Compounds > clitocine
Page last updated: 2024-12-07

clitocine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

clitocine: structure & RN given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID129111
CHEMBL ID304179
CHEBI ID178144
SCHEMBL ID182039
MeSH IDM0156060

Synonyms (25)

Synonym
105798-74-1
(2r,3r,4s,5r)-2-[(6-amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol
CHEBI:178144
clitocine
CHEMBL304179 ,
(2r,3r,4s,5r)-2-(6-amino-5-nitro-pyrimidin-4-ylamino)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
2-(6-amino-5-nitro-pyrimidin-4-ylamino)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
bdbm50100587
6-amino-5-nitro-4-(ribofuranosylamino)pyrimidine
unii-9z4qxq98qw
9z4qxq98qw ,
beta-d-ribofuranosylamine, n-(6-amino-5-nitro-4-pyrimidinyl)-
(2r,3r,4s,5r)-2-(6-amino-5-nitropyrimidin-4-ylamino)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
SCHEMBL182039
6-amino-5-nitro-4-(beta-d-ribo-furanosylamino) pyrimidine
n-(6-amino-5-nitro-4-pyrimidinyl)-beta-d-ribofuranosylamine
HY-118341
Q16949273
CS-0065721
F82267
MS-24099
DTXSID30909739
STARBLD0000883
AKOS040751216
PD157030

Research Excerpts

Overview

Clitocine is a natural amino nucleoside isolated from mushroom. It has been shown to inhibit cancer cell proliferation in vitro.

ExcerptReferenceRelevance
"Clitocine is a natural amino nucleoside isolated from mushroom and has been shown to inhibit cancer cell proliferation in vitro."( Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo.
Fung, KP; Li, H; Li, X; Liu, FY; Sun, JG; Wu, P; Zeng, X, 2014)		2.57

Treatment

ExcerptReferenceRelevance
"Clitocine treatment inhibited drug-resistant human cancer cell growth in vitro in a dose- and time-dependent manner."( Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo.
Fung, KP; Li, H; Li, X; Liu, FY; Sun, JG; Wu, P; Zeng, X, 2014)		2.57
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
N-glycosyl compoundA glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Adenosine kinaseHomo sapiens (human)IC50 (µMol)26.00000.00050.605210.0000AID91548
Adenosine kinaseHomo sapiens (human)Ki1.93330.01630.74153.0000AID33991; AID33992; AID33994
Adenosine kinaseRattus norvegicus (Norway rat)IC50 (µMol)2.00000.00170.58342.0000AID33996; AID33997
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (7)

Processvia Protein(s)Taxonomy
purine ribonucleoside salvageAdenosine kinaseHomo sapiens (human)
dATP biosynthetic processAdenosine kinaseHomo sapiens (human)
ribonucleoside monophosphate biosynthetic processAdenosine kinaseHomo sapiens (human)
GMP salvageAdenosine kinaseHomo sapiens (human)
AMP salvageAdenosine kinaseHomo sapiens (human)
dAMP salvageAdenosine kinaseHomo sapiens (human)
purine nucleobase metabolic processAdenosine kinaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
RNA bindingAdenosine kinaseHomo sapiens (human)
deoxyadenosine kinase activityAdenosine kinaseHomo sapiens (human)
ATP bindingAdenosine kinaseHomo sapiens (human)
metal ion bindingAdenosine kinaseHomo sapiens (human)
adenosine kinase activityAdenosine kinaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
nucleoplasmAdenosine kinaseHomo sapiens (human)
cytosolAdenosine kinaseHomo sapiens (human)
plasma membraneAdenosine kinaseHomo sapiens (human)
nucleusAdenosine kinaseHomo sapiens (human)
cytosolAdenosine kinaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID33994Inhibition of rabbit liver adenosine kinase1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Synthesis, intramolecular hydrogen bonding, and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside.
AID33991Binding affinity towards adenosine kinase1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Synthesis, intramolecular hydrogen bonding, and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside.
AID217934Inhibition of growth of human B lymphoblast derived W1-L2 cells1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Synthesis, intramolecular hydrogen bonding, and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside.
AID98697In vitro inhibition of L1210 cells1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Synthesis, intramolecular hydrogen bonding, and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside.
AID91548Inhibition of adenosine phosphorylation in confluent IMR-32 (human neuroblastoma) cells.2001Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13
Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor..
AID33992Inhibition of adenosine kinase from undialyzed W1-L2 lysate (0-50 uM)1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Synthesis, intramolecular hydrogen bonding, and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside.
AID33996In vitro inhibition of Adenosine kinase (AK)2001Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13
Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor..
AID33997In vitro inhibition of Adenosine kinase of rat brain cytosol.2001Bioorganic & medicinal chemistry letters, Sep-17, Volume: 11, Issue:18
Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (8.33)18.7374
1990's0 (0.00)18.2507
2000's5 (41.67)29.6817
2010's6 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.73

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.73 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.00 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.73)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
abt 702
[no description available]		210bipyridines
5'-amino-5'-deoxyadenosine
[no description available]		2.4120
abt-737
[no description available]		7.110aromatic amine;
aryl sulfide;
biphenyls;
C-nitro compound;
monochlorobenzenes;
N-arylpiperazine;
N-sulfonylcarboxamide;
secondary amino compound;
tertiary amino compound		anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor
adenosine kinase
Adenosine Kinase: An enzyme that catalyzes the formation of ADP plus AMP from adenosine plus ATP. It can serve as a salvage mechanism for returning adenosine to nucleic acids. EC 2.7.1.20.		7.3920
nitrophenols
Nitrophenols: PHENOLS carrying nitro group substituents.		2.110
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		01.9710
Chronic Illness
[description not available]		03.0610
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted
[description not available]		03.0610
Cirrhosis, Liver
[description not available]		03.0610
Cancer of Liver
[description not available]		03.0610
Acute Disease
Disease having a short and relatively severe course.		03.0610
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).		03.0610
Hepatitis C
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.		03.0610
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.		03.0610
Liver Neoplasms
Tumors or cancer of the LIVER.		03.0610
Cancer of Colon
[description not available]		02.5220
Colonic Neoplasms
Tumors or cancer of the COLON.		02.5220
Cancer of Ovary
[description not available]		02.1510
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.1510
Cancer of Cervix
[description not available]		02.0410
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX.		02.0410
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		0210