| Assay ID | Title | Year | Journal | Article |
|---|
| AID95665 | The compound was tested for tumor cell growth inhibitory activity against human nasopharynx carcinoma(KB) cell line. | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13
| Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles. |
| AID202816 | The compound was tested for tumor cell growth inhibitory activity against human melanoma (SKMEL-2) cell line. | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13
| Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles. |
| AID103730 | The compound was tested for tumor cell growth inhibitory activity against human breast cancer (MCF-7) cell line. | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13
| Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles. |
| AID96033 | The compound was tested for cytotoxic activity against KB cell line by clonogenic cell survival assay. | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13
| Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles. |
| AID80116 | Inhibitory activity against human cytomegalovirus (HCMV) | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents. |
| AID94331 | Growth inhibitory activity (antiproliferative) against KB/7d cell lines | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors. |
| AID1760332 | Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020). |
| AID84364 | Effective dose of compound against replication of HOS cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| AID1760331 | Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020). |
| AID246896 | Dose required for reduction in human nasopharyngeal KB-7d cancer cells after 3 days incubation | 2004 | Journal of medicinal chemistry, Oct-07, Volume: 47, Issue:21
| Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives. |
| AID201790 | Effective dose of compound against replication of SK-MEL-2 cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| AID78815 | Effective dose of compound against replication of HCT-8 cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| AID53300 | Inhibition of human DNA Topoisomerase II | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 124. New 4 beta-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID52062 | Compound was tested for the % complex formation of cellular protein -DNA complex at a concentration of 10 uM | 1991 | Journal of medicinal chemistry, Dec, Volume: 34, Issue:12
| Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID211317 | Stimulation of in vitro Topoisomerase II-Linked DNA Complex Formation and Interference with Etoposide-Induced Cleavage at concentration 100 uM; Not determined | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors. |
| AID2963 | Effective dose of compound against replication of 1A9 cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| AID8466 | Effective dose of compound against replication of A549 cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| AID667142 | Cytotoxicity against human DU145 cells by SRB assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of novel podophyllotoxin analogs. |
| AID96387 | Compound was tested for the concentration to afford 50% reduction in KB cell number after a 3-day incubation | 1991 | Journal of medicinal chemistry, Dec, Volume: 34, Issue:12
| Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID156027 | Effective dose of compound against replication of PC-3 cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| AID492486 | Cytotoxicity against human KB-7d cells after 72 hrs by MTT assay | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. |
| AID57061 | Percentage of intracellular covalent DNA-topoisomerase II complexes formed | 2002 | Journal of medicinal chemistry, May-23, Volume: 45, Issue:11
| Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method. |
| AID335669 | Inhibition of strand rejoining activity of human DNA topoisomerase 2 assessed as protein-DNA complex formation at 10 uM by cell-based assay | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8
| Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID95840 | Growth inhibitory activity (antiproliferative) against KB cell lines | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors. |
| AID42742 | GI values against CAKI-1 cells(renal carcinoma) | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents. |
| AID96389 | Concentration for 50% reduction in cell number after 3-day incubation | 1990 | Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
| Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID93836 | GI values against KB cells (nasopharyngeal carcinoma) | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents. |
| AID57193 | The compound was tested for inhibitory activity against human DNA topoisomerase-2. | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13
| Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles. |
| AID52061 | Effect on cellular protein DNA complex formation(%) at 10 uM in comparison with etoposide | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 124. New 4 beta-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID103709 | Effective dose of compound against replication of MCF-7 cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| AID253085 | Ratio of ED50 for KB-7d cells to that of KB cells | 2004 | Journal of medicinal chemistry, Oct-07, Volume: 47, Issue:21
| Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives. |
| AID667143 | Cytotoxicity against human KB cells by SRB assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of novel podophyllotoxin analogs. |
| AID42573 | The compound was tested for tumor cell growth inhibitory activity against human renal cancer(CAKI-1) cell line | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13
| Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles. |
| AID667144 | Cytotoxicity against human KBVIN cells by SRB assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of novel podophyllotoxin analogs. |
| AID94007 | Compound was evaluated for cytotoxicity against KB-7d cells at 10 uM concentration | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
| Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors. |
| AID1760330 | Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020). |
| AID94009 | Effective dose required for inhibition of KB-7d cell replication after 3 days of continuous treatment | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
| Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors. |
| AID57202 | Compound was tested for the inhibition of DNA topoisomerase II | 1991 | Journal of medicinal chemistry, Dec, Volume: 34, Issue:12
| Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID492484 | Cytotoxicity against human KB cells after 72 hrs by MTT assay | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. |
| AID243343 | Percentage of protein-linked DNA breaks in KB cells by [3H]thymidine incorporation | 2004 | Journal of medicinal chemistry, Oct-07, Volume: 47, Issue:21
| Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives. |
| AID96351 | Concentration required for 50% reduction in KB cell number after 3-day incubation | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 124. New 4 beta-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID211320 | Stimulation of in vitro Topoisomerase II-Linked DNA Complex Formation and Interference with Etoposide-Induced Cleavage at concentration 50 uM | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors. |
| AID95512 | Compound was evaluated for cytotoxicity against KB cells at 10 uM concentration | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
| Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors. |
| AID94330 | Effective dose of compound against replication of KB/7d cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| AID492485 | Cytotoxicity against human KB1 cells after 72 hrs by MTT assay | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. |
| AID52064 | Inhibition of cellular protein-DNA complex formation at 10 uM | 1990 | Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
| Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID95650 | Effective dose of compound against replication of KB cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| AID667141 | Cytotoxicity against human A549 cells by SRB assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of novel podophyllotoxin analogs. |
| AID96350 | Concentration required for 50% reduction in KB cell number after 3-day incubation | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins. |
| AID96044 | Cellular protein-DNA complex breaking activity against KB cells labeled with tritiated thymidine. | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13
| Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles. |
| AID230161 | The differential toxicity ratio was defined as IC50(KB/7d)/IC50(KB) | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors. |
| AID9244 | GI values against A549 cells (lung cancer) | 2001 | Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
| Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents. |
| AID246904 | Dose required to cause reduction in human nasopharyngeal KB cancer cells after 3 days incubation | 2004 | Journal of medicinal chemistry, Oct-07, Volume: 47, Issue:21
| Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives. |
| AID492487 | Cytotoxicity against human vincristine-resistant KB cells after 72 hrs by MTT assay | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. |
| AID53299 | Compound was evaluated for the inhibition of human DNA Topoisomerase II | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins. |
| AID57205 | Inhibitory activity against human DNA topoisomerase II | 1990 | Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
| Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. |
| AID243353 | Percentage of protein-linked DNA breaks in KB cells by [3H]thymidine incorporation at 5 ug/mL | 2004 | Journal of medicinal chemistry, Oct-07, Volume: 47, Issue:21
| Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives. |
| AID96032 | Lethal dose against KB cells when treated for 30 min | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
| Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors. |
| AID335666 | Cytotoxicity against human KB cells assessed as reduction in cell number after 3 days | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8
| Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID214403 | Effective dose of compound against replication of U87MG cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| AID94011 | Lethal dose against KB-7d cells when treated for 30 min | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
| Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors. |
| AID52060 | Effect on cellular protein DNA complex formation(%) at 10 uM in comparison with etoposide | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins. |
| AID211458 | Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Antitumor agents. 163. Three-dimensional quantitative structure-activity relationship study of 4'-O-demethylepipodophyllotoxin analogs using the modified CoMFA/q2-GRS approach. |
| AID335667 | Inhibition of human DNA topoisomerase 2 | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8
| Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II. |
| AID1597989 | Inhibition of HIF-1alpha in human U373 cells | 2019 | Journal of medicinal chemistry, 06-27, Volume: 62, Issue:12
| Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications. |
| AID211319 | Stimulation of in vitro Topoisomerase II-Linked DNA Complex Formation and Interference with Etoposide-Induced Cleavage at concentration 1 uM; Not determined | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors. |
| AID78823 | The compound was tested for tumor cell growth inhibitory activity against human ileocecal carcinoma (HCT-8) cell line | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13
| Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles. |
| AID94322 | Effective dose of compound against replication of KB-Vin cell line was evaluated | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |