA topoisomerase 2-beta	Homo sapiens (human)
regulation of cell growth	Protein kinase C theta type	Homo sapiens (human)
regulation of DNA-templated transcription	Protein kinase C theta type	Homo sapiens (human)
protein phosphorylation	Protein kinase C theta type	Homo sapiens (human)
membrane protein ectodomain proteolysis	Protein kinase C theta type	Homo sapiens (human)
inflammatory response	Protein kinase C theta type	Homo sapiens (human)
axon guidance	Protein kinase C theta type	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	Protein kinase C theta type	Homo sapiens (human)
positive regulation of interleukin-17 production	Protein kinase C theta type	Homo sapiens (human)
positive regulation of interleukin-2 production	Protein kinase C theta type	Homo sapiens (human)
positive regulation of interleukin-4 production	Protein kinase C theta type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C theta type	Homo sapiens (human)
CD4-positive, alpha-beta T cell proliferation	Protein kinase C theta type	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Protein kinase C theta type	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Protein kinase C theta type	Homo sapiens (human)
positive regulation of T cell activation	Protein kinase C theta type	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Protein kinase C theta type	Homo sapiens (human)
positive regulation of telomerase activity	Protein kinase C theta type	Homo sapiens (human)
cell chemotaxis	Protein kinase C theta type	Homo sapiens (human)
negative regulation of T cell apoptotic process	Protein kinase C theta type	Homo sapiens (human)
regulation of platelet aggregation	Protein kinase C theta type	Homo sapiens (human)
positive regulation of telomere capping	Protein kinase C theta type	Homo sapiens (human)
positive regulation of T-helper 17 type immune response	Protein kinase C theta type	Homo sapiens (human)
positive regulation of CD4-positive, alpha-beta T cell proliferation	Protein kinase C theta type	Homo sapiens (human)
positive regulation of T-helper 2 cell activation	Protein kinase C theta type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C theta type	Homo sapiens (human)
microtubule cytoskeleton organization	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of cell-matrix adhesion	Protein kinase C zeta type	Homo sapiens (human)
protein phosphorylation	Protein kinase C zeta type	Homo sapiens (human)
inflammatory response	Protein kinase C zeta type	Homo sapiens (human)
signal transduction	Protein kinase C zeta type	Homo sapiens (human)
cell surface receptor signaling pathway	Protein kinase C zeta type	Homo sapiens (human)
long-term memory	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of cell population proliferation	Protein kinase C zeta type	Homo sapiens (human)
cell migration	Protein kinase C zeta type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C zeta type	Homo sapiens (human)
establishment of cell polarity	Protein kinase C zeta type	Homo sapiens (human)
negative regulation of protein-containing complex assembly	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of interleukin-10 production	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of interleukin-13 production	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of interleukin-4 production	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of interleukin-5 production	Protein kinase C zeta type	Homo sapiens (human)
cellular response to insulin stimulus	Protein kinase C zeta type	Homo sapiens (human)
negative regulation of apoptotic process	Protein kinase C zeta type	Homo sapiens (human)
establishment or maintenance of epithelial cell apical/basal polarity	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of T-helper 2 cell differentiation	Protein kinase C zeta type	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of insulin receptor signaling pathway	Protein kinase C zeta type	Homo sapiens (human)
vesicle transport along microtubule	Protein kinase C zeta type	Homo sapiens (human)
negative regulation of peptidyl-tyrosine phosphorylation	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of protein transport	Protein kinase C zeta type	Homo sapiens (human)
membrane depolarization	Protein kinase C zeta type	Homo sapiens (human)
membrane hyperpolarization	Protein kinase C zeta type	Homo sapiens (human)
long-term synaptic potentiation	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Protein kinase C zeta type	Homo sapiens (human)
protein kinase C signaling	Protein kinase C zeta type	Homo sapiens (human)
protein localization to plasma membrane	Protein kinase C zeta type	Homo sapiens (human)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Protein kinase C zeta type	Homo sapiens (human)
neuron projection extension	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of excitatory postsynaptic potential	Protein kinase C zeta type	Homo sapiens (human)
positive regulation of T-helper 2 cell cytokine production	Protein kinase C zeta type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C zeta type	Homo sapiens (human)
protein phosphorylation	Protein kinase C delta type	Homo sapiens (human)
apoptotic process	Protein kinase C delta type	Homo sapiens (human)
DNA damage response	Protein kinase C delta type	Homo sapiens (human)
signal transduction	Protein kinase C delta type	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to oxidative stress	Protein kinase C delta type	Homo sapiens (human)
regulation of signaling receptor activity	Protein kinase C delta type	Homo sapiens (human)
immunoglobulin mediated immune response	Protein kinase C delta type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C delta type	Homo sapiens (human)
peptidyl-threonine phosphorylation	Protein kinase C delta type	Homo sapiens (human)
termination of signal transduction	Protein kinase C delta type	Homo sapiens (human)
negative regulation of actin filament polymerization	Protein kinase C delta type	Homo sapiens (human)
positive regulation of endodeoxyribonuclease activity	Protein kinase C delta type	Homo sapiens (human)
negative regulation of protein binding	Protein kinase C delta type	Homo sapiens (human)
activation of protein kinase activity	Protein kinase C delta type	Homo sapiens (human)
positive regulation of superoxide anion generation	Protein kinase C delta type	Homo sapiens (human)
regulation of actin cytoskeleton organization	Protein kinase C delta type	Homo sapiens (human)
negative regulation of glial cell apoptotic process	Protein kinase C delta type	Homo sapiens (human)
cellular response to UV	Protein kinase C delta type	Homo sapiens (human)
positive regulation of protein dephosphorylation	Protein kinase C delta type	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Protein kinase C delta type	Homo sapiens (human)
B cell proliferation	Protein kinase C delta type	Homo sapiens (human)
neutrophil activation	Protein kinase C delta type	Homo sapiens (human)
positive regulation of protein import into nucleus	Protein kinase C delta type	Homo sapiens (human)
defense response to bacterium	Protein kinase C delta type	Homo sapiens (human)
negative regulation of MAP kinase activity	Protein kinase C delta type	Homo sapiens (human)
regulation of mRNA stability	Protein kinase C delta type	Homo sapiens (human)
post-translational protein modification	Protein kinase C delta type	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Protein kinase C delta type	Homo sapiens (human)
negative regulation of inflammatory response	Protein kinase C delta type	Homo sapiens (human)
negative regulation of peptidyl-tyrosine phosphorylation	Protein kinase C delta type	Homo sapiens (human)
protein stabilization	Protein kinase C delta type	Homo sapiens (human)
negative regulation of filopodium assembly	Protein kinase C delta type	Homo sapiens (human)
cell chemotaxis	Protein kinase C delta type	Homo sapiens (human)
cellular response to hydrogen peroxide	Protein kinase C delta type	Homo sapiens (human)
cellular response to hydroperoxide	Protein kinase C delta type	Homo sapiens (human)
negative regulation of platelet aggregation	Protein kinase C delta type	Homo sapiens (human)
cellular senescence	Protein kinase C delta type	Homo sapiens (human)
positive regulation of phospholipid scramblase activity	Protein kinase C delta type	Homo sapiens (human)
cellular response to angiotensin	Protein kinase C delta type	Homo sapiens (human)
regulation of ceramide biosynthetic process	Protein kinase C delta type	Homo sapiens (human)
positive regulation of ceramide biosynthetic process	Protein kinase C delta type	Homo sapiens (human)
positive regulation of glucosylceramide catabolic process	Protein kinase C delta type	Homo sapiens (human)
positive regulation of sphingomyelin catabolic process	Protein kinase C delta type	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Protein kinase C delta type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C delta type	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase D1	Homo sapiens (human)
angiogenesis	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Serine/threonine-protein kinase D1	Homo sapiens (human)
apoptotic process	Serine/threonine-protein kinase D1	Homo sapiens (human)
inflammatory response	Serine/threonine-protein kinase D1	Homo sapiens (human)
Golgi organization	Serine/threonine-protein kinase D1	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase D1	Homo sapiens (human)
integrin-mediated signaling pathway	Serine/threonine-protein kinase D1	Homo sapiens (human)
nervous system development	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of autophagy	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of endothelial cell migration	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of gene expression	Serine/threonine-protein kinase D1	Homo sapiens (human)
regulation of keratinocyte proliferation	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of neuron projection development	Serine/threonine-protein kinase D1	Homo sapiens (human)
regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril	Serine/threonine-protein kinase D1	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase D1	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase D1	Homo sapiens (human)
sphingolipid biosynthetic process	Serine/threonine-protein kinase D1	Homo sapiens (human)
cell differentiation	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Serine/threonine-protein kinase D1	Homo sapiens (human)
cellular response to amino acid starvation	Serine/threonine-protein kinase D1	Homo sapiens (human)
cellular response to oxidative stress	Serine/threonine-protein kinase D1	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase D1	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of protein import into nucleus	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Serine/threonine-protein kinase D1	Homo sapiens (human)
innate immune response	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of osteoblast differentiation	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of angiogenesis	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of cell size	Serine/threonine-protein kinase D1	Homo sapiens (human)
negative regulation of endocytosis	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Serine/threonine-protein kinase D1	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of protein export from nucleus	Serine/threonine-protein kinase D1	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Serine/threonine-protein kinase D1	Homo sapiens (human)
Golgi vesicle transport	Serine/threonine-protein kinase D1	Homo sapiens (human)
defense response to Gram-negative bacterium	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Serine/threonine-protein kinase D1	Homo sapiens (human)
regulation of release of sequestered calcium ion into cytosol	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of sarcomere organization	Serine/threonine-protein kinase D1	Homo sapiens (human)
cellular response to hydroperoxide	Serine/threonine-protein kinase D1	Homo sapiens (human)
cellular response to norepinephrine stimulus	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of peptide hormone secretion	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of NLRP3 inflammasome complex assembly	Serine/threonine-protein kinase D1	Homo sapiens (human)
cellular response to angiotensin	Serine/threonine-protein kinase D1	Homo sapiens (human)
cellular response to phorbol 13-acetate 12-myristate	Serine/threonine-protein kinase D1	Homo sapiens (human)
cellular response to endothelin	Serine/threonine-protein kinase D1	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Serine/threonine-protein kinase D1	Homo sapiens (human)
regulation of integrin-mediated signaling pathway	Serine/threonine-protein kinase D1	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Serine/threonine-protein kinase D1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (54)

Process	via Protein(s)	Taxonomy
diacylglycerol-dependent serine/threonine kinase activity	Serine/threonine-protein kinase D3	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase D3	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase D3	Homo sapiens (human)
kinase activity	Serine/threonine-protein kinase D3	Homo sapiens (human)
metal ion binding	Serine/threonine-protein kinase D3	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase D3	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase D3	Homo sapiens (human)
protein kinase activity	Protein kinase C gamma type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C gamma type	Homo sapiens (human)
calcium,diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C gamma type	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Protein kinase C gamma type	Homo sapiens (human)
protein binding	Protein kinase C gamma type	Homo sapiens (human)
ATP binding	Protein kinase C gamma type	Homo sapiens (human)
zinc ion binding	Protein kinase C gamma type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C gamma type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C gamma type	Homo sapiens (human)
chromatin binding	Protein kinase C beta type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C beta type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C beta type	Homo sapiens (human)
protein kinase C binding	Protein kinase C beta type	Homo sapiens (human)
calcium channel regulator activity	Protein kinase C beta type	Homo sapiens (human)
protein binding	Protein kinase C beta type	Homo sapiens (human)
ATP binding	Protein kinase C beta type	Homo sapiens (human)
zinc ion binding	Protein kinase C beta type	Homo sapiens (human)
nuclear receptor coactivator activity	Protein kinase C beta type	Homo sapiens (human)
histone H3T6 kinase activity	Protein kinase C beta type	Homo sapiens (human)
histone binding	Protein kinase C beta type	Homo sapiens (human)
nuclear androgen receptor binding	Protein kinase C beta type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C beta type	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	DNA topoisomerase 1	Homo sapiens (human)
DNA binding	DNA topoisomerase 1	Homo sapiens (human)
chromatin binding	DNA topoisomerase 1	Homo sapiens (human)
double-stranded DNA binding	DNA topoisomerase 1	Homo sapiens (human)
single-stranded DNA binding	DNA topoisomerase 1	Homo sapiens (human)
RNA binding	DNA topoisomerase 1	Homo sapiens (human)
DNA topoisomerase type I (single strand cut, ATP-independent) activity	DNA topoisomerase 1	Homo sapiens (human)
protein serine/threonine kinase activity	DNA topoisomerase 1	Homo sapiens (human)
protein binding	DNA topoisomerase 1	Homo sapiens (human)
ATP binding	DNA topoisomerase 1	Homo sapiens (human)
DNA binding, bending	DNA topoisomerase 1	Homo sapiens (human)
protein domain specific binding	DNA topoisomerase 1	Homo sapiens (human)
supercoiled DNA binding	DNA topoisomerase 1	Homo sapiens (human)
magnesium ion binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
chromatin binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
RNA binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein kinase C binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
ATP binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
ATP-dependent activity, acting on DNA	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA binding, bending	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein homodimerization activity	DNA topoisomerase 2-alpha	Homo sapiens (human)
ubiquitin binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein heterodimerization activity	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein kinase activity	Protein kinase C alpha type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C alpha type	Homo sapiens (human)
calcium,diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C alpha type	Homo sapiens (human)
integrin binding	Protein kinase C alpha type	Homo sapiens (human)
protein binding	Protein kinase C alpha type	Homo sapiens (human)
ATP binding	Protein kinase C alpha type	Homo sapiens (human)
zinc ion binding	Protein kinase C alpha type	Homo sapiens (human)
enzyme binding	Protein kinase C alpha type	Homo sapiens (human)
histone H3T6 kinase activity	Protein kinase C alpha type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C alpha type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C alpha type	Homo sapiens (human)
diacylglycerol binding	Protein kinase C alpha type	Homo sapiens (human)
protein kinase activity	Protein kinase C eta type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C eta type	Homo sapiens (human)
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	Protein kinase C eta type	Homo sapiens (human)
protein binding	Protein kinase C eta type	Homo sapiens (human)
ATP binding	Protein kinase C eta type	Homo sapiens (human)
enzyme binding	Protein kinase C eta type	Homo sapiens (human)
small GTPase binding	Protein kinase C eta type	Homo sapiens (human)
metal ion binding	Protein kinase C eta type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C eta type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C eta type	Homo sapiens (human)
protein kinase activity	Protein kinase C iota type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C iota type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C iota type	Homo sapiens (human)
protein binding	Protein kinase C iota type	Homo sapiens (human)
ATP binding	Protein kinase C iota type	Homo sapiens (human)
phospholipid binding	Protein kinase C iota type	Homo sapiens (human)
metal ion binding	Protein kinase C iota type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C iota type	Homo sapiens (human)
actin monomer binding	Protein kinase C epsilon type	Homo sapiens (human)
protein kinase activity	Protein kinase C epsilon type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C epsilon type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C epsilon type	Homo sapiens (human)
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	Protein kinase C epsilon type	Homo sapiens (human)
protein binding	Protein kinase C epsilon type	Homo sapiens (human)
ATP binding	Protein kinase C epsilon type	Homo sapiens (human)
enzyme activator activity	Protein kinase C epsilon type	Homo sapiens (human)
enzyme binding	Protein kinase C epsilon type	Homo sapiens (human)
signaling receptor activator activity	Protein kinase C epsilon type	Homo sapiens (human)
ethanol binding	Protein kinase C epsilon type	Homo sapiens (human)
metal ion binding	Protein kinase C epsilon type	Homo sapiens (human)
14-3-3 protein binding	Protein kinase C epsilon type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C epsilon type	Homo sapiens (human)
DNA binding	DNA topoisomerase 2-beta	Homo sapiens (human)
chromatin binding	DNA topoisomerase 2-beta	Homo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	DNA topoisomerase 2-beta	Homo sapiens (human)
protein binding	DNA topoisomerase 2-beta	Homo sapiens (human)
ATP binding	DNA topoisomerase 2-beta	Homo sapiens (human)
ribonucleoprotein complex binding	DNA topoisomerase 2-beta	Homo sapiens (human)
metal ion binding	DNA topoisomerase 2-beta	Homo sapiens (human)
protein kinase activity	Protein kinase C theta type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C theta type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C theta type	Homo sapiens (human)
protein binding	Protein kinase C theta type	Homo sapiens (human)
ATP binding	Protein kinase C theta type	Homo sapiens (human)
metal ion binding	Protein kinase C theta type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C theta type	Homo sapiens (human)
protein kinase activity	Protein kinase C zeta type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C zeta type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C zeta type	Homo sapiens (human)
protein binding	Protein kinase C zeta type	Homo sapiens (human)
ATP binding	Protein kinase C zeta type	Homo sapiens (human)
potassium channel regulator activity	Protein kinase C zeta type	Homo sapiens (human)
protein kinase binding	Protein kinase C zeta type	Homo sapiens (human)
phospholipase binding	Protein kinase C zeta type	Homo sapiens (human)
insulin receptor substrate binding	Protein kinase C zeta type	Homo sapiens (human)
protein-containing complex binding	Protein kinase C zeta type	Homo sapiens (human)
metal ion binding	Protein kinase C zeta type	Homo sapiens (human)
14-3-3 protein binding	Protein kinase C zeta type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C zeta type	Homo sapiens (human)
protein kinase activity	Protein kinase C delta type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C delta type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C delta type	Homo sapiens (human)
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	Protein kinase C delta type	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Protein kinase C delta type	Homo sapiens (human)
protein binding	Protein kinase C delta type	Homo sapiens (human)
ATP binding	Protein kinase C delta type	Homo sapiens (human)
enzyme activator activity	Protein kinase C delta type	Homo sapiens (human)
enzyme binding	Protein kinase C delta type	Homo sapiens (human)
protein kinase binding	Protein kinase C delta type	Homo sapiens (human)
insulin receptor substrate binding	Protein kinase C delta type	Homo sapiens (human)
metal ion binding	Protein kinase C delta type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C delta type	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase D1	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Serine/threonine-protein kinase D1	Homo sapiens (human)
protein kinase C binding	Serine/threonine-protein kinase D1	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase D1	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase D1	Homo sapiens (human)
kinase activity	Serine/threonine-protein kinase D1	Homo sapiens (human)
heat shock protein binding	Serine/threonine-protein kinase D1	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase D1	Homo sapiens (human)
metal ion binding	Serine/threonine-protein kinase D1	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase D1	Homo sapiens (human)
phosphatidylinositol 3-kinase activator activity	Serine/threonine-protein kinase D1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (74)

Process	via Protein(s)	Taxonomy
nucleoplasm	Serine/threonine-protein kinase D3	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase D3	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase D3	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase D3	Homo sapiens (human)
nucleus	Protein kinase C gamma type	Homo sapiens (human)
cytosol	Protein kinase C gamma type	Homo sapiens (human)
plasma membrane	Protein kinase C gamma type	Homo sapiens (human)
cell-cell junction	Protein kinase C gamma type	Homo sapiens (human)
postsynaptic density	Protein kinase C gamma type	Homo sapiens (human)
dendrite	Protein kinase C gamma type	Homo sapiens (human)
calyx of Held	Protein kinase C gamma type	Homo sapiens (human)
perinuclear region of cytoplasm	Protein kinase C gamma type	Homo sapiens (human)
synaptic membrane	Protein kinase C gamma type	Homo sapiens (human)
presynaptic cytosol	Protein kinase C gamma type	Homo sapiens (human)
postsynaptic cytosol	Protein kinase C gamma type	Homo sapiens (human)
nucleus	Protein kinase C beta type	Homo sapiens (human)
nucleoplasm	Protein kinase C beta type	Homo sapiens (human)
cytoplasm	Protein kinase C beta type	Homo sapiens (human)
centrosome	Protein kinase C beta type	Homo sapiens (human)
cytosol	Protein kinase C beta type	Homo sapiens (human)
plasma membrane	Protein kinase C beta type	Homo sapiens (human)
brush border membrane	Protein kinase C beta type	Homo sapiens (human)
calyx of Held	Protein kinase C beta type	Homo sapiens (human)
extracellular exosome	Protein kinase C beta type	Homo sapiens (human)
presynaptic cytosol	Protein kinase C beta type	Homo sapiens (human)
spectrin	Protein kinase C beta type	Homo sapiens (human)
nuclear chromosome	DNA topoisomerase 1	Homo sapiens (human)
P-body	DNA topoisomerase 1	Homo sapiens (human)
fibrillar center	DNA topoisomerase 1	Homo sapiens (human)
male germ cell nucleus	DNA topoisomerase 1	Homo sapiens (human)
nucleus	DNA topoisomerase 1	Homo sapiens (human)
nucleoplasm	DNA topoisomerase 1	Homo sapiens (human)
nucleolus	DNA topoisomerase 1	Homo sapiens (human)
perikaryon	DNA topoisomerase 1	Homo sapiens (human)
protein-DNA complex	DNA topoisomerase 1	Homo sapiens (human)
nucleolus	DNA topoisomerase 1	Homo sapiens (human)
nucleolus	DNA topoisomerase 2-alpha	Homo sapiens (human)
nuclear chromosome	DNA topoisomerase 2-alpha	Homo sapiens (human)
centriole	DNA topoisomerase 2-alpha	Homo sapiens (human)
chromosome, centromeric region	DNA topoisomerase 2-alpha	Homo sapiens (human)
condensed chromosome	DNA topoisomerase 2-alpha	Homo sapiens (human)
male germ cell nucleus	DNA topoisomerase 2-alpha	Homo sapiens (human)
nucleus	DNA topoisomerase 2-alpha	Homo sapiens (human)
nucleoplasm	DNA topoisomerase 2-alpha	Homo sapiens (human)
nucleolus	DNA topoisomerase 2-alpha	Homo sapiens (human)
cytoplasm	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein-containing complex	DNA topoisomerase 2-alpha	Homo sapiens (human)
ribonucleoprotein complex	DNA topoisomerase 2-alpha	Homo sapiens (human)
nucleus	DNA topoisomerase 2-alpha	Homo sapiens (human)
ciliary basal body	Protein kinase C alpha type	Homo sapiens (human)
nucleoplasm	Protein kinase C alpha type	Homo sapiens (human)
cytoplasm	Protein kinase C alpha type	Homo sapiens (human)
mitochondrion	Protein kinase C alpha type	Homo sapiens (human)
endoplasmic reticulum	Protein kinase C alpha type	Homo sapiens (human)
cytosol	Protein kinase C alpha type	Homo sapiens (human)
plasma membrane	Protein kinase C alpha type	Homo sapiens (human)
mitochondrial membrane	Protein kinase C alpha type	Homo sapiens (human)
perinuclear region of cytoplasm	Protein kinase C alpha type	Homo sapiens (human)
extracellular exosome	Protein kinase C alpha type	Homo sapiens (human)
alphav-beta3 integrin-PKCalpha complex	Protein kinase C alpha type	Homo sapiens (human)
cytoplasm	Protein kinase C eta type	Homo sapiens (human)
cytosol	Protein kinase C eta type	Homo sapiens (human)
plasma membrane	Protein kinase C eta type	Homo sapiens (human)
cell-cell junction	Protein kinase C eta type	Homo sapiens (human)
extracellular exosome	Protein kinase C eta type	Homo sapiens (human)
Golgi membrane	Protein kinase C iota type	Homo sapiens (human)
nucleus	Protein kinase C iota type	Homo sapiens (human)
nucleoplasm	Protein kinase C iota type	Homo sapiens (human)
endosome	Protein kinase C iota type	Homo sapiens (human)
cytosol	Protein kinase C iota type	Homo sapiens (human)
plasma membrane	Protein kinase C iota type	Homo sapiens (human)
brush border	Protein kinase C iota type	Homo sapiens (human)
bicellular tight junction	Protein kinase C iota type	Homo sapiens (human)
microtubule cytoskeleton	Protein kinase C iota type	Homo sapiens (human)
apical plasma membrane	Protein kinase C iota type	Homo sapiens (human)
cell leading edge	Protein kinase C iota type	Homo sapiens (human)
Schmidt-Lanterman incisure	Protein kinase C iota type	Homo sapiens (human)
intercellular bridge	Protein kinase C iota type	Homo sapiens (human)
extracellular exosome	Protein kinase C iota type	Homo sapiens (human)
tight junction	Protein kinase C iota type	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Protein kinase C iota type	Homo sapiens (human)
glutamatergic synapse	Protein kinase C iota type	Homo sapiens (human)
PAR polarity complex	Protein kinase C iota type	Homo sapiens (human)
Golgi apparatus	Protein kinase C epsilon type	Homo sapiens (human)
nucleus	Protein kinase C epsilon type	Homo sapiens (human)
cytoplasm	Protein kinase C epsilon type	Homo sapiens (human)
mitochondrion	Protein kinase C epsilon type	Homo sapiens (human)
endoplasmic reticulum	Protein kinase C epsilon type	Homo sapiens (human)
cytosol	Protein kinase C epsilon type	Homo sapiens (human)
plasma membrane	Protein kinase C epsilon type	Homo sapiens (human)
intracellular membrane-bounded organelle	Protein kinase C epsilon type	Homo sapiens (human)
intermediate filament cytoskeleton	Protein kinase C epsilon type	Homo sapiens (human)
synapse	Protein kinase C epsilon type	Homo sapiens (human)
perinuclear region of cytoplasm	Protein kinase C epsilon type	Homo sapiens (human)
cell periphery	Protein kinase C epsilon type	Homo sapiens (human)
nucleolus	DNA topoisomerase 2-beta	Homo sapiens (human)
heterochromatin	DNA topoisomerase 2-beta	Homo sapiens (human)
nucleus	DNA topoisomerase 2-beta	Homo sapiens (human)
nucleoplasm	DNA topoisomerase 2-beta	Homo sapiens (human)
nucleolus	DNA topoisomerase 2-beta	Homo sapiens (human)
cytosol	DNA topoisomerase 2-beta	Homo sapiens (human)
ribonucleoprotein complex	DNA topoisomerase 2-beta	Homo sapiens (human)
nucleus	DNA topoisomerase 2-beta	Homo sapiens (human)
immunological synapse	Protein kinase C theta type	Homo sapiens (human)
cytosol	Protein kinase C theta type	Homo sapiens (human)
plasma membrane	Protein kinase C theta type	Homo sapiens (human)
aggresome	Protein kinase C theta type	Homo sapiens (human)
centriolar satellite	Protein kinase C theta type	Homo sapiens (human)
stress fiber	Protein kinase C zeta type	Homo sapiens (human)
nuclear envelope	Protein kinase C zeta type	Homo sapiens (human)
cytoplasm	Protein kinase C zeta type	Homo sapiens (human)
endosome	Protein kinase C zeta type	Homo sapiens (human)
microtubule organizing center	Protein kinase C zeta type	Homo sapiens (human)
cytosol	Protein kinase C zeta type	Homo sapiens (human)
plasma membrane	Protein kinase C zeta type	Homo sapiens (human)
cell-cell junction	Protein kinase C zeta type	Homo sapiens (human)
bicellular tight junction	Protein kinase C zeta type	Homo sapiens (human)
postsynaptic density	Protein kinase C zeta type	Homo sapiens (human)
membrane	Protein kinase C zeta type	Homo sapiens (human)
apical plasma membrane	Protein kinase C zeta type	Homo sapiens (human)
nuclear matrix	Protein kinase C zeta type	Homo sapiens (human)
cell junction	Protein kinase C zeta type	Homo sapiens (human)
cell leading edge	Protein kinase C zeta type	Homo sapiens (human)
vesicle	Protein kinase C zeta type	Homo sapiens (human)
myelin sheath abaxonal region	Protein kinase C zeta type	Homo sapiens (human)
axon hillock	Protein kinase C zeta type	Homo sapiens (human)
apical cortex	Protein kinase C zeta type	Homo sapiens (human)
perinuclear region of cytoplasm	Protein kinase C zeta type	Homo sapiens (human)
extracellular exosome	Protein kinase C zeta type	Homo sapiens (human)
tight junction	Protein kinase C zeta type	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Protein kinase C zeta type	Homo sapiens (human)
glutamatergic synapse	Protein kinase C zeta type	Homo sapiens (human)
PAR polarity complex	Protein kinase C zeta type	Homo sapiens (human)
extracellular region	Protein kinase C delta type	Homo sapiens (human)
nucleus	Protein kinase C delta type	Homo sapiens (human)
nucleoplasm	Protein kinase C delta type	Homo sapiens (human)
cytoplasm	Protein kinase C delta type	Homo sapiens (human)
mitochondrion	Protein kinase C delta type	Homo sapiens (human)
endoplasmic reticulum	Protein kinase C delta type	Homo sapiens (human)
cytosol	Protein kinase C delta type	Homo sapiens (human)
plasma membrane	Protein kinase C delta type	Homo sapiens (human)
cell-cell junction	Protein kinase C delta type	Homo sapiens (human)
nuclear matrix	Protein kinase C delta type	Homo sapiens (human)
azurophil granule lumen	Protein kinase C delta type	Homo sapiens (human)
endolysosome	Protein kinase C delta type	Homo sapiens (human)
perinuclear region of cytoplasm	Protein kinase C delta type	Homo sapiens (human)
extracellular exosome	Protein kinase C delta type	Homo sapiens (human)
autophagosome membrane	Serine/threonine-protein kinase D1	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase D1	Homo sapiens (human)
trans-Golgi network	Serine/threonine-protein kinase D1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase D1	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase D1	Homo sapiens (human)
cell-cell junction	Serine/threonine-protein kinase D1	Homo sapiens (human)
cell cortex	Serine/threonine-protein kinase D1	Homo sapiens (human)
Z disc	Serine/threonine-protein kinase D1	Homo sapiens (human)
perinuclear region of cytoplasm	Serine/threonine-protein kinase D1	Homo sapiens (human)
Golgi apparatus	Serine/threonine-protein kinase D1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase D1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (71)

Assay ID	Title	Year	Journal	Article
AID40215	Antimicrobial activity on Bacillus cereus	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID247972	In vitro antiproliferative activity against murine leukemia L1210 cells	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.
AID164640	Inhibition of Protein Kinase A (PKA).	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID135924	Antitumor activity against mice with B16 melanoma was assessed from the ratio of median survival time of treated animals (T) to controls animals, at 64 mg/Kg	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID40213	Antimicrobial activity against Bacillus cereus	1997	Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21	Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
AID210944	Inhibition of calf thymus Topoisomerase-I	1997	Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21	Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
AID361673	Anticancer activity against human K562 cells	2008	Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16	A concise approach to 1,11-didechloro-6-methyl-4'-O-demethyl rebeccamycin and its binding to human serum albumin: fluorescence spectroscopy and molecular modeling method.
AID163166	Inhibition of Protein kinase C alpha	1997	Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21	Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
AID139421	In vivo efficacy study on mice with P388 Leukemia Cells determined after administration of 2 mg/kg/day dosage	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID155030	Compound was tested for drug bound to cell pellet (P388 leukemia) after centrifugation at 320 nm.	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID152986	Ratio of IC50 of p388 and p388CPT5 cell lines	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID209054	Antimicrobial activity against gram-positive Streptococcus chartreusis NRRL 11407 was determined by antibiogram test.++ means growth inhibition zone was 8-9 mm.	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID139418	In vivo efficacy study on mice with B16 Melanoma cells determined after administration of 2 mg/kg/day dosage	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID57052	Inhibitory activity towards Topoisomerase 2 from calf thymus	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID56700	Inhibitory activity towards Topoisomerase 1 from calf thymus.	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID235711	Selectivity was measured [Selectivity = (CC50/IC50) against HIV-1 infected CEM-SS cells]	1998	Journal of medicinal chemistry, May-07, Volume: 41, Issue:10	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
AID154139	In vitro inhibitory concentration against murine P388CPT5 leukemia cell proliferation	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID247635	Inhibitory concentration against K5662 leukemia cell line in MTS assay	2005	Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7	Syntheses and biological activities of rebeccamycin analogues with uncommon sugars.
AID39123	Inhibition of murine B16 Melanoma cell proliferation	1997	Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21	Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
AID8281	Antiproliferative activity in vitro against A549 (human non-small lung carcinoma) cell line.	2002	Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6	Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens.
AID235560	Selectivity Index (SI) refers to the ratio of the anti HIV activities CC50/IC50 in HIV-1 Lai infected CEM-SS cells.	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID45186	The cytotoxicity was evaluated in in HIV -I Lai infected CEM-SS cells.	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID45177	Cytotoxicity against HIV-1 Lai infected CEM-SS cells	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID39106	Antiproliferative activity against B16 mouse melanoma cells	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID208030	In Vitro growth inhibitory effect of compounds against Gram-Positive Bacteria Streptomyces chartreusis NRRL11407	1998	Journal of medicinal chemistry, May-07, Volume: 41, Issue:10	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
AID46218	Cytotoxic concentration is tested against CEM-SS cells	1998	Journal of medicinal chemistry, May-07, Volume: 41, Issue:10	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
AID40214	Antimicrobial activity is tested against Bacillus cereus	1998	Journal of medicinal chemistry, May-07, Volume: 41, Issue:10	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
AID165270	Inhibition of protein kinase C (PKC)	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID139417	In vivo efficacy study on mice with B16 Melanoma cells determined after administration of 16 mg/kg/day dosage	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID38066	Antiproliferative activity measured against murine B16 melanoma cells	1998	Journal of medicinal chemistry, May-07, Volume: 41, Issue:10	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
AID150379	Antiproliferative activity against P388 Murine Leukemia cells	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID494538	Cytotoxicity activity against human DU145 cells by MTT assay	2010	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15	Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents.
AID152507	Compound was tested for drug bound to whole cells (P388 leukemia) before centrifugation at 320 nm.	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID96457	Antiproliferative activity tested in vitro against L1210 (murine leukemia) cell line.	2002	Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6	Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens.
AID95647	Antiproliferative activity in vitro against K-562 (human leukemia) cell line.	2002	Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6	Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens.
AID211126	Inhibition of calf thymus Topoisomerase-2	1997	Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21	Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
AID135923	Antitumor activity against mice with B16 melanoma was assessed from the ratio of median survival time of treated animals (T) to controls animals, at 2 mg/Kg	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID150511	Cytotoxicity against P388 leukemia cells	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID135925	Antitumor activity against mice with P388 leukemia cell was assessed from the ratio of median survival time of treated animals (T) to controls animals, at 16 mg/Kg	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID135926	Antitumor activity against mice with P388 leukemia cell was assessed from the ratio of median survival time of treated animals (T) to controls animals, at 2 mg/Kg	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID40204	Antimicrobial activity against gram-positive Bacillus cereusATCC 14579 was determined by antibiogram test.++ means growth inhibition zone was 8-9 mm.	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID211110	Compound was tested for anti microbial activity against topoisomerase I.	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID153542	Cytotoxicity against P388/CPT5 leukemia cells.	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID165134	Inhibition of Protein Kinase C(PKC)	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID46072	Selective Index of against HIV -I Lai infected CEM-SS cells.	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID135922	Antitumor activity against mice with B16 melanoma was assessed from the ratio of median survival time of treated animals (T) to controls animals, at 16 mg/Kg	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID154138	Antiproliferative activity measured against P388CPT5 cells resistant to Topoisomerase I inhibitor Camptothecin	1998	Journal of medicinal chemistry, May-07, Volume: 41, Issue:10	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
AID55322	Variation in melting temperature (delta Tm) of helix-to-coil transition of DNA was reported.	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID155031	Fraction change in percent is observed.	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID361672	Anticancer activity against human SW620 cells	2008	Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16	A concise approach to 1,11-didechloro-6-methyl-4'-O-demethyl rebeccamycin and its binding to human serum albumin: fluorescence spectroscopy and molecular modeling method.
AID135927	Antitumor activity against mice with P388 leukemia cell was assessed from the ratio of median survival time of treated animals (T) to controls animals, at 64 mg/Kg	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID247867	Inhibitory concentration against SW620 colorectal carcinoma cell line in MTS assay	2005	Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7	Syntheses and biological activities of rebeccamycin analogues with uncommon sugars.
AID494537	Cytotoxicity activity against mouse L1210 cells by MTT assay	2010	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15	Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents.
AID151244	Antiproliferative activity measured against P388 Leukemia cells	1998	Journal of medicinal chemistry, May-07, Volume: 41, Issue:10	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
AID40327	Minimum inhibitory concentration against gram-positive Bacillus cereus	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID56701	Minimum inhibitory concentration against DNA topoisomerase I	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID235100	Resistance Index (RI) refers to the ratio of the [IC50 (P388/CPT5)] / IC50 P388.	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID139420	In vivo efficacy study on mice with P388 Leukemia Cells determined after administration of 16 mg/kg/day dosage	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID211093	Inhibition of human Topoisomerase I	1998	Journal of medicinal chemistry, May-07, Volume: 41, Issue:10	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
AID150657	In vitro inhibitory concentration against murine P388 leukemia cell proliferation	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID40208	In Vitro growth inhibitory effect of compounds against Gram-Positive Bacteria Bacillus cereus ATCC 14579	1998	Journal of medicinal chemistry, May-07, Volume: 41, Issue:10	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
AID40318	Compound was tested for antimicrobial activity against a gram-positive bacterium Bacillus cereus	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID150519	Inhibition of P388 murine leukemia cell proliferation	1997	Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21	Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
AID84287	Antiproliferative activity in vitro against HT-29 (human colon carcinoma) cell line.	2002	Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6	Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens.
AID248432	In vitro antiproliferative activity against human prostate cancer DU145 cells; not determined	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.
AID248062	In vitro antiproliferative activity against human colon carcinoma HT-29 cells	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.
AID45880	Anti-HIV-1 activity in CEM-SS cells was measured by the quantification of the reverse transcriptase activity, associated with the virus particles released from HIV-1 infected cells in the culture medium.	1999	Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
AID46452	Inhibitory concentration is tested in HIV-1 Lai-infected CEM-SS cells	1998	Journal of medicinal chemistry, May-07, Volume: 41, Issue:10	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
AID45899	Compound was tested for anti-HIV activity in HIV -I Lai infected CEM-SS cells.	1999	Journal of medicinal chemistry, May-20, Volume: 42, Issue:10	Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
AID139422	In vivo efficacy study on mice with P388 Leukemia Cells determined after administration of 64 mg/kg/day dosage	1996	Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
AID96451	Effect on the cell cycle of L1210 cells and expressed as percent of L1210 cells in G2+M phases at 1 uM concentration	2002	Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6	Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (1.08)	18.7374
1990's	16 (17.20)	18.2507
2000's	56 (60.22)	29.6817
2010's	16 (17.20)	24.3611
2020's	4 (4.30)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	5 (5.10%)	5.53%
Reviews	6 (6.12%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	87 (88.78%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	7	1	0	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
imidazole imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.	2.03	1	0	imidazole
indol-3-yl pyruvic acid 3-(indol-3-yl)pyruvic acid : A 2-oxo monocarboxylic acid that is pyruvic acid substituted by a 1H-indol-3-yl group at position 3. It has been found in Lycopersicon esculentum	1.97	1	0	2-oxo monocarboxylic acid; indol-3-yl carboxylic acid	plant metabolite; Saccharomyces cerevisiae metabolite
propylene glycol Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.. propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.	2.05	1	0	glycol; propane-1,2-diols	allergen; human xenobiotic metabolite; mouse metabolite; protic solvent
pyridine azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.	7.03	1	0	azaarene; mancude organic heteromonocyclic parent; monocyclic heteroarene; pyridines	environmental contaminant; NMR chemical shift reference compound
cetyl alcohol cetyl alcohol: has been used for eczema, skin irritations; RN given refers to parent cpd; structure. hexadecanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of sixteen carbon atoms.. hexadecan-1-ol : A long-chain primary fatty alcohol that is hexadecane substituted by a hydroxy group at position 1.	2.17	1	0	hexadecanol; long-chain primary fatty alcohol	algal metabolite; flavouring agent; human metabolite; plant metabolite
staurosporine aglycone staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor	2.93	4	0
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	1.97	1	0	mitomycin	alkylating agent; antineoplastic agent
serine Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	2	1	0	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2	1	0	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	8.12	5	0	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
carbazole carbazole: structure in first source	2.42	2	0	carbazole
quinoxalines quinoxaline : A naphthyridine in which the nitrogens are at positions 1 and 4.	2	1	0	mancude organic heterobicyclic parent; naphthyridine; ortho-fused heteroarene
carvone carvone: an oxidized derivative of limonene; RN given refers to cpd without isomeric designation; L-carvone has spearmint flavor, D-carvone has dill/caraway flavor. carvone : A p-menthane monoterpenoid that consists of cyclohex-2-enone having methyl and isopropenyl substituents at positions 2 and 5, respectively.	2.17	1	0	botanical anti-fungal agent; carvones	allergen
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	2.76	3	0	pyrrole; secondary amine
tetrahydrofuran oxolane : A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.	2.17	1	0	cyclic ether; oxolanes; saturated organic heteromonocyclic parent; volatile organic compound	polar aprotic solvent
thiazoles [no description available]	2.17	1	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
violacein [no description available]	2.44	2	0
pyrrolnitrin Pyrrolnitrin: 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole. Antifungal antibiotic isolated from Pseudomonas pyrrocinia. It is effective mainly against Trichophyton, Microsporium, Epidermophyton, and Penicillium.. pyrrolnitrin : A member of the class of pyrroles carrying chloro and 3-chloro-2-nitrophenyl substituents at positions 3 and 4 respectively.	2.17	1	0	alkaloid; C-nitro compound; monochlorobenzenes; pyrroles	antifungal drug; bacterial metabolite
tetrabutylammonium tetrabutylammonium: lipophilic probe; RN given refers to parent cpd	2.01	1	0	quaternary ammonium ion
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.91	4	0	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	2.01	1	0	diatomic chlorine; gas molecular entity	bleaching agent
daunorubicin Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.	2.44	2	0	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	6.44	7	2	D-glucopyranose	epitope; mouse metabolite
becatecarin becatecarin: a rebeccamycin deriviative	5.98	4	2
tryptoline tryptoline: neurotoxic factor that may be involved in development of Parkinson's disease; enzymatic prep from human brain converts tryptamine to tryptoline; RN given refers to parent cpd; structure	2.06	1	0	beta-carbolines
indolo(3,2-b)carbazole indolo(3,2-b)carbazole: potent inducer of cytochrome P-4501A1-dependent monooxygenase	2.01	1	0
at 2433-b1 AT 2433-B1: indolocarbazole from Actinomadura melliaura; iso-AT2433-B1 is a diastereoisomer; structure in first source	2.11	1	0
s-adenosylhomocysteine S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.. S-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine.	2.04	1	0	adenosines; amino acid zwitterion; homocysteine derivative; homocysteines; organic sulfide	cofactor; EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor; EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor; epitope; fundamental metabolite
1,5-dihydro-fad 1,5-dihydro-FAD: chromophore component of E coli DNA photolyase	2.02	1	0	flavin adenine dinucleotide	Escherichia coli metabolite; mouse metabolite
glycosides [no description available]	1.97	1	0
flavin-adenine dinucleotide Flavin-Adenine Dinucleotide: A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)	2.95	4	0	flavin adenine dinucleotide; vitamin B2	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; prosthetic group
7-deoxy-13-dihydroadriamycinone 7-deoxy-13-dihydroadriamycinone: a metabolite of epidoxorubicin	2.02	1	0
7-chlorotryptophan 7-chlorotryptophan: RN given refers to (DL)-isomer. 7-chloro-L-tryptophan : An L-tryptophan derivative having a chloro substituent at the 7-position.. 7-chlorotryptophan : A tryptophan derivative having a chloro substituent at the 7-position of the indole ring.	7.43	2	0	7-chlorotryptophan; amino acid zwitterion; L-tryptophan derivative; non-proteinogenic L-alpha-amino acid
arcyriaflavin a arcyriaflavin A: from marine ascidian, Eudistoma sp.; structure given in first source	2.72	3	0	indolocarbazole
staurosporine staurosporinium : Conjugate acid of staurosporine.	5.58	13	0	ammonium ion derivative
nb 506 NB 506: an indolocarbazole antitumor agent; structure given in first source; a DNA topoisomerase I inhibitor	2.4	2	0
tjipanazole d tjipanazole D: isolated from Fischerella ambigua; structure in first source	2.02	1	0
chromopyrrolic acid chromopyrrolic acid: structure in first source. chromopyrrolic acid : A pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups.	7.11	1	0	indoles; pyrroledicarboxylic acid	bacterial metabolite
barbamide barbamide: from the marine Carribean cyanobacterium Lyngbya majuscula; structure in first source	2.17	1	0	fatty amide
calcimycin Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.	1.98	1	0	benzoxazole
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	2.03	1	0	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
oligonucleotides [no description available]	7	1	0
s-adenosylmethionine (R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.	2.03	1	0	organic cation; sulfonium compound	coenzyme; cofactor; human metabolite; micronutrient; Mycoplasma genitalium metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
pacidamycin d pacidamycin D: isolated from the fermentation broth of the Streptomyces coeruleorubiduns strain; structure in first source	2.17	1	0
isogranulatimide isogranulatimide: G2 checkpoint inhibitor; structure in first source	2.03	1	0
goadsporin goadsporin: structure in first source	3.14	1	0

Condition	Relationship Strength	Studies	Trials
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	2.9	4	0
Carcinoma, Non-Small Cell Lung [description not available]	3.81	2	1
Leukemia L 1210 [description not available]	2.68	3	0
Cancer of Lung [description not available]	4.67	3	2
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	3.81	2	1
Lung Neoplasms Tumors or cancer of the LUNG.	4.67	3	2
Leucocythaemia [description not available]	2.43	2	0
Cancer of Prostate [description not available]	2.05	1	0
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	2.43	2	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.05	1	0
ER-Negative PR-Negative HER2-Negative Breast Cancer [description not available]	2.41	1	0
Triple Negative Breast Neoplasms Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.	2.41	1	0
Bladder Cancer [description not available]	7.6	1	0
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.6	1	0
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	2.11	1	0
Carcinoma, Oat Cell [description not available]	3.46	1	1
Local Neoplasm Recurrence [description not available]	3.46	1	1
Carcinoma, Small Cell An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)	3.46	1	1
Cancer of Ovary [description not available]	2.07	1	0
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.07	1	0
Disease Exacerbation [description not available]	3.81	2	1
Benign Neoplasms [description not available]	3.33	2	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.33	2	0
Adenocarcinoma Of Kidney [description not available]	3.4	1	1
Cancer of Kidney [description not available]	3.4	1	1
Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	3.4	1	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	3.4	1	1
Benign Meningeal Neoplasms [description not available]	2.02	1	0
Meningeal Neoplasms Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.	2.02	1	0
Breast Cancer [description not available]	8.42	1	1
Breast Neoplasms Tumors or cancer of the human BREAST.	3.42	1	1
Hematologic Malignancies [description not available]	8.43	1	1
Bacterial Disease [description not available]	3.43	1	1
Viral Diseases [description not available]	3.43	1	1
Bacterial Infections Infections by bacteria, general or unspecified.	3.43	1	1
Virus Diseases A general term for diseases caused by viruses.	3.43	1	1
Hematologic Neoplasms Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.	3.43	1	1
Experimental Leukemia [description not available]	2	1	0
Adenocarcinoma, Basal Cell [description not available]	1.97	1	0
B16 Melanoma [description not available]	1.97	1	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1.97	1	0

rebeccamycin

Description

Cross-References

Synonyms (30)

Research Excerpts

Overview

Pharmacokinetics

Compound-Compound Interactions

Dosage Studied

Drug Classes (4)

Pathways (1)

Protein Targets (14)

Inhibition Measurements

Other Measurements

Biological Processes (264)

Molecular Functions (54)

Ceullar Components (74)

Bioassays (71)

Research

Studies (93)

Market Indicators

Research Demand Index: 27.13

Study Types

rebeccamycin

Description

Cross-References

Synonyms (30)

Research Excerpts

Overview

Pharmacokinetics

Compound-Compound Interactions

Dosage Studied

Drug Classes (4)

Pathways (1)

Protein Targets (14)

Inhibition Measurements

Other Measurements

Biological Processes (264)

Molecular Functions (54)

Ceullar Components (74)

Bioassays (71)

Research

Studies (93)

Market Indicators

Research Demand Index: 27.13

Study Types

Related Drugs (47)

Related Conditions (41)