Sphingomyelin phosphodiesterase 2

A sphingomyelin phosphodiesterase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60906]

EC 3.1.4.12;
Lyso-platelet-activating factor-phospholipase C;
Lyso-PAF-PLC;
Neutral sphingomyelinase;
N-SMase;
nSMase;
nSMase1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
scyphostatin	Homo sapiens (human)	IC50	1.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
sphingomyelin phosphodiesterase activity	molecular function	Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+. [EC:3.1.4.12, RHEA:19253]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
phosphoric diester hydrolase activity	molecular function	Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. [EC:3.1.4.-]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

This protein is located in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 3 target(s):

Target	Category	Definition
cell periphery	cellular component	The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. [GOC:pdt]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
caveola	cellular component	A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. [GOC:mah, ISBN:0721662544, PMID:16645198]

This protein is involved in 4 target(s):

Target	Category	Definition
sphingomyelin catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]
sphingolipid catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732]
ceramide biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. [GOC:ai]
sphingomyelin metabolic process	biological process	The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. [ISBN:0198506732]