| Assay ID | Title | Year | Journal | Article |
|---|
| AID1249491 | Invivo inhibition of steroid sulfatase activity in rat liver at 10 mg/kg/day, po for 7 days | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health. |
| AID70989 | Compound was evaluated for its percent inhibition against the estrone sulfatase enzyme at a concentration of 10 uM | 2002 | Bioorganic & medicinal chemistry letters, May-20, Volume: 12, Issue:10
| Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). |
| AID1903873 | Inhibition of STS in human MCF7 cells assessed as residual enzyme activity using [3H]E1S as substrate at 100 nM incubated for 20 hrs by radioisotope cellular assay relative to control | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Development of Sulfamoylated 4-(1-Phenyl-1 |
| AID70847 | Compound was evaluated for its inhibitory activity against estrone sulfatase enzyme | 2002 | Bioorganic & medicinal chemistry letters, May-20, Volume: 12, Issue:10
| Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). |
| AID70999 | Inhibitory activity against estrone sulfatase expressed as potency | 2001 | Bioorganic & medicinal chemistry letters, Sep-17, Volume: 11, Issue:18
| Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES). |
| AID70851 | Inhibition of Estrone sulfatase | 2001 | Bioorganic & medicinal chemistry letters, Mar-26, Volume: 11, Issue:6
| Novel inhibitors of the enzyme estrone sulfatase (ES). |
| AID71002 | Relative potency EMATE against Estrone sulfatase | 2001 | Bioorganic & medicinal chemistry letters, Mar-26, Volume: 11, Issue:6
| Novel inhibitors of the enzyme estrone sulfatase (ES). |
| AID257062 | Inhibition of recombinant human cytosolic isozyme CA I | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23
| Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. |
| AID70841 | In vivo inhibition against Estrone sulfatase (E1-STS) after preincubating the enzyme with 10 uM | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates. |
| AID1249490 | Inhibition of STS activity in human MCF7 cells | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health. |
| AID70998 | In vitro inhibition of estrone sulfatase at 1 mM. | 2002 | Bioorganic & medicinal chemistry letters, May-06, Volume: 12, Issue:9
| The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds. |
| AID205794 | Inhibitory potency against recombinant human steroid sulfatase relative to compound 3 = 1 | 2000 | Bioorganic & medicinal chemistry letters, May-01, Volume: 10, Issue:9
| New fluorogenic substrate for the first continuous steroid sulfatase assay. |
| AID70813 | In vitro inhibition of Estrone Sulfatase in placental microsomes at a concentration of 10 uM. | 1998 | Journal of medicinal chemistry, Mar-26, Volume: 41, Issue:7
| Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase. |
| AID70812 | In vitro inhibition of Estrone Sulfatase in intact MCF-7 breast cancer cells at a concentration of 10 uM. | 1998 | Journal of medicinal chemistry, Mar-26, Volume: 41, Issue:7
| Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase. |
| AID70855 | In vitro inhibition of estrone sulfatase. | 2002 | Bioorganic & medicinal chemistry letters, May-06, Volume: 12, Issue:9
| The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds. |
| AID26792 | Partition coefficient (logP) | 2001 | Bioorganic & medicinal chemistry letters, Sep-17, Volume: 11, Issue:18
| Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES). |
| AID70849 | Inhibitory activity against Estrone Sulfatase | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17
| Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID55982 | In vivo inhibition against dehydroepiandrosterone sulfatase (DHA-STS) in placental microsomes | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates. |
| AID70814 | In vitro inhibition of Estrone Sulfatase in placental microsomes at a concentration of 100 uM. | 1998 | Journal of medicinal chemistry, Mar-26, Volume: 41, Issue:7
| Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase. |
| AID257065 | Inhibition of cloned human transmembrane, tumor-associated isozyme CA IX | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23
| Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. |
| AID70818 | Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes) | 2002 | Bioorganic & medicinal chemistry letters, May-20, Volume: 12, Issue:10
| A novel type of nonsteroidal estrone sulfatase inhibitors. |
| AID70842 | In vivo inhibition against Estrone sulfatase (E1-STS) at 10 uM concentration | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates. |
| AID1903876 | Inhibition of STS in human MCF7 cells assessed as reduction in [3H]estradiol and [3H]estrone formation using [3H]estrone sulfate as substrate incubated for 20 hrs | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Development of Sulfamoylated 4-(1-Phenyl-1 |
| AID70816 | Tested for the inhibitory activity against Estrone Sulfatase | 2001 | Bioorganic & medicinal chemistry letters, Dec-03, Volume: 11, Issue:23
| Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism. |
| AID70848 | Inhibitory activity against estrone sulfatase enzyme | 1999 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 9, Issue:12
| Derivation of a possible transition-state for the reaction catalysed by the enzyme estrone Sulfatase (ES). |
| AID1438382 | Inhibition of placental microsomal steroid sulfatase (unknown origin) | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors. |
| AID257063 | Inhibition of recombinant human cytosolic isozyme CA II | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23
| Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. |
| AID70815 | In vitro inhibition of Estrone Sulfatase in placental microsomes at a concentration of 50 uM. | 1998 | Journal of medicinal chemistry, Mar-26, Volume: 41, Issue:7
| Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase. |
| AID70823 | Inhibitory activity against Estrone sulfatase (E1-STS) in MCF-7 breast cancer cells at 0.1 uM | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates. |
| AID70839 | Estrogenic potency against Estrone sulfatase (E1-STS) was determined in vivo by administering to rats | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates. |
| AID71010 | Inhibition of estrone sulfatase | 2004 | Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
| Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID71004 | Relative potency against Estrone sulfatase | 2001 | Bioorganic & medicinal chemistry letters, Mar-26, Volume: 11, Issue:6
| Novel inhibitors of the enzyme estrone sulfatase (ES). |
| AID70853 | Inhibition of estrone sulfatase (ES) | 2001 | Bioorganic & medicinal chemistry letters, Sep-17, Volume: 11, Issue:18
| Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES). |
| AID19447 | Partition coefficient (logP) | 2004 | Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
| Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID19203 | Calculated partition coefficient (clogP) | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17
| Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID71001 | Inhibitory activity against estrone sulfatase relative to Estrone-3-sulfamate (EMATE) | 2001 | Bioorganic & medicinal chemistry letters, Sep-17, Volume: 11, Issue:18
| Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES). |
| AID257064 | Inhibition of recombinant human mitochondrial isozyme CA VA | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23
| Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. |
| AID205787 | Tested for inhibitory potency against recombinant human steroid sulfatase | 2000 | Bioorganic & medicinal chemistry letters, May-01, Volume: 10, Issue:9
| New fluorogenic substrate for the first continuous steroid sulfatase assay. |
| AID1600012 | Inhibition of steroid sulfatase (unknown origin) | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Sulfamates in drug design and discovery: Pre-clinical and clinical investigations. |
| AID26348 | pKa value was determined | 2004 | Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
| Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID70811 | In vitro inhibition of Estrone Sulfatase in intact MCF-7 breast cancer cells at a concentration of 1.0 uM. | 1998 | Journal of medicinal chemistry, Mar-26, Volume: 41, Issue:7
| Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase. |
| AID71013 | Inhibitory activity against estrone sulfatase at 12 uM (initial screening) | 2004 | Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
| Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID70682 | In vitro inhibition of Estrone Sulfatase in intact MCF-7 breast cancer cells at a concentration of 0.1 uM. | 1998 | Journal of medicinal chemistry, Mar-26, Volume: 41, Issue:7
| Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase. |
| AID19659 | Partition coefficient (logP) | 2002 | Bioorganic & medicinal chemistry letters, May-20, Volume: 12, Issue:10
| Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). |
| AID70991 | Compound was tested for the Inhibitory activity against the Estrone Sulfatase at a concentration of 10 uM | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17
| Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID70993 | Compound was tested for the Inhibitory activity against the Estrone Sulfatase at a concentration of 50 uM | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17
| Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |