| Assay ID | Title | Year | Journal | Article |
|---|
| AID234527 | Selectivity of trypsin compared to tryptase | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9
| Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID75209 | Effect (decrease in dynamic lung compliance) on pulmonary mechanics of ovalbumin-sensitized guinea pigs following allergen induced bronchoconstriction upon intratracheal dosage of 75 ug/kg 10 min prior to ovalbumin challenge | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID91664 | In vitro inhibition of human tryptase. | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID233108 | Selectivity for human tryptase compared to human urokinase plasminogen activator. | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID1384601 | Antithrombotic activity in rabbit model of venous thrombosis | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Factor XIa Inhibitors as New Anticoagulants. |
| AID233106 | Selectivity for human tryptase compared to human tissue plasminogen activator tissue. | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID213382 | Inhibitory concentration against human tryptase | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis of potent and highly selective inhibitors of human tryptase. |
| AID547678 | Inhibition of human Tryptase | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12
| 2-Azetidinone--a new profile of various pharmacological activities. |
| AID1384598 | Inhibition of human lung tryptase using Z-glypro-arg-AMC incubated for 3 mins by spectrophotometry | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Factor XIa Inhibitors as New Anticoagulants. |
| AID158331 | Inhibitory activity against plasmin | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9
| Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID1074166 | Irreversible inhibition of human factor 11a | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors. |
| AID233105 | Selectivity for human tryptase compared to human thrombin. | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID24273 | Aqueous stability was evaluated as half life at 37 degree C at pH 9 | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis of potent and highly selective inhibitors of human tryptase. |
| AID232622 | Ratio of inhibitory activities against human tryptase to that of human urokinase plasminogen activator (microPa) | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis of potent and highly selective inhibitors of human tryptase. |
| AID213372 | Inhibitory activity against human tryptase | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9
| Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID77517 | Effect (increase in lung resistance (Rlung)) on pulmonary mechanics of ovalbumin-sensitized guinea pigs following allergen induced bronchoconstriction | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID232621 | Ratio of inhibitory activities against human tryptase to that of human trypsin | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis of potent and highly selective inhibitors of human tryptase. |
| AID24272 | Aqueous stability was evaluated as half life at 37 degree C at pH 7 | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis of potent and highly selective inhibitors of human tryptase. |
| AID232618 | Ratio of inhibitory activities against human tryptase to that of human plasmin | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis of potent and highly selective inhibitors of human tryptase. |
| AID213436 | Inhibitory activity against Urokinase-type plasminogen activator | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9
| Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID77518 | Effect (increase in lung resistance (Rlung)) on pulmonary mechanics of ovalbumin-sensitized guinea pigs following allergen induced bronchoconstriction upon intratracheal dosage of 75 ug/kg 10 min prior to ovalbumin challenge | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID52005 | Inhibitory activity against Coagulation factor X | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9
| Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID24271 | Aqueous Stability (half-life period) at pH 9 and 37 degrees | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID211916 | Inhibitory activity against thrombin | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9
| Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID24270 | Aqueous Stability (half-life period) at pH 7 and 37 degrees | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID213371 | Inhibitory activity of compound against human tryptase was determined | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9
| Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase. |
| AID232620 | Ratio of inhibitory activities against human tryptase to that of human tissue plasminogen activator (tissue plasminogen activator) | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis of potent and highly selective inhibitors of human tryptase. |
| AID1384602 | Antithrombotic activity in rabbit model of electrolytic-mediated carotid arterial thrombosis | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Factor XIa Inhibitors as New Anticoagulants. |
| AID233107 | Selectivity for human tryptase compared to human trypsin. | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID215727 | Inhibitory activity against trypsin | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9
| Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID75208 | Effect (decrease in dynamic lung compliance) on pulmonary mechanics of ovalbumin-sensitized guinea pigs following allergen induced bronchoconstriction | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID233104 | Selectivity for human tryptase compared to human plasmin. | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID1384599 | Inhibition of trypsin (unknown origin) using Chromozyme-TRY substrate incubated for 3 mins by spectrophotometry | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Factor XIa Inhibitors as New Anticoagulants. |
| AID1384600 | Antithrombotic activity in rabbit model of arteriovenous-shunt thrombosis | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Factor XIa Inhibitors as New Anticoagulants. |
| AID210912 | Inhibitory activity against tissue type plasminogen activator | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9
| Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID232619 | Ratio of inhibitory activities against human tryptase to that of human thrombin | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis of potent and highly selective inhibitors of human tryptase. |
| AID75653 | Dose required for the inhibition of the cellular inflammatory response in ovalbumin-sensitized guinea pigs was evaluated by the reduction in cell count by 70-80% | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID214871 | Inhibitory activity against bovine trypsin | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9
| Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. |
| AID1384597 | Inhibition of human factor 11a using S-2366 substrate incubated for 3 mins by spectrophotometry | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Factor XIa Inhibitors as New Anticoagulants. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |