methylphosphonothiolate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	197063
CHEMBL ID	122577
CHEBI ID	187906
SCHEMBL ID	26114
MeSH ID	M0146428

Synonyms (15)

Synonym
brn 2345158
phosphonothioic acid, methyl-
methylphosphonothioic acid
methylphosphonothiolate
bdbm50131869
CHEMBL122577 ,
methyl-phosphonothioic acid
dihydroxy-methyl-sulanylidene-lambda5-phosphane
CHEBI:187906
5994-73-0
methanephosphonothioic acid
AKOS006277926
SCHEMBL26114
DTXSID70208652
dihydroxy-methyl-sulfanylidene-lambda5-phosphane

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
organothiophosphorus compound	An organothiophosphorus compound is an organophosphorus compound which contains a phosphorus-sulfur bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (2)

Process	via Protein(s)	Taxonomy
dephosphorylation	Alkaline phosphatase, germ cell type	Homo sapiens (human)
defense response	Protein tyrosine phosphatase receptor type C-associated protein	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Process	via Protein(s)	Taxonomy
alkaline phosphatase activity	Alkaline phosphatase, germ cell type	Homo sapiens (human)
metal ion binding	Alkaline phosphatase, germ cell type	Homo sapiens (human)
protein binding	Protein tyrosine phosphatase receptor type C-associated protein	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Process	via Protein(s)	Taxonomy
extracellular region	Alkaline phosphatase, germ cell type	Homo sapiens (human)
plasma membrane	Alkaline phosphatase, germ cell type	Homo sapiens (human)
side of membrane	Alkaline phosphatase, germ cell type	Homo sapiens (human)
plasma membrane	Alkaline phosphatase, germ cell type	Homo sapiens (human)
plasma membrane	Protein tyrosine phosphatase receptor type C-associated protein	Homo sapiens (human)
plasma membrane	Protein tyrosine phosphatase receptor type C-associated protein	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID164683	Inhibitory activity against Serine/Threonine Protein phosphatase 2C (PP2C)	2003	Journal of medicinal chemistry, Aug-14, Volume: 46, Issue:17	A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors.
AID213547	Inhibitory activity against Tyrosine phosphatase from Yersinia (Yop protein)	2003	Journal of medicinal chemistry, Aug-14, Volume: 46, Issue:17	A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors.
AID32833	Inhibitory activity against Escherichia coli Alkaline Phosphatase; no inhibition	2003	Journal of medicinal chemistry, Aug-14, Volume: 46, Issue:17	A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors.
AID159822	Inhibition of Human Placental alkaline Phosphatase (PLAP)	2003	Journal of medicinal chemistry, Aug-14, Volume: 46, Issue:17	A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors.
AID99563	Inhibitory activity against Serine/Threonine Protein Phosphatase (Lambda protein phosphatase)	2003	Journal of medicinal chemistry, Aug-14, Volume: 46, Issue:17	A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (37.50)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (50.00)	29.6817
2010's	1 (12.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.76 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.06 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.76)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbachol Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.	1.97	1	ammonium salt; carbamate ester	cardiotonic drug; miotic; muscarinic agonist; nicotinic acetylcholine receptor agonist; non-narcotic analgesic
tabun tabun: proposed as military nerve gas and exptl cholinesterase inhibitor; extremely poisonous; structure	2.05	1
soman Soman: An organophosphorus compound that inhibits cholinesterase. It causes seizures and has been used as a chemical warfare agent.	2.05	1	phosphonic ester
sarin Sarin: An organophosphorus ester compound that produces potent and irreversible inhibition of cholinesterase. It is toxic to the nervous system and is a chemical warfare agent.. isopropyl methylphosphonofluoridate : A phosphinic ester that is the isopropyl ester of methylphosphonofluoridic acid.. sarin : A racemate composed of equal amounts of (R)- and (S)-sarin. A potent and irreversible inhibitor of acetylcholinesterase that is toxic to the nervous system and is employed as a chemical warfare agent.	2.05	1	fluorine molecular entity; phosphinic ester
phenylphosphate phenylphosphate: structure given in first source. phenyl phosphate : An aryl phosphate resulting from the mono-esterification of phosphoric acid with phenol.	2.01	1	aryl phosphate	mouse metabolite
methylphosphonic acid methylphosphonic acid : A one-carbon compound that is phosphonic acid in which the hydrogen attached to the phosphorus is substituted by a methyl group.	2.01	1	one-carbon compound; phosphonic acids
vx VX nerve agent : A organic thiophosphate that is the ethyl ester of S-{2-[di(propan-2-yl)amino]ethyl} O hydrogen methylphosphonothioate. A toxic nerve agent used in chemical warfare.	7	1	organic thiophosphate; tertiary amino compound	EC 3.1.1.7 (acetylcholinesterase) inhibitor; neurotoxin
cyclohexyl methylphosphonofluoridate cyclohexyl methylphosphonofluoridate: acetylcholinesterase inhibitor	2.05	1
benzylphosphonic acid [no description available]	2.01	1	benzenes
oligonucleotides [no description available]	2.21	1
cyclic gmp Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed). 3',5'-cyclic GMP : A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.	1.97	1	3',5'-cyclic purine nucleotide; guanyl ribonucleotide	Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite

Condition	Relationship Strength	Studies
Becker Muscular Dystrophy [description not available]	2.21	1
Adult Spinal Muscular Atrophy [description not available]	2.21	1
Muscular Atrophy, Spinal A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)	2.21	1
Muscular Dystrophy, Duchenne An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)	2.21	1
Cancer of Ovary [description not available]	2.01	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.01	1
Arrhythmia [description not available]	2.37	2
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	2.37	2

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